Balazs Sarkadi#

l. Gárdos, G., Szász, I. Sarkadi, B.: Mechanism of Ca-dependent K transport in human red cells. In: Biomembranes: Structure and Function, (eds. G. Gárdos, I. Szász), Akadémiai Kiadó, Budapest, North Holland P.Co. Amsterdam, pp. 167-l80, (1975)

2. Sarkadi, B., Tosteson, D.C.: Active cation transport in human red cells. In: Membrane Transport in Biology, Vol. 2. (eds. G. Giebisch, D.C. Tosteson, and H.H. Ussing), Springer Verlag, Berlin, pp.117-160, (l978)

3. Sarkadi, B., Enyedi, A., Szász, I., Gárdos, G.: Effect of calmodulin on active calcium uptake and membrane phosphorylation in inside-out red cell membrane vesicles. In: Genetics, Structure and Function of Blood Cells (eds. S.R. Hollan, G. Gárdos, B. Sarkadi), Pergamon Press, Akadémiai Kiadó, Budapest, pp. l8l-188 (l980)

4. Szász, I., Sarkadi, B., Gárdos, G.: Calcium-sensitivity of calcium dependent functions in human red blood cells. In: Genetics, Structure and Function of Blood Cells, (eds. S.R. Hollán, G. Gárdos, B. Sarkadi), Pergamon Press, Akadémiai Kiadó, Budapest, pp. 211-222 (l980)

5. Sarkadi, B., Szebeni, J., Gárdos, G.: Effects of calcium on cation transport processes in inside-out red cell membrane vesicles. In: Membrane Transport in Erythrocytes, Alfred Benson Symposium 14. (eds. U.V. Lassen, H.H. Ussing, J.O. Wieth), Munksgaard, Copenhagen, pp. 220-231, (l980)

6. Gárdos, G., Szász, I., Sarkadi, B., Szebeni, J.: Various pathways for passive cation transport in red cells. In: Membrane Transport in Erythrocytes, Alfred Benson Symposium 14. (eds. U.V. Lassen, H.H. Ussing, J.O. Wieth), Munksgaard, Copenhagen, pp. 163-174, (l980)

7. Sarkadi, B.: Active calcium transport in human red cells. Biochem. Biophys. Acta, Reviews on Biomembranes, 604, l59-190, (1980)

8. Sarkadi, B., Szász, I., Gárdos, G.: Calcium and calmodulin in the regulation of blood cell functions. Haematologia l4, l21-136, (1981)

9. Grinstein, S., Rothstein, A., Sarkadi, B., Gelfand, E.W.: Responses of human lymphocytes to anisotonic media: volume-regulating behaviour. Am. J. Physiol. 246, C204-C215, (l984)

10. Sarkadi, B., and Gárdos, G.: Calcium-induced potassium transport in cell membranes. In: Enzymes of Biological Membranes, 2nd ed. (A. Martonosi, ed.), Vol. 3, pp. 193-234, Plenum Publ. Co. (1985)

11. Sarkadi, B., and Gárdos, G.: Drug actions on potassium fluxes in red cells. In: The Red Cell Membrane: A Model For Solute Transport, (B.U. Raess and G.Tunnicliff, eds.), Humana Publ. Co, (1989)

12. Sarkadi, B., Parker, C.: Activation of ion transport pathways by changes in cell volume. Biochim. Biophys. Acta, Reviews on Biomembranes, 1071, 407-427, (1991)

13. Homolya, L., Müller, M., Holló, Zs., Sarkadi, B.: Fluorescence assay for studying P-glycoprotein function at single cell level. In: Fluorescence Microscopy and Fluorescent Probes, pp. 241-245, (J. Slavik, ed.) Plenum Press, NY, (1996)

14. Sarkadi, B., Müller, M. : Search for specific inhibitors of the multidrug transporters. Sem. Cancer Biol. 8, 171-182 (1997)

15. Váradi, A., Tusnády, G.E., Bakos, É., Sarkadi, B.: Membrane topology of the human multidrug resistance-associated protein (MRP) and its homologs. Cytotechnology 27, 71-79 (1998), and In: Multiple Drug Resistance in Cancer 2, M. Clynes, ed., Kluwer Acad. Pub, pp. 71-80 (1998)

16. Klein, I., Sarkadi, B., Váradi, A.: An inventory of the human ABC proteins. Biochim. Biophys. Acta, 1461, 237-262 (1999)

17. Váradi, A., Szakács, G., Bakos, É., and Sarkadi, B.: P glycoprotein and the mechanism of multidrug resistance. In: Mechanism of Drug Resistance in Epilepsy – Lessons from Oncology. John Wiley and sons, LTD, Novartis Foundation, pp. 54-68 (2002).

18. Szakács, G., and Sarkadi, B.: Multidrug resistance in cancer and modulation of drug effects by ABC transporters. In: Molecular Pathomechanisms and New Trends in Drug Research, Harwood Acad. Publ., The Netherlands, 2003.

19. Váradi, A., Tusnády, G.E., and Sarkadi, B.: Membrane topology of ABC transporters. In: ABC Proteins: From Bacteria to Man, Elsevier, 2003.

