Anders Björklund - Most recent publications #

• Shin E, Tronci E, Carta M, Role of Serotonin Neurons in L-DOPA- and Graft-Induced Dyskinesia in a Rat Model of Parkinson's Disease, Parkinson's Disease, Volume 2012 (2012), Accepted 10 April 2012

• Shin E, Garcia J, Winkler C, Björklund A, Carta M., Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease. Neurobiol Dis. 2012 Apr 12.

• Parmar M, Björklund A., Generation of Transplantable Striatal Projection Neurons from Human ESCs, Cell Stem Cell. Volume 10, Issue 4, 6 April 2012, Pages 349–350.

• Politis M, Wu K, Loane C, Quinn N P, Brooks D J, Oertel W H, Björklund A, Lindvall O, Piccini P., Serotonin Neuron Loss and Nonmotor Symptoms Continue in Parkinson’s Patients Treated with Dopamine Grafts. Science Translational Medicine. 4 April 2012 4:128ra41.

• Tronci E, Shin E, Björklund A, Carta M., Amphetamine-induced rotation and l-DOPA-induced dyskinesia in the rat 6-OHDA model: A correlation study. Neuroscience Research. Available online 16 March 2012.

• Decressac M, Mattsson B, Björklund A., Comparison of the behavioural and histological characteristics of the 6-OHDA and α-synuclein rat models of Parkinson's disease., Experimental Neurology. Available online 25 February 2012.

• Lundblad M, Decressac M, Mattsson B, Björklund A., Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons. Proc Natl Acad Sci USA. 2012 Feb 6.

• Decressac M, Mattsson B, Lundblad M, Weikop P, Björklund A., Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons, Neurobiology of Disease. Available online: 11 December 2011.

• Lindvall O, Björklund A., Cell Therapeutics in Parkinson's Disease. Neurotherapeutics. 2011 Sep 9.

• Decressac M, Ulusoy A, Mattsson B, Georgievska B, Romero-Ramos M, Kirik D, Björklund A., GDNF fails to exert neuroprotection in a rat {alpha}-synuclein model of Parkinson's disease., Brain. 2011 Jun 28.

• Pfisterer U, Kirkeby A, Torper O, Wood J, Nelander J, Dufour A, Björklund A, Lindvall O, Jakobsson J, Parmar M. Direct conversion of human fibroblasts to dopaminergic neurons., Proc Natl Acad Sci U S A. 2011 Jun 6.

• Politis M, Oertel WH, Wu K, Quinn NP, Pogarell O, Brooks DJ, Bjorklund A, Lindvall O, Piccini P., Graft-induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio. , Mov Disord. 2011 May 24. doi: 10.1002/mds.23743.

• Björklund A, Björklund T. , Gene therapy for Parkinson's disease shows promise., Sci Transl Med. 2011 Apr 20;3(79):79ed1.

• Politis M, Wu K, Loane C, Quinn NP, Brooks DJ, Rehncrona S, Bjorklund A, Lindvall O, Piccini P., Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants., Sci Transl Med. 2010 Jun 30;2(38):38-46.

• Denham M, Thompson LH, Leung J, Pébay A, Björklund A, Dottori M., Gli is an inducing factor in generating floor plate progenitor cells from human embryonic stem cells., Stem Cells. Oct;28(10):1805-15.

• Sachdeva R, Jönsson ME, Nelander J, Kirkeby A, Guibentif C, Gentner B, Naldini L, Björklund A, Parmar M, Jakobsson J., Tracking differentiating progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors., Proc Natl Acad Sci U S A. Jun 22;107(25):11602-7. Epub 2010 Jun 7.

• Ulusoy A, Decressac M, Kirik D, Björklund A., Viral vector mediated expression of a-synuclein as a progressive model of Parkinson´s Disease. Prog Brain Res, 2010;184:89-111.

• Lane EL, Björklund A, Dunnett SB, Winkler C., Neural grafting in Parkinson's disease: unraveling the mechanisms underlying graft-induced dyskinesia. Prog Brain Res. 2010;184:295-309.

• Carta M, Carlsson T, Muñoz A, Kirik D, Björklund A., Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease. Mov Disord. 2010;25 Suppl 1:S174-9.

