Alexander Schier - Selected Publications#
1990
1. Gibson, G., Schier, A., LeMotte, P. and Gehring, W.J. (1990). The specificities of Antennapedia and Sex combs reduced are defined by a distinct portion of each protein that includes the homeodomain. Cell 62, 1087-1103.
2. Pick, L., Schier, A., Affolter, M., Schmidt-Glenewinkel, T. and Gehring, W.J. (1990). Analysis of the ftz upstream element: germ-layer specific enhancers are independently autoregulated. Genes Dev. 4, 1224-1239.
3. Affolter, M., Schier, A. and Gehring, W.J. (1990). Homeodomain proteins and the regulation of gene expression. Current Opinions in Cell Biology 2, 485-495.
1992
4. Schier, A.F. and Gehring, W.J. (1992). Direct homeodomain-DNA interactions in the autoregulation of the Drosophila segmentation gene fushi tarazu. Nature 356, 804-807.
1993
5. Affolter, M., Walldorf, U., Kloter, U., Schier, A.F., and Gehring, W.J. (1993) Regional repression of a Drosophila POU box gene in the endoderm involves inductive interactions between germ layers. Development 117, 1199-1210.
6. Schier, A.F. and Gehring, W.J. (1993). Analysis of a fushi tarazu autoregulatory element: multiple sequence elements contribute to enhancer activity. EMBO J. 12, 1111-1119.
7. Schier, A.F. and Gehring, W.J. (1993) Functional specificity of the homeodomain protein fushi tarazu: The role of DNA-binding specificity in vivo. Proc. Natl. Acad. Sci. USA 90, 1450-1454.
1994
8. Gehring, W.J., Qian, Y.Q., Billeter, M., Furukubo-Tokunaga, K., Schier, A.F., Resendez-Perez, D., Affolter, M., Otting, G., and Wuethrich, K. (1994). Homeodomain-DNA recognition. Cell, 78, 211-223.
9. Solnica-Krezel, L., Schier, A.F., and Driever, W. (1994) Efficient recovery of ENU-induced mutations from the zebrafish germline. Genetics 136, 1401-1420.
10. Driever, W., Stemple, D., Schier, A., and Solnica-Krezel, L. (1994). Zebrafish: Genetic tools for studying vertebrate development. Trends in Genetics, 10, 152-159.
1995
11. Andjelkovic, M., Jones, P.F., Grossniklaus, U., Cron, P., Schier, A.F., Dick, M., Bilbe, G., and B.A. Hemmings (1995). Developmental regulation of expression and activity of multiple forms of the Drosophila RAC protein kinase. Journal of Biological Chemistry 270, 4066-4075.
1996
12. Driever, W., Solnica-Krezel, L., Schier, A.F., Neuhauss, S. C. F., Malicki, J., Stemple, D. L., Stainier, D. Y. R., Zwartkruis, F., Abdelilah, S., Rangini, Z., Belak, J. and Boggs, C. (1996). A genetic screen for mutations affecting embryogenesis in zebrafish. Development 123, 37 - 46
13. Solnica-Krezel, L., Stemple, D. L., Mountcastle-Shah, E., Rangini, Z., Neuhauss, S. C. F., Malicki, J., Schier, A.F., Stainier, D. Y. R., Zwartkruis, F., Abdelilah, S. and Driever, W. (1996). Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish. Development 123, 67 - 80
14. Stemple, D. L., Solnica-Krezel, L., Zwartkruis, F., Neuhauss, S. C. F., Schier, A.F., Malicki, J., Stainier, D. Y. R., Abdelilah, S., Rangini, Z., Mountcastle-Shah, E. and Driever, W. (1996). Mutations affecting development of the notochord in zebrafish. Development 123, 117 - 128
15. Abdelilah, S., Mountcastle-Shah, E., Harvey, M., Solnica-Krezel, L., Schier, A.F., Stemple, D.L., Malicki, J., Neuhauss, S. C. F., Zwartkruis, F., Stainier, D. Y. R., Rangini, Z. and Driever, W. (1996). Mutations affecting neural survival in the zebrafish, Danio rerio. Development 123, 217 - 227
16. Malicki, J., Neuhauss, S. C. F., Schier, A.F., Solnica-Krezel, L., Stemple, D. L., Stainier, D.Y.R., Abdelilah, S., Zwartkruis, F., Rangini, Z. and Driever, W. (1996). Mutations affecting development of the zebrafish retina. Development 123, 263 - 273
17. Malicki, J., Schier, A.F., Solnica-Krezel, L., Stemple, D. L., Neuhauss, S. C. F., Stainier, D.Y.R., Abdelilah, S., Rangini, Z., Zwartkruis, F. and Driever, W. (1996). Mutations affecting development of the zebrafish ear. Development 123, 275 - 283
18. Stainier, D. Y. R., Fouquet, B., Chen, J.-N., Warren, K. S., Weinstein, B. M., Meiler, S., Mohideen, M.-A. P. K., Neuhauss, S. C. F., Solnica-Krezel, L., Schier, A.F., Zwartkruis, F., Stemple, D. L., Malicki, J., Driever, W. and Fishman, M. C. (1996). Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development 123, 285 - 292
19. Weinstein, B. M., Schier, A.F., Abdelilah, S., Malicki, J., Solnica-Krezel, L., Stemple, D. L., Stainier, D. Y. R., Zwartkruis, F., Driever, W. and Fishman, M. C. (1996). Hematopoietic mutations in the zebrafish. Development 123, 303 - 309
20. Pack, M., Solnica-Krezel, L., Malicki, J., Neuhauss, S. C. F., Schier, A.F., Stemple, D. L., Driever, W. and Fishman, M. C. (1996). Mutations affecting development of zebrafish digestive organs. Development 123, 321 - 328
21. Neuhauss, S. C. F., Solnica-Krezel, L., Schier, A.F., Zwartkruis, F., Stemple, D. L., Malicki, J., Abdelilah, S., Stainier, D. Y. R. and Driever, W. (1996). Mutations affecting craniofacial development in zebrafish. Development 123, 357 - 367
22. Schier, A.F., Neuhauss, S. C. F., Harvey, M., Malicki, J., Solnica-Krezel, L., Stainier, D. Y. R., Zwartkruis, F., Abdelilah, S., Stemple, D. L., Rangini, Z., Yang, H. and Driever, W. (1996). Mutations affecting the development of the embryonic zebrafish brain. Development 123, 165 - 178
23. Schier, A.F., Joyner, A.L., Lehmann, R., and Talbot, W.S. (1996) From screens to genes: prospects for insertional mutagenesis in zebrafish. Genes Dev. 10, 3077-3080.
