Heini Murer - List of Publications#
Original papers 2002 – present
2002
Köhler K, Forster IC, Stange G, Biber J and Murer H: Identification of functionally important sites in the first intracellular loop of the Na/Pi-IIa cotransporter. Am J Physiol 282:F687-F696, 2002
Forster IC, Köhler K, Stange G, Biber J and Murer H: Modulation of renal type IIa Na+/Pi-cotransporter kinetics by the arginine modifier phenylglyoxal. J Mem Biol 187:85-96, 2002
Ehnes C, Forster IC, Köhler K, Biber J and Murer H: Functional studies on a split type II Na/Pi-cotransporter. J Mem Biol 188:227-236, 2002
Murer H, Köhler K, Lambert G, Stange G, Biber J, Forster I: The renal type IIa Na/Pi-cotransporter: structure/function relationships. Cell Biochem Biophys 36:215-220, 2002
Bagorda A, Guerra L, Di Sole F, Helmle Kolb C, Reshkin SJ, Gisler S, Murer H and Casavola V: Reciprocal PKA regulatory interactions between CFTR and NHE3 in a renal polarized epithelial cell model. J Biol Chem 277(24):21480-21488, 2002
Hernando N, Deliot N, Gisler S, Lederer E, Weinman EJ, Biber J and Murer H: PDZ-domain interactions and apical expression of type IIa Na/Pi-cotransporters. Proc Natl Acad Sci 99:11957-11692, 2002
Köhler K, Forster IC, Stange G, Biber J and Murer H: Transport function of the renal type IIa Na+/Pi cotransporter is co-determined by residues in two opposing linker regions: evidence that uniport and cotransport modes share the same pathway, J Gen Physiol 120:693-705, 2002
2003
Bacic D, Schulz N, Biber J, Kaissling B, Murer H and Wagner CA: Involvement of the MAPK-kinase pathway in the PTH mediated regulation of the proximal tubule type IIa Na+/Pi cotransporter in mouse kidney. Pflug Arch Eur J Phy 446:52-60, 2003
Köhler K, Forster IC, Stange G, Biber J and Murer H: Essential cysteine residues of the type IIa Na+/Pi cotransporter. Pflug Arch Eur J Phy 446:203-210, 2003
Khadeer MA, Tang Z, Eiden MV, Murer H, Hernando N, Tenenhouse HS, Weinman EJ, Ramesh V, Chellaiah MA and Gupta A: Na+-dependent Phosphate-cotransporters in the Osteoclast: Cellular distributions and protein interactions Am J Phyiolol 284: C1633-C1644, 2003
Bacic D, Capuano P, Gisler SM, Pribanic S, Christensen EI, Biber J, Loffing J, Kaissling B, Wagner CA and Murer H: Impaired PTH-induced endocytotic down-regulation of the renal type IIa Na+/Pi-cotransporter in RAP deficient mice with reduced megalin expression. Pflug Arch Eur J Phy 446:475-484, 2003
Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J and Murer H: Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells. Am J Physiol 285:784-791, 2003
Radanovic T, Murer H and Biber J: Expression of the Na/Pi-cotransporter type IIb in Sf9 cells: functional characterization and purification, J Mem Biol 194:91-96, 2003
Gisler SM, Pribanic S, Bacic D, Forrer P, Sabourin LA, Tsuji A, Zhao Z, Manser E, Biber J and Murer H: PDZK1: I. A major scaffolder in brush borders of proximal tubular cells, Kidney Int 64(5):1733-1745, 2003
Gisler SM, Madjdpour C, Pribanic S, Bacic D, Taylor SS, Biber J and Murer H: PDZK1: II. An anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells, Kidney Int, 64(5):1746-1754, 2003
Pribanic S, Loffing J, Madjdpour C, Bacic D, Gisler S, Braunewell K-H, Biber J and Murer H: Expression of visinin-like protein – 3 (VILIP-3) in mouse kidney, Nephron/Physiology 95:76-82, 2003
Virkki L, Forster IC, Hernando N, Biber J and Murer H: Functional characterization of two naturally occuring mutations in the human sodium-phosphate cotransporter type IIa. J Bone Miner Res 18(12):2135-2141, 2003
2004
Di Sole F, Cerull R, Babich V, Quiñones H, Gisler SM, Biber J, Murer H, Burckhardt G, Helmle-Kolb C and Moe OW: Acute Regulation of Na/H Exchanger NHE3 by Adenosine A1 receptors is Mediated by Calcineurin Homolgous Protein (CHP). J Biol Chem 279:2962-2974, 2004