20. Glavinas H., Krajcsi, P., Cserepes, J., Sarkadi B.. : The role of ABC transporters in drug resistance, metabolism, and toxicity. Current Drug Delivery, 1, 27-42 (2004)

21. Sarkadi, B., Özvegy-Laczka, Cs., Német, K., Váradi, A.: ABCG2 – a transporter for all seasons. Minireview. FEBS Lett. 567, 116-120 (2004)

22. Tusnády GE, Sarkadi B, Simon, I., Váradi, A.: Membrane topology of human ABC proteins. FEBS Lett. 580, 1017-1022 [Epub 2005 Dec 1] (2006)

23. Sarkadi B, Homolya L, Szakács G, Váradi A.: Human Multidrug Resistance ABCB and ABCG Transporters: Participation in a Chemoimmunity Defense System. Physiol. Rev. 86, 1179-1236 (2006)

24. Szakács, G., Váradi, A, Özvegy-Laczka, C, and Sarkadi, B. : The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicology (ADME-Tox) Drug Discovery Today, 13, 379-93. Epub 2008 Feb 20. (2008)

25. Hegedűs C, Szakács, G., Homolya, L., Orbán, T.I., Telbisz, Á., Jani, M., and Sarkadi, B.: Ins and outs of the ABCG2 multidrug transporter: an update of in vitro functional assays. Advanced Drug Delivery Reviews, 61, 47–56 (2009)

26. Hegedűs, C, Özvegy-Laczka, C., Szakács, G., and Sarkadi, B. : Interaction of anticancer protein kinase inhibitors with ABC multidrug transporters: substrates and/or inhibitors? Current Cancer Drug Targets, 9:252-272 (2009)

Publications in international journals:

1. Spät, A., Sarkadi, B., Intôdy, Zs., Körner, A., Szántó, J.: Effect of renal papillary lipids and prostaglandin E-2 on corticosteroid production in the rat. Acta Physiol. Acad. Sci. Hung. 40, 187-199, (l971)

2. Sarkadi, B., Schubert, A.: Energy consumption of active sodium transport in isolated frog skin. Acta Biochim. Biophys. Acad. Sci. Hung. 7, 367-376, (l972)

3. Goldschmidt, B., Sarkadi, B., Gárdos, G., Matláry, A.: Platelet production and survival in cyanotic congenital heart disease. Scand. J. Haematol. 13, 110-115, (l974)

4. Szász, I., Sarkadi, B., Gárdos, G.: Erythrocyte parameters during induced Ca-dependent rapid K- efflux: optimum conditions for kinetic analysis. Haematologia 8, 143-151, (l974)

5. Sarkadi, B., Szász, I., Gárdos, G.: The use of ionophores for rapid loading of human red cells with radioactive cations for cation pump studies. J. Membrane Biol. 26, 357-370, (l976)

6. Sarkadi, B., Szász, I., Gerlóczi, A., Gárdos, G.: Transport parameters and stoichiometry of active calcium ion extrusion in intact human red cells. Biochim. Biophys. Acta 464, 93-107, (l977)

7. Schubert, A., Sarkadi, B.: Kinetic studies on the calcium-dependent potassium transport in human red blood cells. Acta Biochim. Biophys. Acad. Sci. Hung. 12, 207-216, (l977)

8. Szász, I., Sarkadi, B., Gárdos, G.: Mechanism of Ca-dependent selective rapid K-transport induced by propranolol in red cells. J. Membrane Biol. 35, 75-93, (l977)

9. Gárdos, G., Szász, I., Sarkadi, B.: Effect of intracellular calcium on the cation transport processes in human red cells. Acta Biol. Med. Germ. 36, 823-829, (l977)

10. Szász, I., Sarkadi, B., Gárdos, G.: Changes in the Ca-transport processes of red cells during cold storage in ACD. Brit. J. Haematol. 39, 559-568, (l978)

11. Szász, I., Sarkadi, B., Schubert, A., Gárdos, G.: Effects of lanthanum on calcium-dependent phenomena in human red cells. Biochim. Biophys. Acta 512, 331-340, (l978)

11/a. Szász I., Hasitz, M., Sarkadi, B., Gárdos, G.: Phosphorylation of the Ca-pump intermediate in intact red cells, isoltaed membranes and inside-out vesicles. Mol. Cell. Biochem. 22, 147-152 (1978)

12. Sarkadi, B., Macintyre, J.D., Gárdos, G.: Kinetics of active calcium transport in inside-out red cell membrane vesicles. FEBS Letters 89, 78-82, (l978)

13. Pandey, G.B., Sarkadi, B., Haas, M., Gunn, R.B., Davis, J.M., Tosteson, D.C.: Lithium transport pathways in human red cells. J. Gen. Physiol. 72, 233-247, (l978)

14. Sarkadi, B., Alifimoff, J.K., Gunn, R.B., Tosteson, D.C.: Kinetics and stoichiometry of Na-dependent Li transport in human red blood cells. J. Gen. Physiol. 72, 249-265, (l978)

15. Szász, I., Sarkadi, B., Gárdos, G.: Effects of drugs on the calcium-dependent rapid potassium transport in calcium-loaded intact red cells. Acta Biochim. Biophys. Acad. Sci. Hung. 13, 133-141 (l978)

16. Sarkadi, B., Schubert, A., Gárdos, G.: Effects of Ca-EGTA buffers on active calcium transport in inside-out red cell membrane vesicles. Experientia 35, 1045-1047, (l979)

l7. Sarkadi, B., Szász, I., Gárdos, G.: Comments on the red blood cell calcium pump:an estimate of stoichiometry. J. Membrane Biol. 46, l83-l84, (l979)

18. Sarkadi, B., Szász, I., Gárdos, G.: Characteristics and regulation of active calcium transport in inside-out red cell membrane vesicles. Biochim. Biophys. Acta 598, 326-338, (l980)

19. Sarkadi, B., Enyedi, A., Gárdos, G.: Molecular properties of the red cell calcium pump:I. Effects of calmodulin, proteolytic digestion and drugs on the kinetics of active calcium uptake in inside-out red cell membrane vesicles. Cell Calcium l, 287-297, (1980)

