Francesco Blasi - Publications#

• Degryse, M. Resnati, S. Rabbani, A. Villa, F. Fazioli and Blasi, F. (1999) Src-depensence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis, and cytoskeleton reorganization in rat smooth muscle cells via the urokinase receptor. Blood, 94, 649-662.

• Berthelsen, J., Zappavigna, V., Mavilio, F. and Blasi, F. (1998) Prep1, a novel functional partner of Pbx proteins. EMBO J., 17, 1423-1433.

• Berthelsen, J., Zappavigna, V., Ferretti, E., Mavilio, F. and Blasi, F. (1998) Prep1, a novel partner of Pbx proteins, modifies Pbx-Hox protein cooperativity. EMBO J., 17, 1434-1445.

• Ferretti, E., Schulz, H., Talarico, D., Blasi, F. and Berthelsen, J. (1999) The Pbx-Regulating Protein Prep-1 is present in a Pbx-complexed form throughout mouse embryogenesis. Mech. Of Devel., 83, 53-64.

• Ibañez-Tallon, I., Caretti, G., Blasi F., and Crippa, M.P. (1999) "In vivo" analysis of the state of the human uPA enhancer following induction by TPA. Oncogene, 18, 2836-2845.

• Berthelsen, J., Kilstrup-Nielsen, C., Blasi, F., Mavilio, F. and Zappavigna, V. (1999) The subcellular localization of PBX1 and EXD proteins depends on nuclear impoprt and export signals and is modulated by association with PREP1 and HTH. Gen. Dev., 13, 946-953.

• E. Ferretti, H. Marshall, H. Pöpperl, M. Maconochie, R. Krumlauf and F. Blasi. (2000) A complex site including both Pbx-Hox and Prep-Meis-responsive elements and binding a retinoic acid-inducible ternary Hoxb1-Pbx-Prep1 complex is required for HOXB2 rhombomere 4 expression. Development, 127, 155-166.

• Sidenius, N., Olsen, J.E., Sier, C.F.M. Blasi, F., Ullum, H. (2000) Increased plasma levels of soluble urokinase receptor in HIV infected patients are highly correlated with survival. Blood, 96, 4091-4095.

• Manzanares, M., Bel-Vialar, S., Ariza-McNaughton, L., Ferretti, E., Marshall, H., Maconochie, M.M., Blasi, F. and Krumlauf, R. (2001) Independent regulation of initiation and maintenance phases of Hoxa3 expression in the vertebrate hindbrain. Development,128, 3595-3607.

• Degryse, B., Orlando,S., Resnati, M., Rabbani, S.A. and Blasi,F. (2001) Urokinase/Urokinase Receptor and Vitronectin/?v?3 integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways. Oncogene, 20, 2032-2043.

• Blasi, F. and Carmeliet, P. (2002) uPAR: a versatile signaling orchestrator. Nature Rev. Mol. Biol., Vol 3, 932-943.

• Ibanez-Tallon, I., Ferrai, C., Longobardi, E., Facetti, I., Blasi, F. and Crippa, M. (2002) Binding of Sp1 to the proximal promoter links constitutive expression of the human uPA gene and metastatic potential of PC3 cells. Blood, 100, 3325-3332.

• Sidenius, N., Andolfo, A., Fesce, R. and Blasi, F. (2002) Urokinase regulates vitronectin binding in vitro and in vivo by controlling urokinase receptor oligomerization. J. Biol. Chem., 277, 27982-27990.

• Alfano, M., Sidenius, N., Panzeri, B., Blasi, F. and Poli, G. (2002) Urokinase/Urokinase Receptor Interaction Mediates an Inhibitory Signal for HIV-1 Replication. Proc. Natl. Acad. Sci.USA. 99, 8862-8867.

• Fognani, C. Kilstrup-Nielsen,C. Ferretti, E., Zappavigna, V. and Blasi, F. (2002) Human PREP-2, a novel interactor of PBX proto-oncogene, defines a novel sub-family of TALE homeodomain transcription factors., Nucl. Ac. Res., 30, 2043-2051.

• Resnati, M., Pallavicini, I., Wang, J.M., Oppenheim, J., Serhan, C.N., Romano, M. e Blasi, F. (2002) The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R. Proc. Natl. Acad. Sci. U.S.A., 99, 1359-1364.

• Sidenius, N. and Blasi, F. (2003). The urokinase plasminogen activator system in cancer: Recent advances and implication for prognosis and therapy. Cancer and Metastasis Reviews, 22, 205-222.

