Martin Koltzenburg - Selected Publications#

More than 140 peer-reviewed articles. Co-Editor of Wall and Melzack’s Textbook of Pain, the standard text of the field. H-index (Google Scholar) of 85. More than 28,500 citations: 1 publication cited over 4000 times, additional 13 cited over 500 times and additional 60 cited 100 times or more.

Tankisi H, Pia H, Strunge K, Howells J, Cengiz B, Samusyte G, Koltzenburg M, Fuglsang-Frederiksen A, and Bostock H. Three different short-interval intracortical inhibition methods in early diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener 24: 139-147, 2023.

Ruijs TQ, Koopmans IW, de Kam ML, van Esdonk MJ, Koltzenburg M, Groeneveld GJ, and Heuberger J. Effects of mexiletine and lacosamide on nerve excitability in healthy subjects: a randomized, double-blind, placebo-controlled, crossover study. Clin Pharmacol Ther 112: 1008-1019, 2022.

Rudge P, Jaunmuktane Z, Hyare H, Ellis M, Koltzenburg M, Collinge J, Brandner S, and Mead S. Early neurophysiological biomarkers and spinal cord pathology in inherited prion disease. Brain 142: 760-770, 2019.

Samusyte G, Bostock H, Rothwell J, and Koltzenburg M. Short-interval intracortical inhibition: Comparison between conventional and threshold-tracking techniques. Brain Stimul 11: 806-817, 2018.

Clark AJ, Menendez G, AlQatari M, Patel N, Arstad E, Schiavo G, and Koltzenburg M. Functional imaging in microfluidic chambers reveals sensory neuron sensitivity is differentially regulated between neuronal regions. Pain 159: 1413-1425, 2018.

This article was the Editor’s Choice.

Raftopoulos R, Hickman SJ, Toosy A, Sharrack B, Mallik S, Paling D, Altmann DR, Yiannakas MC, Malladi P, Sheridan R, Sarrigiannis PG, Hoggard N, Koltzenburg M, Gandini Wheeler-Kingshott CA, Schmierer K, Giovannoni G, Miller DH, and Kapoor R. Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trial. Lancet Neurol 15: 259-269, 2016.

Park SB, Davare M, Falla M, Kennedy WR, Selim MM, Wendelschafer-Crabb G, and Koltzenburg M. Fast-adapting mechanoreceptors are important for force control in precision grip but not for sensorimotor memory. J Neurophysiol 115: 3156-3161, 2016.

McMahon SB, Koltzenburg M, Tracey I, and Turk DC. Wall and Melzack's Textbook of Pain. Philadelphia: Elsevier, 2013.

Mead S, Gandhi S, Beck J, Caine D, Gallujipali D, Carswell C, Hyare H, Joiner S, Ayling H, Lashley T, Linehan JM, Al-Doujaily H, Sharps B, Revesz T, Sandberg MK, Reilly MM, Koltzenburg M, Forbes A, Rudge P, Brandner S, Warren JD, Wadsworth JDF, Wood NW, Holton JL, and Collinge J. A novel prion disease associated with diarrhea and autonomic neuropathy. N Engl J Med 369: 1904-1914, 2013.

Park SB, Goldstein D, Krishnan AV, Lin CS, Friedlander ML, Cassidy J, Koltzenburg M, and Kiernan MC. Chemotherapy-induced peripheral neurotoxicity: a critical analysis. CA Cancer J Clin 63: 419-437, 2013.

Park U, Vastani N, Guan Y, Raja SN, Koltzenburg M, and Caterina MJ. TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception. J Neurosci 31: 11425-11436, 2011.

Mantyh PW, Koltzenburg M, Mendell LM, Tive L, and Shelton DL. Antagonism of nerve growth factor-TrkA signaling and the relief of pain. Anesthesiology 115: 189-204, 2011.

Schmalhofer WA, Calhoun J, Burrows R, Bailey T, Kohler MG, Weinglass AB, Kaczorowski GJ, Garcia ML, Koltzenburg M, and Priest BT. ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors. Mol Pharmacol 74: 1476-1484, 2008.

Andang M, Hjerling-Leffler J, Moliner A, Lundgren TK, Castelo-Branco G, Nanou E, Pozas E, Bryja V, Halliez S, Nishimaru H, Wilbertz J, Arenas E, Koltzenburg M, Charnay P, El Manira A, Ibanez CF, and Ernfors P. Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation. Nature 451: 460-464, 2008.

Tuffereau C, Schmidt K, Langevin C, Lafay F, Dechant G, and Koltzenburg M. The rabies virus glycoprotein receptor p75NTR is not essential for rabies virus infection. J Virol 81: 13622-13630, 2007.

Maurer K, Bostock H, and Koltzenburg M. A rat in vitro model for the measurement of multiple excitability properties of cutaneous axons. Clin Neurophysiol 118: 2404-2412, 2007.

Hjerling-Leffler J, AlQatari M, Ernfors P, and Koltzenburg M. Emergence of functional sensory subtypes as defined by transient receptor potential channel expression. J Neurosci 27: 2435-2443, 2007.

The article was the cover story .

Hunt SP, and Koltzenburg M. The Neurobiology of Pain. Oxford: Oxford University Press, 2005.

Seymour B, O'Doherty JP, Koltzenburg M, Wiech K, Frackowiak R, Friston K, and Dolan R. Opponent appetitive-aversive neural processes underlie predictive learning of pain relief. Nat Neurosci 8: 1234-1240, 2005.

Seymour B, O'Doherty JP, Dayan P, Koltzenburg M, Jones AK, Dolan RJ, Friston KJ, and Frackowiak RS. Temporal difference models describe higher-order learning in humans. Nature 429: 664-667, 2004.

