Ling Qin - Selected Publications#
* Corresponding author; papers from Web of Science (WoS) 2021 updated on Sept. 30, 2022
1. Qin L*, Genant HK, Griffith J, Leung KS (eds). Advanced Bioimaging Technologies in Assessment of Quality of Bone and Scaffold Biomaterials. Springer Verlag 2007 (Book: ISBN:9783540454540; with a total 600 pages and 457 figures, and co-editor and authors from many European countries) (weblink). This book serves as a reference for international community to adopt advanced technology for advanced diagnosis of challenging bone metabolic disorders and R&D for innovative therapies, including innovative bioactive scaffolds as bone substitutes for new and/or better clinical applications. As a significant contribution this book has been used as an essential reference for developing biomedical imaging education program that formed a foundation for receiving prestigious recognition as AIMBE College of Fellows Class 2013 (Weblink) and invited as international scientific advisory board member for MgSafe, an European Training Network within the framework of Horizon 2020 for promoting patient safety by a novel combination of imaging technologies for biodegradable magnesium implants (Weblink).
2. Leung KS, Qin YX, Cheung WH, Qin L* (eds.). A Practical Manual for Musculoskeletal Research. World Scientific 2008 (Book: ISBN-13 978-981-270-610-2; with a total 897 pages and 276 figures) (Weblink). This book provides both conventional and advanced experimental protocols for musculoskeletal research, composed of both theoretical background and practical testing protocols or advice, a technical foundation for many successful research grants and academic publications, establishment of guidelines and standards for testing innovative orthopaedic products.
3. Zhang G*, Guo BS, Wu H, Tang T, Zhang BT, Zheng LZ, He YX, Yang ZJ, Pan XH, Chow HL, To KW, Li YP, Li DH, Wang XL, Wang YX, Lee KM, Hou ZB, Dong N, Li G, Leung KS, Hung LK, He FC, Zhang LQ*, Qin L*. A delivery system targeting bone formation surface to facilitate RNAi-based bone anabolic therapy. Nature Medicine 18(2):307-14, 2012 (Weblink) (WoS: IF: 87.241; Citation 347). This work is a pioneer one to develop bone targeting anabolic drugs for treating challenging osteoporosis and its significance and contribution have been highlighted in Nature Review Rheumatology, and subsequently awarded with PRC invention patent that also formed a foundation for been elected as ASBMR Fellow (Weblink).
4. Wang JL, Witte F, Xi TF, Zhang YF, Yang K, Yang YS, Zhao DW, Meng J, Li YD, Li WR, Chan KM, Qin L*. Recommendation for modifying current cytotoxicity testing standards for biodegradable magnesium-based materials. Acta Biomaterialia 21:237-49, 2015 (Weblink) (WoS: IF: 10.633; Citation: 266). This study is a milestone that has laid down a scientific foundation for regulatory bodies to recognize the limitations of current ISO testing protocol for cytotoxicity test of Class III medical implants and has established a new ISO standard with a proposed alternative testing protocol for facilitating clinical translation of innovative biometals, especially magnesium (Mg)-based one as Class III medical implants, especially for developing revolutionary biodegradable metals for orthopaedic applications.
5. Zhao DW*, Witte F, Lu F, Wang JL, Li J, Qin L*. Current status on clinical applications of magnesium-based orthopaedic implants: a review from clinical translational perspective. Biomaterials 112:287-302, 2016 (Weblink) (WoS: IF: 15.304; Citation: 545 as WoS Highly Cited Paper). As an important R&D direction, this paper co-authored with our European colleague systemically and critically reviewed the history and current development of innovative biometals, especially with critical analysis and potential solutions or recommendations for developing Mg-based biodegradable metals for clinical applications.
6. Zhao DW*, Huang SB, FQ Lu, Wang BJ, Yang L, Qin L*, Yang K, Li YD, Li WR, Wang W, Tian SM, Zhang XZ, Gao WB, Wang ZP, Xie XH, Wang JL, Li JL. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head. Biomaterials 81: 84-92, 2016 (Weblink) (WoS: IF: 15.304; Citation: 145). This paper provides evidence on clinical safety and efficacy of an innovative and biodegradable Mg hip screw as a very first clinical study in China to demonstrate its great potential for challenging hip preservation surgery in patients with osteonecrosis. The efforts on innovation to clinical translation formed a foundation for been selected Fellow of International Orthopaedic Research (Weblink).
