Carl Gahmberg - Selected publications#

Developmental endothelial locus-1 attenuates complement-dependent phagocytosis through inhibition of Mac-1-integrin Mitroulis, I., Kang, Y-Y., Gahmberg, C. G., Siegert, G., Hajishengallis, G., Chavakis, T. & Choi, E-Y. 05.2014 In : Thrombosis and Haemostasis. 111, 5, p. 1004-1006 3 p.

Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based hemophilic adhesions Gahmberg, C. G., Tian, L., Recacha, R., Jiménez, D., Barredo, R. & Casasnovas, J. 2014 In : Acta Crystallographica. Section D: Biological Crystallography. 70, 7, p. 1934 1943 p.

ICAM-5 - a neuronal dendritic adhesion molecule involved in immune and neuronal functions Gahmberg, C. G., Ning, L. & Paetau, S. F. 2014 Cell adhesion molecules: implications in neurological diseases. Advances in neurobiology, vol.8 . Berezin, L. & Walmod, P. S. (eds.). Springer, Vol. 8, p. 117-132 16 p.

In Vivo Targeting of Activated Leukocytes by a beta(2)-Integrin Binding Peptide Ranta, T-M., Suojanen, J., Penate-Medina, O., Will, O., Tower, R. J., Glueer, C., Kairemo, K., Gahmberg, C. G., Koivunen, E., Sorsa, T., Saris, P. E. J. & Reunanen, J. 2014 In : Molecular diagnosis & therapy. 18, 1, p. 39-44 6 p.

Interactions between intercellular adhesion molecule-5 positive elements and their surroundings in the rodent visual cortex. Gahmberg, C. G., Kelly, E. A., Tremblay, M-E., Tian, L. & Majewska, A. K. 2014 In : Communicative & integrative biology . 6, 6

Regulation of integrin activity by phosphorylation. Gahmberg, C. G., Grönholm, M. & Uotila, L. 2014 In ´ I domain integrins´. D.Gullberg, ed. Springer.. Springer, p. 85-96

Specific phosphorylations transmit signals from leukocyte β2-to β1-integrins and regulate adhesion Gahmberg, C. G., Uotila, L., Grönholm, M., Jahan, F., Melandri, E. & Hinojosa, L. S. 2014 In : Journal of Biological Chemistry. 289, p. 32230-32242 12 p.

Subcellular Localization of Intercellular Adhesion Molecule-5 (Telencephalin) in the Visual Cortex Is Not Developmentally Regulated in the Absence of Matrix Metalloproteinase-9 Kelly, E. A., Tremblay, M-E., Gahmberg, C. G., Tian, L. & Majewska, A. K. 2014 In : Journal of Comparative Neurology. 522, 3, p. 676-688 13 p.

2013

Integrin CD11c/CD18 alpha-Chain Phosphorylation Is Functionally Important Uotila, L. M., Aatonen, M. & Gahmberg, C. G. 2013 In : Journal of Biological Chemistry. 288, 46, p. 33494-33499 6 p.

Interactions between Intercellular Adhesion Molecule-5 (ICAM-5) and β1 integrins regulate neuronal synapse formation. Ning, L., Tian, L., Smirnov, S., Vihinen, H., Llano Sanchez, O., Vick, K., Davis, R. L., Rivera Baeza, C. & Gahmberg, C. G. 2013 In : Journal of Cell Science. 126, 1, p. 77-89 13 p.

Pilus Adhesin RrgA Interacts with Complement Receptor 3, Thereby Affecting Macrophage Function and Systemic Pneumococcal Disease Orrskog, S., Rounioja, S., Spadafina, T., Gallotta, M., Norman, M., Hentrich, K., Fälker, S., Ygberg-Eriksson, S., Hasenberg, M., Johansson, B., Uotila, L. M., Gahmberg, C. G., Barocchi, M., Gunzer, M., Normark, S. & Henriques-Normark, B. 2013 In : mBio. 4, 1, p. e00535-12 12 p.

Potato Crop as a Source of Emetic Bacillus cereus and Cereulide-Induced Mammalian Cell Toxicity Hoornstra, D., Andersson, M. A., Teplova, V. V., Mikkola, R., Uotila, L. M., Andersson, L. C., Roivainen, M., Gahmberg, C. G. & Salkinoja-Salonen, M. S. 2013 In : Applied and Environmental Microbiology. 79, 12, p. 3534-3543 10 p.

