Bertil Fredholm- Publication list#

• Sällström J, Carlström M, Olerud J, Fredholm BB, Kouzmine M, Sandler S, Persson AEHigh protein-induced glomerular hyperfiltration is independent of the tubuloglomerular feedback mechanism and nitric oxide synthasesAm J Physiol Regul Integr Comp Physiol. 2010 Aug 25.
• Li L, Hao JX, Fredholm BB, Schulte G, Wiesenfeld-Hallin Z, Xu XJ Peripheral adenosine A(2A) receptors are involved in carrageenan-induced mechanical hyperalgesia in mice.Neuroscience. 2010 Aug 3.
• Piccinin S, Di Angelantonio S, Piccioni A, Volpini R, Cristalli G, Fredholm BB, Limatola C, Eusebi F, Ragozzino D.CX3CL1-induced modulation at CA1 synapses reveals multiple mechanisms of EPSC modulation involving adenosine receptor subtypes Journal of Neuroimmunology, 224(1-2):85-92, 2010.
• Kara FM, Doty SB, Boskey A, Goldring S, Zaidi M, Fredholm BB, Cronstein BN Adenosine A(1) receptors regulate bone resorption in mice: adenosine A(1) receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A(1) receptor-knockout mice Arthritis Rheumatism 62(2): 534-541, 2010.
• Fredholm BB Adenosine receptors as drug targets Experimental Cell Research 316(8): 1284-1288, 2010
• Kara FM, Chitu V, Sloane J, Axelrod M, Fredholm BB, Stanley ER, Cronstein BN
• Adenosine A1 receptors (A1Rs) play a critical role in osteoclast formation and function FASEB Journal, 24(7):2325-2333, 2010
• Burnstock G, Fredholm BB, North RA, Verkhratsky A The birth and postnatal development of purinergic signalling Acta Physiol 199: 93-147, 2010
• Lauro C, Cipriani R, Catalano M, Trettel F, Chece G, Brusadin V, Antonilli L, van Rooijen N, Eusebi F, Fredholm BB, Limatola C Adenosine A(1) receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death Neuropsychopharmacology 35: 1550-1559, 2010
• Sawynok J, Reid AR, Fredholm BB Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A(1) receptors: Insights using knockout mice Neuroscience Letters 473: 178-181, 2010
• Wang Y, Yang JN, Arner A, Boels PJM, Fredholm BB Adenosine A(1) receptors and vascular reactivity Acta Physiol 199: 211-220, 2010
• Yang JN, Wang Y, Garcia-Roves PM, Bjornholm M, Fredholm BB Adenosine A(3) receptors regulate heart rate, motor activity and body temperature Acta Physiol 199: 221-230, 2010
• Boison D, Chen JF, Fredholm BB Adenosine signaling and function in glial cells Cell Death and Differentiation 17: 1071-1082, 2009
• Fredholm BB, Jacobson KA Adenosine Receptors: The Contributions by John W. Daly Heterocycles 79: 73-83, 2009
• Jenner P, Mori A, Hauser R, Morelli M, Fredholm BB, Chen JF Adenosine, adenosine A(2A) antagonists, and Parkinson's diseaseParkinsonism and Related Disorders 15: 406-413, 2009
• Maggi L, Trettel F, Scianni M, Bertollini C, Eusebi F, Fredholm BB, Limatola CLTP impairment by fractalkine/CX(3)CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A(3)R).Journal of Neuroimmunology 215: 36-42, 2009
• Salehi A, Parandeh F, Fredholm BB, Grapengiesser E, Hellman B Absence of adenosine A(1) receptors unmasks pulses of insulin release and prolongs those of glucagon and somatostatin Life Sciences 85: 470-476, 2009
