Peter Aaby - Publications#

PA has published 695 papers in the medical field; 165 first authored; 197 last/corresponding author; H-index: 87 (Google Scholar): i10:466; 27,975 citations. The 10 most important are:

1. Benn CS, Fisker AB, Rieckmann A, Sørup S, Aaby P. Vaccinology: Time to change paradigm? Lancet Infect Dis. 2020 (in press). [A review of numerous contradictions in vaccinology and definition of 6 six principles which may be the start of a new paradigm].

2. Aaby P, Fisker AB, Björkman A, Benn CS. WHO's rollout of malaria vaccine in Africa: can safety questions be answered after only 24 months? BMJ. 2020 Jan 24;368:16920. doi: 10.1136/bmj.l6920. [The new non-live malaria vaccine, RTS,S, being tested by WHO is associated with increased female mortality]

3. Andersen A, Fisker AB, Rodrigues A, Martins C, Ravn H, Lund N, Biering-Sørensen S, Benn CS, Aaby P. National Immunization Campaigns with Oral Polio Vaccine Reduce All-Cause Mortality: A Natural Experiment within Seven Randomized Trials. Front Public Health. 2018 Feb 2;6:13. [The first documentation that oral polio vaccination (OPV) campaigns have had a major impact on child mortality levels in low-income countries even though there is virtually no polio infection any longer. Boosting with OPV has beneficial non-specific effects for child survival]

4. Mogensen SW, Andersen A, Rodrigues A, Benn CS, Aaby P. The Introduction of Diphtheria-Tetanus-Pertussis and Oral Polio Vaccine Among Young Infants in an Urban African Community: A Natural Experiment. EBioMedicine. 2017;17:192-198. [The first natural experiment testing the effect of the non-live diphtheria-tetanus-pertussis (DTP) in an unbiased way. Receiving DTP was associated with 5-fold higher mortality than not being DTP-vaccinated yet. The effect was particularly bad for girls]

5. Aaby P, Ravn H, Benn CS. The WHO Review of the Possible Nonspecific Effects of Diphtheria-Tetanus-Pertussis Vaccine. Pediatr Infect Dis J. 2016 Nov;35(11):1247-1257 [A review showing that previous reviews of DTP had major survival bias. If studies with survival bias are excluded, DTP vaccination is associated with 2-fold higher mortality, the effect being particularly bad for girls]

6. Aaby P, Martins CL, Garly ML, Andersen A, Fisker AB, Claesson MH, Ravn H, Rodrigues A, Whittle HC, Benn CS. Measles vaccination in the presence or absence of maternal measles antibody: impact on child survival. Clin Infect Dis. 2014;59:484-92 [Christine Benn and I showed in the first study that child mortality was more than 50% lower when measles vaccine had been received in the presence of maternal measles antibody, contradicting the major assumptions in current vaccinology for the public health impact of measles vaccine]

7. Aaby P, Martins CL, Garly ML, Bale C, Andersen A, Rodrigues A, Ravn H, Lisse IM, Benn CS, Whittle H. Non-specific effects of standard measles vaccine at 4.5 and 9 months of age on childhood mortality: Randomised controlled trial. BMJ 2010;341:c6495 [The first randomised trial of live measles vaccine (MV) with mortality as the main outcome. MV reduced child mortality, the effect being particularly beneficially for girls]

8. Aaby P, Jensen H, Samb B, Cisse B, Sodeman M, Jakobsen M, Poulsen A, Rodrigues A, Lisse IM, Simondon F, Whittle H. Differences in female-male mortality after high-titre measles vaccine and association with subsequent vaccination with diphtheria-tetanus-pertussis and inactivated poliovirus: re-analysis of West African studies. Lancet 2003;361: 2183-88 [This review exlained why high-titre measles vaccine (HTMV) was associated with 2-fold higher female mortality and had to be withdrawn by WHO. HTMV was given early at 4-5 months of age and the children therefore received DTP after HTMV and this was deleterious for girls]

9. Aaby P, Samb B, Simondon F, Coll Seck AM, Knudsen K, Whittle H. Non-specific beneficial effect of measles immunisation: analysis of mortality studies from developing countries. BMJ 1995;311:481-485 [The first paper in recent times to suggest that a vaccine (measles vaccine) may have beneficial effects for child survival which are not explained by the prevention of measles infection]

10. Aaby P, Bukh J, Lisse IM, Smits AJ. Overcrowding and intensive exposure as determinants of measles mortality. Am J Epidemiol 1984; 120:49 63 [We showed in Guinea-Bissau that the very high measles case fatality (>20%) was not due to malnutrition but to intensive exposure to infection within the home, caused by overcrowding. The same principle was later shown to apply also to chickenpox, whooping cough and polio infection]