20. Enyedi, A., Sarkadi, B., Szász, I., Bot, G., Gárdos, G.: Molecular properties of the red cell calcium pump:II. Effects of calmodulin, proteolytic digestion and drugs on the calcium-induced membrane phosphorylation by ATP in inside-out red cell membrane vesicles. Cell Calcium 1, 299-310, (l980)

21. Sarkadi, B., Enyedi, A., Gárdos, G.: Metal-ATP complexes as substrates and free metal ions as activators of the red cell calcium pump. Cell Calcium 2, 449-458, (l981)

22. Szász, I., Sarkadi, B., Gárdos, G.: Operation of a Ca-dependent K(Rb)-transport in human lymphocytes. Haematologia 15, 83-89, (l981)

23. Marino, D., Sarkadi, B., Gárdos, G., Bolis, L.: Calcium-induced alkali cation transport in nucleated red cells. Mol. Physiol. 1, 295-300, (l981)

24. Enyedi, A., Sarkadi, B., Nyers, A., Gárdos, G.: Effects of divalent metal ions on the calcium pump and membrane phosphorylation in human red cells. Biochim. Biophys. Acta 690, 41-49, (l982)

25. Sarkadi, B., Enyedi, A., Szász, I., Gárdos, G.: Active calcium transport and calcium-dependent membrane phosphorylation in human peripheral blood lymphocytes. Cell Calcium 3, 163-182, (l982)

26. Sarkadi, B., Enyedi, A., Nyers, A., Gárdos, G.: The function and regulation of the calcium pump in the erythrocyte membrane. Ann. N. Y. Acad. Sci. 402, 329-346, (l982)

27. Enyedi, A., Sarkadi, B., Gárdos, G.: On the substrate specificity of the red cell calcium pump. Biochim. Biophys. Acta 687, 109-112, (l982)

28. Sarkadi, B., Enyedi, A., Faragó, A., Mászáros, G., Kremmer, T., Gárdos, G.: Cyclic AMP-dependent protein kinase stimulates the formation of polyphosphoinositides in lymphocyte plasma membrane. FEBS Letters 152, 195-198, (l983)

29. Enyedi, A., Faragó, A., Sarkadi, B., Szász, I., Gárdos, G.: Cyclic AMP-dependent protein kinase stimulates the formation of polyphosphoinositides in the plasma membranes of different blood cells. FEBS Letters 161, 158-162, (l983)

30. Grinstein, S., Cohen, S., Sarkadi, B., Rothstein, A.: Induction of 86-Rb fluxes by Ca and volume changes in thymocytes and their isolated membranes. J. Cell. Physiol. 116, 352-362, (l983)

31. Sarkadi, B., Mack, E., Rothstein, A.: Ionic events during the volume response of human peripheral blood lymphocytes to hypotonic media: I. Distinctions between volume-activated Cl and K conductance pathways. J. Gen. Physiol. 83, 497-512, (l984)

32. Sarkadi, B., Mack, E., Rothstein, A.: Ionic events during the volume response of human peripheral blood lymphocytes to hypotonic media: II. Volume-and time-dependent activation and inactivation of ion transport pathways. J.Gen. Physiol. 83, 513-527, (l984)

33. Sarkadi, B., Attisano, L., Grinstein, S., Buchwald, M., Rothstein, A.: Volume regulation of Chinese hamster ovary cells in anisoosmotic media. Biochim. Biophys. Acta 774, 159-164, (l984)

34. Enyedi, A., Faragó, A., Sarkadi, B., Gárdos, G.: Cyclic AMP-dependent protein kinase and Ca-calmodulin stimulate the formation of polyphosphoinositides in a sarcoplasmic reticulum preparation of rabbit heart. FEBS Letters, l76, 235-238, (1984)

35. Farkas, G., Enyedi, A., Sarkadi, B., Gárdos, G., Nagy, Z., Faragó, A.: Cyclic AMP-dependent protein kinase stimulates the phosphorylation of phosphatidylinositol to phosphatidylinositol-4-monophosphate in a plasma membrane preparation from pig granulocytes. Biochem. Biophys. Res. Commun., 124, 871-876, (1984)

36. Sarkadi, B., Cheung, R., Mack, E., Grinstein, S., Gelfand, E.W., Rothstein, A.: Cation and anion transport pathways in the volume regulatory response of human lymphocytes to hypoosmotic media. Am. J. Physiol. 248, C48O-C487, (1985)

37. Sarkadi, B., Grinstein, S., Rothstein, A., Gárdos, G.: Analysis of Ca-induced K transport by human erythrocytes in propionate media. Acta Biochim. Biophys. Acad. Sci. Hung., 20, 193-202, (1985)

38. Sarkadi, B., Enyedi, A., Földes-Papp, Z., Gárdos, G.: Molecular characterization of the in situ red cell membrane calcium pump by limited proteolysis. J. Biol. Chem. 261, 9552-9557, (l986)

39. Enyedi, A., Sarkadi, B., Földes-Papp, Z., Monostory, S., Gárdos, G.: Demonstration of two distinct calcium pumps in human platelet membrane vesicles. J. Biol. Chem. 261, 9558-9563, (1986)

40. Sarkadi, B., Enyedi, A., Gárdos, G.: Conformational changes of the in situ red cell membrane calcium pump affect its proteolysis. Biochim. Biophys. Acta, 899, 129-133 (1987)

41. Enyedi, A., Flura, M., Sarkadi, B., Gárdos, G., Carafoli, E.: Maximum activity and the calcium affinity of the red cell membrane calcium pump may be regulated independently. J. Biol. Chem. 262, 6425-6430, (1987)

