Zhao-Qi Wang - Selected publications#

1. Wang, Z.-Q., Ovitt, C., Grigoriadis, A. E., Möhle-Steinlein, U., Rüther, U. & Wagner, E. F. Bone And Haematopoiesis Defects In Mice Lacking C-Fos. Nature 360:741-745 (1992)
   
2. Grigoriadis, A.E., Wang, Z.-Q., Cecchini, M.G., Hofstetter, W., Felix, R., Fleisch, H. A. & Wagner, E.F. C-Fos: A Key Regulator Of Osteoclast/Macrophage Lineage Determination And Bone Remodeling. Science 266:443-448 (1994)
   
3. Wang, Z.-Q., Auer, B., Stingl, L., Berghammer, H., Haidacher, D., Schweiger, M. & Wagner, E.F. Mice Lacking ADPRT And Poly(ADP-Ribosyl)Ation Develop Normally But Are Susceptible To The Skin Lesions. Genes & Devel. 9:509-520 (1995)
   
4. Wang, Z.-Q., Kiefer, F., Urbanek, P. & Wagner, E.F. Generation Of Completely Embryonic Stem Cell-Derived Mutant Mice Using Tetraploid Blastocyst Injection. Mech. Devel. 62:137-145 (1997)
   
5. Wang, Z.-Q., Stingl, L., Morrison, C., Jantsch, M., Los, M., Schulze-Osthoff, K., & Wagner, E. F. PARP Is Important For Genomic Stability But Dispensable In Apoptosis. Genes & Devel. 11:2347-2358 (1997)
   
6. Eliasson, M. J. L., Sampei, K., Mandir, A. S., Hurn, P. D., Traystman, R. J., Bao, J., Pieper, A., Wang, Z.-Q., Dawson, T. M., Snyder, S. H. & Dawson, V. L. Poly(ADP-Ribose) Polymerase Gene Disruption Renders Mice Resistant To Cerebral Ischemia. Nature Med. 3:1089-1095 (1997)
   
7. Morrison, C., Smith, G.C.M., Stingl., L., Jackson, S.P., Wagner, E.F. & Wang, Z.-Q. Genetic Interaction Between PARP And DNA-PK In V(D)J Recombination And Tumorigenesis. Nature Genet. 17:479-482 (1997)
   
8. Burkart, V., Wang, Z.-Q., Radons, J., Heller, B., Herceg, Z., Stingl, L., Wagner, E.F. & Kolb, H. Mice Lacking The Poly(ADP-Ribose) Polymerase Gene Are Resistant To Pancreatic Beta-Cell Destruction And Diabetes Development Induced By Streptozotocin. Nature Med. 5:314-319 (1999)
   
9. D’Adda di Fagagna, F., Hande, M.P., Tong, W.-M., Lansdorp, P.M., Wang, Z.-Q. & Jackson, S.P. Functions Of Poly(ADP-Ribose) Polymerase In Controlling Telomere Length And Chromosomal Stability. Nature Genet. 23:76-80 (1999)
   
10. Tong, W.-M., Hande, M.P., Lansdorp, P.M. & Wang, Z.-Q. DNA Strand Break-Sensing Molecule Poly(ADP-Ribose) Polymerase Cooperates With P53 In Telomere Function, Chromosome Stability, And Tumor Suppression. Mol. Cell. Biol. 21:4046-4054 (2001)
    
11. Herceg, Z., Hulla, W., Gell, D., Cuenin, C., Lleonart, M., Jackson, S.P. & Wang, Z.-Q. Trrap Disruption Causes Early Embryonic Lethality And Defects In Cell Cycle Progression. Nature Genet. 29:206-211 (2001)
    
12. Tong, W.-M., Cortes U., Hande M. P., Ohgaki H., Cavalli L. R., Lansdorp P. M., Haddad B. R., & Wang Z.-Q. Synergistic Role Of Ku80 And Poly(ADP-Ribose) Polymerase In Suppressing Hepatocellular Carcinoma In Mice. Cancer Res. 62:6990-6996 (2002).
    
