Elina Ikonen -Publications#

TOTAL 264 PUBLICATIONS, 29212 CITATIONS, H-INDEX 63 (Google Scholar, Dec 31, 2021)

10 major publications:

Combot Y, Salo VT, Chadeuf G, Hölttä M, Ven K, Pulli I, Ducheix S, Pecqueur C, Renoult O, Lak B, Li S, Karhinen L, Belevich I, Le May C, Rieusset J, Le Lay S, Croyal M, Tayeb KS, Vihinen H, Jokitalo E, Törnqvist K, Vigoureux C, Cariou B, Magre J, Larhlimi A, Ikonen E*, and Prieur X* (2022), *co-corresponding authors

Seipin localizes at MAMs to control mitochondrial calcium import and metabolism in adipocytes. Cell Rep., in press.

(Scientific impact: A pool of the endoplasmic reticulum membrane protein seipin, defective in human lipodystrophy, functions at mitochondria-associated membranes)

Takahashi K, Kanerva K, Vanharanta L, Almeida-Souza L, Lietha D, Olkkonen VM, and Ikonen E (2021)

ORP2 couples LDL-cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange. EMBO J., e106871.

(LDL-cholesterol spreads from lysosomes to recycling endosomes, activating a key regulator of cell adhesion; 4 citations)

Li S, Prasanna X, Salo VT, Vattulainen I, and Ikonen E (2019)

An efficient auxin-inducible degron system with low basal degradation in human cells. Nat. Methods, 16: 866-869.

(Novel inducible protein degradation system that enables rapid depletion of endogenous human transmembrane, cytoplasmic and nuclear proteins; 57 citations)

Salo VT, Li S, Vihinen H, Hölttä-Vuori M, Szkalisity A, Horvath P, Belevich I, Peränen J, Thiele C, Somerharju P, Zhao H, Santinho A, Thiam AR*, Jokitalo E*, and Ikonen E* (2019) *co-corresponding authors

Seipin facilitates triglyceride flow to lipid droplet and counteracts droplet ripening via ER contact. Dev. Cell, 50: 478-493.

(Seipin controls triglyceride transport in the ER; when it is missing, the biophysical forces of ripening dominate triglyceride flux between ER and lipid droplets; 92 citations)

Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomes R, Prive GG, Annaert W, Schwake M, Heeren J, Lullmann-Rauch R, Grinstein S*, Ikonen E*, Saftig P*, and Neculai D*. (2019) *co-corresponding authors

Lysosomal Integral Membrane Protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export. Nat. Commun., 10: 3521.

(Identification of a novel pathway for lysosomal cholesterol export, via a lysosomal membrane protein; 44 citations)

Sandhu J, Li S, Fairall L, Pfisterer SG, Weston TA, Gurnett JE, Xiao X, Vashi D, Ferrari A, Orozco JL, Kim J, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Rajbhandari P, Sallam T, Ferng A, Lee R, Ford DA, Young SG, Ikonen E*, Schwabe JWR*, and Tontonoz P* (2018) * co-last authors

Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells. Cell, 175: 514-529.

(Identification of cholesterol-interacting membrane contact site proteins involved in a physiologically critical cholesterol transport process; 103 citations)

Pfisterer SG, Gateva G, Horvath P, Pirhonen J, Salo VT, Karhinen L, Varjosalo M, Ryhänen SJ, Lappalainen P, and Ikonen E (2017)
Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage. Nat. Commun., 8: 14858.

(First characterization of actin-nucleating machinery and contractile actin filaments on lipid droplets, controlling lipid storage; 29 citations)

Salo VT, Belevich I, Li S, Karhinen L, Vihinen H, Vigouroux C, Magre J, Thiele C, Hölttä-Vuori M, Jokitalo E, and Ikonen E (2016)

Seipin regulates ER-lipid droplet contacts and cargo delivery. EMBO J., 35: 2699-2716.

(Seipin stabilizes ER-lipid droplet contacts, enabling lipid and protein exchange between ER and lipid droplets; 202 citations)

Blom T, Li S, Dichlberger A, Bäck N, Kim YA, Loizides-Mangold U, Riezman H, Bittman R, and Ikonen E (2015)

LAPTM4B facilitates late endosomal ceramide export to control cell death pathways. Nat. Chem. Biol., 11: 799-806.

(Identification of the first ceramide-interacting transmembrane protein in humans and a candidate for sphingolipid-targeting cancer therapies; 47 citations)

Kanerva K, Uronen R-L, Blom T, Li S, Bittman R, Lappalainen P, Peränen J, Raposo G, and Ikonen E (2013)

LDL-cholesterol recycles to the plasma membrane via a Rab8a-Myosin5b-actin –dependent membrane transport route. Dev. Cell, 27: 249-262.

(Identification of a membrane transport route for LDL-cholesterol to the plasma membrane, affected in human cholesterol storage disease; 84 citations)