René Medema - Selected publications#

1. Janssen A, van der Burg M, Szuhai K, Kops GJ, and Medema R.H. (2011) Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science 333,1895-1898.

2. Tanenbaum, M., Macurek, L., van der Vaart, B., Galli, M., Akhmanova, A., and Medema R.H. (2011) A complex of Kif18b and MCAK promotes microtubule depolymerisation and is negatively regulated by Aurora kinases. Curr Biol 21, 1356-1365.

3. Lindqvist, A., de Bruijn, M., Macurek, L., Bras, A., Mensinga, A., Bruinsma, W., Voets, O., Kranenburg, O. and Medema, R. H. (2009) Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression. EMBO J 28, 3196-3206.

4. Janssen, A., Kops, G. J. and Medema, R. H. (2009) Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells. Proc Natl Acad Sci USA 106, 19108-19113.

5. Macurek, L., Lindqvist, A., Lim, D., Lampson, M. A., Klompmaker, R., Freire, R., Clouin, C., Taylor, S. S., Yaffe, M. B. and Medema, R. H. (2008) Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature 455, 119-123.

6. Laoukili, J., Kooistra, M. R., Bras, A., Kauw, J., Kerkhoven, R. M., Morrison, A., Clevers, H. and Medema, R. H. (2005) FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat Cell Biol 7, 126-136.

7. van Vugt, M. A., Bras, A. and Medema, R. H. (2004) Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Mol Cell 15, 799-811.

8. Kops, G. J., Dansen, T. B., Polderman, P. E., Saarloos, I., Wirtz, K. W., Coffer, P. J., Huang, T. T., Bos, J. L., Medema, R. H.[1] and Burgering, B. M.[1] (2002) Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419, 316-321.

9. Smits, V. A., Klompmaker, R., Arnaud, L., Rijksen, G., Nigg, E. A. and Medema, R. H. (2000) Polo-like kinase-1 is a target of the DNA damage checkpoint. Nat Cell Biol 2, 672-676.

10. Medema, R. H.[1], Kops, G. J.[1], Bos, J. L. and Burgering, B. M. (2000) AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404, 782-787.

[1] equal contribution

Scientific metrics: H-index 50, 140 peer-reviewed papers with 10840 citations total (Scopus)