1997
24. Schier, A.F., Neuhauss, S., Helde, K., Talbot, W., and Driever, W. (1997). The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail. Development 124, 327-342
25. Driever, W., Schier, A., Malicki, J., and Stemple, D. (1997). Genetic analysis of pattern formation in the zebrafish nervous system. In: From Membrane to Mind; eds N. Elsner and H. Wässle. Georg Thieme Verlag Stuttgart. 119-137.
26. Schier, A.F. (1997). Genetics of neural development in zebrafish. Current Opinion in Neurobiology 7, 119-126
1998
27. Drummond, I.A., Majumdar, A., Hentschel, H., Elger, M., Solnica-Krezel, L., Schier, A.F., Neuhauss, S.C.F., Stemple, D.L., Zwartkruis, F., Rangini, Z., Driever, W. and Fishman, M.C. (1998). Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function. Development 125, 4655-5667
28. Zhang, J., Talbot, W.S., and Schier, A.F. (1998). Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation. Cell 92, 241-251.
29. Schier, A.F. and Talbot, W.S. (1998). The zebrafish organizer. Current Opinion in Genetics and Development 8, 464-471.
30. Feldman, B., Gates, M.A., Egan, E.S., Dougan, S.T., Rennebeck, G., Sirotkin, H.I., Schier, A.F., and Talbot, W.S. (1998). Zebrafish organizer and germ-layer formation require nodal-related signals. Nature 395, 181-185.
1999
31. Talbot, W.S. and Schier, A.F. (1999). Positional cloning of mutated genes in zebrafish. Methods in Cell Biology 60, 259-286.
32. Fekany, K., Yamanaka, Y., Leung, T., Topczewski, J., Sirotkin, H., Gates, M., Hibi, M., Renucci, A., Stemple, D., Radbill, A., Schier, A.F., Driever, W., Hirano, T., Talbot, W.S., and Solnica-Krezel, L. (1999). The zebrafish bozozok locus encodes the homeodomain protein Dharma sufficient in the extraembryonic yolk syncytial layer for gastrula organizer formation. Development 126, 1427-1438.
33. Karlstrom, R.O., Talbot, W.S., and Schier, A.F. (1999). Comparative synteny cloning of zebrafish you-too: mutations in the hedgehog target gli2 affect ventral forebrain patterning. Genes & Development 13, 388-393.
34. Gates, M.A., Kim, L, Egan, E.S., Cardozo, T, Sirotkin, H.I., Dougan, S.T., Lashkari, D., Abagyan, R., Schier, A.F., and Talbot, W.S. (1999). A genetic linkage map for zebrafish: Comparative analysis and localization of genes and expressed sequences. Genome Research 9, 334-347.
35. Geisler, R., Rauch, G.-J., Baier, H., van Bebber, F., Broß, L., Dekens, M. P. S., Finger, K., Fricke, C., Gates, M. A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnügge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J. M., Roehl, H., Roeser, T., Schauerte, H. E., Schier, A. F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W. S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999). A radiation hybrid map of the zebrafish genome. Nature Genet. 23, 86-89.
36. Gritsman, K., Zhang, J., Cheng, S., Heckscher, E., Talbot, W.S., and Schier, A.F. (1999). The EGF-CFC protein one-eyed pinhead is essential for nodal signaling. Cell 97, 121-132.
37. Meno, C*., Gritsman, K*., Ohishi, S., Ohfuji, Y., Heckscher, E., Mochida, K., Shimono, A., Kondoh, H., Talbot, W.S., Robertson, E.J., Schier, A.F.*, and Hamada, H.* (1999) Mouse lefty-2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Molecular Cell 4, 287-298
38. Yan, Y.-T.*, Gritsman, K.*, Ding, J., Burdine, R.D., Corrales, J., Price, S.M., Talbot, W.S., Schier, A.F.*, and Shen, M.M.* (1999). Conserved role for EGF-CFC genes in vertebrate left-right axis formation. Genes & Development 13, 2527-2537
2000
39. Dick, A., Hild, M., Bauer, H., Imai, Y., Maifeld, H., Schier, A.F., Talbot, W.S., Bouwmeester, T. and Hammerschmidt, M. (2000). Essential role of Bmp7 (snailhouse) and its prodomain in dorsoventral patterning of the zebrafish embryo. Development 127, 343-354.
40. Schier, A.F. and Shen, M.M. (2000). Nodal signalling in vertebrate development. Nature 403, 385-389.
41. Gritsman, K., Talbot, W.S. and Schier, A.F. (2000). Nodal signaling patterns the organizer. Development 127, 921-932.
42. Imai, Y , Feldman, B., Schier, A.F. and Talbot, W.S. (2000). Analysis of chromosomal rearrangements induced by postmeiotic mutagenesis with ethylnitrosourea in zebrafish. Genetics 155, 261-272.
43. Kelly, P.D., Chu, F., Woods, I.G., Ngo-Hazelett, P., Cardozo, T., Huang, H., Kimm, F., Liao, L., Yan, Y.-L. Zhou, Y., Johnson, S.L., Abagyan, R., Schier, A.F., Postlethwait, J.H., and Talbot, W.S. (2000). Genetic linkage mapping of zebrafish genes and ESTs. Genome Research, 10, 558-567.
