Wendy Bickmore - Selected publications#

1. W.A. Bickmore and B.van Steensel. (2013) Genome architecture: Domain organization of Interphase chromosomes. Cell. March 14. In press.

2. I. Williamson, R. Eskeland, L. Lettice, A. Hill, S. Boyle, G. Grimes, R.E. Hill and W.A. Bickmore. (2012). Anterior-posterior differences in HoxD chromatin topology in limb development. Develop. 139: 3157-3167.

3. M. M. Pradeepa, H.G.Sutherland, J. Ule, G.R.Grimes. and W.A. Bickmore. (2012) Psip1/Ledgf p52 binds methylated histone H3K36 and contributes to the regulation of alternative splicing. PLoS Genet. 8(5): e1002717. (6 citations)

4. R. Eskeland, M. Leeb, G. Grimes, C. Kress, S. Boyle, D. Sproul, N. Gilbert, Y. Fan, A. I. Skoultchi, A.Wutz and W. A. Bickmore. (2010) Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination. Mol Cell. 38: 452-464. (84 citations)
This paper overturns the received model of how polycomb repressive complexes control gene expression and was accompanied by a News and Views “Chromatin compaction at Hox loci: a polycomb tale beyond histone tails” by Jeffrey Simon.

5. S. Kocanova, E.A. Kerr, S. Rafique, S. Boyle, E. Katz, A. Caze-Subra, W.A. Bickmore# & K. Bystricky# (2010). Activation of estrogen responsive genes does not require their nuclear co-localisation. PLoS Genetics 6:e1000922. # joint corresponding authors (20 citations)

6. C. Morey, C. Kress, Nelly R. Da Silva, Paul Perry & W. A. Bickmore. (2009) Lack of bystander activation shows that localisation exterior to chromosome territories is not sufficient to upregulate gene expression. Genome Res. 19: 1184-1194. (28 citations)
This paper was highlighted in a Nature Journal club (2009, vol 460, p15)

7. H.G.E. Sutherland & W.A. Bickmore. (2009) Transcription factories: gene expression in unions? Nat. Rev Genet. 10: 457-466. (104 citations)

8. L.E. Finlan, D. Sproul, I. Thomson, S. Boyle, E. Kerr, P. Perry, B. Ylstra, J.R. Chubb, & W.A. Bickmore. (2008) Recruitment to the nuclear periphery can alter expression of genes in human cells. PloS Genetics. 4: e1000039. doi:10.1371/journal.pgen.1000039. (148 citations)
This paper demonstrates experimentally that the non-random organisation of human chromosomes in the nucleus can have a direct impact on gene expression. It was the subject of a News and Views article in Developmental Cell (vol 14, 461) : “Brushed aside and silenced” by Peter Fraser.

9. S.Chambeyron, N.R.Da Silva, K.A.Lawson & W.A.Bickmore (2005) Nuclear re-organisation of the HoxB complex during mouse embryonic development. Development. 132:2215-2223 (108 citations).

10. N.Gilbert, S.Boyle, H.Fiegler, K.Woodfine, N.P.Carter & W.A.Bickmore (2004) The chromatin architecture of the human genome: domains of high gene density are in open chromatin fibres. Cell 118:555-566. (234 citations)
This paper was one of the first genome-wide chromatin maps of the human genome and was highlighted in Research News in Genome Biology (vol 5, 1-2) in Nature Reviews Genetics (vol 5, 719) and in The Scientist magazine (Sept 6, 2004). It was also the subject of a News and Views article in Molecular Cell (vol 15, 844): “Stopping for FISH and Chips along the chromatin fiber superhighway” by David Spector. h index = 49, total citations = 8450