Manuel Serrano - Biography#

Manuel Serrano obtained his PhD in 1991, at the University of Madrid (UAM). From 1991 to 1996, Serrano worked as a postdoctoral researcher in the team of David Beach in Cold Spring Harbor Laboratory, NY. During this period, Serrano made one of his most important discoveries with the identification and characterization of the gene p16, a key tumor suppressor and inducer of cellular senescence. In 1997, Serrano reported the phenomenon of "oncogene-induced senescence", which has been transformative for the understanding of cancer development and cancer therapy. Serrano returned to Spain in 1997 to lead a research group, first at the National Center of Biotechnology (CNB), and then, from 2003 to 2017, at the Spanish National Cancer Research Center (CNIO), both in Madrid. In 2017, Serrano moved to the Institute for Research in Biomedicine (IRB), in Barcelona.

Manuel Serrano is internationally recognized in the field of tumor suppression, senescence and aging. The Serrano team was pioneer in the generation of genetically-modified mice resistant to damage and cancer. During the last years, the research interests of his group have extended to cellular reprogramming in relation to aging. The Serrano laboratory was first in demonstrating that cellular reprogramming into pluripotency is possible within tissues in vivo, and this was considered Advance of the Year 2013 by Nature Medicine. The focus of his laboratory is to apply their knowledge on senescence and reprogramming to degenerative diseases such as lung, kidney and heart fibrosis, as well as, to cancer therapy.

H-index: 75
Accumulated number of citations: 37,915 citations
Total number of peer reviewed papers: 292
List of publications