• Grealish S, Mattsson B, Draxler P, Björklund A. Characterisation of behavioural and neurodegenerative changes induced by intranigral 6-hydroxydopamine lesions in a mouse model of Parkinson's disease. , Eur J Neurosci. 2010 Jun 1.

• Li JY, Englund E, Widner H, Rehncrona S, Björklund A, Lindvall O, Brundin P. Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease Mov Disord. 2010 Mar 2.

• Grealish S, Jönsson ME, Li M, Kirik D, Björklund A, Thompson LH. The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease. Brain. 2010 Feb;133(Pt 2):482-95.
• Kadkhodaei B, Ito T, Joodmardi E, Mattsson B, Rouillard C, Carta M, Muramatsu S, Sumi-Ichinose C, Nomura T, Metzger D, Chambon P, Lindqvist E, Larsson NG, Olson L, Björklund A, Ichinose H, Perlmann T. Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons. J Neurosci. 2009 Dec 16;29(50):15923-32.

• Björklund A, Björklund T, Kirik D. Gene therapy for dopamine replacement in Parkinson's disease. Sci Transl Med. 2009 Oct 14;1(2):2ps2.

• Thompson LH, Björklund A. Transgenic reporter mice as tools for studies of transplantability and connectivity of dopamine neuron precursors in fetal tissue grafts. Prog Brain Res. 2009;175:53-79.

• Jönsson ME, Ono Y, Björklund A, Thompson LH. Identification of transplantable dopamine neuron precursors at different stages of midbrain neurogenesis. Exp Neurol. 2009 Sep;219(1):341-54.

• Muñoz A, Carlsson T, Tronci E, Kirik D, Björklund A, Carta M. Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model. Exp Neurol. 2009 Sep;219(1):298-307.

• Thompson LH, Grealish S, Kirik D, Björklund A. Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain. Eur J Neurosci. 2009 Aug;30(4):625-38.

• Friling S, Andersson E, Thompson LH, Jönsson ME, Hebsgaard JB, Nanou E, Alekseenko Z, Marklund U, Kjellander S, Volakakis N, Hovatta O, El Manira A, Björklund A, Perlmann T, Ericson J. Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7613-8. Epub 2009 Apr 21.

• Carlsson T, Carta M, Muñoz A, Mattsson B, Winkler C, Kirik D, Björklund A., Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration. Brain. 2009 Feb;132(Pt 2):319-35

• Muñoz A, Li Q, Gardoni F, Marcello E, Qin C, Carlsson T, Kirik D, Di Luca M, Björklund A, Bezard E, Carta M Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia. Brain. 2008 Dec;131(Pt 12):3380-94

• Carta, M, Carlsson, T, Munoz, A, Kirik, D, and Bjorklund, A. Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias. Prog Brain Res. 2008;172:465-78

• Carta, M, Carlsson, T, Munoz, A, Kirik, D, and Bjorklund, A., Involvement of the serotonin system in L-dopa-induced dyskinesias., Parkinsonism Relat Disord. 2008;14 Suppl 2:S154-8

• Irvin DK, Kirik D, Björklund A, Thompson LH., In vivo gene delivery to proliferating cells in the striatum generated in response to a 6-hydroxydopamine lesion of the nigro-striatal dopamine pathway., Neurobiol Dis. 2008 Jun;30(3):343-52

• Li, J, Englund, E, Holton, JL, Soulet, D, Hagell, P, Lees, AJ, Lashley, T, Quinn, NP, Rehncrona, S, Bjorklund, A, Widner, H, Revesz, T, Lindvall, O, and Brundin, P., Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation., Nat Med. 2008 May;14(5):501-3

• Thompson LH, Kirik D, Björklund A., Non-dopaminergic neurons in ventral mesencephalic transplants make widespread axonal connections in the host brain., Exp Neurol. 2008 Jun 17

• Nygren JM, Ljuba K, Breitbach M, Stott S, Thorén L, Roell W, Geisen C, Sasse P, Kirik D, Björklund A, Nerlov C, Felischmann BK, Jovinge S, Jacobsen SE., Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion., Nat Cell Biol. 2008 May;10(5):584-92

• Barraud, P, Stott, S, Mollgard, K, Parmar, M, and Bjorklund, A., In vitro characterization of a human neural progenitor cell coexpressing SSEA4 and CD133., J Neurosci Res. 2007 Feb 1;85(2):250-9.