44. Feldman, B., Dougan, S.T., Schier, A.F. and Talbot, W.S. (2000). Nodal-related signals establish mesendodermal and trunk neural fates in zebrafish. Curr. Biol., 10, 531-534.
45. Burdine, R.D. and Schier, A.F. (2000). Conserved and divergent mechanisms in left-right axis formation. Genes & Development 14, 763-776
46. Sirotkin, H.I., Dougan, S.T., Schier, A.F. and Talbot, W.S. (2000). bozozok and squint act in parallel to specify dorsal mesoderm and anterior neuroectoderm. Development 127, 2583-2592.
47. Shen, M.M. and Schier, A.F. (2000). The EGF-CFC gene family in vertebrate development. Trend in Genetics 16, 303-309.
48. Sirotkin, H.I., Gates, M.A., Kelly, P.D., Schier, A.F., and Talbot, W.S. (2000). fast1 is required for the development of dorsal axial structures in zebrafish. Curr. Biol. 10, 1051–1054.
49. Bamford, R.N., Roessler, E.*, Burdine, R.D.*, Saplakoglu, U.*, dela Cruz, J., Splitt, M., Towbin, J., Bowers, P., Marino, B., Schier, A.F., Shen, M.M., Muenke, M. & Casey, B. (2000). Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects. Nature Genetics 26, 365-369.
50. Concha, M.L.*, Burdine, R.D.*, Russell, C., Schier, A.F.*, and Wilson, S.W.* (2000). A Nodal signalling pathway regulates the laterality of neuroanatomical asymmetries in the zebrafish forebrain. Neuron 28, 399-409. (*equal contribution)
2001
51. Schier, A.F. and Talbot, W.S. (2001). Nodal signaling and the zebrafish organizer. International Journal of Developmental Biology (Special Isssue: 75 years of the organizer) 45, 289-297.
52. Imai, Y., Gates, M.A., Melby, A.E., Kimelman, D., Schier, A.F. and Talbot, W.S. (2001). The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish. Development 128, 2407-2420.
53. Chen, Y. and Schier, A.F. (2001). The zebrafish nodal signal squint functions as a morphogen. Nature 411, 607-610.
54. Schier, A.F. (2001). Zebrafish axis formation and patterning. Curr. Opin. Genetics and Development 11, 393-404.
55. Carmany-Rampey, A. and Schier, A.F. (2001). Single-cell internalization during zebrafish gastrulation. Current Biology 11, 1261–1265.
2002
56. Yamashita, S, Miyagi, C., Carmany-Rampey, C., Shimizu, T., Fujii, R., Schier, A.F. and Hirano, T. (2002). Stat3 controls cell movements during zebrafish gastrulation. Developmental Cell 2, 263-275.
57. dela Cruz, J.M., Bamford, R.N., Burdine, R.D., Roessler, E., Barkovich, J., Donnai, D., Schier, A.F. and Muenke, M. (2002). A loss-of-function mutation in the CFC domain of TDGF-1 is associated with human forebrain defects. Human Genetics 110, 422-428.
58. Kimelman, D. and Schier, A.F. (2002). Mesoderm induction and patterning. in Zebrafish pattern formation (Springer Verlag)
59. Moon, H.-S., Jacobson, E.M., Khersonsky, S.M., Luzung, M.R., Walsh, D.P., Xiong, W., Lee, J.W., Parikh, P.B., Lam, J.C., Kang, T.-W., Rosania, G.R., Schier, A.F., and Chang, Y.-T. (2002). A Novel Microtubule destabilizing Entity from Orthogonal Synthesis of Triazine Library and Zebrafish Embryo Screening. Journal of American Chemical Society 124, 11608-9.
60. Chen, Y. and Schier, A.F. (2002). Lefty proteins are long-range inhibitors of Squint-mediated Nodal signaling. Current Biology 2, 2124-8.
61. Ciruna, B., Weidinger, G., Knaut, H., Thisse, B., Thisse, C., Raz, E. and Schier, A.F. (2002). Production of maternal-zygotic mutant zebrafish by germ-line replacement. Proc. Natl. Acad. Sci. USA 99, 14919-24.
2003
62. Cheng, S.K., Olale, F., Bennett, J.T., Brivanlou, A.H. and Schier, A.F. (2003) EGF-CFC Proteins are essential Co-Receptors for the TGF-ß signals Vg1 and GDF1. Genes & Development 17, 31-36.
63. Karlstrom, R.O., Tyurina, O.V., Kawakami, A., Talbot, W.S., Sasaki, H. and Schier, A.F. (2003). Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development. Development 130, 1549-64.
64. Schier, A.F. (2003) Chemokines and germ cells: Rules of attraction. Current Biology 13, R192-04.
65. Dougan, S.T., Warga, R.M., Kane, D.A., Schier, A.F., and Talbot, W.S. (2003). Elevated dorsal requirement for Nodal function during zebrafish mesendoderm induction. Development 130, 1837-51.
66. Kunwar, P., Zimmerman, S., Bennett, J., Chen, Y., Whitman, M. and Schier, A.F. (2003). Mixer and FoxH1 have overlapping roles in Nodal signaling and mesendoderm induction. Development 130, 5589-5599.
67. Schier, A.F. (2003). Nodal signaling in vertebrate development. Annual Review of Cell and Developmental Biology 19, 589-621.
2004
68. Schier, A.F. (2004). Tail of decay. Nature 427, 403-404.
69. Nakano, Y., Kim, H.R., Kawakami, A., Roy, S., Schier, A.F. and Ingham, P.W. (2004). Inactivation of dispatched1 by the chameleon mutation disrupts hedgehog signalling in the zebrafish embryo. Developmental Biology 269, 381-92.
70. Cheng, S.K., Olale, F., Brivanlou, A.H. and Schier, A.F. (2004). Lefty blocks a subset of TGF-ß signals by antagonizing EGF-CFC coreceptors. Public Library of Science Biology 2, 215-226.
