David P. Lane - Selected publications#

Lane, D.P. and Crawford, L.V. (1979) SV40 T antigen is bound to a host protein in V40 transformed cells. Nature 278, 261-263.

Yewdell, J.W., Gannon, J.V. and Lane, D.P. (1986) Monoclonal antibody analysis of p53 expression in normal and transformed cells. J.Virol. 59. 444-452.

Iggo, R. Gatter K.G. Bartek, J., Lane, D. and Harris, A.L. (1990) Increased expression of mutant forms of the p53 oncogene in primary lung cancer. Lancet 335, 675-679.

Bartek, J. Bartkova, J. Vojtesek, B. Staskova, Z. Lukas, J. Rejthar, A. Kovarik, J. Midgley, C.A. Gannon, J.V. and Lane, D.P. (1991) Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies. Oncogene 6, 1699-1703.

Lane, D.P. (1992) Cancer - p53, Guardian of the Genome. Nature, 358, 15-16. Hupp, T.R., Meek, D.W., Midgley, C.A. and Lane, D.P. (1992) Regulation of the DNA binding function of p53. Cell 71, 875-886.

Lu, X. and Lane, D.P. (1993) Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosone instability syndromes? Cell 75, 765-778.

Hall, P.A., McKee, P.H., Menage, H du P., Dover, R. and Lane, D.P. (1993) High levels of p53 protein in UV irradiated normal human skin. Oncogene 8, 203-207.

Bottger, A., Bottger, V., Sparks, A., Liu,, W.L., Howard, S. and Lane, D.P. (1997) Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo. Curr Biol. 7, 860-869.

Hupp, T.R., Sparks, A. and Lane, D.P. (1995) Small peptides activate the latent sequence specific DNA binding function of p53 Cell 83 237-245

Xirodimas, D.P., Saville, M.K., Bourdon, J.C., Hay, R.T. and Lane, D.P. (2004) Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell. 9, 83-97.

Bourdon, J.C., Fernandes, K., Murray-Zmijewski, F., Liu, G., Diot, A., Xirodimas, D.P., Saville, M.K. and Lane, D.P. (2005) p53 isoforms can regulate p53 transcriptional activity. Genes Dev. 19(18), 2122-37.

Chen, J., Ruan, H., Ng, S.M., Gao, C., Soo, H.M., Wu, W., Zhang, Z., Wen, Z., Lane, D.P. and Peng, J. (2005) Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes Dev. 19, 2900-11.

Kontopidis, G., Wu, S.Y., Zheleva, D.I., Taylor, P., McInnes, C, Lane, D.P., Fischer, P.M. and Walkinshaw, M.D. (2005) From the Cover: Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design. Proc Natl Acad Sci U S A. Feb 8;102(6):1871-6. Epub 2005 Jan 28

Stevenson, L.F., Sparks, A., Allende-Vega, N., Xirodimas, D.P., Lane, D.P. and Saville, M.K. (2007) The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO J. 26, 976-86.

Cheok, C.F., Dey, A. and Lane, D.P. (2007) Cyclin-dependent kinase inhibitors sensitize tumor cells to nutlin-induced apoptosis: a potent drug combination. Mol Cancer Res. 5, 1133-45.

Dey, A., Wong, E.T., Cheok, C.F., Tergaonkar, V. and Lane, D.P. (2008) R-Roscovitine simultaneously targets both the p53 and NF-kappaB pathways and causes potentiation of apoptosis: implications in cancer therapy. Cell Death Differ. 15, 263-73.

Lee, K.C., Goh, W.L., Xu, M., Kua, N., Lunny, D., Wong, J.S., Coomber, D., Vojtesek, B., Lane, E.B. and Lane, D.P. (2008) Detection of the p53 response in zebrafish embryos using new monoclonal antibodies. Oncogene. Jan 24;27 (5) 629-40

Lain, S., Hollick, J.J., Campbell, J., Staples, O.D., Higgins, M., Aoubala, M., McCarthy, A., Appleyard, V., Murray, K.E., Baker, L., Thompson, A., Mathers, J., Holland, S.J., Stark, M.J.R., Pass, G., Woods, J., Lane, D.P. and Westwood, N.J. (2008) Discovery, in vivo activity and mechanism of action of a small-molecule p53 activator. Cancer Cell 13, 454-63.

