Johanna Myllyharju - Selected Publications#

134 original articles and reviews in international scientific journals with referee practice, Hirsch index 47

1. Cockman ME*, Lippl K*, Tian Y-M*, Pegg HB, Figg Jr WD, Abboud MI, Heilig R, Fischer R, Myllyharju J#, Schofield CJ# & Ratcliffe PJ#. Lack of catalytic activity of recombinant HIF prolyl hydroxylase (PHD) enzymes on reported non-HIF substrates. * and #, Equal contributions. eLife 8: e46490, 2019.

2. Zou Y*, Donkervoort S*, Salo AM*, Barnes AM, Hu Y, Reghan Foley A, Makareeva E, Leach ME, Dastgir J, Cohn RD, DiNonno W, Leikin S, Marini JC, Myllyharju J & Bönnemann CG. P4HA1 mutations cause a unique congenital disorder of connective tissue involving tendon, bone, muscle and the eye. *Equal contribution. Hum Mol Genet 26: 2207-2217, 2017.

3. Sharma U*, Carrique L*, Vadon-Le Goff S*, Mariano N, Georges RN, Delolme F, Koivunen P, Myllyharju J, Moali C, Aghajari N# & Hulmes DJS#: Why collagen I is normally a heterotrimer. * and #, Equal contributions. Nat Commun 8: 14671, 2017.

4. Leinonen H*, Rossi M*, Salo AM, Tiainen P, Hyvärinen J, Sormunen R, Miinalainen I, Zhang C, Soininen R, Kivirikko KI, Pitkänen M, Koskelainen A, Tanila H, Myllyharju J# & Koivunen P#. P4H-TM deficiency results in age-related retinal and renal alterations in mice. * and #, Equal contributions. Hum Mol Genet 25: 3810-3823, 2016.

5. Aro E*, Salo A*, Khatri R, Finnilä M, Miinalainen I, Sormunen R, Pakkanen O, Holster T, Soininen R, Tuukkanen J, Schipani E# & Myllyharju J#. Mice lacking collagen prolyl 4-hydroxylase isoenzyme II in combination with reduced amount of isoenzyme I display abnormalities in skeletogenesis. * and #, Equal contributions. J Biol Chem 290: 16964-16978, 2015.

6. Laitala A, Aro E, Walkinshaw G, Mäki JM, Rossi M, Heikkilä M, Savolainen E-R, Arend M, Kivirikko KI, Koivunen P* & Myllyharju J*. A transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating erythropoietin production and erythropoiesis. *Equal contribution. Blood 120: 3336-3344, 2012.

7. Hyvärinen J, Hassinen IE, Sormunen R, Mäki JM, Kivirikko KI, Koivunen P* & Myllyharju J*. Hearts of hypoxia-inducible factor prolyl 4-hydroxylase 2 hypomorphic mice show protection against acute ischemia-reperfusion injury. *Equal contribution. J Biol Chem 285: 13646-13657, 2010.

8. Qi HH, Ongusaha PP, Myllyharju J, Chen D, Pakkanen O, Shi Y, Lee SW, Peng J & Shi Y. Prolyl 4-hydroxylation regulates Argonaute 2 stability. Nature 455: 421-425, 2008.

9. Hirsilä M, Koivunen P, Günzler V, Kivirikko KI & Myllyharju J. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-induciple factor. J Biol Chem 278: 30772-30780, 2003.

10. Myllyharju J & Kivirikko KI. Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase. EMBO J 16: 1173-1180, 1997.