71. Schier, A.F. (2004). Q&A. Current Biology R494.
72. Schier, A.F. (2004). Nodal signaling during gastrulation. in Gastrulation (ed. C. Stern; CSHL Press). 491-504.
2005
73. Tyurina, O.V., Guner, B., Popova, E., Feng, J., Schier, A.F., Kohtz, J.D., Karlstrom, R.O. (2005). Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling. Developmental Biology 277, 537-56.
74. Le Good, J.A., Joubin, K., Giraldez, A.J., Ben-Haim, N., Beck, S., Chen, Y., Schier, A.F., and Constam, D.B. (2005). Nodal stability determines signaling range. Current Biology 15, 31-6.
75. Dutta, S., Dietrich, J.-E., Aspöck, G., Burdine, R.D., Schier, A.F., Westerfield, M. and Varga, Z.M. (2005). pitx3 defines an equivalence domain for lens and anterior pituitary placode. Development 132, 1579-90.
76. Kramer-Zucker, A.G., Olale, F., Haycraft, C.J., Yoder, B.Y., Schier, A.F., Drummond, I.A. (2005). Cilia-driven fluid flow in the zebrafish pronephros, brain, and Kupffer’s vesicle is required for normal organogenesis. Development 132, 1907-1921.
77. Giraldez, A.J., Cinalli, R. Glasner, M.E., Enright, A., Thomson, J.M., Baskerville, S., Hammond, S.M., Bartel, D. and Schier, A.F. (2005). MicroRNAs regulate brain morphogenesis in zebrafish. Science 308, 833-838.
78. Sagasti, A., Guido, M., Raible, D.R. and Schier, A.F. (2005). Repulsive interactions shape the morphologies and functional arrangement of zebrafish peripheral sensory arbors. Current Biology 15, 804-814.
79. Knaut, H., Blader, P., Straehle, U., and Schier, A.F. (2005). Assembly of trigeminal sensory ganglia by chemokine signaling. Neuron 47, 653-666.
80. Schier, A.F. and Talbot, W.S. (2005). Molecular genetics of zebrafish axis formation. Annual Review of Genetics 39, 561-613.
81. Schier, A.F. (2005). Axis formation: Squint comes into focus. Current Biology 15, R1002-04.
2006
82. Ciruna, B., Jenny, A., Lee, D., Mlodzik, M. and Schier, A.F. (2006). Planar cell polarity signalling couples cell division and morphogenesis during neurulation. Nature 439, 220-224.
83. Giraldez, A.J., Mishima, Y., Rihel, J., Grocock, R.J., Van Dongen, S., Inoue, K., Enright, A.J. and Schier, A.F. (2006). Zebrafish miR-430 promotes deadenylation and clearance of maternal mRNAs. Science 312, 75-79.
84. Obara, T., Mangos, S., Liu, Y., Shao, J., Wiessner, S., Kramer-Zucker, A.G., Olale, F. Schier, A.F., and Drummond, I. (2006). Polycystin-2 immunolocalization and function in zebrafish. J Am Soc Nephrol. 17, 2706-18.
85. Mishima, Y.*, Giraldez, A.J.*. Takeda, Y., Fujiwara, T., Sakamoto, H., Schier, A.F.*, and Inoue K.* (2006). Differential Regulation of Germline mRNAs in Soma and Germ Cells by Zebrafish miR-430. Current Biology 16,2135-42.
86. Prober, D.A., Rihel, J., Onah, A.A., Sung, R.-J., and Schier, A.F. (2006). Hypocretin/Orexin Overexpression Induces An Insomnia-Like Phenotype in Zebrafish. Journal of Neuroscience 26, 13400-10.
87. Schier, A.F. and Giraldez, A.J. (2006). MicroRNA function and mechanism: insights from zebra fish. Cold Spring Harb Symp Quant Biol. 71:195-203.
2007
88. Bennett, J.T., Joubin, K., Cheng, S., Aanstad, P., Herwig, R., Clark, M., Lehrach, H., and Schier, A.F. (2007). Nodal signaling activates differentiation genes during zebrafish gastrulation. Dev Biol. 304, 525-40. PMCID: PMC1885460
89. Schier AF. (2007) The maternal-zygotic transition: death and birth of RNAs. Science. 316, 406-7.
90. Choi, W.-Y., Giraldez, A.J. and Schier, A.F. (2007). Target Protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430. Science 318, 271-274.
91. Bennett, J.T., Stickney, H.L., Choi, W.-Y., Ciruna, B., Talbot, W.S., and Schier, A.F. (2007) Maternal Nodal and Zebrafish Embryogenesis. Nature 450, E1-2.
92. Karkera, J.D., Lee, J.S., Roessler, E., Banjeree-Basu, S., Ouspenskaia, M.V., Mez, J., Goldmuntz, E., Bowers, P., Towbin, J., Belmont, J.W., Baxevanis, A.D., Schier, A.F., and Muenke, M. (2007) Loss-of-function mutations in Growth Differentiation Factor-1 (GDF1) are associated with congenital heart defects in humans. American Journal of Human Genetics 81, 987-94. PMCID: PMC2265655
2008
93. Choi, P.S., Zakhary, L., Choi, W.-Y., Caron, S., Alvarez-Saavedra, E., Miska, E.A., McManus, M., Harfe, B., Giraldez, A.J., Horvitz, R.H., Schier, A.F., and Dulac, C. (2008). Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron 57, 41-55. PMCID: PMC2204047
94. Knaut, H. and Schier, A.F. (2008). Clearing the path for germ cells. Cell 132, 337-9.
95. Woods, I.G., and Schier, A.F. (2008). Targeted mutagenesis in zebrafish. Nature Biotechnology 26, 650-1. PMCID: PMC2602797
96. Douglass, A.D., Kraves, S., Deisseroth, K., Schier, A.F., and Engert, F. (2008). Escape behavior elicited by single, channelrhodopsin-2-evoked spikes in zebrafish somatosensory neurons. Curr. Biol. 18, 1133-7.