42. Szirmai, M., Sarkadi, B., Szász, I., Gárdos, G.: Volume regulatory mechanisms in human platelets. Haematologia, 21, 33-40 (1988)

43. Hunyady, L., Sarkadi, B., Cragoe, E.J., Spät, A., Gárdos, G.: Activation of sodium-proton exchange is not a prerequisite for Ca mobilization and aggregation in human platelets. FEBS Letters, 225, 72-76 (1987)

44. Sarkadi, B., Enyedi, A., Penniston, J.T., Verma, A.K., Dux, L., Molnár, E., Gárdos, G.: Characterization of membrane calcium pumps by simultaneous immunoblotting and 32-P radiography. Biochim. Biophys. Acta, 939, 40-46 (1988)

45. Újhelyi, E., Onódy, K., Minh, D.Q., Sarkadi, B., Füst, G.: Enhancing effect of L-interferon on the C-2 synthesis by cultured human monocytes. Immunol. Letters 15, 41-44, (1987)

46. Magócsi, M., Enyedi, A., Sarkadi, B., Gárdos, G.: Effects of phosphoinositides on calcium movements in human platelet membrane vesicles. Biochim. Biophys. Acta, 944, 202-212 (1988)

47. Papp, B., Sarkadi, B., Enyedi, A., Caride, A.J., Penniston, J.T., and Gárdos, G.: Functional domains of the in situ red cell membrane calcium pump revealed by proteolysis and monoclonal antibodies. Possible sites of regulation by calpain and acidic lipids. J. Biol. Chem., 264, 4577-4582 (1989)

48. Tordai, A., Sarkadi, B., Görög, Gy., Gárdos, G.: Inhibition of the CD3-mediated calcium signal by protein kinase C activators in human T (Jurkat) lymphoblastoid cells. Immunol. Letters, 20, 47-52 (1989)

49. Magócsi, M., Sarkadi, B., Kovács, T., Gárdos, G.: Thrombin-induced activation of calcium transport pathways and their role in platelet functions. Biochim. Biophys. Acta 984, 88-96 (1989)

50. Kovács, T., Szász, I., Sarkadi, B., Brezanoczi, F., Gárdos, G.: Volume regulatory mechanisms of human granulocytes in hypoosmotic media. Acta Biochim. Biophys. Hung. 24, 83-99 (1989)

51. Enouf, J., Bredoux, R., Bourdeau, N., Sarkadi, B., Levy-Toledano, S.: Further characterization of the plasma membrane- and intracellular membrane-associated platelet Ca-transport systems. Biochem. J. 263, 547-552 (1989)

52. Sarkadi, B., Tordai, A., Gárdos, G.: Membrane depolarization selectively inhibits receptor-operated calcium channels in human T (Jurkat) lymphoblasts. Biochim. Biophys. Acta 1027, 130-140 (1990)

53. Sarkadi, B., Tordai, A., Müller, M., Gárdos, G.: Regulation of stimulus-induced calcium transport pathways in human T (Jurkat) lymphoblasts. Mol. Immunol. 27, 1297-1306 (1990)

54. Kovács, T., Tordai, A., Szász, I., Sarkadi, B., Gárdos, G.: Membrane depolarization inhibits thrombin-induced calcium influx and aggregation in human platelets. FEBS Letters 266, 171-174 (1990)

55. Sarkadi, B., Tordai, A., Homolya, L., Scharff, O., Gárdos, G.: Calcium influx and intracellular calcium release in anti-CD3 antibody-stimulated and thapsigargin-treated human T lymphoblasts. J. Membrane Biol. 123, 9-21 (1991)

56. Papp, B., Enyedi, A., Kovács, T., Sarkadi, B., Wuytack, F., Thastrup, O., Gárdos, G., Bredoux, R., Levy-Toledano, S., Enouf, J.: Demonstration of two forms of calcium pumps by thapsigargin inhibition and radio-immunoblotting in platelet membrane vesicles. J. Biol. Chem. 266, 14593-14596 (1991)

57. Sarkadi, B., Bauzon, D., Huckle, J.R., Earp, H.S., Berry, A., Suchindran, H., Price, E.M., Olsen, J.C., Boucher, R.C., Scarborough, G.A.: Biochemical characterization of the cystic fibrosis transmembrane conductance regulator in normal and cystic fibrosis epithelial cells. J. Biol. Chem. 267, 2087-2095 (1992)

58. Sarkadi, B., Price, E.M., Boucher, R.C., Germann, U., Scarborough, G.A.: Expression of the human multidrug resistance cDNA in insect cells generates a high-activity drug-stimulated ATPase. J. Biol. Chem. 267, 4854-4858 (1992)

59. Olsen, J.C., Johnson, L.G., Stutts, J.M., Sarkadi, B., Yankaskas, J.R., Swanstrom, R., Boucher, R.C.: Correction of the apical membrane chloride permeability defect in polarized cystic fibrosis airway epithelia following retroviral-mediated gene transfer. Human Gene Therapy 3, 253-266 (1992)

60. Johnson, L.G., Olsen, J.C., Sarkadi, B., Moore, K.L., Swanstrom, R., Boucher, R.C.: Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis. Nature Genet. 2, 21-25 (1992)

61. Papp, B., Enyedi, Á., Pászty, K., Kovács, T., Sarkadi, B., Gárdos, G., Magnier, C., Wuytack, F., Enouf, J. : Simultaneous presence of two distinct endoplasmic reticulum type calcium pump isoforms in human cells. Characterization by radio-immunoblotting and inhibition by 2,5-di-(t-butyl)-1,4-benzohydroquinone. Biochem. J. 288, 297-302 (1992)