• Yang JN, Bjorklund O, Lindstrom-Tornqvist K, Lindgren E, Eriksson TM, Kahlstrom J, Chen JF, Schwarzschild MA, Tobler I, Fredholm BB Mice heterozygous for both A1 and A(2A) adenosine receptor genes show similarities to mice given long-term caffeine J Appl Physiol 106: 631-639, 2009
• Yu L, Coelho J, Zhang X, Fu Y, Tillman A, Karaoz U, Fredholm BB, Weng Z, Chen JF.Uncovering multiple molecular targets for caffeine by a drug target validation strategy of combined A2A receptor knockouts and microarray profiling. Physiol Genomics. Mar 3. (Epub ahead of print)(2009)
• Conte C, Grottelli S, Prudenzi E, Bellezza I, Fredholm BB, Minelli A. A(1) and A(3) adenosine receptors alter glutathione status in an organ-specific manner and influence the changes after inhibition of gamma-glutamylcysteine ligase. Free Radic Res.Mar;43(3):304-11.(2009)
• Yang JN, Chen JF, Fredholm BB.Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine. Am J Physiol Heart Circ.Physiol.Apr;296(4):H1141-9. Epub Feb 13.(2009)
• Björklund O, Kahlström J, Salmi P, Fredholm BB.Perinatal caffeine, acting on maternal adenosine A(1) receptors, causes long-lasting behavioral changes in mouse offspring.PLoS ONE. 3(12):e3977. Epub Dec 18.(2008)
• Oishi Y, Huang ZL, Fredholm BB, Urade Y, Hayaishi O.Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep.Proc Natl Acad Sci U S A. Dec 16;105(50):19992-7. Epub Dec 9.(2008)
• Yang JN, Björklund O, Lindström-Törnqvist K, Lindgren E, Eriksson TM, Kahlström J, Chen JF, Schwarzschild MA, Tobler I, Fredholm BB.Mice heterozygous for both A1 and A(2A) adenosine receptor genes show similarities to mice given long-term caffeine.J Appl Physiol. Feb;106(2):631-9. Epub Nov 26 (2008)
• Björklund O, Halldner-Henriksson L, Yang J, Eriksson TM, Jacobson MA, Daré E, Fredholm BB.Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice.Physiol Behav. Dec 15;95(5):668-76. Epub Sep 27 (2008)
• Roseti C, Martinello K, Fucile S, Piccari V, Mascia A, Di Gennaro G, Quarato PP, Manfredi M, Esposito V, Cantore G, Arcella A, Simonato M, Fredholm BB, Limatola C, Miledi R, Eusebi F.Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors.Proc Natl Acad Sci U S A. Sep 30;105(39):15118-23. Epub Sep 22 (2008)
• Johansson SM, Lindgren E, Yang JN, Herling AW, Fredholm BB Adenosine A1 receptors regulate lipolysis and lipogenesis in mouse adipose tissue-interactions with insulin.Eur J Pharmacol.Nov 12;597(1-3):92-101. Epub Aug 31.(2008)
• Björklund O, Shang M, Tonazzini I, Daré E, Fredholm BB.Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage.Eur J Pharmacol. Oct 31;596(1-3):6-13. Epub Aug 13. (2008)
• Li T, Quan Lan J, Fredholm BB, Simon RP, Boison D.Adenosine dysfunction in astrogliosis: cause for seizure generation?Neuron Glia Biol. 2007 Nov;3(4):353-66
• Brand F, Klutz AM, Jacobson KA, Fredholm BB, Schulte G.Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC.Eur J Pharmacol. Aug 20;590(1-3):36-42. Epub Jul 4(2008)
• Sawynok J, Reid AR, Fredholm BB. Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors.Neurosci Lett. Aug 1;440(2):181-4. Epub May 24.(2008)
• Hua X, Chason KD, Fredholm BB, Deshpande DA, Penn RB, Tilley SL.Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells.J Allergy Clin Immunol. Jul;122(1):107-13, 113.e1-7. Epub May 9 (2008)
