Zsuzsanna Helyes - Selected Publications#

The following publications contributed to development of new drug candidates and clinical trials for chronic and inflammatory pain with the final goal to help millions of patients (see point 4.1).

1. Bölcskei K, Helyes Zs (equal first authorship), Szabó Á, Sándor K, Elekes K, Németh J, Almási R, Pintér E, Pethő G, Szolcsányi J. Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice. Equal first authorship
PAIN 117: pp. 368 - 376. (2005); H-index: 238; IF: 5.487; D1; Citation: 333

2. Helyes Zs, Pintér E, Sándor K, Elekes K, Bánvölgyi Á, Keszthelyi D, Szoke É, Tóth DM, Sándor Z, Kereskai L, Pozsgai G, Allen J P, Emson PC, Markovics A, Szolcsányi J. Impaired defense mechanism against inflammation, hyperalgesia, and airway hyperreactivity in somatostatin 4 receptor gene-deleted mice.
P NATL ACAD SCI USA 106: pp. 13088 - 13093. (2009); H-index: 699; IF: 9.449; D1; Citation: 81

3. Tekus V, Hajna Zs, Borbely E, Markovics A, Bagoly T, Szolcsanyi J, Thompson V, Kemeny A, Helyes Zs. Goebel A (equal last authorship): A CRPS-IgG-Transfer-Trauma Model Reproducing Inflammatory and Positive Sensory Signs associated with Complex Regional Pain Syndrome.
PAIN 155:299 - 308. (2014); H-index: 238; IF: 6.366; D1; Citation: 104

4. Borbely E, Botz B, Bölcskei K, Kenyer T, Kereskai L, Kiss T, Szolcsanyi J, Pinter E, Csepregi JZ, Mocsai A, Helyes Zs. Capsaicin-sensitive sensory nerves exert complex regulatory functions in the serum-transfer mouse model of autoimmune arthritis. BRAIN BEHAV IMMUN 45:50-59. (2015)
H-index: 127; IF: 6.513; D1; Citation: 65

5. Horváth Á, Tékus V, Boros M, Pozsgai G, Botz B, Borbély É, Szolcsányi J, Pintér E, Helyes Z. Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: in vivo study using TRPA1-deficient mice. Arthritis Res Ther. 8;18:6. (2016)
H-index: 132; IF: 4.475; D1; Citation: 88 (Highlighted in Nature Rheumatology)

6. Helyes Z, Tékus V, Szentes N, Pohóczky K, Botz B, Kiss T, Kemény Á, Környei Z, Tóth K, Lénárt N, Ábrahám H, Pinteaux E, Francis S, Sensi S, Dénes Á, Goebel A. Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1-induced mechanisms. Proc Natl Acad Sci U S A. 25;116(26):13067-13076. (2019)
H-index: 699; IF: 9.346; D1; Citation: 81

7. Aczél T, Körtési T, Kun J, Urbán P, Bauer W, Herczeg R, Farkas R, Kovács K, Vásárhelyi B, Karvaly GB, Gyenesei A, Tuka B, Tajti J, Vécsei L, Bölcskei K, Helyes Z. Identification of disease- and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis. J Headache Pain. 6;22(1):117. (2021)
IF: 8.59; D1; Citation: 18

8. K Pohóczky, J Kun, N Szentes, T Aczél, P Urbán, A Gyenesei, É Szőke, ... Discovery of novel targets in a complex regional pain syndrome mouse model by transcriptomics: TNF and JAK-STAT pathways. Pharmacological Research 182, 106347 (2022)
IF: 9.3; Citation: 7

9. Borbély É, Simon M, Fuchs E, Wiborg O, Czéh B, Helyes Z.: Novel drug developmental strategies for treatment-resistant depression. Br J Pharmacol. 179(6):1146-1186. (2022)
IF: 7.4; D1; Citation: 37

10. Ngoc KH, Kecskés A, Kepe E, Nabi L, Keeble J, Borbély É, Helyes Z.: Expression of the Transient Receptor Potential Vanilloid 1 ion channel in the supramammillary nucleus and the antidepressant effects of its antagonist AMG9810 in mice. Eur Neuropsychopharmacol. 6;73:96-107. (2023).
IF: 5.6; D1; Citation: 1