Joan J. Guinovart - Selected publications#

• LIVER GLYCOGEN REDUCES FOOD INTAKE AND ATTENUATES OBESITY IN A HIGH-FAT DIET-FED MOUSE MODEL López-Soldado I, Zafra D, Duran J, Adrover A, Calbó J and Guinovart JJ. Diabetes, (2014)

• STRUCTURAL BASIS FOR THE RECRUITMENT OF GLYCOGEN SYNTHASE BY GLYCOGENIN Zeqiraj E, Tang X, Hunter RW, García-Rocha M, Judd A, Deak M, von Wilamowitz-Moellendorff A, Kurinov I, Guinovart JJ, Tyers M, Sakamoto K and Sicheri F.Proc Natl Acad Sci U S A, 111 (28), E2831-40 (2014)

• NEURONAL GLYCOGEN SYNTHESIS CONTRIBUTES TO PHYSIOLOGICAL AGING Sinadinos C, Valles-Ortega J, Boulan L, Solsona E, Tevy MF, Marquez M, Duran J, Lopez-Iglesias C, Calbó J, Blasco E, Pumarola M, Milán M* and Guinovart JJ Aging Cell, 13 (5), 935-945 (2014)

• NEURONS HAVE AN ACTIVE GLYCOGEN METABOLISM THAT CONTRIBUTES TO TOLERANCE TO HYPOXIA Saez I, Duran J, Sinadinos C, Beltran A, Yanes O, Tevy MF, Martínez-Pons C, Milán M and Guinovart JJ. J Cerebr Blood F Met, 34 (6), 945-55 (2014)

• GLYCOGEN ACCUMULATION UNDERLIES NEURODEGENERATION AND AUTOPHAGY IMPAIRMENT IN LAFORA DISEASE Duran J, Gruart A, García-Rocha M, Delgado-García JM and Guinovart JJ. Hum Mol Genet, 23 (12), 3147-56 (2014)

• SODIUM TUNGSTATE MODULATES ATM FUNCTION UPON DNA DAMAGE Rodriguez-Hernandez CJ, Llorens-Agost M, Calbó J, Murguia JR and Guinovart JJ. Febs Lett, 587 (10), 1579-86 (2013)

• MUSCLE GLYCOGEN SYNTHASE ISOFORM IS RESPONSIBLE FOR TESTICULAR GLYCOGEN SYNTHESIS: GLYCOGEN OVERPRODUCTION INDUCES APOPTOSIS IN MALE GERM CELLS Villarroel-Espíndola F, Maldonado R, Mancilla H, vander Stelt K, Acuña AI, Covarrubias A, López C, Angulo C, Castro MA, Slebe JC, Durán J, García-Rocha M, Guinovart JJ and Concha II. J Cell Biochem, 114 (7), 1653-64 (2013)

• IMPAIRMENT IN LONG-TERM MEMORY FORMATION AND LEARNING-DEPENDENT SYNAPTIC PLASTICITY IN MICE LACKING GLYCOGEN SYNTHASE IN THE BRAIN Duran J, Saez I, Gruart A, Guinovart JJ and Delgado-García JM. J Cerebr Blood F Met, 33 (4), 550-6 (2013)

• TUNGSTATE REDUCES THE EXPRESSION OF GLUCONEOGENIC ENZYMES IN STZ RATS Nocito L, Zafra D, Calbó J, Domínguez J and Guinovart JJ. PLoS One, 7 (8), e42305 (2012)

• LYASE ACTIVITY OF GLYCOGEN SYNTHASE: IS AN ELIMINATION/ADDITION MECHANISM A POSSIBLE REACTION PATHWAY FOR RETAINING GLYCOSYLTRANSFERASES? Díaz A, Díaz-Lobo M, Grados E, Guinovart JJ, Fita I and Ferrer JC. Iubmb Life, 64 (7), 649-58 (2012)

• DELETERIOUS EFFECTS OF NEURONAL ACCUMULATION OF GLYCOGEN IN FLIES AND MICE Duran J, Tevy MF, Garcia-Rocha M, Calbó J, Milán M* and Guinovart JJ*. EMBO Mol Med, 4 (8), 719-29 (2012)

• ANTI-DIABETIC AND ANTI-OBESITY AGENT SODIUM TUNGSTATE ENHANCES GCN PATHWAY ACTIVATION THROUGH GLC7P INHIBITION Rodriguez-Hernandez CJ, Guinovart JJ and Murguia JR. Febs Lett, 586 (3), 270-6 (2012)

• AMP-ACTIVATED PROTEIN KINASE PHOSPHORYLATES AND INACTIVATES LIVER GLYCOGEN SYNTHASE Bultot L, Guigas B, Von Wilamowitz-Moellendorff A, Maisin L, Vertommen D, Hussain N, Beullens M, Guinovart JJ, Foretz M, Viollet B, Sakamoto K, Hue L and Rider MH. Biochem J, 443 (1), 193-203 (2012)