62. Yankaskas, J.R., Haizlip, J.E., Conrad, M., Koval, D., Lazarowski, E., Paradiso, A.M., Rinehart, C.A., Sarkadi, B., Schlegel, R., Boucher, R,C.: Papilloma virus immortalized tracheal epithelial cells retain a well-differentiated phenotype. Am. J. Physiol, Cell Physiol. 264, C1219-C1230, (1993)

63. Papp, B., Pászty, K., Kovács, T., Sarkadi, B., Gárdos, G., Enouf, J., and Enyedi, Á: Characterization of the inositol trisphosphate-sensitive and -insensitive calcium stores by selective inhibition of the endoplasmic reticulum type calcium pump isoforms in isolated platelet membrane vesicles. Cell Calcium, 14, 531-538, (1993)

64. Homolya, L., Holló, Zs., Germann, U.A., Pastan, I., Gottesman, M.M., and Sarkadi, B. : Fluorescent cellular indicators are extruded by the multidrug resistance protein. J. Biol. Chem. 268, 21493-21496 (1993)

65. König, T., Kapus, A., Sarkadi, B. : Effects of equisetin on rat liver mitochondria: evidence for inhibition of substrate anion carriers of the inner membrane. J. Bioenerg. Biomembr. 25, 537-545 (1993)

66. Kovács, T., Corvazier, E., Papp, B., Magnier, C., Bredoux, R., Enyedi, Á., Sarkadi, B., Enouf, J.: Controlled proteolysis of Ca-ATPases in human platelet and non-muscle cell membrane vesicles. J. Biol. Chem. 269, 6177-6184 (1994)

67. Stutts, M. J., Gabriel, S.E., Price, E.M., Sarkadi, B., Olsen, J.C., and Boucher, R.C.: Pyridine nucleotide redox potential modulates cystic fibrosis transmembrane regulator chloride conductance. J. Biol. Chem. 269, 8867-8874 (1994)

68. Holló, Zs., Homolya, L., Davis, C.W., and Sarkadi, B. : Calcein accumulation as a fluorometric functional assay of the multidrug transporter. Biochim. Biophys. Acta, 1191, 384-388 (1994)

69. Sarkadi, B., Müller, M., Homolya, L., Holló, Zs., Seprôdi, J., Germann, U.A., Gottesman, M.M., Price, E., and Boucher, R.C. : Interaction of bioactive peptides with the human multidrug transporter. FASEB Journal, 8, 766-770 (1994)

70. Welker, E., Szabó, K., Holló, Zs., Müller, M., Sarkadi, B., Váradi, A. : Drug-stimulated ATPase activity of a deletion mutant of the human multidrug-resistance protein (MDR1). Biochem. Biophys. Res. Comm. 216, 602-609 (1995)

71. Müller, M., Bakos, É., Welker, E., Váradi, A., Germann, U.A., Gottesman, M.M., Morse, B., S., Roninson, I.B., Sarkadi, B. : Altered drug-stimulated ATPase activity in mutants of the human multidrug transporter. J. Biol. Chem. 271, 1877-1883 (1996)

72. Homolya, L., Holló, Zs., Müller, M., Mechetner, E.B., Sarkadi, B. : A new method for quantitative assessment of P-glycoprotein related multidrug resistance in tumor cells. British J. Cancer, 73, 849-855 (1996)

73. Holló, Zs., Homolya, L., Hegedûs, T., Sarkadi, B. : Transport properties of the multidrug resistance associated protein (MRP) in human tumour cells. FEBS Letters, 383, 99-104 (1996)

74. Bakos, É., Hegedûs, T., Holló, Zs., Welker, E., Tusnády, G.E., Zaman, G, Flens, M.J., Váradi, A., and Sarkadi, B.: Membrane topology and glycosylation of the human multidrug resistance associated protein (MRP). J. Biol. Chem. 271, 12322-12326 (1996)

75. Sarkadi, B., Müller, M., Holló, Zs. : The multidrug transporters - proteins of an ancient immune system. Immunol. Let. 54, 215-219 (1996)

76. Tusnády, G.E., Bakos, É., Váradi, A., Sarkadi, B. : Membrane topology distinguishes a subfamily of ATP-binding casette (ABC) transporters. FEBS Letters, 402, 1-3 (1997)

77. Bakos, É., Klein, I., Welker, E., Szabó, K., Müller, M., Sarkadi, B., and Váradi, A.: Characterization of the human multidrug resistance protein containing mutations in the ATP-binding cassette signature region. Biochem. J. 323, 777-783 (1997)

78. Szabó, K., Bakos, É., Welker, E., Müller, M., Goodfellow, H. R., Higgins, C. F., Váradi, A., and Sarkadi, B. : Phosphorylation site mutations in the human multidrug transporter (MDR1) modulate its drug-stimulated ATPase activity. J. Biol. Chem., 272, 23165-23171 (1997)

79. Szabó, K., Welker, E., Bakos, É., Müller, M., Roninson, I., Váradi, A., and Sarkadi, B. : Drug-stimulated nucleotide trapping in the human multidrug transporter (MDR1): co-operation of the nucleotide binding domains J. Biol. Chem., 273, 10132-10138 (1998)

80. Holló, Zs., Homolya, L., Hegedûs, T., Müller, M., Szakács, G., Jakab, K., Antal, F., and Sarkadi, B.: Parallel functional and immunological detection of human multidrug resistance proteins, P-glycoprotein and MRP1. Anticancer Res., 18, 2981-2988 (1998)