97. Caron, S.J.C, Prober, D., Choy, M. and Schier, A.F. (2008). In Vivo Birthdating by BAPTISM Reveals that Trigeminal Sensory Neuron Diversity Depends on Early Neurogenesis. Development 135, 3259-69. PMCID: PMC2596952
98. Prober, D.A., Zimmerman, S., Myers, B.R., McDermott Jr., B.M., Kim, S.-H., Caron, S., Rihel, J., Solnica-Krezel, L., Julius, D., Hudspeth, A.J., and Schier, A.F. (2008). Zebrafish TRPA1 Channels are Required for Chemosensation but not for Thermosensation or Mechanosensory Hair Cell Function. Journal of Neuroscience 28, 10102-10. PMCID: PMC2728686
99. de Campos-Baptista, M.I., Holtzman, N.G., Yelon, D., and Schier, A.F. (2008) Nodal signaling promotes the speed and directional movement of cardiomyocytes in zebrafish. Developmental Dynamics 237, 3624-33. PMCID: PMC2632806
2009
100. Schier, A.F. (2009) Nodal morphogens. In Morphogen Gradients, Cold Spring Harbor Perspect Biology 1, a003459. PMCID: PMC2773646
101. Schier A.F. and Needleman D. (2009). The rise of the source-sink model. Nature 461, 480-1.
102. Huang, P. and Schier, A.F. (2009). Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia. Development 136, 3089-98. PMCID: PMC2730366
2010
103. Rihel, J., Prober, D., Arvanites, A., Lam, K., Zimmerman, S., Jang, S., Haggarty, S.J., Kokel, D., Rubin, L.L., Peterson, R.T. and Schier, A.F. (2010). Behavioral profiling links drugs to biological targets and the regulation of rest/wake states. Science 15, 348-51. PMCID: PMC2830481
104. Naumann, E.A., Kampff, A.R., Prober, D.A., Schier, A.F., and Engert, F. (2010). Monitoring neural activity with bioluminescence during natural behavior. Nature Neuroscience 13, 513-20. PMCID: PMC2846983
105. Harvey, S.A., Tümpel, S., Dubrulle, J., Schier, A.F., Smith, J.C. (2010) no tail integrates two modes of mesoderm induction. Development 137, 1127-35. PMCID: PMC2835328
106. Vastenhouw, N.L.*, Zhang, Y.*, Woods, I.G., Imam, F., Regev, A., Liu, X.S.*, Rinn, J.*, and Schier, A.F.* (2010). Chromatin signature of embryonic pluripotency is established during genome activation. Nature 464, 922-6.
107. Rihel, J., Prober, D., and Schier, A.F. (2010). Monitoring sleep and arousal in zebrafish. In Methods in Cell Biology: The Zebrafish 3rd Edition,100, 281-94.
2011
108. Pan, A., Livet, J., Sanes, J., Lichtman, J., and Schier, A.F. (2011). Multicolor Brainbow imaging in zebrafish. In Imaging in Developmental Biology: A Laboratory Manual. Cold Spring Harbor Protocols. pdb.prot5546. doi: 10.1101/pdb.prot5546.
109. Pauli, A., Rinn, J.L., and Schier, A.F. (2011). Non-coding RNAs as regulators of embryogenesis. Nature Review Genetics 12, 136-49.
110. Rihel, J. and Schier A.F. (2011) Behavioral screening for neuroactive drugs. Developmental Neurobiology [Epub ahead of print]]
111. Müller, P. and Schier, A.F. (2011) Extracellular movement of signaling molecules. Developmental Cell 21, 145-58.
112. Rogers, K.W. and Schier, A.F. (2011). Morphogen Gradients: From Generation to Interpretation. Annual Review of Cell and Developmental Biology 27, 377-407.
2012
113. Pauli, A., Valen, E., Lin, M.F., Garber, M., Vastenhouw, N.L., Levin, J.Z., Fan, L., Sandelin, A., Rinn, J.L., Regev, A., and Schier, A.F. (2012) Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis. Genome Research 22, 577-91. Epub 2011 Nov 22
114. Pan, Y.A., Choy, M., Prober, D.A., and Schier, A.F. (2012). Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons. Development 139, 591-600. Epub 2011 Dec 21.
115. Pan, A., Caron, S. and Schier, A.F. (2012). BAPTI and BAPTISM birthdating of neurons in zebrafish. In Imaging in Developmental Biology: A Laboratory Manual (CSHL Press). Cold Spring Harbor Protocols 1, 87-92
116. Xu, C., Fan, Z.P., Müller, P., Fogley, R., DiBiase, A., Trompouki, E., Unternaehrer, J., Xiong, F., Torregroza, I., Evans, T., Megason, S.G., Daley, G.Q., Schier, A.F., Young, R.A., and Zon LI. (2012). Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway. Dev Cell 13, 625-38.
117. Stooke-Vaughan, G.A., Huang, P., Hammond, K.L., Schier, A.F., and Whitfield, T.T. (2012). The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle. Development 139, 1777-87.
118. Low, S.E., Woods, I.G., Lachance, M., Ryan, J., Schier, A.F.*, and Saint-Amant, L.* (2012). Touch responsiveness in zebrafish requires voltage-gated calcium channel 2.1b. J. Neurophysiology 108, 148-59
119. Müller, P., Rogers, K.W., Jordan, B.M., Lee, J.S., Robson, D., Ramanathan, S., and Schier, A.F. (2012). Differential diffusivity of Nodal and Lefty underlies a reaction-diffusion patterning system. Science 336, 721-4.