• RESTORATION OF HEPATIC GLYCOGEN DEPOSITION REDUCES HYPERGLYCAEMIA, HYPERPHAGIA AND GLUCONEOGENIC ENZYMES IN A STREPTOZOTOCIN-INDUCED MODEL OF DIABETES IN RATS Ros S, García-Rocha M, Calbó J and Guinovart JJ. Diabetologia, 54 (10), 2639-48 (2011)

• PROCESSIVITY AND SUBCELLULAR LOCALIZATION OF GLYCOGEN SYNTHASE DEPEND ON A NON-CATALYTIC HIGH AFFINITY GLYCOGEN-BINDING SITE Díaz A, Martínez-Pons C, Fita I, Ferrer JC and Guinovart JJ. J Biol Chem, 286 (21), 18505-14 (2011)

• NEURODEGENERATION AND FUNCTIONAL IMPAIRMENTS ASSOCIATED WITH GLYCOGEN SYNTHASE ACCUMULATION IN A MOUSE MODEL OF LAFORA DISEASE Valles-Ortega J, Duran J, Garcia-Rocha M, Bosch C, Saez I, Pujadas L, Serafin A, Cañas X, Soriano E, Delgado-García JM, Gruart A and Guinovart JJ. EMBO Mol Med, 3 (11), 667-81 (2011)

• HEPATIC OVEREXPRESSION OF A CONSTITUTIVELY ACTIVE FORM OF LIVER GLYCOGEN SYNTHASE IMPROVES GLUCOSE HOMEOSTASIS Ros S, Zafra D, Valles-Ortega J, García-Rocha M, Forrow S, Domínguez J, Calbó J and Guinovart JJ. J Biol Chem, 285 (48), 37170-7 (2010)

• HYPOXIA PROMOTES GLYCOGEN ACCUMULATION THROUGH HYPOXIA INDUCIBLE FACTOR (HIF)-MEDIATED INDUCTION OF GLYCOGEN SYNTHASE 1 Pescador N, Villar D, Cifuentes D, Garcia-Rocha M, Ortiz-Barahona A, Vazquez S, Ordoñez A, Cuevas Y, Saez-Morales D, Garcia-Bermejo ML, Landazuri MO, Guinovart J and del Peso L. PLoS One, 5 (3), e9644 (2010)

• CONTROL OF LIVER GLYCOGEN SYNTHASE ACTIVITY AND INTRACELLULAR DISTRIBUTION BY PHOSPHORYLATION Ros S, García-Rocha M, Domínguez J, Ferrer JC and Guinovart JJ. J Biol Chem, 284 (10), 6370-8 (2009)

• THE GLUCOSE-LOWERING AGENT SODIUM TUNGSTATE INCREASES THE LEVELS AND TRANSLOCATION OF GLUT4 IN L6 MYOTUBES THROUGH A MECHANISM ASSOCIATED WITH ERK1/2 AND MEF2D Girón MD, Sevillano N, Vargas AM, Domínguez J, Guinovart JJ and Salto R Diabetologia, 51 (7), 1285-95 (2008)

• REGULATION OF GLYCOGEN SYNTHESIS BY THE LAFORIN-MALIN COMPLEX IS MODULATED BY THE AMP-ACTIVATED PROTEIN KINASE PATHWAY Solaz-Fuster MC, Gimeno-Alcañiz JV, Ros S, Fernandez-Sanchez ME, Garcia-Fojeda B, Criado Garcia O, Vilchez D, Dominguez J, Garcia-Rocha M, Sanchez-Piris M, Aguado C, Knecht E, Serratosa J, Guinovart JJ, Sanz P and Rodriguez de Córdoba S Hum Mol Genet, 17 (5), 667-78 (2008)

• HEPATIC GLYCOGEN SYNTHESIS IN THE ABSENCE OF GLUCOKINASE: THE CASE OF EMBRYONIC LIVER Cifuentes D, Martínez-Pons C, García-Rocha M, Galina A, Ribas de Pouplana L and Guinovart JJ. J Biol Chem, 283 (9), 5642-9 (2008)

• MECHANISM SUPPRESSING GLYCOGEN SYNTHESIS IN NEURONS AND ITS DEMISE IN PROGRESSIVE MYOCLONUS EPILEPSY Vilchez D, Ros S, Cifuentes D, Pujadas Ll, Vallès J, García-Fojeda B, Criado-García O, Fernández-Sánchez E, Medraño MI, Domínguez J, García Rocha M, Soriano E, Rodríguez de Córdoba S and Guinovart JJ Nat Neurosci, 10 (11), 1407-13 (2007)

• CRYSTAL STRUCTURE OF AN ARCHAEAL GLYCOGEN SYNTHASE: INSIGHTS INTO OLIGOMERIZATION AND SUBSTRATE BINDING OF EUKARYOTIC GLYCOGEN SYNTHASES Horcajada C, Guinovart JJ, Fita I and Ferrer JC. J Biol Chem, 281 (5), 2923-31 (2006)