Bazbek Davletov - Curriculum Vitae#

Honorary Professor, University of Sheffield, England
President, Neuresta Company, San Diego, USA

Scientific achievements:

• Development of botulinum drugs for chronic pain alleviation (2012 - 2024)
  
• Development of botulinum-related animal replacement assays (2014 - 2024)
  
• Development of protein stapling for biotechnology and drug design (2009 - 1915)
  
• Elucidation of molecular mechanisms underlying synaptic neurotransmission (1991 - 2009). Identification of black widow spider neurotoxin receptors (1988 - 1997)
  

Career history:

• 2021 Founder and President of NEURESTA, Inc., San Diego, CA
  
• 2012 - 2022 Chair in Biomedical Science and Director of Impact, Department of Biomedical Science, University of Sheffield. Research Projects: ‘New treatments for chronic pain and potency assays for botulinum drugs’. 29 publications.
• 1997 - 2012 Programme Leader, Medical Research Council Laboratory of Molecular Biology (MRC LMB), Cambridge. Research Project: ‘Molecular mechanisms of synaptic vesicle exocytosis’. Eight former postdocs and students now hold independent Principal Investigator posts around the world. 60 publications including Nature, Neuron, and EMBO journals.
  
• 1995 - 1997 Wellcome Trust Research Fellow, Imperial College of Science, Technology and Medicine, London. Research Project: ‘Identification of neuronal latrotoxin receptors’. Supervisor: Prof. Yuri Ushkaryov. 6 publications.
  
• 1992 - 1994 PhD, University of Texas Southwestern Medical Center, Dallas.
  Research Project: ‘Functional characterization of the calcium sensor in synaptic neurotransmission’. Supervisor: Prof. Thomas Sudhof, Nobel Prize in Physiology and Medicine 2013. 11 publications including Nature, Cell, and Science journals.
  
• 1988 - 1991 Research Associate, Institute of Bioorganic Chemistry, Moscow. Project: ‘Characterization of brain proteins interacting with black widow spider toxin’.
  
• 1985 - 1987 Research Associate, Institute of Cardiology, Bishkek, Kyrgyzstan
  
• 1980 - 1985 BA, MSc in Bioorganic Chemistry, Moscow State University, Moscow, Russia

Publication Record:

100 papers in peer-reviewed journals, including Cell, Neuron, Nature, Nature Medicine, Science and EMBO journals. Average citations per paper – 100, h-index –50.

Invited Lectures:

World Congress on Toxins, Berlin, Germany, 2024; Pain Therapeutics Summit, USA, 2021; IBRCC Meeting, Maryland, USA, 2019; World Congress on Toxins, Copenhagen, Denmark, 2019; Royal Society for Chemistry, UK, 2018; IBRCC Meeting, San Francisco, USA, 2017; World Congress on Neuropathic pain, Gottenberg, Sweden, 2017; World Congress on Botulinum Toxins, Madrid, Spain, 2017; Biologics Symposia, London, UK, 2017; Challenges of Chronic Pain, Cambridge, UK, 2015; Stem Cells in Neurobiology, Hannover, Germany, 2014; Recombinant Protein Therapeutics, Palm Springs, USA, 2013; Therapeutic Protein Production, Stevenage, UK, 2013; ISCCB meeting, Rouen, France, 2013; Botulinum Congress, Miami, USA, 2012.

Mentoring:

My former trainees now hold independent PI positions including F. Darios (France), K. Broersen (Netherlands), E. Ferrari (UK), S. Fedorovich (Belarus), F. Meunier (Australia), and C. Rickman (UK). I successfully supervised nine PhD students and eleven Master's students. I supervised the Advanced course in Cellular and Molecular Biology at level 2 Biomedical Science along with other teaching duties.

Research Funding:

• 2022 Ongoing NIH funding of Neuresta - $25,000,000
  
• 2022 - 2024 BBRC grant ‘Cell-based assay for botulinum toxins’ - £230,000
  
• 2021 - 2022 Supernus industrial grant on Botulinum B drug testing - £155,000
  
• 2020 - 2021 Merck industrial collaboration grant on Tetanus vaccines - £150,000
  
• 2020 - 2021 Medical Research Council Confidence-in-Concept grant – £97,000
  
• 2019 - 2023 Medical Research Council Project Grant with Prof S. Hunt – £512,000
  
• 2018 - 2021 National Centre for the 3Rs grant with Dr. A. Peden – £392,000
  
• 2018 - 2019 University Commercialisation Fund – £70,000
  
• 2018 - 2019 Allergan Collaboration grant – £257,000
  
• 2018 - 2018 Medical Research Council (MRC) Proximity to Discovery – £36,000
  
• 2017 - 2018 Medical Research Council Confidence-in-Concept grant– £94,000
  
• 2015 - 2018 National Centre for the 3Rs grant – £172,000
  
• 2013 - 2017 Medical Research Council Project Grant with Prof S. Hunt – £843,000
  
• 1997 - 2012 Medical Research Council Programme Grant - £3,700,000
  
• 1995 - 1997 Welcome Trust Research Fellowship - £150,000