7. Zhang Y, Xu J, Ruan YC, Yu MK, O'Laughlin M, Wise H, Chen D, Tian L, Shi D, Wang J, Chen S, Feng JQ, Chow DH, Xie X, Zheng L, Huang L, Huang S, Leung K, Lu N, Zhao L, Li H, Zhao D, Guo X, Chan K, Witte F, Chan HC, Zheng Y*, Qin L*. Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats. Nature Medicine 22(10):1160-9, 2016 (Weblink) (WoS: IF: 87.241; Citation 478 as WoS Highly Cited Paper). This is the first mechanistic and proof-concept study to reveal a previously undefined role of magnesium (Mg) in promoting CGRP-mediated osteogenic differentiation, together with an innovative design of a Mg-containing intramedullary nail. The product illustrated in this paper has been awarded Gold Medal at Geneva Invention Convention, apart from obtaining 1 USA and 1 PRC invention patents. This original contribution laid down a solid basis for subsequent successful grant applications, including two top comparative research funds in Hong Kong: “Theme-based Research Scheme (TRS)” and “Area of Excellence (AoE)”, with research highlight published in Nature “seeking innovative biodegradable orthopaedic implants for clinical use” (Weblink) apart from been selected as CUHK‘s Impact Case (Weblink) and as foundation of becoming IUSBSE Fellows Class 2020 (Weblink).
8. Lai YX*, Li Y, Cao HJ, Long J, Wang XL, Ki K, Li CR, Jia QY, Teng B, Tang TT, Peng J, Eglin D, Alini M, Grijpma DW, Richards G, Qin L*. Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect. Biomaterials 197:207-19, 2019 (Weblink) (WoS: IF: 15.304; Citation: 206 as WoS Highly Cited Paper). This is one of the study series to design and demonstrate our innovative approach in developing and validating an innovative Mg-composite scaffold to repair challenging bone defect. The systemic assessments show great potential for its clinical translation. Our invention has been awarded with National Invention Award (Silver medal, PRC China), Geneve Invention Award (Silver medal), and more importantly awarded with National Innovation Certificate to get into fast track for facilitating a multi-center clinical trial for innovative Class-III medical Implant developed for treatment of challenging bone defect repair. Our collective efforts will lead to a marketable implant by end of 2023. A start-up company has also been established to realize our translational efforts to bring our innovation to bedside and benefit our patients directly. Such preclinical R&D work has been supported by NSFC-DG-RTD Joint Scheme and the European Union’s 7th Framework Programme with our EU partners from Netherlands, Switzerland, and UK.
9. Wang JL, Xu JK, Hopkins C, Chow DH, Qin L*. Biodegradable magnesium-based implants in orthopedics - a general review and perspectives. Advanced Sciences 28;7(8):1902443, 2020 (Weblink) (WoS: IF=15.804; Citation 18 as WoS Highly Cited Paper). This review paper updated biodegradable Mg‐based metals as promising orthopedic implants for treating challenging bone diseases by summarizing its current status and future research trends with focus on in vitro and in vivo degradation mechanism and cellular and molecular mechanism underlying its osteogenic and angiogenic effects in bone regeneration. Our work laid down a solid foundation for developing a new era in the treatment of challenging bone diseases. This has been listed WoS highly cited paper – a reflection of our leading role in this relevant clinical field who inspires future R&D and clinical translation of biodegradable Class III orthopaedic implants.
10. Zheng NY, Xu JK, Ruan YC, Chang L, Wang XL, Yao H, Wang JL, Zhang R, Xue QY, Tang N, Schilcher J, O'Keefe RJ*, Qin L*. Magnesium facilitates the healing of atypical femoral fractures: A single-cell transcriptomic study. Materials Today 52:43-62, 2022 (Weblink) (WoS: IF: 26.943; Citation 6). This work reports for the first time that our patented Mg-containing intramedullary nail can be cost-effective and easy applicable for treatment of challenging atypical fracture in patients with osteoporosis and under long-term osteoporosis treatment using bisphosphonates as a popular anti-osteoporosis drug. The underlying mechanism has been elaborated that can be generalized for many medical conditions where fibrosis is the key pathology that prevents tissue repair or healing. Targeted therapy has been developed from our research that recently also been highlighted as novel scientific contribution with significant clinical significant by Science (Weblink).