Koltzenburg M, and Bendszus M. Imaging of peripheral nerve lesions. Curr Opin Neurol 17: 621-626, 2004.

Bendszus M, Koltzenburg M, Bartsch AJ, Goldbrunner R, Gunthner-Lengsfeld T, Weilbach FX, Roosen K, Toyka KV, and Solymosi L. Heparin and air filters reduce embolic events caused by intra-arterial cerebral angiography: a prospective, randomized trial. Circulation 110: 2210-2215, 2004.

Hanz S, Perlson E, Willis D, Zheng JQ, Massarwa R, Huerta JJ, Koltzenburg M, Kohler M, van-Minnen J, Twiss JL, and Fainzilber M. Axoplasmic importins enable retrograde injury signaling in lesioned nerve. Neuron 40: 1095-1104, 2003.

This article was featured as the Editor’s choice entitled Finding the way back, Science 303 (2004) 147. This paper was rated as “Exceptional” by the Faculty of 1000.

Mantyh PW, Clohisy DR, Koltzenburg M, and Hunt SP. Molecular mechanisms of cancer pain. Nat Rev Cancer 2: 201-209, 2002.

Bendszus M, and Koltzenburg M. Visualization of denervated muscle by gadolinium-enhanced MRI. Neurology 57: 1709-1711, 2001.

Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, and Julius D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288: 306-313, 2000.

This article was the cover story. The paper was included in the citation of the Nobel Assembly of Karolinska Institutet of the 2021 Novel Prize in Physiology or Medicine of David Julius.

Koltzenburg M, Bennett DL, Shelton DL, and McMahon SB. Neutralization of endogenous NGF prevents the sensitization of nociceptors supplying inflamed skin. Eur J Neurosci 11: 1698-1704, 1999.

Bendszus M, Koltzenburg M, Burger R, Warmuth-Metz M, Hofmann E, and Solymosi L. Silent embolism in diagnostic cerebral angiography and neurointerventional procedures: a prospective study. Lancet 354: 1594-1597, 1999.

This article was highlighted by an editorial entitled Silent embolism after cerebral angiography - what harm?

Koltzenburg M, Wall PD, and McMahon SB. Does the right side know what the left is doing? Trends Neurosci 22: 122-127, 1999.

Koltzenburg M. The changing sensitivity in the life of the nociceptor. Pain Suppl 6: S93-102, 1999.

Carroll P, Lewin GR, Koltzenburg M, Toyka KV, and Thoenen H. A role for BDNF in mechanosensation. Nat Neurosci 1: 42-46, 1998.

An illustration of this paper was chosen for the cover picture of this inaugural issue of Nature Neuroscience and this image was re-used in the tenth anniversary issue. The paper was highlighted by an editorial entitled How do you feel? Neurotrophins and Mechanosensation

Woolf CJ, Bennett GJ, Doherty M, Dubner R, Kidd B, Koltzenburg M, Lipton R, Loeser JD, Payne R, and Torebjörk E. Towards a mechanism-based classification of pain? Pain 77: 227-229, 1998.

Koltzenburg M, Stucky CL, and Lewin GR. Receptive properties of mouse sensory neurons innervating hairy skin. J Neurophysiol 78: 1841-1850, 1997.

Koltzenburg M. The sympathetic nervous system and pain. In: The Pharmacology of Pain, edited by Dickenson A, and Besson J-M. Berlin: Springer Verlag, 1997, p. 61-91.

Airaksinen MS, Koltzenburg M, Lewin GR, Masu Y, Helbig C, Wolf E, Brehm G, Toyka KV, Thoenen H, and Meyer M. Specific sub-types of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation. Neuron 16: 287-295, 1996.

An illustration of this paper was chosen for the cover picture and the paper was highlighted in an editorial ”minireview” entitled Neurotrophins cause a new sensation.

Koltzenburg M, Torebjörk HE, and Wahren LK. Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain. Brain 117: 579-591, 1994.

Handwerker HO, and Koltzenburg M. Vegetatives Nervensystem. In: Physiologie, edited by Deetjen P, and Speckmann E-J. München: Urban & Schwarzenberg, 1994, p. 511-538.

Kilo S, Schmelz M, Koltzenburg M, and Handwerker HO. Different patterns of hyperalgesia induced by experimental inflammation in human skin. Brain 117 ( Pt 2): 385-396, 1994.

McMahon SB, and Koltzenburg M. Itching for an explanation. Trends Neurosci 15: 497-501, 1992.

This article was the cover story and an illustration was chosen for the cover.

Koltzenburg M, Lundberg LE, and Torebjörk HE. Dynamic and static components of mechanical hyperalgesia in human hairy skin. Pain 51: 207-219, 1992.

Jänig W, and Koltzenburg M. What is the interaction between the sympathetic terminal and the primary afferent fiber. In: Towards a New Pharmacotherapy of Pain, edited by Basbaum AI, and Besson J-M. Chichester: John Wiley, 1991, p. 331-352.

McMahon SB, and Koltzenburg M. Novel classes of nociceptors: beyond Sherrington. Trends Neurosci 13: 199-201, 1990.

Häbler H-J, Jänig W, and Koltzenburg M. Activation of unmyelinated afferent fibres by mechanical stimuli and inflammation of the urinary bladder in the cat. J Physiol 425: 545-562, 1990.

Fitzgerald M, and Koltzenburg M. The functional development of descending inhibitory pathways in the dorsolateral funiculus of the newborn rat spinal cord. Dev Brain Res 24: 261-270, 1986.