Laurence Harris Pearl - Selected Publications#

10 major publications selected from 131 publications 2001-2011; H-index = 53; Average annual citations 2008-2011 = 1100

1. Dajani, R., Fraser,E., Roe,S.M., Young,N., Good,V., Dale,T.C. and Pearl,L.H. (2001) Crystal structure of glycogen synthase kinase 3β : Structural basis for phosphate-primed substrate specificity and auto-inhibition, Cell 105, 721-732. Citations : 303

2. Roe, S.M., M.M.U. Ali, Meyer, M., Vaughan, C.K., Panaretou, B., Piper, P.W., Prodromou, C. and Pearl, L.H. (2004) ‘The mechanism of Hsp90 regulation by the protein kinase-specific co-chaperone p50cdc37’, Cell, 116, 87-98. Citations : 112

3. Zhang,M., Windheim,M., Roe,S.M., Peggie,M., Cohen,P., Prodromou,C. and Pearl,L.H. (2005) ‘Chaperoned ubiquitylation – Crystal structures of the CHIP U-box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex’, Mol. Cell, 20, 525-538. Citations : 126

4. Ali,M.M.U., Roe,S.M., Vaughan.C.K., Meyer,P., Panaretou,B., Piper,P.W., Prodromou,C. and Pearl,L.H. (2006) ‘Crystal structure of an Hsp90–nucleotide-p23/Sba1 closed chaperone complex’, Nature, 440, 1013-1017. Citations : 207

5. Spagnolo,L., Rivera-Calzada,A., Pearl,L.H. and Llorca,O. (2006) ‘Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA double-strand break repair’, Mol. Cell, 22, 511-519. Citations : 82

6. Vaughan,C.K., Gohlke,U., Sobot,F., Robinson,C.V., Ali,M.M.U., Prodromou,C., Saibil,H.R. and Pearl,L.H. (2006) ‘Structure of an Hsp90 – Cdc37 – Cdk4 complex’, Mol. Cell, 29, 697-707. Citations : 102

7. Vaughan,C.K., Mollapour,M., Smith,J.R., Truman,A., Hu,B., Good,V.M., Panaretou,B., Neckers,L., Clarke,P.A., Workman,P., Piper,P.W., Prodromou,C. and Pearl,L.H. (2008) ‘Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37’, Mol. Cell, 31, 886–895. Citations : 26

8. Doré,A.S., Kilkenny,M.L., Rzechorzek,N.J. and Pearl,L.H. (2009) ‘Crystal Structure of the Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex – Implications for Clamp Loading and Regulation’, Mol. Cell, 34, 735-745. Citations : 30

9. Zhang, M., Kadota, Y., Prodromou, C., Shirasu, K. and Pearl, L.H. (2010) ‘Structural basis for assembly of Hsp90-Sgt1-CHORD protein complexes: implications for chaperoning of NLR innate immunity receptors’, Mol. Cell, 39, 269-281. Citations : 10

10. Garcas, F., Pearl, L.H. and Oliver, A.W. (2011) ‘The structural basis for substrate recognition by mammalian polynucleotide kinase 3’ phosphatase’, Mol Cell, 44, 385-396. Citations : 0