• Bjorklund, A and Dunnett, SB., Dopamine neuron systems in the brain: an update Trends Neurosci. 2007 May;30(5):194-202

• Carta M, Carlsson T, Kirik D, Bjorklund A., Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesias in parkinsonian rats., Brain, 2007 130: 1819-1833

• Breysse, N, Carlsson, T, Winkler, C, Bjorklund, A, and Kirik, D., The functional impact of the intrastriatal dopamine neuron grafts in parkinsonian rats is reduced with advancing disease., J Neurosci. 2007 May 30 27(22):5849-56

• Carlsson, T, Carta, M, Winkler, C, Bjorklund, A, and Kirik, D., Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease., J Neurosci, 2007 Jul 25;27(30):8011-22

• Björklund, A, Dunnett, SB., Fifty years of dopamine research., Trends Neurosci, 2007, 30, 5, 185-7
• Andersson E, Jensen JB, Parmar M, Guillemot F, Björklund A., Development of the mesencephalic dopaminergic neuron system is compromised in the absence of Neurogenin2., Development, 2006 133:507-516

• Carlsson, T, Winkler, C, Lundblad, M, Cenci, MA, Bjorklund, A, and Kirik, D., Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia., Neurobiol Dis, 2006 21(3):657-68

• Thompson, LH, Andersson, E, Jensen, JB, Barraud, P, Guillemot, F, Parmar, M, Bjorklund, A., Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon., Exp Neurol, 2006 198(1):183-98

• Carlsson T, Winkler C, Burger C, Muzyczka N, Mandel RJ, Cenci A, Bjorklund A, Kirik D., Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors. Brain. 2005 128:559-69.

• Thompson L, Barraud P, Andersson E, Kirik D, Bjorklund A., Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections. J Neurosci. 2005 25:6467-77.

• Barraud P, Thompson L, Kirik D, Bjorklund A, Parmar M., Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse. Eur J Neurosci. 2005 22(7):1555-69.

• Sorensen AT, Thompson L, Kirik D, Bjorklund A, Lindvall O, Kokaia M. Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts. Eur J Neurosci. 2005 21:2793-9.

• Ahn YH, Bensadoun JC, Aebischer P, Zurn AD, Seiger A, Bjorklund A, Lindvall O, Wahlberg L, Brundin P, Kaminski Schierle GS. Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor. Brain Res Bull. 2005 66(2):135-42.

• Piccini P, Pavese N, Hagell P, Reimer J, Bjorklund A, Oertel WH, Quinn NP, Brooks DJ, Lindvall O. Factors affecting the clinical outcome after neural transplantation in Parkinson's disease. Brain. 2005 128(Pt 12):2977-86.

• Winkler C, Kirik D, Bjorklund A. Cell transplantation in Parkinson's disease: how can we make it work? Trends in Neurosciences. 2005 28(2):86-92.

• Kirik D, Bjorklund A. Histological analysis of fetal dopamine cell suspension grafts in two patients with Parkinson's disease gives promising results. Brain. 2005 128(Pt 7):1478-9.

• Bjorklund A. Cell therapy for Parkinson's disease: problems and prospects. Novartis Found Symp. 2005 265:174-86.

• Dunnett SB, Bentivoglio M. Björklund, A., Hökfelt, T. (Eds) Handbook of Chemical Neuroanatomy Vol. 21: Dopamine. Elsevier, Amsterdam 2005 pp 1–588.

• Georgievska B, Kirik D, Bjorklund A. Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system. J Neurosci. 2004 24:6437-45.

• Jensen JB, Bjorklund A, Parmar M. Striatal neuron differentiation from neurosphere-expanded progenitors depends on Gsh2 expression. J Neurosci. 2004 24:6958-67.

• Kirik D, Georgievska B, Bjorklund A. Localized striatal delivery of GDNF as a treatment for Parkinson disease. Nat Neurosci. 2004 7(2):105-110.

• Lindvall O, Bjorklund A. Cell replacement therapy: helping the brain to repair itself. NeuroRx. 2004 1(4):379-81.

