Zhigang Tian - Selected Publications#

Total 407 publications in English in peer reviewed journal with 18,585 citations and H-index 68 in Web of Science.

1. Bai L, Vienne M, Tang L, Kerdiles Y, Etiennot M, Escalière B, Galluso J, Wei H, Sun R*, Vivier E*, Peng H*, Tian Z*. Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop. Science 2021; 371(6536):eaba4177

(Almetric: in the top 5% of all research outputs; 13 cites including 3 by Nat Rev Immunol and 2 by Nat Immunol; this study demonstrated the origin of ILC1/liver-resident NK cells (lrNK cells or CD49a+ NK cells) we founded in 2013--Peng H ... Tian Z*. Liver-resident NK cells confer adaptive immunity in skin-contact inflammation. J Clin Invest. 2013, 123(4):1444-1456.)

2. Zhou Y, Fu B*,Xu X, Zhang J, Tong X, Wang Y, Dong Z, Zhang X, Shen N, Zhai Y, Kong X, Sun R, Tian Z*, Wei H*. PBX1 expression in uterine natural killer cells drives fetal growth. Sci.Transl. Med. 2020; 12:1798. (Almetric: in the top 25%; 13 cites; demonstrating our CD49a+ NK cells in uterine support fetus growth by cytokines transcriptionally controlled by PBX1.)

3. Zhou J, Peng H*, Li K, Qu K, Wang B, Wu Y, Ye L, Dong Z, Wei H, Sun R, Tian Z*. Liver-resident NK cells control antiviral activity of hepatic T cells via PD-1/PD-L1 axis. Immunity 2019; 50:403-417. (Almetric: in the top 5%; 60 cites by Nat Rev Immunol, Nature, Immunity, Nat Immunol and Sci Immunol, etc.; demonstrating local homeostatic controlling of T cells by our CD49a+ NK cells.)

4. Zheng X, Qian Y, Fu B, Jiao D, Jiang Y, Chen P, Shen Y, Zhang H, Sun R, Tian Z*, Wei H*. Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance. Nat Immunol 2019; 20:1656-1667. (Almetric: in the top 5%; 59 cites by Cell, Immunity, Nat Immunol (3 cites), etc. with 1 NI Editorial entitled with "How to wake a killer" demonstrating manipulating mitochondrial morphology of exhausted tumor-derive NK cells restores their metablic fitness.)

5. Sun H, Huang Q, Huang M, Wen H, Lin R, Zheng M, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z*, Sun C* . Human CD96 correlates to NK cell exhaustion and predicts the prognosis of human hepatocellular carcinoma. Hepatology. 2019 Jul;70(1):168-183. (Almetric: in the top 25%; 80 cites by Nature, Immunity and Annual Rev Cancer Biol, etc., demonstrating human CD96 inhibitory receptor involves in exhaustion of liver tumor-derive NK cells in HCC patients.)

6. Zhang Q, Bi J, Zheng X, Chen Y, Wang H, Wu W, Wang Z, Wu Q, Peng H, Wei H, Sun R*, Tian Z*. Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity. Nat Immunol 2018; 723–732 . (Almetric: in the top 5%; 341 cites by Nature, Cell, Immunity, Nat Immunol, Sci Immunol, Nat Cancer, Nat Cell Biol, Nat Rev Immunol, Nat Rev Cancer, Nat Rev Clinic Oncol, Annual Rev Immunol, Annual Rev Cancer Biol, etc. with an NI Editorial entitled with "Checkpoint inhibition: NK cells enter the scene" firstly demonstrating targeting TIGIT on tumor-infiltrating NK cells reverses their exhaustion.)

7. Cong J, Wang X, Zheng X, Wang D, Fu B, Sun R, Tian Z*, Wei H*. Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression. Cell Metab 2018: 28:243-255. (Almetric: in the top 25%; 96 cites by Nat Rev Immunol, Nat Immunol with 2, Nat Rev Drug Disc, Cell Stem Cell, Annual Rev Cancer Biol and Cell Metabol with 1 Editorial entitled with "Sweet Killers: NK cells need glycolysis to kill tumors". )

8. Wang X, Peng H*, Cong J, Wang X, Lian Z, Wei H, Sun R*, Tian Z*. Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis. Nat Commun. 2018 Nov 19;9(1):4854. (Almetric: in the top 25%; 23 cites; this is the first study to comprehensively describe how memory formation of innate lymphocyte with our CD49a+ NK cells/ILC1 as an example.)

9. Fu B, Zhou Y, Ni X, Tong X, Xu X, Dong Z, Sun R, Tian Z*, Wei H*. Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors. Immunity 2017; 47:1100-1113. (Almetric: in the top 5%; 405 cites by Science, Sci Tranl Med, Nat Med, Nat Neurosci, Nat Rev Neurosci, Nat Rev Dis Prim, Immunity, etc. this is the first study to demonstrate our CD49a+ uterine NK cells support fetus growth by producing cytokines.)

10. Chen S, Yang M, Du J, Li D, Li Z, Cai C, Ma Y, Zhang L, Tian Z*, Dong Z*. The Self-Specific Activation Receptor SLAM Family Is Critical for NK Cell Education. Immunity 2016; 45:292-304. (Almetric: in the top 25%; 23 cites including 2 by Immunity. this is the first study to demonstrate SLAM receptor family plays a critical role in NK cell education and maturation.)