81. Bakos, É., Evers, R., Szakács, G., Tusnády, E.G., Welker, E., Szabó, K., de Haas, M., van Deemter, L., Borst, P., Váradi, A., and Sarkadi, B. : Functional multidrug resistance protein (MRP) lacking the N-terminal transmembrane domain. J. Biol. Chem., 273, 32167-32175 (1998) 82. Szakács, G., Jakab, K., Antal, F., and Sarkadi, B. : Diagnostics of multidrug resistance in cancer. Pathology Oncology Research, 4, 251-257 (1998)

83. Szabó, K., Szakács, G., Hegedûs, T., and Sarkadi, B: Nucleotide occlusion in the human CFTR: Different patterns in the two nucleotide binding domains. J. Biol. Chem., 274, 12209-12212 (1999)

84. Sharom, F.J. Yu, X.,. Lu, P., Liu, R., Chu, J.W.K, Szabó, K., Müller, M., Hose, C.D., Monks, A., Váradi, A., Seprôdi, J., and Sarkadi, B. : Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems and intact cells. Biochem. Pharmacol., 58, 571-586, (1999)

85. Ito, S., Woodland, C., Sarkadi, B., Hockmann, G., Walker, S.E., Koren, G. : Modeling of P-glycoprotein-involved epithelial drug transport in MDCK cells. Am. J. Physiol., (Renal) 277, F84-F96 (1999)

86. Bakos, É., Evers, R., Sinkó, E., Váradi, A., Borst, P., Sarkadi, B. : Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol. Pharmacol., 57, 760-768 (2000)

87. Smith, A.J., van Helvoort, A., van Meer, G., Szabó, K., Welker, E., Szakács, G., Váradi, A., Sarkadi, B., Borst, P. : MDR3 P-glycoprotein a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping. J. Biol. Chem., 275, 23530-23569 (2000)

88. Kern, A., Felföldi, F., Sarkadi, B., and Váradi, A. : Expression and characterization of the N- and C-terminal ATP-binding domains of MRP1. Biochem. Biophys. Res. Commun. 273, 913-919 (2000)

89. Bakos, É., Evers, R., Calenda, J., Tusnády, G.E., Szakács, G., Váradi, A., Sarkadi, B.: Characterization of the amino-terminal regions in the human multidrug resistance protein (MRP1). J. Cell Science, 113, 4451-4461 (2000)

90. Szakács G, Özvegy C, Bakos É, Sarkadi B, Váradi A. : Transition-state formation in ATPase-negative mutants of human MDR1 protein. Biochem. Biophys. Res. Commun. 276, 1314-1319 (2000).

91. Karászi, É., Jakab, K., Homolya, L., Szakács, G., Holló, Z., Telek, B., Kiss, A., Rejtô, L., Nahajevszky, S., Sarkadi, B., and Kappelmayer, J. : Calcein assay for multidrug resistance reliably predicts therapy response and survival rate in acute myeloid leukaemia Br. J. Haematol. 112, 308-314 (2001)

92. Szakács, G., Özvegy, Cs., Bakos, É., Sarkadi, B., and Váradi, A. : The role of glycine-534 and glycine-1179 of human MDR1 in drug-mediated control of ATP hydrolysis. Biochem. J., 356, 71-75 (2001)

93. Özvegy, Cs. Litman, T., Szakács, G. Nagy, Z., Bates, S., Váradi, A., and Sarkadi, B.: Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem. Biophys. Res. Commun., 285, 111-117 (2001)

94. Szakács, G., Langmann, T., Özvegy, Cs., Orsó, E., Schmitz, G., Váradi, A., and Sarkadi, B.: Characterization of the ATPase cycle of human ABCA1: implications for its function as a regulator rather than an active transporter. Biochem. Biophys. Res. Commun., 288, 1258-1264 (2001)

95. Connolly, L., Moran, E., Larkin, A., Scheffer, G., Scheper, R., Sarkadi, B., Kool, M., Clynes, M.: A new monoclonal antibody, P2A8(6), that specifically recognizes a novel epitope on the Multidrug Resistance-Associated Protein 1 (MRP1), but not on MRP2 nor MRP3. Hybrid Hybridomics. 20, 333-341 (2001) 96. Hegedűs, T, Őrfi, L., Seprődi, A., Váradi, A., Sarkadi, B., Kéri, G.: Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1. Biochim. Biophys. Acta, 1587, 318-325 (2002)

97. Iliás, A., Urbán, Z., Le Saux, O., Seidl, T.L., Sinkó, E., Boyd, C.D., Sarkadi, B., and Váradi, A. : Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6) J. Biol. Chem., 277, 16860-16867 (2002)

98. Özvegy C, Váradi A, Sarkadi B.: Characterization of drug transport, ATP hydrolysis and nucleotide trapping by the human ABCG2 multidrug transporter: modulation of substrate specificity by a point mutation. J. Biol. Chem. 277, 47980-47990 (2002)

99. Bodó, A., Bakos, É, Szeri, F., Váradi, A., and Sarkadi, B. : The role of multidrug transporters in drug availability, metabolism and toxicity. Toxicol. Letters, 140-141, 133-143 (2003)

100. Ujhelly, O., Özvegy, Cs., Várady, G. Cervenak, J., Homolya, L., Grez, M., Scheffer, G., Roos, D., Bates, S.R., Váradi, A., Sarkadi B., and Német, K. : Application of a human multidrug transporter (ABCG2) variant as selectable marker in gene transfer to progenitor cells. Human Gene Therapy, 14, 403-412 (2003)

101. Hegedűs T, Sessler, T., Scott, R., Thelin, W., Bakos, E., Váradi, A., Szabó, K., Homolya, L., Milgram, S.L., Sarkadi, B. : C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins. Biochem. Biophys. Res. Commun. 302, 454-461 (2003)