• Lindvall O, Bjorklund A. Cell Therapy in Parkinson's Disease. Neurorx. 2004 Oct;1(4):382-393

• Kirik, D, Annett, LE, Burger, C, Muzyczka, N, Mandel, RJ, Björklund A Nigrostriatal a-synucleinopathy induced by viral vector-mediated overexpression of human a-synuclein: A new primate model of Parkinson's disease. Proc Natl Acad Sci U S A. 2003 100:2884-2889

• Eriksson C, Bjorklund A, Wictorin K. Neuronal differentiation following transplantation of expanded mouse neurosphere cultures derived from different embryonic forebrain regions. Exp Neurol. 2003 184(2):615-35.

• Parmar M, Sjoberg A, Bjorklund A, Kokaia Z. Phenotypic and molecular identity of cells in the adult subventricular zone in vivo and after expansion in vitro. Mol Cell Neurosci. 2003 24(3):741-52.

• Winkler C, Bentlage C, Cenci MA, Nikkhah G, Bjorklund A. Regulation of neuropeptide mRNA expression in the basal ganglia by intrastriatal and intranigral transplants in the rat Parkinson model. Neuroscience. 2003 118(4):1063-77.

• Bjorklund A, Dunnett SB, Brundin P, Stoessl AJ, Freed CR, Breeze RE, Levivier M, Peschanski M, Studer L, Barker R. Neural transplantation for the treatment of Parkinson's disease. Lancet Neurol. 2003 2(7):437-45

• Kirik D, Björklund A Modeling CNS neurodegeneration by overexpressing disease causing proteins using viral vectors. TINS, 2003 26: 386-392.

• Quirion, R., Björklund, A., Hökfelt, T. (Eds) Handbook of Chemical NeuroanatomyVol. 20: Peptide receptors, Part II. Elsevier, Amsterdam 2003, pp 1–423

• Englund U., Fricker-Gates R. A., Lundberg C., Björklund A., and Wictorin K. Transplantation of human neural progenitor cells into the neonatal rat brain: extensive migration and differentiation with long-distance axonal projections. Exp Neurol. 2002 173, 1-21.

• Englund U, Björklund A and Wictorin K. Migration patterns and phenotypic differentiation of long-term expnded human neural progenitor cells after transplantation into the adult rat brain. Brain Res.,Dev Brain Research, 2002 134,123-141.

• Lundberg C, Englund U, Trono D, Björklund A and Wictorin K. Differentiation of the RN33B cell line into forebrain projection neurons after transplantation into the neonatal rat brain. Exp Neurology, 2002 175, 370-387.

• Georgievska B, Kirik D, Rosenblad C, Lundberg C, Björklund A. Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector. Neuroreport 2002 13:75-82.

• Kirik D, Rosenblad C, Burger C, Lundberg C, Johansen TE, Muzyczka N, Mandel RJ, Björklund A. Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system. J Neurosci. 2002 22(7):2780-91.

• Kirik, D., Georgievska B, Burger C, Winkler C, Muzyczka N, Mandel R and Björklund A. Reversal of motor impairments in Parkinsonian rats by continuous intrastriatal delivery of L-DOPA using AAV-mediated gene transfer. Proc. Natl. Acad. Sci. 2002 99(7) 4708-13.

• Englund U, Björklund A, Wictorin K, Lindvall O, Kokaia M. Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry. Proc Natl Acad Sci U S A. 2002 99, 17089-17094.

• Winkler C, Kirik D, Björklund A, Cenci MA L-DOPA induced dyskinesia in the intrastriatal model of Parkinson’s disease: Relation to motor and cellular parameters of nigrostriatal function. Neurobiol. Dis. 2002 10:165-86.

• Georgievska. B, Kirik D, Björklund A. Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by striatal overexpression of GDNF. Exp Neurol 2002 177:461-474.

• Parmar M, Skogh C, Bjorklund A, Campbell K. Regional specification of neurosphere cultures derived from subregions of the embryonic telencephalon. Mol Cell Neurosci. 2002 21(4):645-656.

• Hagell P, Piccini P, Bjorklund A, Brundin P, Rehncrona S, Widner H, Crabb L, Pavese N, Oertel WH, Quinn N, Brooks DJ, Lindvall O. Dyskinesias following neural transplantation in Parkinson's disease. Nat Neurosci. 2002 5(7):627-8.