Luke O’Neill - Selected Publications#

1. O'Neill LA, Cooper MA. Canakinumab for Atherosclerotic Disease. N Engl J Med. 2018 Jan 11;378(2):198-9. doi: 10.1056/NEJMc1714635

2. Mills, EL, Ryan, DG, Prag, HA, Dikovskaya, D, Menon, D, Zaslona, Z, 1, Jedrychowski, MP, Costa, ASG, Higgins, M, Hams, E, Szpyt, J, Runtsch, MC, King, M, McGouran, JF, Fischer, R, Kessler, BM, McGettrick, Hughes, MM, Carroll, RG, Booty, LM, Knatko, EV, Meakin, PJ, Ashford, MLJ, Modis, LK, Brunori, G, Sévin, DC, Fallon, PG, Caldwell, ST, Kunji, ERS, Chouchani, ET, Frezza, C, Dinkova-Kostova, AT, Hartley, RC, Murphy, MP and O’Neill1, LA. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature 2018 April 6th doi: 10.1038/nature25986

3. Galván-Peña S, Carroll RG, Newman C, Hinchy EC, Palsson-McDermott E, Robinson EK, Covarrubias S, Nadin A, James AM, Haneklaus M, Carpenter S, Kelly VP, Murphy MP, Modis LK, O'Neill LA.(2019) Malonylation of GAPDH is an inflammatory signal in macrophages. Nat Commun. 2019 Jan 18;10(1):338. doi: 10.1038/s41467-018-08187-6

4. Angiari S, Runtsch MC, Sutton CE, Palsson-McDermott EM, Kelly B, Rana N, Kane H, Papadopoulou G, Pearce EL, Mills KHG, (2020) Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity.Cell Metab. 2020 Feb 4;31(2):391-405

5. Ryan DG, O'Neill LAJ Krebs Cycle Reborn in Macrophage Immunometabolism. Annu Rev Immunol. 2020 Jan 27. doi: 10.1146/annurev-immunol-081619-104850

6. O'Neill LAJ, Netea MG. BCG-induced trained immunity: can it offer protection against COVID-19? Nat Rev Immunol. 2020 Jun;20(6):335-337. doi: 10.1038/s41577-020-0337-y.

7. Hooftman A, Angiari S, Hester S, Corcoran SE, Runtsch MC, Ling C, Ruzek MC, Slivka PF, McGettrick AF, Banahan K, Hughes MM, Irvine AD, Fischer R, O'Neill LAJ. The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation. Cell Metab. 2020 Sep 1;32(3):468-478.e7. doi: 10.1016/j.cmet.2020.07.016.

8. Runtsch MC, Angiari S, Hooftman A, Wadhwa R, Zhang Y, Zheng Y, Spina JS, Ruzek MC, Argiriadi MA, McGettrick AF, Mendez RS, Zotta A, Peace CG, Walsh A, Chirillo R, Hams E, Fallon PG, Jayamaran R, Dua K, Brown AC, Kim RY, Horvat JC, Hansbro PM, Wang C, O'Neill LAJ.Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages. Cell Metab. 2022 Mar 1;34(3):487-501.e8. doi: 10.1016/j.cmet.2022.02.002.

9. Hooftman A, O'Neill LAJ.Nanoparticle asymmetry shapes an immune response. Nature. 2022 Jan;601(7893):323-325. doi: 10.1038/d41586-021-03806-7.

10. Hooftman, A, Peace C, Ryan DG, Day E, Yang M, McGettrick A, Yin M, Montano E, Huo L, Toller-Kawahisa J, Zecchini V, Ryan TAJ, Bolado-Carrancio A, Casey AM, Prag HA, Costa AS, De Los Santo G, Ishimori M, Walace DJ, Venuturupalli S, Nikitopoulou E, Frizzell N, Johansson C, Von Kriegsheim A, Murphy MP, Jefferies C, Frezza C and O’Neill LAJ Targeting fumarate hydratase promotes mitochondrial RNA-medicated interferon production. Nature (2023) In Press