Manuel Serrano - Selected Publications#

Serrano M, Hannon G, Beach D (1993). A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature, 336, 704-707.
Citations: 3207

Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602.
Citations: 3322

Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher AJ, Barradas M, Benguría A, Zaballos A, Flores JM, Barbacid M, Beach D, Serrano M (2005). Senescence in premalignant tumours. Nature 436, 642.
Citations: 936

Efeyan A, García-Cao I, Herranz D, Velasco-Miguel S, Serrano M (2006). Policing of oncogene activity by p53. Nature 443, 159.
Matheu A, Maraver A, Klatt P, Flores I, García-Cao I, Borras C, Flores JM, Viña J, Blasco MA, Serrano M (2007). Delayed aging through damage protection by the Arf/p53 pathway. Nature 448, 375-379.
Citations: 349

Li H, Collado M, Villasante A, Strati K, Ortega S, Cañamero M, B3207lasco MA, Serrano M (2009). The Ink4/Arf locus is a barrier for iPS reprogramming. Nature 460, 1136-1139.
Citations: 673

Abad M, Mosteiro L, Pantoja C, Cañamero M, Rayón T, Ors I, Graña O, Megías D, Domínguez O, Martínez D, Manzanares M, Ortega S, Serrano M (2013). Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature 502, 340-345 (2013).
Awarded "Major Advance of the Year 2013" in the field of stem cells by Nature Medicine

Muñoz-Espín D, Cañamero M, Maraver A, Gómez-López G, Contreras J, Murillo-Cuesta S. Rodríguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M (2013). Programmed cellular senescence during embryonic development. Cell 21, 1104-1118 (2013).
Citations: 430

Mosteiro L, Pantoja C, Alcazar N, Marión RM, Chondronasiou D, Rovira M, Fernández-Marcos PJ, Muñoz-Martin M, Blanco-Aparicio C, Pastor J, Gómez-López G, de Martino A, Blasco MA, Abad M and Serrano M (2016). Tissue damage and senescence provide critical signals for cellular reprogramming in vivo. Science 354, 6315. pii: aaf4445.

Lynch, C.J., Bernard, R., Martínez-Val, A., Shahbazi, M.N., Nóbrega-Pereira, S., Calvo, I., Blanco-Aparicio, C., Tarantino, C., Garreta, E., Richart-Ginés, L., Alcazar, N., Graña-Castro, O., Gómez-Lopez, G., Aksoy, I., Muñoz-Martín, M., Martinez, S., Ortega, S., Prieto, S., Simboeck, E., Camasses, A., Stephan-Otto Attolini, C., Fernández, A.F., Sierra, M.I., Fraga, M.F., Pastor, J., Fisher, D., Montserrat, N., Savatier, P., Muñoz, J., Zernicka-Goetz, M. and Serrano, M. (2020). Global hyperactivation of enhancers stabilizes human and mouse naïve pluripotency. Nat. Cell Biol. 22, 1223-1238.