SHARPIN regulates uropod detachment in migrating lymphocytes Pouwels, J., Nicole, F. D., Rantakari, P., Auvinen, K., Karikoski, M., Mattila, E., Potter, C., Sundberg, J. P., Hogg, N., Gahmberg, C. G. & Salmi, M. 2013 In : Cell Reports. 5, 3, p. 619-628 10 p.

2011

TCR-Induced Activation of LFA-1 Involves Signaling through Tiam1 Grönholm, M., Jahan, F., Marchesan, S., Karvonen, U., Aatonen, M., Narumanchi, S. & Gahmberg, C. G. 2011 In : Journal of Immunology. 187, 7, p. 3613-3619 7 p.

Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots Shulman, Z., Cohen, S. J., Roediger, B., Kalchenko, V., Jain, R., Grabovsky, V., Klein, E., Shinder, V., Stoler-Barak, L., Feigelson, S. W., Meshel, T., Nurmi, S. M., Goldstein, I., Hartley, O., Gahmberg, C. G., Etzioni, A., Weninger, W., Ben-Baruch, A. & Alon, R. 2011 In : Nature immunology.13, 1, p. 67-76 10 p.

Ulla Hamberg (1918-1985) Pyykkö, P. & Gahmberg, C. G. 2011 European Women in Chemistry. Apotheker, J. & Sardaki, L. S. (eds.). Weinheim: Wiley-VCH, p. 199-201 3 p.

2010

Hydrophobic Interaction between the SH2 Domain and the Kinase Domain Is Required for the Activation of Csk Mikkola, E. T. & Gahmberg, C. G. 2010 In : Journal of Molecular Biology. 399, 4, p. 618-627 10 p.

2009

Neuronal regulation of immune responses in the central nervous system Tian, L., Rauvala, H. & Gahmberg, C. G. 2009 In : Trends in Immunology. 30, 2, p. 91-99 9 p.

PKCε regulation of an α5 integrin-ZO-1 complex controls Lamellae formation in migrating cancer cells Tuomi, S., Mai, A., Nevo, J., Laine, J. O., Vilkki, V., Öhman, T. J., Gahmberg, C. G., Parker, P. J. & Ivaska, J. 2009 In : Science signaling. 2, 77, p. ra32 15 p.

Regulation of integrin activity and signalling Gahmberg, C. G., Fagerholm, S. C., Nurmi, S. M., Chavakis, T., Marchesan, S. & Grönholm, M. 2009 In : Biochimica et Biophysica Acta. General Subjects. 1790, 6, p. 431-444 14 p.

Role of leukemia cell invadosome in extramedullary infiltration Stefanidakis, M., Karjalainen, K., Jaalouk, D. E., Gahmberg, C. G., O'Brien, S., Pasqualini, R., Arap, W. & Koivunen, E. 2009 In : Blood. 114, 14, p. 3008-3017 10 p.

2008

β2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding Takala, H., Nurminen, E., Nurmi, S. M., Aatonen, M., Strandin, T., Takatalo, M., Kiema, T., Gahmberg, C. G., Ylänne, J. & Fagerholm, S. C. 01.09.2008 In : Blood. 112, 5, p. 1853-1862 10 p.

Regulation of LFA-1-dependent inflammatory cell recruitment by Cb1-b and 14-3-3 proteins Choi, E. Y., Orlova, V. V., Fagerholm, S. C., Nurmi, S. M., Zhang, L., Ballantyne, C. M., Gahmberg, C. G. & Chavakis, T. 01.04.2008 In : Blood. 111, 7, p. 3607-3614 8 p.

An Unusual Allosteric Mobility of the C-Terminal Helix of a High-Affinity L Integrin I Domain Variant Bound to ICAM-5 Zhang, H., Casasnovas, J. M., Jin, M., Liu, J., Gahmberg, C. G., Springer, T. A. & Wang, J. 2008 In : Molecular Cell. 31, 3, p. 432-437 6 p.

Betydelsefull finsk publikation: Kai Simons, Elina Ikonen. Functional rafts in cell membranes. Nature 1997: vol 387:569-72 Gahmberg, C. G. 2008 In : Klinisk biokemi i Norden.20, 1, p. 50-51 2 p.

Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment Choi, E. Y., Chavakis, E., Czabanka, M. A., Langer, H. F., Fraemohs, L., Economopoulou, M., Kundu, R. K., Orlandi, A., Zheng, Y. Y., Prieto, D. A., Ballantyne, C. M., Constant, S. L., Aird, W. C., Papayannopoulou, T., Gahmberg, C. G., Udey, M. C., Vajkoczy, P., Quertermous, T., Dimmeler, S., Weber, C., Chavakis, T. & Gahmberg, C. 2008 In : Science. 322, 5904, p. 1101-1104 4 p.