Bachmann S, Schlichting U, Geist B, Mutig K, Petsch T, Bacic D, Wagner CA., Kaissling B, Biber J, Murer H and Willnow TE: Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa). J Am Soc Nephrol 15:892-900, 2004
Madjdpour C, Bacic D, Kaissling B, Murer H and Biber J: Segment-specific Expression of Sodium-Phosphate Cotransporters NaPi IIa and -IIc and Interacting Proteins in Mouse Renal Proximal Tubules, Pflug Arch Eur J Phy 448:402-410, 2004
Palmada M, Dieter M, Speil A, Böhmer C, Mack AF, Wagner HJ, Klingel K, Kandolf R, Murer H, Biber J, Closs EI and Lang F: Regulation of intestinal phosphate cotransporter NaPiIIb by ubiquitin ligase Nedd4-2 and by serum and glucocoriticoid-dependent kinase SGK1. Am J Physiol Gastrointest Liver Physiol 287:143-150, 2004
Ehnes C, Forster IC, Koehler K, Bacconi A, Stange G, Biber J and Murer H: Structure-function relations of the first and fourth predicted extracellular linkers of the type IIa Na+/Pi cotransporter: I. Cysteine Scanning Mutagenesis J Gen Physiol 124:475-488, 2004
Ehnes C, Forster IC, Bacconi A, Kohler K, Biber J and Murer H: Structure-function relations of the 1st and 4th predicted extracellular linkers of the type IIa Na+/Pi cotransporter: II. Substrate Interaction and voltage dependency of tow functionally important sites. J Gen Physiol 124:489-503, 2004
2005
Capuano P, Radanovic T, Wagner CA, Bacic D, Kato S, Uchiyama Y, St-Arnoud R, Murer and Biber J: Intestinal and renal adaptation to a low-Pi diet of type II Na-Pi cotransporters in Vitamin D receptor- and 1-OHase-deficient mice. Am J Physiol Cell Physiology 288: C429-434, 2005
Radanovic T, Wagner CA, Murer H and Biber J: Regulation of intestinal phosphate transport: I. Segmental expression and adaptation to phosphate deprivation of type IIb Na/Pi-cotransporter in mouse small intestine. Am J Physiol 288:496-500, 2005
Stauber A, Radanovic T, Stange G, Murer H, Wagner CA and Biber J: Regulation of intestinal phosphate transport: II. Metabolic acidosis stimulates Na+-dependent phosphate absorption and expression of Na/Pi-cotransporter NaPi-IIb in small intestine. Am J Physiol 288:501-506, 2005
Bacic D, Capuano P, Baum M, Zhang J, Stange G, Biber J, Kaissling B, Moe OW, Wagner CA and Murer H: Activation of dopamine D1-like receptors induces acute internalization of the renal Na+/phosphate cotransporter NaPi-IIa in mouse kidney and OK-cells. Am J Physiol 288:740-747, 2005
Capuano P, Bacic D, Stange G, Hernando N, Kaissling B, Pal R, Kocher O, Biber J, Wagner CA and Murer H: Expression and regulation of the renal Na/Phosphate cotransporter NaPi-IIa in a mouse model deficient for the PDZ Protein PDZK1, Pflug Arch Eur J Phy 499:392-402, 2005
Virkki L, Forster IC, Biber J and Murer H: Substrate interactions in the human type II sodium-phosphate cotransporter (NaPi-IIa), Am J Physiol 288(5):F969-981, 2005
Frei P, Gao B, Stieger B, Hagenbuch B, Mate A, Biber J, Murer H and Meier PJ: Identification and Localization of Sodium/Phosphate cotransporters in Hepatocytes and Cholangiocytes of Rat Liver. Gastroenterology 288(4):G771-778, 2005 Deliot N, Hernando N, Liu-Horst Z, Gisler SM, Capuano P. Wagner CA, Bacic D, O’Brien S, Biber J and Murer H: Parathyroid hormone treatment induces dissociation of type IIa Na+-Pi cotransporter-Na+/H+ exchanger regulatory factor-1 complexes. Am J Physiol 289:C159-167, 2005
Bacconi A, Virkki LV, Biber J, Murer H and Forster IC: Renouncing electroneutrality is not free of charge: switching on electrogenicity in a Na+-coupled phosphate cotransporter, Proc Natl Acad Sci 30;102(35):12606-11, 2005
Virkki LV, Forster IC, Bacconi A, Biber J and Murer H: Functionally important residues in the third transmembrane domain of the type IIa sodium-phosphate cotransporter (NaPi-IIa), J Mem Biol 206(3):227-238, 2005, erschienen Feb 2006.
