Robin Angus Silver - Publications#

Selection of original research papers:

Gleeson P, Cantarelli M, Marin B, Quintana A, Earnshaw M, Sadeh S, Piasini E, Birgiolas J, Cannon RC, Cayco-Gajic NA, Crook S, Davison AP, Dura-Bernal S, Ecker A, Hines ML, Idili G, Lanore F, Larson SD, Lytton WW, Majumdar A, McDougal RA, Sivagnanam S, Solinas S, Stanislovas R, van Albada SJ, van Geit W, Silver RA. (2019) Open Source Brain: A Collaborative Resource for Visualizing, Analyzing, Simulating, and Developing Standardized Models of Neurons and Circuits. Neuron, pii: S0896-6273(19)30444-1. doi: 10.1016/j.neuron.2019.05.019.

Cayco-Gajic, N.A. & Silver R.A. (2019) Re-evaluating Circuit Mechanisms Underlying Pattern Separation. Neuron. 101(4):584-602. doi: 10.1016/j.neuron.2019.01.044.

Cantarelli M, Marin B, Quintana A, Earnshaw M, Court R, Gleeson P, Dura-Bernal S, Silver RA, Idili G. (2018) Geppetto: a reusable modular open platform for exploring neuroscience data and models. Philos Trans R Soc Lond B Biol Sci;373(1758). pii: 20170380. doi: 10.1098/rstb.2017.0380.

Rothman JS, Silver RA. (2018) NeuroMatic: An Integrated Open-Source Software Toolkit for Acquisition, Analysis and Simulation of Electrophysiological Data. Front Neuroinform. 2018 Apr 4;12:14. doi: 10.3389/fninf.2018.00014. eCollection 2018.

Sadeh S, Silver RA, Mrsic-Flogel TD, Muir DR. (2017) Assessing the Role of Inhibition in Stabilizing Neocortical Networks Requires Large-Scale Perturbation of the Inhibitory Population Journal of Neuroscience, 37(49):12050-12067. doi: 10.1523/JNEUROSCI.0963-17.2017.

Nadella, K. M. N. S., Roš, H., Baragli, C., Griffiths, V.A., Konstantinou, G., Koimtzis, T., Evans, G.J., Kirkby, P.A. and Silver, R.A. (2016) Random-access scanning microscopy for 3D imaging in awake behaving animals. Nature Methods, 13(12):1001-1004. doi: 10.1038/nmeth.4033.

Szoboszlay, M., Lőrincz, A., Lanore, F., Vervaeke, K., Silver, R.A., Nusser, Z. (2016) Functional properties of dendritic gap junctions in cerebellar Golgi cells. Neuron. 90, 1043-1056. doi:10.1016/j.neuron.2016.03.029.

Konstantinou G, Kirkby PA, Evans GJ, Naga Srinivas Nadella KM, Griffiths VA, Mitchell JE, Angus Silver R (2016). Dynamic wavefront shaping with an acousto-optic lens for laser scanning microscopy. Opt Express; 24(6):6283-99. doi: 10.1364/OE.24.006283.

Rothman JS, Kocsis L, Herzog E, Nusser Z, Silver RA. (2016) Physical determinants of vesicle mobility and supply at a central synapse. Elife ;5. pii: e15133. doi: 10.7554/eLife.15133.

Nakamura Y, Harada H, Kamasawa N, Matsui K, Rothman JS, Shigemoto R, Silver RA, DiGregorio DA, Takahashi T. (2015) Nanoscale distribution of presynaptic Ca(2+) channels and its impact on vesicular release during development. Neuron; 85(1):145-158. doi: 10.1016/j.neuron.2014.11.019.

Evans GJ, Kirkby PA, Naga Srinivas Nadella KM, Marin B, Angus Silver R. (2015) Development and application of a ray-based model of light propagation through a spherical acousto-optic lens. Opt Express; 23(18):23493-510. doi: 10.1364/OE.23.023493.

Cannon RC, Gleeson P, Crook S, Ganapathy G, Marin B, Piasini E, Silver RA. (2014) LEMS: a language for expressing complex biological models in concise and hierarchical form and its use in underpinning NeuroML 2. Front Neuroinform. 8:79. doi: 10.3389/fninf.2014.00079. eCollection 2014.