102. Bodó, A., Bakos, É., Szeri, F., Váradi, A., Sarkadi B. : Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions. J. Biol. Chem. 278, 23529-23537 (2003)

103. Sinkó, E., Iliás, A., Ujhelly, O., Homolya, L., Scheffer, G.L., Bergen A.A., Sarkadi, B., Váradi, A.: Subcellular localization and N-glycosylation of human ABCC6, expressed in MDCKII cells. Biochem. Biophys. Res. Commun. 308, 263-269 (2003)

104. Homolya, L., Váradi, A., Sarkadi, B.: Multidrug resistance-associated proteins: Export pumps for conjugates with glutathione, glucuronate or sulfate. Biofactors 17, 103-114 (2003)

105. Szentpétery, Zs., Sarkadi, B., Bakos É., Váradi A.: Functional studies on the MRP1 multidrug transporter: Characterization of ABC signature mutant variants. Anticancer Res., 24, 449-456 (2004)

106. Chu, X., Huskey, S-E., Braun, M.P., Sarkadi, B., Evans, D.C., Evers, R.: Transport of ethinylestradiol glucuronide and ethinylestradiol sulfate by the multidrug resistance proteins MRP1, MRP2, and MRP3. J. Pharmacol. Exp. Therap. 309, 156-164 (2004).

107. Kern A, Szentpetery Z, Liliom K, Bakos E, Sarkadi B, Varadi A.: Nucleotide and transported substrates modulate different steps of the ATPase catalytic cycle of MRP1 multidrug transporter. Biochem J. 380, 549-60 (2004).

108. Özvegy, Cs., Hegedűs, T., Várady, Gy. Ujhelly, O., Schuetz, J.D., Váradi, A., Kéri, G. Német, K., and Sarkadi, B.: High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter. Mol. Pharmacol. 65, 1485-1495 (2004).

109. Krishnamurthy, P., Ross, D.D., Nakanishi, T., Bailey-Dell, K., Zhou, S., Mercer, K.E., Sarkadi, B., Sorrentino, B.P., Schuetz, J.D.: The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J. Biol. Chem. 279, 24218-25. Epub 2004 Mar 24. (2004).

110. Szentpétery Z., Kern, A., Liliom, K., Sarkadi, B., Váradi, A., Bakos, É: The role of the conserved glycines of ABC signature motifs of MRP1 in the communications between the substrate binding site and the catalytic centers. J. Biol. Chem. 279:41670-41678. Epub 2004 Jul 12 (2005).

111. Cserepes, J., Szentpétery, Z., Seres, L., Özvegy-Laczka, C., Langmann, T., Schmitz, G., Glavinas, H., Klein, I., Homolya, L., Váradi, A., Sarkadi B, Elkind N.B.: Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization. Biochem. Biophys. Res. Commun. 320, 860-867 (2004).

112. Özvegy-Laczka C, Várady G, Köblös G, Ujhelly O, Cervenak J, Schuetz JD, Sorrentino BP, Koomen GJ, Váradi A, Német K, Sarkadi B. Function-dependent conformational changes of the ABCG2 multidrug transporter modify its interaction with a monoclonal antibody on the cell surface. J. Biol. Chem. 280, 4219-4227, epub. 2004 Dec 2. (2005)

113. Özvegy-Laczka, Cs., Köblös, G., Sarkadi, B., Váradi, A.: Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition Biochim. Biophys. Acta, 1668, 53-63 (2005)

114. Elkind, N.B., Szentpétery, Z., Apáti, A., Özvegy-Laczka, C. Várady, G., Ujhelly, O., Szabó, K., Homolya, L., Váradi, A., Buday, L., Kéri, G., Német, K., Sarkadi, B.: The multidrug transporter ABCG2 prevents tumor cell death induced by the EGF receptor inhibitor Iressa (ZD1839, Gefitinib). Cancer Research, 65:1770-1777 (2005)

115. Morisaki, K., Robey, R., Özvegy-Laczka Cs., Honjo, Y., Polgár, O., Steadman, K., Sarkadi, B., and Bates, S.: Single nucleotide polymorphisms modify the transporter activity of ABCG2. Cancer Chemotherapy and Pharmacology, 56, 161-172 (2005)

116. Jakab K, Gopcsa L, Adam E, Domjan G, Sarkadi B, Paloczi K.: Application of flow cytometry immunophenotyping and multidrug resistance assay in B-cell acute lymphoid leukemia and multiple myeloma. Neoplasma, 52, 36-42 (2005).

117.Ozvegy-Laczka C, Cserepes J, Elkind NB, Sarkadi B.: Tyrosine kinase inhibitor resistance in cancer: role of ABC multidrug transporters. Drug Resist Update 8, 15-26 (2005).

118. Cervenak, J., Andrikovics, H., Özvegy-Laczka, Cs., Tordai, A., Német, K., Váradi, A., Sarkadi, B.: The role of the Human ABCG2 Multidrug Transporter and its Variants in Cancer Therapy and Toxicology. Cancer Letters, 234, 62-72 (2005).