13. Dumon-Jones, V., Frappart, P.-O., Tong, W.M., Sajithal, G., Hulla, W., Schmid, G., Herceg, Z., Digweed, M. & Wang, Z.-Q. Nbn Heterozygosity Renders Mice Susceptible To Tumor Formation And Ionizing Ration-Induced Tumorigenesis. Cancer Res. 63:7263-7269 (2003)
    
14. Zong, W.-X., Ditsworth, D., Bauer, D., Wang, Z.-Q. & Thompson, C.B. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes & Devel. 18:1272-1282 (2004)
    
15. Perspectives by Deirdre A. Nelson and Eileen White: Exploiting different ways to die. Genes & Devel 18:1223-1226 (2004)
    
16. Cortes, U., Tong, W.-M., Coyle, D.L., Meyer-Ficca, M.L., Meyer, R.G., Petrilli, V., Herceg, Z., Jacobson, E.L., Jacobson, M.K. & Wang, Z.-Q. Depletion of the 110-Kilodalton isoform of Poly(ADP-Ribose) Glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice. Mol. Cell Biol. 24(16):7163-7178 (2004)
    
17. Nakanishi K., Yang Y.-G., Pierce, A.J., Taniguchi, T., Digweed, M., D'Andrea, A.D., Wang, Z.-Q. & Jasin, M. Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair at an early step. Proc. Natl. Acad. Sci. USA, 102:1110-1115 (2005)
    
18. Cuzzocrea, S, Di Paola, R., Mazzon, E., Cortes, U., Genovese, T., Muià, C., Li, W., Xu, W., Li, J.-H., Zhang, J. & Wang, Z.-Q. Inactivation of poly(ADP-ribose) glyhydrolase (PARG) attenuates intestinal injury induced by splanchnic artery occlusion and reperfusion. FASEB J, 19(6):558-566 (2005)
    
19. Frappart, P.-O., Tong, W.-M., Demuth, I., Radovanovic, I., Herceg, Z., Aguzzi, A., Digweed, M., & Wang, Z.-Q. An essential function for Nijmegen Breakage Syndrome gene (NBS1) and DNA damage response in the prevention of ataxia and cerebellar defects. Nature Med., 11:538-544 (2005)
    
20. News and Views by Carrollee Barlow and Kai Treuner: DNA instability in the brain:survival of the “fittest”. Nat. Med. 11:474-475 (2005)
    
21. Murr, R., Loizou J., Yang, Y.-G., Cuenin, C., Li, H., Wang, Z.-Q. & Herceg, Z. Histone acetylation by Trrap/Tip60 HAT modulates loading of repair proteins to DNA breaks and repair of DNA double strand breaks. Nature Cell Biol., 8(1):91-99. (2006)
    
22. News & Views by Michael Downey & Daniel Durocher: Chromatin and DNA repair: the benefits of relaxation. Nature Cell Biol., 8(1):9-10. (2006)
    
23. Yang, Y.-G., Saidi, A., Frappart, P.-O., Min, W., Barrucand, C., Dumon-Jones, V., Michelon, J., Herceg, Z., & Wang, Z.-Q. Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks. EMBO. J 25(23):5527-5538 (2006)
    
24. Gruber, R., Zhou, Z., Sukchev, M., Joerss, T., Frappart, P.-O. & Wang, Z.-Q. MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry via the Chk1-Cdc25 pathway. Nat. Cell Biol. 13(11):1325-34 (2011).
    
25. Dispatch by Priyanka Singh & Clemens Cabernard. Neurogenesis: Prmature mitotic entry lets cleavage planes take off! Curr. Biol. 22(1):R25-R28 (2011)
    
26. Zhou, Z., Bruhn, C., & Wang, Z.-Q. Differential Function Of NBS1 And ATR In Neurogenesis. DNA Repair 11(2):210-21 (2012).
    
27. Lee, M. K. Tong, W.-M., Wang, Z.-Q. & Sabapathy, K. Mutant p53 functions in vivo - dominant-negative effect is cell-type specific, dose-dependent and regulates acute response whereas gain-of-function property is mutation-type specific. Cancer Cell (2012) in press.