120. Vastenhouw, N.L. and Schier, A.F. (2012). Bivalent histone modifications in early embryogenesis. Curr Opin Cell Biol. 24, 374-86
121. Panizzi, J.R., Becker-Heck, A., Castleman, V.H., Al-Mutairi, D.A., Liu, Y., Loges, N.T., Pathak, N., Austin-Tse, C., Sheridan, E., Schmidts, M., Olbrich, H., Werner, C., Häffner, K., Hellman, N., Chodhari, R., Gupta, A., Kramer-Zucker, A., Olale, F., Burdine, R.D., Schier, A.F., O'Callaghan, C., Chung, E.M., Reinhardt, R., Mitchison, H.M., King, S.M., Omran, H., and Drummond, I.A. (2012). CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms. Nature Genetics 44, 714-9
122. Ahrens, M.B., Li, J.M., Orger, M.B., Robson, D.N., Schier, A.F., Engert, F., and Portugues, R. (2012). Brain-wide neuronal dynamics during motor adaptation in zebrafish. Nature 485, 471-7
123. Huang, P., Xiong, F., Megason, S.G., and Schier, A.F. (2012). Attenuation of Notch and Hedgehog signaling is required for fate specification in the spinal cord. PLoS Genetics e1002762. PMCID: PMC3369957
124. Bianco, I.H., Ma, L.H., Schoppik, D., Robson, D.N., Orger, M.B., Beck, J.C., Li, J.M., Schier, A.F., Engert, F., and Baker R. (2012). The tangential nucleus controls a gravito-inertial vestibulo-ocular reflex. Current Biology 22, 1285-95.
2013
125. Varshney GK, Lu J, Gildea DE, Huang H, Pei W, Yang Z, Huang SC, Schoenfeld D, Pho NH, Casero D, Hirase T, Mosbrook-Davis D, Zhang S, Jao LE, Zhang B, Woods IG, Zimmerman S, Schier AF, Wolfsberg TG, Pellegrini M, Burgess SM, Lin S. (2013). A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome Research 23,727-35.
126. Levitz J, Pantoja C, Gaub B, Janovjak H, Reiner A, Hoagland A, Schoppik D, Kane B, Stawski P, Schier AF, Trauner D, Isacoff EY. (2013). Optical control of metabotropic glutamate receptors. Nature Neuroscience 16, 507-16.
127. Müller P, Rogers KW, Yu SR, Brand M, Schier AF. (2013) Morphogen transport. Development 140,1621-38.
128. Schier AF. (2013). Zebrafish earns its stripes. Nature 496, 443-4.
129. Xiong F, Tentner AR, Huang P, Gelas A, Mosaliganti KR, Souhait L, Rannou N, Swinburne IA, Obholzer ND, Cowgill PD, Schier AF, Megason SG. (2013). Specified neural progenitors sort to form sharp domains after noisy shh signaling. Cell 153, 550-61.
130. Pan, Y.A., Freundlich, T., Weissman, T.A., Schoppik, D., Wang, X.C., Zimmerman, S., Ciruna, B., Sanes, J.R., Lichtman, J.W., and Schier, A.F. (2013). Zebrabow: multispectral cell labeling for cell tracing and lineage analysis in zebrafish. Development, 140, 2835-46.
131. Chew, G.-L., Pauli, A., Rinn, J.L., Regev, A., Schier, A.F.*, and Valen, E.* (2013). Ribosome profiling reveals resemblance between long non-coding RNAs and 5’ leaders of coding RNAs. Development 140, 2828-34.
132. Rihel, J. and Schier, A.F. (2013). Sites of action of sleep and wake drugs: insights from model organisms. Current Opinion in Neurobiology 23, 831-40.
133. Schier, A.F. (2013). Should I stay or should I go: neuromodulators of behavioral states. Cell. 154, 955-6.
134. Zhang, Y., Vastenhouw, N.L., Feng, J., Fu, K., Wang, C., Ge, Y., van Hummelen, P., Schier, A.F.*, Liu, X.S.* (2013) Canonical nucleosome organization at promoters forms during genome activation. Genome Research 24, 260-6
2014
135. Pauli, A., Norris, M.L., Valen, E., Chew, G.-L., Gagnon, J.A., Zimmerman, S., Mitchell, A., Ma, J., Dubrulle, J., Reyon, D., Tsai, S.Q., Joung, J.K., Saghatelian, A., and Schier, A.F. (2014). Toddler: an embryonic signal that promotes cell movement via Apelin receptors. Science 343, 1248636
136. Woods, I.G., Schoppik, D., Shi, V.J., Zimmerman, S., Coleman, H.A., Greenwood, J., Soucy, E.R., and Schier, A.F. (2014) Neuropeptidergic signaling partitions arousal behaviors in zebrafish. Journal of Neuroscience 34, 3142-60
137. Gagnon, J.A., Valen, E., Thyme, S.B., Huang, P., Ahkmetova, L., Pauli, A., Montague, T.G., Zimmerman, S., Richter, C., and Schier, A.F. (2014). Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs. PLoS One. 9:e98186
138. Schier, A.F. (2014). Obituary: Walter J. Gehring (1939-2014). Development 141,3289-91.
139. Richter, C., Woods, I.G., and Schier, A.F. (2014). Neuropeptidergic control of sleep and wakefulness. Annual Review Neuroscience 37, 503-31.
140. With Julian Lewis: Development of multicellular organisms. Chapter 21 in Alberts et al. Molecular Biology of the Cell 6t edition
141. Rabani, R Raychowdhury, M Jovanovic, M Rooney, DJ Stumpo, A Pauli, N. Hacohen, A.F. Schier, P.J. Blackshear, N. Friedman, I. Amit, and A. Regev (2014). High-Resolution Sequencing and Modeling Identifies Distinct Dynamic RNA Regulatory Strategies. Cell 159, 1698-1710.
2015
142. Pauli, A., Valen, E., and Schier A.F. (2015). Identifying (non-)coding RNAs and small peptides: Challenges and opportunities. Bioessays 37 (1), 103-112.
143. Haesemeyer, M., and Schier, A.F. (2015). The study of psychiatric disease genes and drugs in zebrafish. Current Opinion in Neurobiology 30, 122-130.
