Eugene Vasilevich Grishin - Curriculum Vitae#
Education and employment:
- Deputy Director of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Professor of Department Bioorganic Chemistry, M.V.Lomonosov Moscow State University, Biological Faculty
Education:
- M.Sc. in Chemistry, 1969, Moscow State University Chemical Department
- Ph.D. in Chemistry, 1973, Shemyakin Institute of Bioorganic Chemistry
- D.Sc. in Chemistry, 1985, Shemyakin Institute of Bioorganic Chemistry
Professional Experience:
- 1967-1969 M.Sc. thesis, Moscow State University.
- 1969-1976 Junior Scientist, Shemyakin Institute of Bioorganic Chemistry.
- 1976-1987 Senior Scientist, Shemyakin Institute of Bioorganic Chemistry.
- 1987-present Head of the Laboratory for Neuroreceptors and Neuroregulators, Shemyakin Institute of Bioorganic Chemistry
- 1988-present Deputy Director of Shemyakin Institute of Bioorganic Chemistry.
- 1988-present Professor of Biological Department of Moscow State University.
- 1990-present Professor of Shemyakin Institute of Bioorganic Chemistry.
- 1997-present Corresponding Member of Russian Academy of Sciences
Research Activities:
- Protein Chemistry: primary structure of cytoplasmic aspartate aminotransferase from pig heart muscle, structure of latrotoxins, protein modification and crystallization.
- Toxinology: isolation of polypeptide toxins from snake, scorpion , spider and ant venoms; structure of polypeptide toxins; tetrodotoxin modification; structure-function relationships of natural toxins; spatial structure of polypeptide toxins; cloning of cDNA encoding protein toxins; analysis of spider venom EST databases, functional expression and mutagenesis of polypeptide toxins; polyamine spider toxins; neurotoxins as tools for study of receptor components.
- Neuroreceptors: interaction of natural neurotoxins with sodium and potassium channels; isolation of sodium channel components from rat brain; α-latrotoxin receptor from bovine brain; latrophilin; glutamate receptor, hERG channel, TRPV1 and P2X receptors. Electrophysiology of ionic channels, receptor expression in Xenopus oocytes, recombinant DNA technique: site-directed mutagenesis, PCR techniques.
Other Skills and Experience:
Electrophysiology of ionic channels, receptor expression in Xenopus oocytes. Recombinant DNA technique: site-directed mutagenesis, PCR techniques, hybridization and immunological screening of recombinant products; expression systems for genetically engineered proteins.
Current interests:
Toxinology and Molecular Neurobiology in general
Teaching Experience:
- Protein chemistry
- Biochemistry
- Natural toxins
- Membrane transport systems
Affiliations:
- Russian Biochemistry Society
- Russian Society for Neurochemistry
- European Society for Neurochemistry
- International Society for Neurochemistry
- International Society of Toxinology
Honours:
- 1975 State Jr. Scientist Prize
- 1981 State Citizenship Award
- 1985 State Research Prize
- 1994 Ovchinnikov Prize Russian Acad. Sci.
- 2003-present President of Russian Society for Neurochemistry
- 2004 Member of Academia Europaea
- 2004 Doctor Honoris Causa of Universidad Nacional Mayor de San Marcos (Lima, Peru)
- 2004 Doctor Honoris Causa of Universidad Ricardo Palma (Lima, Peru)
Publications:
~320 Papers and Abstracts