• Xia S, Dun XP, Hu PS, Kjaer S, Zheng K, Qian Y, Solén C, Xu T, Fredholm B, Hökfelt T, Xu ZQ.Postendocytotic traffic of the galanin R1 receptor: a lysosomal signal motif on the cytoplasmic terminus.Proc Natl Acad Sci U S A.Apr 8;105(14):5609-13. Epub Apr 2(2008)
• Chen L, Fredholm BB, Jondal M. Adenosine, through the A1 receptor, inhibits vesicular MHC class I cross-presentation by resting DC.Mol Immunol.Apr;45(8):2247-54. Epub Feb 21 (2008)
• Minelli A, Bellezza I, Collodel G, Fredholm BB Promiscuous coupling and involvement of protein kinase C and extracellular signal-regulated kinase 1/2 in the adenosine A1 receptor signalling in mammalian spermatozoa.Biochem Pharmacol.Feb 15;75(4):931-41. Epub Oct 30 (2008)
• Ohta A, Lukashev D, Jackson EK, Fredholm BB, Sitkovsky M.1,3,7-trimethylxanthine (caffeine) may exacerbate acute inflammatory liver injury by weakening the physiological immunosuppressive mechanism.J Immunol. Dec 1;179(11):7431-8 (2007)
• Björklund O, Kahlström J, Salmi P, Ogren SO, Vahter M, Chen JF, Fredholm BB, Daré E.The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administration.Toxicology. Nov 30;241(3):119-33. Epub Aug 31 (2007)
• Johansson SM, Salehi A, Sandström ME, Westerblad H, Lundquist I, Carlsson PO, Fredholm BB, Katz A A1 receptor deficiency causes increased insulin and glucagon secretion in mice.Biochem Pharmacol. Dec 3;74(11):1628-35. Epub Aug 9 (2007)
• Fredholm BB, Chern Y, Franco R, Sitkovsky M.Aspects of the general biology of adenosine A2A signaling.Prog Neurobiol. Dec;83(5):263-76. Epub Aug 1. (2007)
• Wendler CC, Amatya S, McClaskey C, Ghatpande S, Fredholm BB, Rivkees SA.A1 adenosine receptors play an essential role in protecting the embryo against hypoxia.Proc Natl Acad Sci U S A. Jun 5;104(23):9697-702. Epub May 23.(2007)
• Johansson SM, Yang JN, Lindgren E, Fredholm BB.Eliminating the antilipolytic adenosine A1 receptor does not lead to compensatory changes in the antilipolytic actions of PGE2 and nicotinic acid.Acta Physiol (Oxf). May;190(1):87-96.(2007)
• Yang JN, Tiselius C, Daré E, Johansson B, Valen G, Fredholm BB.Sex differences in mouse heart rate and body temperature and in their regulation by adenosine A1 receptors.Acta Physiol (Oxf). May;190(1):63-75.(2007)
• Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair.Cell Death Differ. Jul;14(7):1315-23. Epub Mar 30. Review.(2007)
• Tabata T, Kawakami D, Hashimoto K, Kassai H, Yoshida T, Hashimotodani Y, Fredholm BB, Sekino Y, Aiba A, Kano M.G protein-independent neuromodulatory action of adenosine on metabotropic glutamate signalling in mouse cerebellar Purkinje cells.J Physiol. Jun 1;581(Pt 2):693-708. Epub Mar 22.(2007)
• Karovic O, Tonazzini I, Rebola N, Edström E, Lövdahl C, Fredholm BB, Daré E.Toxic effects of cobalt in primary cultures of mouse astrocytes. Similarities with hypoxia and role of HIF-1alpha.Biochem Pharmacol. Mar 1;73(5):694-708. Epub Nov 17 (2006)
• Lai EY, Patzak A, Steege A, Mrowka R, Brown R, Spielmann N, Persson PB, Fredholm BB, Persson AE.Contribution of adenosine receptors in the control of arteriolar tone and adenosine-angiotensin II interaction.Kidney Int. Aug;70(4):690-8. (2006)