144. Rogers, K.W., Bläßle, A., Schier, A.F., Müller, P. (2015). Measuring Protein Stability in Living Zebrafish Embryos Using Fluorescence Decay After Photoconversion (FDAP). J Vis Exp. Jan 28;(95). doi: 10.3791/52266.
145. Merkle, F.T., Maroof, A., Wataya, T., Sasai, Y., Studer, L., Eggan, K. *, and Schier, A.F. * (2015). Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development 142, 633-43.
146. Liu, J., Merkle, F.T., Gandhi, A.V., Gagnon, J.A., Woods, I.G., Chiu, C.N., Shimogori, T., Schier, A.F., and Prober, D.A. (2015) Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9. Development 142,1113-24
147. Satija, R.*, Farrell, J.*, Gennert, D., Schier, A.F.*, and Regev, A.* (2015). Seurat: Spatial reconstruction of single-cell gene expression. Nature Biotechnology 33, 495-502.
148. Mundell, N., Beier, K., Pan, Y., Lapan, S., Göz, A.D., Berezovskii, V., Wark, A., Drokhlyansky, E., Bielecki, J., Born, R., Schier, A., Cepko, C. (2015). Vesicular stomatitis virus enables gene transfer and transsynaptic tracing in a wide range of organisms. J. Comparative Neurology doi: 10.1002/cne.23761
149. Dubrulle, J., Jordan, B.M., Akhmetova, L., Farrell, J.A., Kim, S.-H., Solnica-Krezel, L. and Schier, A.F. Response to Nodal morphogen gradient is shaped by the kinetics of target gene induction. eLIFE doi: 10.7554/eLife.05042.
150. Merkle, F.T., Neuhausser, W.M., Santos, D., Valen, E., Gagnon, J.A., Maas, K., Sandoe, J., Schier, A.F., and Eggan, K. (2015). Efficient CRISPR-Cas9-mediated generation of knockin human pluripotent stem cells lacking undesired mutations at the targeted locus. Cell Reports 11, 875-83.
151. Lacoste, A.M.B., Schoppik, D., Robson, D.N., Haesemeyer, M., Portugues, R., Li, J.M., Randlett, O., Wee, C.L., Engert, F., Schier, A.F. (2015). A convergent and essential interneuron pathway for Mauthner cell mediated escapes. Current Biology 25, 1526-34.
152. Li-Villarreal, N., Forbes, M.M., Loza, A.J., Chen, J., Ma, T., Helde, K., Moens, C.B., Shin, J., Sawada, A., Hindes, A.E., Dubrulle, J., Schier, A.F., Longmore, G.D., Marlow, F.L., and Solnica-Krezel, L. (2015) Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis. Development dev.119800.
153. Pauli, A.*, Montague, T.G.*, Lennox, K.A., Behlke, M.A. and Schier A.F. (2015) Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish. PLoS One doi: 10.1371/journal.pone.0139504.
154. Randlett, O., Wee, C., Naumann, E.A., Nnaemeka, O., Schoppik, D., Fitzgerald, J.E., Portugues, R., Lacoste, A., Riegler, C., Engert, F.*, and Schier, A.F. * (2015). Whole-brain activity mapping onto a zebrafish brain atlas. Nature Methods, 12, 1039-46
155. Haesemeyer, M., Robson, D.N., Li, J.M., Schier, A.F. and Engert, F. (2015). The structure and timescales of heat perception in larval zebrafish. Cell Systems 1, 338-348.
2016
156. Chiu, C.N., Rihel, J., Lee, D.A., Singh, C., Mosser, E.A., Chen, S., Sapin, V., Pham, U., Engle, J., Niles, B.J., Montz, C.J., Chakravarthy, S., Salehi-Ashtiani, K., Vidal, M., Schier, A.F.* and Prober, D.A.* (2016). A zebrafish genetic screen identifies neuromedin U as a regulator of sleep/wake states. Neuron 89, 842-56.
157. Dunn, T.W., Mu, Y., Narayan, S., Randlett, O., Naumann, E.A., Yang, C.T., Schier, A.F., Freeman, J., Engert, F., and Ahrens, M.B. (2016). Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion. Elife 12741.
158. Thyme, S. and Schier, A.F. (2016). Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development. Cell Reports 15, 1611-1613.
159. Chew, G.-L., Pauli, A, and Schier, A.F. (2016). Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish. Nature Communications 7, 11663.
160. Thyme, S.B., Akhmetova, L., Montague, T.G., Valen, E. and Schier, A.F. (2016). Internal guide RNA interactions interfere with Cas9-mediated cleavage. Nature Communications 7, 11750.
161. McKenna, A.*, Findlay, G.F.*, Gagnon, J.A.*, Horwitz, M.S., Schier, A.F.*, and Shendure, J.* (2016). Whole organism lineage tracing by combinatorial and cumulative genome editing. Science aaf7907
2017
162. Hildebrand DGC, Cicconet M, Torres RM, Choi W, Quan TM, Moon J, Wetzel AW, Scott Champion A, Graham BJ, Randlett O, Plummer GS, Portugues R, Bianco IH, Saalfeld S, Baden AD, Lillaney K, Burns R, Vogelstein JT, Schier AF, Lee WA, Jeong WK, Lichtman JW, Engert F. (2017). Whole-brain serial-section electron microscopy in larval zebrafish. Nature 545(7654):345-349. PMID: 28489821
163. Freyer L, Hsu CW, Nowotschin S, Pauli A, Ishida J, Kuba K, Fukamizu A, Schier AF, Hoodless PA, Dickinson ME, Hadjantonakis AK. (2017). Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives. Cell Reports 20(9):2116-2130. PMID: 28854362
164. Schoppik D, Bianco IH, Prober DA, Douglass AD, Robson DN, Li JMB, Greenwood JSF, Soucy E, Engert F, Schier AF (2017). Gaze-stabilizing central vestibular neurons project asymmetrically to extraocular motoneuron pools. J. Neurosci. pii: 1711-17. PMID: 28972121
165. Escamilla CO, Filonova I, Walker AK, Xuan ZX, Holehonnur R, Espinosa F, Liu S, Thyme SB, López-García IA, Mendoza DB, Usui N, Ellegood J, Eisch AJ, Konopka G, Lerch JP, Schier AF, Speed HE, Powell CM. (2017). Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature. 2017 Nov 1. doi: 10.1038/nature24470. PMID: 29088697
166. Norris ML, Andrea Pauli A, Gagnon JA, Lord ND, Rogers KW, Mosimann C, Zon LI, and Schier AF (2017). Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling. eLife pii: e22626. doi: 10.7554/eLife.22626.
