Philippa Saunders - Selected Publications#

Google scholar citations: H index 88, i-10 index 234 (169 since 2016)

1. Saunders PTK and Horne AW. (2021) Endometriosis: etiology, pathobiology and therapeutic prospects. Cell. 184(11):2807-2824. doi: 10.1016/j.cell.2021.04.041. [leading research Journal, invited review, already cited 10 times, social media metrics 133].

2. Kirkwood P, Gibson DA, Smith JR, Wilson-Kanamori JR, Kelepouri O, Esnal-Zufiaurre A, Dobie R, Henderson NC, Saunders PTK. (2021) Single cell RNA sequencing redefines the mesenchymal cell landscape of mouse endometrium. FASEBJ. 35(4):e21285. doi: 10.1096/fj.202002123R [first evidence of 4 subtypes of mesenchyme cells in mouse endometriu; important for comparative biology as well as fertility research].

3. Horne AW, Ahmad SF, Carter R, Simitsidellis I, Morton NM, Saunders PTK. (2019) Repurposing dichloroacetate for the treatment of women with endometriosis. Proc Natl Acad Sci U S A. 16(51):25389-25391. doi: 10.1073/pnas.1916144116. [preclinical studies that identified a new non-hormonal stratety to treat pain in women; has formed the basis of a new clinical trial].

4. Gibson DA, Simitsidellis I, Kelepouri O, Critchley HOD, Saunders PTK. (2018) DHEA Enhances Expression of Proteins Associated with Decidualisation and Endometrial Receptivity in Endometrial Stromal Cells from Women of Advanced Reproductive Age. Fertil Steril. 109:728-734.e2 [widespread media coverage in print and online both national and international; social media, contributed to successful fellowship application by Gibson].

5. Greaves E, Horne AW, Jerina H, Hilferty L, Mitchell R, Fleetwood-Walker S, Saunders PTK. (2017) A mouse model of endometriosis displays behavioral and molecular markers of peripheral and central sensitization. Scientific Reports. 7:44169. doi: 10.1038/srep44169. [first description of preclinical model of endometriosis that models pain symptoms; high impact in the field of translational research, has stimulated new clinical studies and drug development].

6. Sanderson PA, Critchley HO, Williams ARW, Ward C, Arends MJ, Saunders PTK. (2017) New concepts for an old problem: the diagnosis of endometrial hyperplasia. Human Reproduction Update. 23(2):232-254. doi: 10.1093/humupd/dmw042. [influential and highly cited >200, enhanced the career of the first author who was a clinical PhD student].

7. Gibson DA, Simitsidellis I, Cousins FL, Critchley HOD, Saunders PTK. (2016) Intracrine androgens enhance decidualization and modulate expression of human endometrial receptivity genes. Scientific Reports. 6:19970. [F1000 recommended, redefined role of androgen metabolism in endometrial function, led to studies on fertility in older women and media coverage].

8. Greaves E, Cousins FL, Murray A, Esnal-Zufiurre A, Fassbender A, Horne AW, Saunders PTK. (2014) A Novel Mouse Model of Endometriosis Mimics Human Phenotype and Reveals Insights into the Inflammatory Contribution of Shed Endometrium. Am J Path. 184:1930-9. [highly regarded new model of endometriosis that has been widely adopted; cited 124 which is high for a small field; contributed to successful fellowship application for Greaves].

9. De Gendt, K, Swinnen, JV, Saunders PTK, Schoonjans, L Dewerchin, M Devos, A Tan, K Atanassova, N Claessens F, Lécureuil C, Heyns W, Carmeliet, P, Guillou F, Sharpe, RM, and Verhoeven, G. (2004) A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proceedings of the National Academy of Sciences, USA. 101: 1327-1332. [F1000 recommended; collaboration between Saunders group and Belgian team; major advance in understanding of male infertility; led to multiple additional papers, contributed to successful grants and promotion for Saunders to Professor; >800 citations]

10. Critchley HOD, Brenner RM, Drudy TA, Williams K, Nayak, NR, Millar, MR. Saunders PTK. (2001) Estrogen receptor beta, but not estrogen receptor alpha, is present in the vascular endothelium of the human and non-human primate endometrium. J Clin Endo Metab. 86: 1370-1378. [the first definitive evidence that impacts on the endometrial vasculature could be mediated by the less understood beta subtype of ER, data generated using new antibodies developed in Edinburgh; led to further funding from MRC. Cited ~284]