• Fedele DE, Li T, Lan JQ, Fredholm BB, Boison D.Adenosine A1 receptors are crucial in keeping an epileptic focus localized.Exp Neurol. Jul;200(1):184-90. Epub Jun 5. (2006)
• Schotanus SM, Fredholm BB, Chergui K.NMDA depresses glutamatergic synaptic transmission in the striatum through the activation of adenosine A1 receptors: evidence from knockout mice.Neuropharmacology. Aug;51(2):272-82. Epub May 18. (2006)
• Wu WP, Hao JX, Fredholm BB, Wiesenfeld-Hallin Z, Xu XJ.Effect of acute and chronic administration of caffeine on pain-like behaviors in rats with partial sciatic nerve injury.Neurosci Lett. Jul 10;402(1-2):164-6. Epub Apr 27. (2006)
• Jonsson M, Dabrowski M, Gurley DA, Larsson O, Johnson EC, Fredholm BB, Eriksson LI.Activation and inhibition of human muscular and neuronal nicotinic acetylcholine receptors by succinylcholine.Anesthesiology. Apr;104(4):633-4. (2006)
• Brown R, Thorén P, Stege A, Mrowka R, Sällström J, Skött O, Fredholm BB, Persson AEG.The influence of the adenosine A1-receptor on blood pressure regulation and renin release.Am J Physiol Regul Integr Comp Physiol. May;290(5):R1324-9. (2006)
• Lankford AR, Yang J-N, Rose'Meyer R, French BA, Matherne GP, Fredholm BB, Yang Z.Effect of modulating cardiac A1 adenosine receptor expression on protection with ischemic preconditioning.Am J Physiol 290: H1469-H1473. (2006)
• Nergårdh R, Oerther S, Fredholm BB.Differences between A 68930 and SKF 82958 could suggest synergistic roles of D1 and D5 receptors.Pharmacol Biochem Behav 82: 495-505. (2005)
• Ammar A.A., Nergårdh R., Fredholm B.B., Brodin U. and Södersten P.Intake inhibition by NPY and CCK-8: A challenge of the notion of NPY as an "Orexigen".Behavioural Brain Research 161, 82-87. (2005)
• Andersson M., Usiello A., Borgkvist A., Pozzi L., Dominguez C., Fienberg A.A., Svenningsson P., Fredholm B.B., Borelli E., Greengard P. and Fisone G.Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons.J Neurosci 25, 8432-8438. (2005)
• Fredholm B.B., Chen J.F., Masino S.A. and Vaugeois J.M.Actions of adenosine at its receptors in the CNS: Insights from knockouts and drugs.Annual Review of Pharmacology and Toxicology 45, 385-412. (2005)
• Fredholm B.B., Chen J.-F., Cunha R.A., Svenningsson P. and Vaugeois J.-M.Adenosine and brain function.Edited by Bradley R.J., Harris R.A. and Jenner P.International Review of Neurobiology, London. pp 191-270. (2005)
• Ghanem E., Lövdahl C., Daré E., Ledent C., Fredholm B.B., Boeynaems J.M., Van Driessche W. and Beauwens R.Luminal adenosine stimulates chloride secretion through A1 receptor in mouse jejunum.American Journal of Physiology Gastrointestinal and Liver Physiology 288, G972-G977. (2005)
• Giménez-Llort L., Masino S.A., Diao L., Fernández-Teruel A., Tobeña A., Halldner L. and Fredholm B.B.Mice lacking the adenosine A1 receptor have normal spatial learning and plasticity in the CA1 region of the hippocampus, but they habituate more slowly.Synapse 57, 8-16. (2005)
• Huang Z.-L., Qu W.-M., Eguchi N., Chen J.-F., Schwarzschild M.A., Fredholm B.B., Urade Y. and Hayaishi O.Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine.Nat Neurosci 8, 858-859. (2005)