2006
Berndt T, Bielesz B, Craig TA, Tebben PJ, Bacic D, Wagner CA, O’Brien S, Schiavi S, Biber J, Murer H and Kumar R: Secreted frizzled related Protein-4 reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells, Pflug Arch Eur J Phy 451(4):579-587, 2006
Honegger K, Capuano P, Winter C, Bacic D, Stange G, Wagner CA, Biber J, Murer H and Hernando N: Regulation of Sodium-Proton Exchanger NHE3 by PKA and EPAC, Proc Natl Acad Sci 3;103:803-808, 2006
Marks J, Srai SK, Biber J, Murer H, Unwin RJ and Debnam ES: Intestinal phosphate absorption and the effect of Vitamin D: a comparison of rat with mouse, Exp Physiol 91(3): 531-537, 2006
Bacic D, LeHir M, Biber J, Kaissling B, Murer H and Wagner CA: The renal Na+/Phosphate cotransporter NaPi-IIa is internalized via the receptor-mediated endocytic route in response to parathyroid hormone. Kidney Int 69(3): 495-503, 2006
Virkki L, Murer H and Forster IC: Voltage clamp fluorometric measurements on a type II Na+-coupled Pi cotransporter: Shedding light on substrate binding order, J Gen Phys 127(5): 539-555, 2006
Bielesz B, Bacic D, Honegger K, Biber J, Wagner CA and Murer H: Unchanged expression of the sodium-dependent phosphate cotransporter NaPi-IIa despite diurnal changes in renal phosphate excretion, Pflug Arch Eur J Phy 452(6):683-689, 2006
Virkki L, Murer H and Forster IC: Mapping conformational changes of a type IIb Na+/Pi cotransporter by voltage clamp fluorometry. J Biol Chem 281(39):28837-28849, 2006
Patzer L, Hernando N, Ziegler U, Beck-Schimmer B, Biber J and Murer H: Ifosfamide metabolites CAA, 4-OH-Ifo and Ifo-mustard reduce apical phosphate transport by changing NaPi-IIa in OK cells, Kidney Int 70(10):1725-34, 2006
Radanovic T, Gisler SM, Biber J and Murer H: Topology of the type IIa Na+/Pi-cotransporter, J Mem Biol 212(1): 41-49, 2006
2007
Forster I, Virkki L, Bossi E, Murer H and Biber J: Electrogenic Kinetics of a Mammalian Intestinal Type IIb Na+/Pi cotransporter, J Mem Biol 212 (3): 177-190, 2007
Lundquist P, Murer H and Biber J: Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphate, Cellular Physiology and Biochemistry 19:43-56, 2007
Capuano P, Bacic D, Roos M, Gisler SM, Stange G, Biber J, Kaissling B, Weinman EJ, Shenolikar S, Wagner CA and Murer H: Defective coupling of apical PTH-receptors to phospholipase C prevents internalization of the Na+/phosphate Cotransporter NaPi-IIa in NHERF1 deficient mice. Am J Physiol, Cell Physiol 292:927-934, 2007
Bacconi A., Ravera S., Virkki L., Murer H and Forster IC: Temperature-dependency of steady-state and presteady-state kinetics of a type Iib Na+/Pi cotransporter, J Mem Biol
Marks J, Churchill LJ, Srai SK, Biber J, Murer H, Debnam ES and Unwin RJ: Intestinal phosphate absorption in a rat model of chronic renal failure (CRF), Kindney Int Epub
Ravera S, Virkki LV, Murer H and Forster IC: Decipering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements, Am J Physiol, Cell Physiology Epub
Biber J, Stieger B, Stange G and Murer H: Isolation of renal proximal tubular brush border membranes. Nature Protocols 2 (6):1356-1359, 2007
Hillesheim J, Riederer B, Tuo B, Chen M, Manns M, Biber J, Yun C, Kocher O, Seidler U: Down regulation of small intestinal ion transport in PDZK1. Pflug Arch Eur J Phy 454(4):575-86, 2007.