ICAM-5 - A novel two-facetted adhesion molecule in the mammalian brain Gahmberg, C. G., Tian, L., Ning, L. & Nyman-Huttunen, H. 2008 In : Immunology Letters. 117, 2, p. 131-135 5 p.

Importance of molecular studies on major blood groups - intercellular adhesion molecule-4, a blood group antigen involved in multiple cellular interactions Toivanen, A., Ihanus, E., Mattila, M., Lutz, H. U. & Gahmberg, C. G. 2008 In : Biochimica et Biophysica Acta. General Subjects. 1780, p. 456-466 11 p.

Introduction to the special issue on glycobiology and sphingobiology Gahmberg, C. G. & Laine, R. A. 2008 In : Biochimica et Biophysica Acta. General Subjects. 1780, 3, p. 323-324 2 p.

Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins Choi, E. Y., Orlova, V. V., Fagerholm, S. C., Nurmi, S. M., Zhang, L., Ballantyne, C. M., Gahmberg, C. G. & Chavakis, T. 2008 In : Blood. 111, 7, p. 3607-3614 8 p.

Shedded neuronal ICAM-5 suppresses T-cell activation Tian, L., Lappalainen, J., Autero, M., Hänninen, S., Rauvala, H. & Gahmberg, C. G. 2008 In : Blood. 111, 7, p. 3615-3625 11 p.

2007

A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin Orlova, V. V., Choi, E. Y., Xie, C., Chavakis, E., Bierhaus, A., Ihanus, E., Ballantyne, C. M., Gahmberg, C. G., Bianchi, M. E., Nawroth, P. P. & Chavakis, T. 2007 In : EMBO Journal. 26, p. 1129-1139 11 p. P Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage Tian, L., Stefanidakis, M., Ning, L., Van Lint, P., Nyman-Huttunen, H., Libert, C., Itohara, S., Mishina, M., Rauvala, H. & Gahmberg, C. G. 2007 In : Journal of Cell Biology. 178, 4, p. 687-700 14 p.

DC-SIGN binds ICAM-3 isolated from peripheral human leukocytes through Lewis x residues Bogoevska, V., Nollau, P., Lucka, L., Grunow, D., Klampe, B., Uotila, L. M., Samsen, A., Gahmberg, C. G. & Wagener, C. 2007 In : Glycobiology. 17, 3, p. 324-333 10 p.

Phosphorylation of the LFA-1 integrin beta 2-chain on Thr-758 leads to adhesion, Rac-1/Cdc42 activation, and stimulation of CD69 expression in human T cells Nurmi, S. M., Autero, M., Raunio, A. K., Gahmberg, C. G. & Fagerholm, S. C. 2007 In : Journal of Biological Chemistry. 282, 2, p. 968-975 8 p.

Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4 Ihanus, E., Uotila, L. M., Toivanen, A., Varis, M. & Gahmberg, C. G. 2007 In : Blood. 109, 2, p. 802-810 9 p.

2006

P-selectin glycoprotein ligand 1 and beta 2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor Pendu, R., Terraube, V., Christophe, O. D., Gahmberg, C. G., de Groot, P. G., Lenting, P. J. & Denis, C. V. 01.12.2006 In : Blood. 108, 12, p. 3746-3752 7 p.

α-actinin-dependent cytoskeletal anchorage is important for ICAM-5-mediated neuritic outgrowth Nyman-Huttunen, H., Tian, L., Ning, L. & Gahmberg, C. G. 2006 In : Journal of Cell Science. 119, 15, p. 3057-3066 10 p.

α-chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasation Fagerholm, S. C., Varis, M., Stefanidakis, M., Hilden, T. J. & Gahmberg, C. G. 2006 In : Blood. 108, 10, p. 3379-3386 8 p.

Interfering with leukocyte integrin activation: a novel concept in the development of anti-inflammatory drugs Hilden, T. J., Nurmi, S. M., Fagerholm, S. C. & Gahmberg, C. G. 2006 In : Annals of Medicine. 38, p. 503-511 9 p.

Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin Sotiriou, S. N., Orlova, V. V., Al-Fakhri, N., Ihanus, E., Economopoulou, M., Isermann, B., Bdeir, K., Nawroth, P. P., Preissner, K. T., Gahmberg, C. G., Koschinsky, M. L. & Chavakis, T. 2006 In : FASEB Journal. 20, p. 559-561 3 p.