Chen, J., Ng, S.M., Chang, C., Zhang, Z., Bourdon, J.C., Lane, D.P. and Peng, J. (2009) p53 isoform delta113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish. Genes Dev. 23, 278-90.

Brown, C.J., Verma, C.S., Walkinshaw, M.D. and Lane, D.P. (2009) Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site. Cell Cycle. 8, 1905-1911.

Brown, C.J., Dastidar, S.G., See, H.Y., Coomber, D.W., Ortiz-Lombardía, M., Verma, C. and Lane, D.P. (2009) Rational Design and Biophysical Characterization of Thioredoxin-Based Aptamers: Insights into Peptide Grafting. J Mol Biol. 395(4):871-83.

Wan, K.F., Wang, S., Brown, C.J., Yu, V.C., Entzeroth, M., Lane, D.P. and Lee, M.A. (2009) Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-XL. Cell Cycle. 8(23):3943-52.

Lane, D.P., Cheok, C.F., Brown, C., Madhumalar, A., Ghadessy, F.J. and Verma, C. (2010) Mdm2 and p53 are highly conserved from placozoans to man. Cell Cycle. 9(3):540-547.

Cheok, C.F., Kua, N., Kaldis, P. and Lane, D.P. (2010) Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53. Cell Death Differ. 17(9):1486-500.

See, H.Y. and Lane, D.P. A novel unstructured scaffold based on 4EBP1 enables the functional display of a wide range of bioactive peptides. J Mol Biol. 2010 Dec 17;404(5):819-31.

Dastidar, S.G., Raghunathan, D., Nicholson, J., Hupp, T.R., Lane, D.P. and Verma, C.S. (2011) Chemical states of the N-terminal "lid" of MDM2 regulate p53 binding: simulations reveal complexities of modulation. Cell Cycle. 2011 Jan 1;10(1):82-9.

Lane, D.P., Madhumalar, A., Lee, A.P., Tay, B.H., Verma, C., Brenner, S, and Venkatesh B. (2011) Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish. Cell Cycle. 2011 Dec 15; 10(24) 4272-9.

Goh, A.M., Lim, C.Y., Chiam, P.C., Li, L., Mann, M.B., Mann, K.M., Menendez, S. and Lane, D.P. (2012) Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1685-90.

Muller, P.A., Trinidad, A.G., Timpson, P., Morton, J.P., Zanivan, S., van den Berghe, P.V., Nixon, C., Karim, S.A., Caswell, P.T., Noll, J.E., Coffill, C.R., Lane, D.P., Sansom, O.J., Neilsen, P.M., Norman, J.C., Vousden, K.H. (2012) Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene. 2012 May 14.

Coffill, C.R., Muller, P.A., Oh, H.K., Neo, S.P., Hogue, K.A., Cheok, C.F., Vousden, K.H., Lane, D.P., Blackstock, W.P., Gunaratne, J. (2012) Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. EMBO Rep. 2012 Jun 1.

Guo L, Liew HP, Camus S, Goh AM, Chee LL, Lunny DP, Lane EB, Lane DP. (2012) Ionising radiation induces a dramatic persistence of p53 protein accumulation and DNA damage signaling in mutant p53 zebrafish. Oncogene. 2012 Oct 15.

Tao, T., Shi, H., Guan, Y., Huang, D., Chen, Y., Lane, D.P., Chen, J., Peng, J. (2013) Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation. Cell Res. 2013 Jan 29.

Wong, J.S., Warbrick, E., Vojtesk, B., Hill, J., Lane, D.P. (2013) Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth. Oncotarget. 2013 Jul;4(7):1019-36.

Mondal, A.M., Horikawa, I., Pine, S.R., Fujita, K., Morgan, K.M., Vera, E., Mazur, S.J., Appella, E., Vojtesek, B., Blasco, M.A., Lane, D.P., Harris, C.C. (2013) p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes. J Clin Invest. 2013 Dec 2;123(12):5247-57.