• Longobardi, E. and Blasi, F. (2003) Overexpression of PREP-1 leads to a functionally relevant increase of PBX-2 by preventing its degradation. J. Biol. Chem., 278, 39235-39241.

• Alfano, M., Sidenius, N., Blasi, F. and Poli, G. (2003) The role of urokinase plasminogen activator (uPA)/uPA receptor in HIV-1 infection. J. Leukocyte Biol., 74, 750-756.

• Sier, C.F.M., Blasi, F. and Sidenius, N. (2003) Urinary Levels of Urokinase-Type Plasminogen Activator and Its Receptor in the Detection of Bladder Carcinoma. Cancer, 98, 1995-1996.

• Cunningham, O., Andolfo, A., Santovito, M.L., Blasi, F. and Sidenius, N. (2003) Differential lipid raft partitioning of the urokinase receptor regulates its biological functions and is controlled by receptor dimerization. EMBO J., 22, 5994-6003.

• Deflorian, G., Tiso, N., Ferretti, E., Blasi, F., Bortolussi, M. and Argenton, F. (2004). Prep1.1 has essential and unique genetic functions in hindbrain development and neural crest cells differentiation. Development, 131, 613-627.

• Sier, CFM, Nicoletti, I., Santovito, M.L., Frandsen, T., Aletti, G., Ferrari, A., Lissoni, A., Giavazzi, R. Blasi, F. and Sidenius, N. (2004) Metabolism of tumour-derived urokinase receptor and receptor fragments in cancer patients and xenografted mice. Thrombosis and Haemostasis, 91, 403-411.

• Benasciutti, E., Pagès, G., Kenzior, G. Folk, W. Blasi, F. and Crippa, M.P. (2004) Different signal transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription in different cancer cell lines. Blood, 104, 256-262.

• Furlan, F., Orlando, S., Laudanna, C., Resnati, M., Basso, V., Blasi, F. and Mondino, A. (2004) A soluble form of the urokinase receptor inhibits monocyte migration by preventing integrin-dependent cell adhesion. J. Cell Sci., 117, 2909-2916.

• Cinque, P., Nebuloni, M., Santovito, M., Price, R.W. , Gisslen, M., Hagberg,, L., Bestetti, A., Vago, G., Lazzarin, A., Blasi, F. and Sidenius, N. (2004) The urokinase plasminogen activator receptor is highly expressed in brain tissue and cerebrospinal fluid of patient with AIDS dementia complex and other HIV-related neurological manifestations. Ann. Neurol., 55, 687-694.

• Villaescusa, J.C., Verrotti, A.C., Ferretti, E., Farookhi, R. and Blasi, F. (2004) Expression of HOX-Cofactor Genes during Mouse Ovarian Follicular Development and Oocyte Maturation. Gene, 330, 1-7.

• Mondino, A. and Blasi, F. (2004) UPA and uPAR in fibrinolysis, immunity and pathology. Trends in Immunology, 25, 450-455.

• Selleri, C., Montuori, N., Ricci, P., Visconte, V., Carriero, M.V., Sidenius, N., Serio, B., Blasi, F., Rotoli, B., Rossi, G. and Ragno, P. Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell mobilization. Blood, in press.

• Rizzi, C., Crippa, M.P., Adduce, L., Blasi, F., Poli, G. and Alfano, M. Pertussis Toxin B-oligomer inhibits IL-6 induction of HIV-1 and chemokines via modulation of AP-1. Submitted

• Vivani, C., Milanese, G., Fazioli, F., Muzzonigro, G., Blasi, F., Sidenius, N. and Sier, C.F.M. Urinary soluble urokinase receptor is a strong and independent prognostic parameter in transitional cell bladder carcinoma patients. Submitted

• Penkov, D., Ferretti, E., Longobardi, E., Grassi, F., Blasi, F. and Mondino, A. The homeodomain protein Prep-1 is involved in T cell differentiation. Submitted.

• Ferretti, E., Cambronero, F., Blasi, F. and Krumlauf, R. The arrangement of the autoregulatory elements of the HoxB enhancer influences the formation of the Prep-1-Pbx1-Hoxb1 ternary complex and enhancer activity. Submitted.

• Degryse, B., Resnati, M., Czekay, R.-P., Loskutoff, D. and Blasi, F. An integrin-interacting etiope present in domain 2 of the urokinase receptor with intrinsic signaling activity: generation of a new integrin inhibitor.Submitted.