167. Montague TG and Schier AF (2017). Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm. eLife pii: e28183. doi: 10.7554/eLife.28183.
168. Rogers, KW, Lord, ND, Gagnon, JA, Pauli, A, Zimmerman, S, Aksel, DC, Reyon, D, Tsai, SQ, Joung, JK, and Schier, AF (2017). Nodal patterning without Lefty inhibitory feedback is functional but fragile. eLife pii: e28785. doi: 10.7554/eLife.28785.
169. Rabani M, Pieper L, Chew G-L, and Schier AF (2017). Massively parallel reporter assay of 3’UTR sequences identifies in vivo rules for mRNA degradation. Molecular Cell 68, 1083-1094
2018
170. Gagnon, JA, Obbad, K, and Schier, AF (2018). Zebrafish nanog is primarily required in extraembryonic tissue. Development 145(1). pii: dev147793. doi: 10.1242/dev.147793.
171. Raj, B., Wagner, D.E., McKenna, A., Pandey, S., Klein, A.M., Shendure, J., Gagnon, J.A., and Schier, A.F. (2018). Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain by scGESTALT. Nature Biotechnology 36, 442-450.
172. Pandey, S., Shekhar, K., Regev, A., and Schier, A.F. (2018). Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-cell RNA-seq. Current Biology 28,1052-1065
173. Farrell, J.A. *, Wang, Y.*, Riesenfeld, S., Shekhar, K., Regev, A.*, and Schier, A.F.* (2018). Single-cell reconstruction of developmental trajectories during zebrafish embryogenesis. Science eaar3131.
174. Haesemeyer, M., Robson, D.N., Li, J.M., Schier, A.F.*, and Engert, F.* (2018). A Brain-wide Circuit Model of Heat-Evoked Swimming Behavior in Larval Zebrafish. Neuron. S0896-6273(18)30297-6.
175. Almuedo-Castillo, M., Bläßle, A., Mörsdorf, D., Marcon, L., Soh, G.H., Rogers, K.W., Schier, A.F., Müller, P. (2018). Scale-invariant patterning by size-dependent inhibition of Nodal signalling. Nature Cell Biology 20,1032-1042.
176. Raj, B., Gagnon, J.A., and Schier, A.F. (2018). Large-scale reconstruction of cell lineages using single-cell readout of transcriptomes and CRISPR-Cas9 barcodes by scGESTALT. Nature Protocols 13, 2685-2713.
177. Montague, T.G., Gagnon, J.A., and Schier, A.F. (2018) Conserved regulation of Nodal-mediated left-right patterning in zebrafish and mouse. Development. dev.171090. doi: 10.1242/dev.171090.
2019
178. Goudarzi, M., Berg, K., Pieper, L., and Schier, A.F. (2019). Individual long non-coding RNAs have no overt functions in zebrafish embryogenesis, viability and fertility. eLife e40815. doi: 10.7554/eLife.40815
179. Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., and Schier, A.F. (2019). Phenotypic landscape of schizophrenia-associated genes defines candidates and their shared functions. Cell 177, 478-491.
180. Randlett, O., Haesemeyer, M., Forkin, G., Shoenhard, H., Schier, A.F., Engert, F., and Granato, M. (2019). Distributed Plasticity Drives Visual Habituation Learning in Larval Zebrafish. Current Biology 29, 1337-1345
181. Wee, C.L., Nikitchenko, M., Wang, W.C., Luks-Morgan, S.J., Song, E., Gagnon, J.A., Randlett, O., Bianco, I.H., Lacoste, A.M.B., Glushenkova, E., Barrios, J.P., Schier, A.F., Kunes, S., Engert, F., and Douglass, A.D. (2019). Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets. Nature Neuroscience 22, 1477-1492.
182. Haesemeyer, M., Schier, A.F., and Engert, F. (2019). Convergent Temperature Representations in Artificial and Biological Neural Networks. Neuron 103, 1123-1134.
2020
183. Ma, M., Ramirez, A.D., Wang, T., Roberts, R.L., Harmon, K.E., Schoppik, D., Sharma, A., Kuang, C., Goei, S.L., Gagnon, J.A., Zimmerman, S., Tsai, S.Q., Reyon, D., Joung, J.K., Aksay, E.R.F., Schier, A.F., and Pan, Y.A. (2020). Zebrafish dscaml1 Deficiency Impairs Retinal Patterning and Oculomotor Function. J Neurosci. 2020 Jan 2;40(1):143-158. doi: 10.1523/
184. Lin, Q., Manley, J., Helmreich, M., Schlumm, F., Li, J.M., Robson, D.N., Engert, F., Schier, A., Nöbauer, T., and Vaziri, A. C(2020) Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level. Cell 180(3):536-551.
185. Schier, A.F. (2020). Single-cell biology: beyond the sum of its parts. Nat Methods. 17(1):17-20.
186. Lord, N.D., Carte, A.N., Abitua, P.B., and Schier, A.F. (2019) The pattern of Nodal morphogen signaling is shaped by co-receptor expression. bioRxiv doi: https://doi.org/10.1101/2019.12.30.891101
187. Raj, B., Farrell, J.A., McKenna, A., Leslie, J.L., Schier, A.F. (2019) Emergence of neuronal diversity during vertebrate brain development. bioRxiv doi: https://doi.org/10.1101/839860