P-selectin glycoprotein ligand 1 and ß2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor Pendu, R., Terraube, V., Christophe, O. D., Gahmberg, C. G., Groot, P. G. D., Lenting, P. J. & Denis, C. V. 2006 In : Blood. 108, 12, p. 3746-3752 7 p.

14-3-3 proteins bind both filamin and alpha(L)beta(2) integrin in activated T cells Nurmi, S. M., Gahmberg, C. G. & Fagerholm, S. C. 2006 p. 318-325 8 p.

14-3-3 proteins bind both filamin and Lß2 integrin in activated T cells Nurmi, S. M., Gahmberg, C. G. & Fagerholm, S. C. 2006 In : Annals of the New York Academy of Sciences. 1090, p. 318-325 8 p.

2005

Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms Fagerholm, S. C., Hilden, T. J., Nurmi, S. M. & Gahmberg, C. G. 21.11.2005 In : Journal of Cell Biology. 171, 4, p. 705-715 11 p.

A tripeptide mimetic of von Willebrand factor residues 981-983 enhances platelet adhesion to fibrinogen by signaling through integrin αIIbß3 Litjens, P. E. M. H., van Willigen, G., Weeterings, C., Ijsseldijk, M. J. W., van Lier, M., Koivunen, E., Gahmberg, C. G. & Akkerman, J. W. N. 2005 In : Journal of thrombosis and haemostasis.3, p. 1274-1283 10 p.

Imaging of activated leukocytes using integrin targeting phage display peptide derivatives Ranta, T-M., Valtanen, H., Kaukinen, S., Koivunen, E., Gahmberg, C. G., Boermann, O. C., Oyen, W. J. G. & Kairemo, K. 2005 In : Inflammation Research. 54, p. S93-S94 2 p.

LDL-receptor-related protein regulates ß2-integrin-mediated leukocyte adhesion Spijkers, P. P. E. M., da Costa Martins, P., Westein, E., Gahmberg, C. G., Zwaginga, J. J. & Lenting, P. J. 2005 In : Blood. 105, p. 170-177 8 p.

Specific integrin α and ß chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms Fagerholm, S. C., Hilden, T. J., Nurmi, S. M. & Gahmberg, C. G. 2005 In : Journal of Cell Biology. 171, 4, p. 705-715 11 p.

2004

Intercellular and cell-surface localization of a complex between αMβ2 integrin and proMMP-9 progelatinase in neutrophils Stefanidakis, M., Ruohtula, T., Borregaard, N., Gahmberg, C. G. & Koivunen, E. 2004 In : Journal of Immunology. 172, 11, p. 7060-7068 9 p.

P marks the spot: site-specific integrin phosphorylation regulates molecular interactions Fagerholm, S. C., Hilden, T. J. & Gahmberg, C. G. 2004 In : Trends in Biochemical Sciences. 29, 9, p. 504-512 9 p.

2003

Characterization of ICAM-4 binding to the I domains of the CD11a/CD18 and CD11b/CD18 leukocyte integrins Ihanus, E., Uotila, L., Toivanen, A., Stefanidakis, M., Bailly, P., Cartron, J. P. & Gahmberg, C. G. 2003 In : European Journal of Biochemistry. 270, p. 1710-1723 14 p.

2002

Release of soluble ICAM-5, a neuronal adhesion molecule, in acute encephalitis Lindsberg, P. J., Launes, J., Tian, L., Välimaa, H., Subramanian, V., Siren, J., Hokkanen, L., Hyypia, T., Carpen, O. & Gahmberg, C. G. 2002 In : Neurology. 58, p. 446-451 6 p.

2001

Inhibition of beta(2) integrin-mediated leukocyte cell adhesion by leucine-leucine-glycine motif-containing peptides Koivunen, E., Ranta, T. M., Annila, A., Taube, S., Uppala, A., Jokinen, M., van Willigen, G., Ihanus, E. & Gahmberg, C. G. 2001 In : European Journal of Cell Biology. 153, p. 905-915 11 p.

2000

Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion Tian, L., Nyman, H., Kilgannon, P., Yoshihara, Y., Mori, K., Andersson, L. C., Kaukinen, S., Rauvala, H., Gallatin, W. M. & Gahmberg, C. G. 2000 In : Journal of Cell Biology. 150, 1, p. 243-252 10 p.