• Johansson S., Fredholm B.B., Hjort C., Morein T., Kull B. and Hu P.S.Evidence against adenosine analogues being agonists at the growth hormone secretagogue receptor.Biochemical Pharmacology Aug 15;70(4):598-605. (2005)
• Kim M., Yu X., Fredholm B.B. and Rivkees S.A.Susceptibility of the developing brain to acute hypoglycemia involving A1 adenosine receptor activation.Am J Physiol Endocrin Metab 289, 562-569. (2005)
• Kukley M., Schwan M., Fredholm B.B. and Dietrich D.The role of extracellular adenosine in regulating mossy fiber synaptic plasticity.Journal of Neuroscience 25, 2832-2837. (2005)
• Kuzmin A., Johansson B., Ögren S.-O. and Fredholm B.B.Caffeine's locomotor simulatory effect requires concomitant blockade of adenosine A1 and A2A receptors in mice.Eur Neuropsychopharmacol. Feb;16(2):129-36 (2005)
• Salmi P., Chergui K. and Fredholm B.B.Adenosine-dopamine interactions revealed in knockout mice.J Mol Neurosci 26, 239-244. (2005)
• Wu W.P., Hao J.X., Halldner L., Lövdahl C., DeLander G.E., Wiesenfeld-Hallin Z., Fredholm B.B. and Xu X.J.Increased nociceptive response in mice lacking the adenosine A1 receptor.Pain 113, 395-404. (2005)
• Halldner L, Ådén U, Dahlberg V, Johansson B, Ledent C, Fredholm BB.The adenosine A1 receptor contributes to the stimulatory, but not the inhibitory effect of caffeine on locomotion: a study in mice lacking adenosine A1 and/or A2A receptors.Neuropharmacology 46(7): 1008-1017, (2004)
• Halldner L, Lopes LV, Daré E, Lindström K, Johansson B, Ledent C, Cunha RA, Fredholm BB.Binding of adenosine receptor ligands to brain of adenosine receptor knock-out mice: evidence that CGS 21680 binds to A(1) receptors in hippocampus.Naunyn Schmiedebergs Arch Pharmacol 370(4): 270-278. (2004)
• Hammarberg C, Fredholm BB, Schulte G.Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3'-kinase.Biochem Pharmacol 67(1): 129-134. (2004)
• Jonsson M., Wyon N., Lindahl S.G., Fredholm B.B. and Eriksson L.I.Neuromuscular blocking agents block carotid body neuronal nicotinic acetylcholine receptors.European Journal of Pharmacology 497, 173-180. (2004)
• Lopes LV, Halldner L, Rebola N, Johansson B, Ledent C, Chen JF, Fredholm BB, Cunha RA.Binding of the prototypical adenosine A(2A) receptor agonist CGS 21680 to the cerebral cortex of adenosine A(1) and A(2A) receptor knockout mice.Br J Pharmacol 141(6): 1006-1014. (2004)
• Minelli A, Liguori L, Bellezza I, Rambotti MG, Johansson B, Fredholm BB.Involvement of A1 adenosine receptors in the acquisition of fertilizing capacity.J Androl 25(2): 286-292. (2004)
• Olsson T, Cronberg T, Rytter A, Asztély F, Fredholm BB, Smith ML, Wieloch T.Deletion of the adenosine A1 receptor gene does not alter neuronal damage following ischaemia in vivo or in vitro.Eur J Neurosci 20(5): 1197-1204. (2004)
• Schulte G., Sommerschild H., Yang J., Tokuno S., Goiny M., Lövdahl C., Johansson B., Fredholm B.B. and Valen G.Adenosine A receptors are necessary for protection of the murine heart by remote, delayed adaptation to ischaemia.Acta Physiologica Scandinavica 182, 133-143. (2004)