Virkki LV, Biber J, Murer H, Forster IC: Phosphate transporters: a tale of two solute carrier families, Am J hysiol, Renal Physiol 293, F643-F654, 2007
Hernando N, Wagner C, Biber J, Murer H: Kidney kinase network regulates renal ion cotransport,JClin Invest. 2007 Nov 1;117(11):3179-318
2008
Gisler SM, Kittanakom S, Fuster D, Wong V, Bertic M, Radanovic T, Hall RA, Murer H, Biber J,Markovich D, Moe OW, Stagljar I: Monitoring protein-protein interactions between the mammalian integral membrane transporters and PDZ-interacting partners using a modified split-ubiquitin membrane yeast two-hybrid system. Mol Cell Proteomics. 2008 Jul;7(7):1362-77, Epub 2008 Apr 11.
Nowik M, Picard N, Stange G, Capuano P, Tenenhouse HS, Biber J, Murer H, Wagner CA:Renal phosphaturia during metabolic acidosis revisited: molecular mechanisms for decreased renal phosphate reabsorption. Pflugers Arch. 2008 Jun 6.
Thumfart J, Jung S, Amasheh S, Kraemer S, Peters H, Sommer K, Biber J, Murer H, Meij I, Querfeld U,Wagner CA, Muller DN: Magnesium stimulates renal phosphate reabsorption, Am J Physiol Renal Physiol. 2008 Oct;295(4):F1126-33. Epub 2008 Aug 13.
2009
Villa-Bellosta R, Ravera S, Sorribas V, Stange G, Levi M, Murer H, Biber J, Forster IC: The Na+/Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi. Am J Physiol Renal Physiol. 2009 Apr;296(4):F691-9. Epub 2008 Dec 10
Reining SC, Gisler SM, Fuster D, Moe OW Md, O'Sullivan GA, Betz H, Biber J, Murer H, Hernando N: GABARAP deficiency modulates the expression of NaPi-IIa in renal brush border membranes. Am J Physiol Renal Physiol. 2009 May;296(5):F1118-28. Epub 2009 Feb 18.
Ghezzi C, Murer H, Forster IC: Substrate interactions of the electroneutral Na+-coupled inorganic phosphate cotransporter (NaPi-IIc). J Physiol. 2009 Sep 1;587(Pt 17):4293-307. Epub 2009 Jul 13.