1999

Tumor targeting with a selective gelatinase inhibitor Koivunen, E., Arap, W., Valtanen, H., Rainisalo, A., Medina, O. P., Heikkila, P., Kantor, C., Gahmberg, C. G., Salo, T., Konttinen, Y. T., Sorsa, T., Ruoslahti, E. & Pasqualini, R. 1999 In : Nature Biotechnology. 17, p. 768-774 7 p.

1994

SIALYL LEWIS(X)-DEPENDENT AND L-SELECTIN-DEPENDENT SITE-SPECIFIC LYMPHOCYTE EXTRAVASATION INTO RENAL-TRANSPLANTS DURING ACUTE REJECTION TURUNEN, J. P., PAAVONEN, T., MAJURI, M. L., TIISALA, S., MATTILA, P., MENNANDER, A., GAHMBERG, C. G., HAYRY, P., TAMATANI, T., MIYASAKA, M. & RENKONEN, R. 1994 In : European Journal of Immunology. 24, p. 1130-1136 7 p.

TYROSINE PHOSPHORYLATION IF CD45 PHOSPHOTYROSINE PHOSPHATASE BY P50(CSK) KINASE CREATES A BINDING-SITE FOR P56(LCK) TYROSINE KINASE AND ACTIVATES THE PHOSPHATASE AUTERO, M., SAHARINEN, J., PESSAMORIKAWA, T., SOULAROTHHUT, M., OETKEN, C., GASSMANN, M., BERGMAN, M., ALITALO, K., BURN, P., GAHMBERG, C. G. & MUSTELIN, T. 1994 In : Molecular and Cellular Biology. 14, p. 1308-1321 14 p.

1993

THE VASCULAR E-SELECTIN BINDS TO THE LEUKOCYTE INTEGRINS CD11/CD18 KOTOVUORI, P., TONTTI, E., PIGOTT, R., SHEPHERD, M., KISO, M., HASEGAWA, A., RENKONEN, R., NORTAMO, P., ALTIERI, D. C. & GAHMBERG, C. G. 1993 In : Glycobiology. 3, p. 131-136 6 p.

1992 EXPRESSION OF ENDOTHELIAL ADHESION MOLECULES INVIVO - INCREASED ENDOTHELIAL ICAM-2 EXPRESSION IN LYMPHOID MALIGNANCIES RENKONEN, R., PAAVONEN, T., NORTAMO, P. & GAHMBERG, C. G. 1992 In : American Journal of Pathology. 140, p. 763-767 5 p.

INCREASED ENDOTHELIAL ICAM-2 EXPRESSION IN LYMPHOID MALIGNANCIES PAAVONEN, T., NORTAMO, P., GAHMBERG, C. G. & RENKONEN, R. 1992 In : Scandinavian Journal of Immunology. 36, p. 637-637 1 p.

1991

PHOSPHORYLATION OF THE BETA-SUBUNIT OF CD11/CD18 INTEGRINS BY PROTEIN-KINASE-C CORRELATES WITH LEUKOCYTE ADHESION VALMU, L., AUTERO, M., SILJANDER, P., PATARROYO, M. & GAHMBERG, C. G. 1991 In : European Journal of Immunology. 21, p. 2857-2862 6 p.

THE EXPRESSION OF HUMAN INTERCELLULAR-ADHESION MOLECULE-2 IS REFRACTORY TO INFLAMMATORY CYTOKINES NORTAMO, P., LI, R., RENKONEN, R., TIMONEN, T., PRIETO, J., PATARROYO, M. & GAHMBERG, C. G. 1991 In : European Journal of Immunology. 21, p. 2629-2632 4 p.

1985

Identification of the major human sialoglycoprotein from red cells, glycophorin AM, as the receptor for Escherichia coli IH 11165 and characterization of the receptor site Jokinen, M., Ehnholm, C., Väisänen-Rhen, V., Pipkorn, R., Korhonen, T., Kalkkinen, N., Kalkkinen, N. & Gahmberg, C. G. 1985 In : European Journal of Biochemistry. 147, p. 47-52

1982

Blood group M specific hemagglutinin in pyelonphritic Escherichia coli Väisänen, V., Korhonen, T., Jokinen, M., Gahmberg, C. G. & Ehnholm, C. 1982 In : Lancet. 1 (8282), p. 1192

PERICELLULAR MATRIX AND CELL-SURFACE GLYCOPROTEINS OF VIRUS-TRANSFORMED MOUSE EPITHELIAL-CELLS KESKIOJA, J., GAHMBERG, C. G. & ALITALO, K. 1982 In : Cancer Research. 42, p. 1147-1153 7 p.