Mone Zaidi - Selected Publications#

A corpus of contemplative investigation from Mone Zaidi on new actions of pituitary hormones have revolutionized our understanding of endocrine physiology and has led to the unmasking of new therapeutic targets for osteoporosis, obesity and neurodegeneration. H–index: 79.

Abe, E., Marians, R., Wu, X-B., Iqbal, J., Ando, T., Blair, H.C., Davies, T.F., Zaidi, M. (2003) TSH is a negative regulator of bone remodeling. Cell 175: 151-162.

Sun, L., Zhang, Z., Iqbal, J., Zaidi, S., Papachristou, D.J., Zhou, H., Sharrow, A.C., Peng, Y., Yaroslavskiy, B.B., Zhu, L.-L., Zallone, A., Sairam, M.R. Kumar, T.R., Landa, L.C., Schaffler, M.B., Moonga, B.S., Blair, H.C., Zaidi, M. (2006) FSH directly regulates bone mass. Cell 125: 247-260.

Zaidi, M. (2007) Skeletal remodeling in health and disease. Nature Medicine 13: 791-801 (Invited Review).

Sun, L., Zhu, L.-L., Lu, P., Yuen, T., Li, J., Ma, R., Baliram, R., Moonga, S.S., Liu, P., Zallone, A., New, M., Davies, T.F., Zaidi, M. (2013) Genetic confirmation for a central role for TNFα in the direct action of TSH on the skeleton. Proceedings of the National Academy of Sciences 110: 9891-9896.

Sun, L., Tamma, R., Yuen, T., Colaianni, G., Ji, Y., Cuscito, C., Bailey, J., Dhawan, S., Lu, P., Calvani, C.D., Zhu, L.-L., Zambonin, C.G., Di Benedetto, A., Stachnik, A., Liu, P., Grano, M., Colucci, S., Davies, T.F., New, M., Zallone, A., Zaidi, M. (2016) Functions of vasopressin and oxytocin in bone mass regulation. Proceedings of the National Academy of Sciences 113: 164-169.

Liu, P., Ji, Y., Yuen, T., Rendina-Ruedy, E., Demambro, V.E., Dhawan, S., Abu-Amer, W., Izadmehr, S., Zhou, B., Shin, A.C., Latif, R., Thangeshwaran, P., Gupta, A., Li, J., Shnayder, V., Robinson, S.T., Yu, Y.E., Zhang, X., Yang, F., Lu, P., Zhou, Y., Zhu, L.-L., Oberlin, D.J., Davies, T.F., Reagan, M.R., Brown, A., Kumar, T.R., Epstein, S., Iqbal, J., Avadhani, N., New, M.I., Molina, H., van Klinken, J.B., Guo, E.X., Buettner, C., Haider, S., Bian, Z., Sun, L., Rosen, C.J., Zaidi, M. (2017) Blocking FSH induces thermogenic adipose tissue and reduces body fat. Nature 546: 107-112 (article).

Accompanying commentaries in Nature Medicine, Cell Metabolism, New England Journal of Medicine, Nature Endocrinology Reviews, Nature Drug Discovery, New York Times, and Newsweek. Selected by Nature Medicine as one of 8 "Notable Advances" for 2017.

Ji, Y., Liu, P., Yuen, T., Haider, S., Bloch, M., Romero, R., Kim, S.-M., Munshi, L., Iqbal, J., Demambro, V., New, M., Zhuan, B., Rosen, C.J., Sun, L., Zaidi, M. (2018) Epitope-specific antibodies to FSHβ increase bone mass. Proceedings of the National Academy of Sciences 115: 2192-2197.

Gera, S., Sant, D., Haider, S., Korkmaz, F., Kuo, T.-C., matthew, M., Perez-Pina, H, Xie, H., Chen, H., Battista, R., Ma, K., Cheng, Z., Hadelia, E., Robinson, C., MacDonald, A., Miyashita, S., Williams, A., Jebian, G., Miyashita, S., Gumerova, A., Iveleva, K., Taneja, C., Xie, H., Miyashita, H., Iveleva, K., Smith, P., He, J., Ryu, V., DeMambro, V., Quinn, M., Meseck, M., Kim, S.-M., Kumar, T.R., Iqbal J., New, M.I., Lizneva, D., Rosen, C.J., Hsueh, A.J., Yuen, T., Zaidi, M. (2020) First–in–class humanized FSH blocking antibody targets bone and fat. Proceedings of the National Academy of Sciences 117: 28971-28979.

Xiong, J., Kang, S.S., Wang, Z., Liu, X., Kuo, T.-C., Korkmaz, F., Padilla, A., Miyashita, S., Chan, P., Zhang, Z.., Kastel, P., Burgess, J., Gumerova, A., Iveleva, K.., Sant, D., Yu, S-P., Muradova, V., Frolinger, T., Lizneva, D., Iqbal, J., Goosens, K.A., Gera, S., Rosen, C.J., Haroutunian, V., Ryu, V., Yuen, T., Zaidi, M.^, Ye, K^. (2022) FSH inhibition improves cognition in mice with Alzheimer’s disease. Nature 603: 470-476 (Article) (^joint senior authors).

Zaidi, M., Yuen, T., Kim, S.-M. (2023) Pituitary crosstalk with bone, body fat and brain. Nature Reviews Endocrinology doi: 10.1038/s41574-023-00894-5 (Invited Review).