Reviews published 2002 - present
H. Murer: Functional domains in the renal type IIa Na/Pi-cotransporter. Kidney Int 62: 375-382, 2002
B. Stieger, H. Murer: ABC Cassette Proteins in Epithelial Physiology. Kidney Int 62:1495-1523 2002
IC. Forster, K. Köhler, J. Biber and H. Murer: Forging the link between structure and function of electrogenic cotransporters: the renal type IIa Na+/Pi cotransporter as a case study, Progress in Biophysics and Molecular Biology 80:69-108, 2002
H. Murer, N. Hernando, I. Forster and J. Biber: Regulation of Na/Pi transporter in the proximal tubule. Annu Rev Physiol 2003 65:531-542, 2003
Tenenhouse HS and Murer H: Disorders of Renal Tubular Phosphate Transport, J Am Soc Nephrol 14:240-247, 2003
Caverzasio J., Murer H. and Tenenhouse H.S.: Phosphate Homeostasis Regulatory Mechanisms. Glorieux F.H. Editor-in-Chief, Pediatric Bone Biology and Diseases 173-192, 2003
Markovich D., Murer H.: The SLC13 gene family of sodium sulphate/carboxylate cotransporters. Pflug Arch Eur J Phy 447:594-602, 2004
Murer H., Forster I., Biber J.: The sodium phosphate cotransporter family SLC34. Pflug Arch Eur J Phy 447:763-767, 2004
Hernando N, Wagner CA, Gisler SM, Biber J and Murer H: PDZ proteins and proximal ion transport. Curr Opinion in Nephrol and Hypert 13:569-574, 2004
Bacic D, Wagner CA, Hernando N, Kaissling B, Biber J and Murer H: Novel aspects in regulated expression of the renal type IIa Na/Pi-cotransporter Kidney Int Suppl 94:5-12, 2004
Biber J, Gisler SM, Hernando N, Wagner CA and Murer H: PDZ interactions and proximal tubular phosphate reabsorption, Am J Physiol,. Renal 287:871-875, 2004
Biber J, Gisler S, Hernando N, Murer H: Protein/protein interactions (PDZ) in proximal tubules J Mem Biol 203:111-118, 2005
Hernando N, Gisler SM, Pribanic S, Deliot N, Capuano P, Wagner CA, Moe OW, Biber J, Murer H. NaPi-IIa and interacting partners, J Physiol 567(Pt 1):21-26, 2005
Hernando N, Biber J, Forster IC, Murer H. Recent advances on renal posphate transport. Ther Apher Dial 9(4):323-327, 2005
Alpern R, Giebisch G, Murer H: ISN Forefronts in Nephrology 1986-2006 (Editorial), Nature Clinical Practice Nephrology 2(4):173, 2006
Forster IC, Hernando N, Biber J, Murer H: Proximal tubular handling of phosphate – a molecular perspective, Kidney Int 70(9):1548-59, 2006
Forster, I. (2007) Natrium-Phosphat-Kotransporter:Einblick in seinem Mechanismus. Nephro News, Sept. 51-53.
Wagner CA, Biber J, Murer H: What goes in must come out the small intestine modulates renal phosphate excretion. Nephrol Dial Transplant. 2007 Dec;22(12):3411-2. No abstract vailable.
Wagner CA, Murer H: Phosphatonine – neuartige Phosphat-hormone, Schlaglichter Schweiz Med Forum 2008; 8:8-10
Wagner CA, Biber J, Murer H: Of Men and Mice: Who Is in Control of Renal Phosphate Reabsorption? J Am Soc Nephrol. 2008 Sep;19(9):1625-6. Epub 2008 Jul 23
Biber J, Hernando N, Forster I, Murer H: Regulation of phosphate transport in proximal tubules. Pflugers Arch. 2008 Aug 29
Andrini O, Ghezzi C, Murer H, Forster C: The leak mode of type II Na(+)-P(i) cotransporters. Channels (Austin). 2008 Sep 20;2(5).
Bookchapters
Lang F., Murer H: Calcium- und Phosphat-Haushalt, Physiologie des Menschen Heidelberg Springer Verlag 723 – 734, 2004
Murer H., Berger E. Physiologie des Magen-Darm-Traktes Physiologie, München-Jena, Urban & Fischer 591 – 632, 2004
Murer H, Forster IC, Wagner CA, Biber J, Hernando N, Molecular mechanisms in renal phosphate handling: recent advances, Nephrology, Hypertension, Dialysis, Transplantation, Budapest Nephrology School; Hungarian Kidney Foundation 63-71, 2006
Forster IC, Hernando N, Biber J, Murer H: Proximal tubular handling of phosphate – a molecular perspective, Kidney Int 70(9):1548-59, 2006
Wagner CA, Hernando N, Forster IC, Biber J, Murer H: Genetic defects in renal phosphate handling. In: Genetic diseases of the kidney. Lifton RP, Somlo S, Giebsich GH, Seldin D. (eds). Elsevier
