John Iredale - Selected Publications#

The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury.
Campana L, Starkey Lewis PJ, Pellicoro A, Aucott RL, Man J, O'Duibhir E, Mok SE, Ferreira-Gonzales S, Livingstone E, Greenhalgh SN, Hull KL, Kendall TJ, Vernimmen D, Henderson NC, Boulter L, Gregory CD, Feng Y, Anderton SM, Forbes SJ, Iredale JP.
J Immunol. 2018 Feb 1;200(3):1169-1187 . doi: 10.4049/jimmunol 1701247 . Epub 2017 Dec 20.
PMID: 29263216

Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Precliinical evaluation and results of a randomized phase 2 trial.
Snowdon VK, Lachlan NJ, Hoy Am, Hadoke PW, SempleSI, Patel D, Mungall W. Kendall TJ, Thomson A, Lennen RJ, jansen MA, Moran CM, Pellicoro A, Ramachandran P, Shaw I, Aucott RL, Severin T, Saini R, Pak J, Yates D, Dongre N, Duffield JS, Webb DJ, Iredale JP, Hayes PC, Fallowfield JA.
PLoS Med. 2017 Feb 28;14(2):e1002248. doi: 10. 1371/journal.pmed.1002248. eCollection 2017 Feb.
PMID: 28245243

Prostaglandin E2 constrains systemic inflammation through an innate lymphoid cell-IL-22 axis.
Duffin R, O'Connor RA, Crittenden S, Forster T, Yu C, Zheng X, Smyth D, Robb CT, ROssi F, Skouras C, Tang S, Richards J, Pellicoro A, Weller RB, Breyer RM, Mole DJ, Iredale JP, Anderton SM, Narumiya S, Maizels RM, Ghazal P, Howie SE, Rossi AG, Yao C.
Science. 2016 Mar 18;351(6279):1333-8. doi: 10.1126/science.aad9903.

Kynurenine-3-monooxgenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.
Mole DJ, Webster SP, Uings I, Zheng X, Binnie M, Wilson K, Hutchinson JP, Mirguet O, Walker A, Beaufils B, Ancellin N, Trottet L, Beneton V, Mowat CG, Wilkinson M, Rowland P, Haslam C, McBride A, Homer NZ, Baily JE, Sharp MG Garden OJ, Hughes J, Howie SE, Holmes DS, Liddle J, Iredale JP.
Nat Med. 2016 Feb;22(2):202-9. doi: 10. 1038/nm.4020. Epub 2016 Jan 11.
PMID: 26752518

Targeting of av integrin identifies a core molecular pathway that regulates fibrosis in several organs.
Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D.
Nat Med. 2013 Dec;19(12): 1617-24. doi:10.1038/nm.3282. Epub 2013 Nov 10.
PMID: 24216753

Bone marrow injection stimulates hepatic ductular reactions in the absence of injurt via macrophage- mediated TWEAK signalling.
Bird TG, Lu, WY, Boulter L, Gordon-Keylock S, Ridgway RA, Williams MJ, Taube J, Thomas JA, Wojitacha D, Gambardella A, Sansom OJ, Iredale JP, Forbes SJ.
Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6542-7. doi: 10. 1073/pnas. 1302168110. Epub 2013 Apr 1.
PMID: 23576749

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis.
Ramachandran P, Pellicoro A, Vernon MA, Boulter L, Aucott RL, Ali A, Hartland SN, Snowdon VK Cappon A, Gordon-Walker TT, Williams MJ, Dunbar DR, Maning JR, van Rooijen N, Fallowfield JA, Forbes SJ, Iredale JP.
Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):E3186-95. doi: 10.1073/pnas. 1119964109. Epub 2012 Oct 24
PMID: 23100531

Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling.
Hay DC, Flectcher J, Payne C, Terrace JD, Gallagher RC, Snoeys J, Black JR, Wojitacha D, Samuel K, Hannoun Z, Pryde A, Filippi C, Currie IS, Forbes SJ, Ross JA, Newsome PN, Iredale JP.
Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12301-6. doi: 10.1073/pnas.0806522105. Epub 2008 Aug 21.
PMID: 18719101

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
JS Duffield, SJ Forvesm CM Constandinou, S CLay, M Partolina, S Vuthoori, Wu S, Lang R, Iredale J
The Journal of clinical investigation 115 (1), 56-65

Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.
Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, Hovell C, Arthur MJ.
J Clin Invest. 1998 Aug 1;102(3):538-49
PMID: 9691091