119. Polgar O, Ozvegy-Laczka C, Robey RW, Morisaki K, Okada M, Tamaki A, Koblos G, Elkind NB, Ward Y, Dean M, Sarkadi B, Bates SE.: Mutational studies of G553 in TM5 of ABCG2: a residue potentially involved in dimerization. Biochemistry, 45, 5251-5260 (2006)

120. Szatmari I, Vamosi G, Brazda P, Balint BL, Benko S, Szeles L, Jeney V, Ozvegy-Laczka C, Szanto A, Barta E, Balla J, Sarkadi B, Nagy L.: Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells. J. Biol. Chem. 281, 23812-23823 (2006)

121. Muller M, Klein I, Kopacsi S, Remaley AT, Rajnavolgyi E, Sarkadi B, Varadi A.: Co-expression of human ABCG5 and ABCG8 in insect cells generates an androstan stimulated membrane ATPase activity. FEBS Lett. 580, 6139-6144 (2006)

122. Telbisz A, Muller M, Ozvegy-Laczka C, Homolya L, Szente L, Varadi A, Sarkadi B.: Membrane cholesterol selectively modulates the activity of the human ABCG2 multidrug transporter. Biochim Biophys Acta. 1768, 2698–2713 (2007) Jul 10; [Epub ahead of print]

123. Schwab R, Micsik T, Szokoloczi O, Schafer E, Tihanyi B, Tihanyi T, Kupcsulik P, Diofalvi K, Mersich T, Besznyak I Jr, Zarand A, Mihalik R, Sarkadi B, Keri G, Pap A, Jakab F, Kopper L, Petak I.: Functional evaluation of multidrug resistance transporter activity in surgical samples of solid tumors. Assay Drug Dev Technol. 5, 541-550 (2007).

124. Fuller MD, Thompson CH, Zhang ZR, Freeman CS, Schay E, Szakacs G, Bakos E, Sarkadi B, McMaster D, French RJ, Pohl J, Kubanek J, McCarty NA.: State-dependent inhibition of CFTR chloride channels by a novel peptide toxin. J Biol Chem. 282, 37545-37555. Epub 2007 Oct 19. (2007)

125. Orbán TI, Seres L, Ozvegy-Laczka C, Elkind NB, Sarkadi B, Homolya L.: Combined localization and real-time functional studies using a GFP-tagged ABCG2 multidrug transporter. Biochem Biophys Res Commun. 367, 667-73. Epub 2008 Jan 7. (2008)

126. Seres L, Cserepes J, Elkind NB, Törőcsik D, Nagy L, Sarkadi B, Homolya L.: Functional ABCG1 expression induces apoptosis in macrophages and other cell types. Biochim Biophys Acta. 1778, 2378-2387 (2008)

127. Ozvegy-Laczka C, Laczkó R, Hegedus C, Litman T, Várady G, Goda K, Hegedus T, Dokholyan NV, Sorrentino BP, Váradi A, Sarkadi B.: Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter. J Biol Chem. 283, 26059-26070. Epub 2008 Jul 21(2008) 128. Apáti A, Orbán TI, Varga N, Németh A, Schamberger A, Krizsik V, Erdélyi-Belle B, Homolya L, Várady G, Padányi R, Karászi E, Kemna EW, Német K, Sarkadi B. : High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells. Biochim Biophys Acta. 1778, 2700-2709, (2008) Epub Aug 20.

129. Orbán, T, Apáti, A., Németh, A., Varga, N., Krizsik, V., Schamberger, A., Szebényi, K., Erdei, Z., Várady, G., Karászi, E., Homolya, L., Német, K., Gócza, E., Miskey, C., Mayes, L., Ivics, Z., Izsvák, Z., and Sarkadi, B.: Applying a “double-feature” promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery. Stem Cells, 27, 1077-1087, (2009)

130. Polgar O, Ediriwickrema LS, Robey RW, Sharma A, Hegde RS, Li Y, Xia D, Ward Y, Dean M, Ozvegy-Laczka C, Sarkadi B, Bates SE.: Arginine 383 is a crucial residue in ABCG2 biogenesis. Biochim Biophys Acta. 1788, 1434-1443. (2009)

131. Hegedűs, C., Özvegy-Laczka, C., Apáti, A., Magócsi, M., Német, K., Őrfi, L., Kéri, G., Katona, M., Takáts, Z., Szakács, G., Sarkadi, B.: Interaction of the second generation Bcr-Abl inhibitors nilotinib, dasatinib and bosutinib with the MDR1 and ABCG2 multidrug transporters. Brit. J. Pharmacol. 158:1153-1164. Epub 2009 Sep 28. (2009).

132. Hou, Yue-xian; Li, Chang-Zhong; Palaniyandi, Kanagaraj; Magtibay, Paul; Homolya, Laszlo; Sarkadi, Balazs; Chang, Xiu-bao : Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport. Biochemistry 48, 9122-9131 (2009)

133. Katona M, Kiss K, Angyal V, Kucsma N, Sarkadi B, Takáts Z, Szakács G. A mass spectrometry based functional assay for the quantitative assessment of ABC transporter activity. Rapid Commun Mass Spectrom. 23, 3372-3376. (2009)

134. Sarkadi B, Orbán TI, Szakács G, Várady G, Schamberger A, Erdei Z, Szebényi K, Homolya L, Apáti A.: Evaluation of ABCG2 Expression in Human Embryonic Stem Cells: Crossing the Same River Twice? Stem Cells. 2009 Nov 18. [Epub ahead of print]

135. Nathwani SM, Butler S, Fayne D, McGovern NN, Sarkadi B, Meegan MJ, Lloyd DG, Campiani G, Lawler M, Williams DC, Zisterer DM.: Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells. Cancer Chemother Pharmacol. 2009 Dec 18. [Epub ahead of print].

136. Kasza I, Hegyi Z, Szabó K, Andrikovics H, Német K, Váradi A, Sarkadi B, Homolya L.: Model system for the analysis of cell surface expression of human ABCA1. BMC Cell Biol. 2009 Dec 21;10(1):93. [Epub ahead of print]