Billings, G., Piasini, E., Lőrincz, A., Nusser, Z. and Silver, R.A. (2014). Network structure within the cerebellar input layer enables lossless sparse encoding. Neuron 83(4):960-74. doi: 10.1016/j.neuron.2014.07.020.

Farinella, M., Ruedt, D.T., Gleeson, P., Lanore, F. and Silver, R.A.. (2014) Glutamate-bound NMDARs arising from in vivo-like network activity extend spatio-temporal integration in a L5 cortical pyramidal cell model. PLoS Computational Biology. 10(4):e1003590. doi: 10.1371/journal.pcbi.1003590.

Vervaeke, K., Lorincz, A., Nusser, Z., and Silver, R.A. (2012). Gap junctions compensate for sublinear dendritic integration in an inhibitory network. Science 335, 1624-1628. PMID: 22403180.

Vervaeke, K., Lőrincz, A., Gleeson, P., Farinella, M., Nusser Z, Silver, R.A. (2010) Rapid desynchronization of an electrically coupled interneuron network with sparse excitatory synaptic input. Neuron, 67(3):435-51.

Kirkby, P.A., Srinivas Nadella K.M. and Silver, R.A.. (2010) A compact Acousto-Optic Lens for 2D and 3D femtosecond based 2-photon microscopy. Optics Express. 18(13):13721-45.

Silver, R.A. (2010) Neuronal arithmetic. Nature Reviews Neuroscience. 11(7): 474-489.

Gleeson P, Crook S, Cannon RC, Hines ML, Billings GO, Farinella M, Morse TM, Davison AP, Ray S, Bhalla US, Barnes SR, Dimitrova YD, Silver RA. (2010) NeuroML: a language for describing data driven models of neurons and networks with a high degree of biological detail. PLoS Comp. Biol. 6(6):e1000815.

Rothman, J.S., Cathala, L., Steuber, V. and Silver, R.A. (2009) Synaptic depression enables neuronal gain control. Nature 457(7232):1015-8. doi: 10.1038/nature07604.

Arenz, A. Silver, R.A. Schaefer, A.T and Margrie, T.W. (2008). The contribution of single synapses to sensory representation in vivo. Science 321(5891), 977-980.

Kanichay, R.T. and Silver, R.A. (2008) Synaptic and cellular properties of the feedforward inhibitory circuit within the input layer of the cerebellar cortex. Journal of Neuroscience 28(36):8955-67.

Gleeson,P., Steuber,V. and Silver,R.A. (2007). neuroConstruct: a tool for modeling networks of neurons in 3D space. Neuron 54(2), 219-235.

Steuber,V., Mittmann,W., Hoebeek,F.E., Silver,R.A., De Zeeuw,C.I.,Hausser,M. and De Schutter,E. (2007). Cerebellar LTD and pattern recognition by Purkinje cells. Neuron 54(1), 121-136.

Saviane, C. and Silver, R.A. (2006) Fast vesicle reloading and a large pool sustain high bandwidth transmission at a central synapse. Nature, 439, 983-987.

Nielsen TA, DiGregorio DA, Silver RA.(2004) Modulation of glutamate mobility reveals the mechanism underlying slow-rising AMPAR EPSCs and the diffusion coefficient in the synaptic cleft. Neuron; 42(5):757-71.

Silver, R.A., Lübke, J., Sakmann, B. and Feldmeyer, D. (2003) High Probability Uniquantal Transmission at Excitatory Synapses in Barrel Cortex. Science 302, 1981-1984.

Mitchell, S. J. & Silver, R.A. (2003) Shunting inhibition modulates neuronal gain during synaptic excitation. Neuron 38, 433-445.

DiGregorio DA, Nusser Z, Silver RA. (2002) Spillover of glutamate onto synaptic AMPA receptors enhances fast transmission at a cerebellar synapse. Neuron;35(3):521-33.

Mitchell SJ, Silver RA (2000) Glutamate spillover suppresses inhibition by activating presynaptic mGluRs. Nature; 404(6777):498-502.

Silver, R.A., Momiyama, A., and Cull-Candy, S.G. (1998). Locus of frequency-dependent depression identified with multiple-probability fluctuation analysis at rat climbing fibre-Purkinje cell synapses. Journal of Physiology 510 ( Pt 3), 881-902.

Silver, R.A., Traynelis, S.F., and Cull-Candy, S.G. (1992). Rapid-time-course miniature and evoked excitatory currents at cerebellar synapses in situ. Nature 355, 163-166.