G. Paolo Dotto - Selected publications#

1. Hu, B, Castillo, E., Harewood, L., Ostano, P., Reymond, A., Dummer, R., Raffoul, W., Hoetzenecker, W., Hofbauer, G.F.L. and Dotto, G.P. (2012) Loss of mesenchymal CSL signaling leads to field cancerization and multifocal epithelial tumor development. Cell, 149, 1207–1220
   
2. Restivo, G., Nguyen, B.C., Dziunycz, P., Ristorcelli, E., Ryan, R.J., Ozuysal, O.Y., Di Piazza, M., Radtke, F., Dixon, M.J., Hofbauer, G.F., Lefort, K. and Dotto, G.P. (2011). IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes. EMBO J., 30, 4571-85
   
3. Wu, X., Nguyen, B.C., Dziunycz, P., Chang, S., Brooks, Y., Lefort, K., Hofbauer, G.F., and Dotto, G.P. (2010). Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature 465, 368-372. Citations: 24
   
4. Mandinova A, Kolev V, V Neel, B Hu, W Stonely, J Lieb, X Wu, C Colli, R Han, M Pazin, P Ostano, R Dummer, JL Brissette, and Dotto, G.P. An FGFR3/FOXN1 positive loop underlies benign skin keratosis versus squamous cell carcinoma formation. J Clin Invest. 2009: 119, 3127-3137. Citations: 13
   
5. Kolev V, Mandinova A, Guinea-Viniegra J, Hu B, Lefort K, Lambertini C, Neel V, Dummer R, Wagner EF, Dotto, G.P. EGFR signaling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. Nature Cell Biol. 2008: 10, 902-11. Citations: 49
   
6. Lefort K., Mandinova A, Ostano P., Kolev V., Calpini V., Kolfschoten I., Devgan V, Lieb J, Raffoul W, Hohl D, Neel V, Garlick J, Chiorino G, and Dotto, G.P. Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKa kinases. Genes & Dev. 2007; 21, 562-77. Citations: 74
   
7. Nguyen B-C, Lefort K, Mandinova A, Antonini D, Devgan V, Della Gatta G, Koster MI, Zhang Z, Wang J, Tommasi di Vignano A, Kitajewski J, Chiorino G, Roop DR, Missero C and Dotto, G.P. Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes & Dev. 2006; 20, 1028-42. Citations: 135
   
8. Devgan V, Mammucari C, Millar SE, Brisken C & Dotto G.P. p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes & Dev. 2005; 19:1485–1495. Citations: 106
   
9. Mammucari, C., Tommasi di Vignano, A., Sharov, A. A., Havrda, M. C., Roop, D. R., Botchkarev, V. A., Crabtree, G. R. & Dotto, G.P. Integration of Notch1 and Calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Dev Cell 2005; 8:665-76. Citations: 103
   
10. Talora, C., Sgroi, D.C., Crum, C.P. and Dotto, G.P. Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes & Dev., 2002; 16:2252–2263. Citations: 173