Pierre Paoletti - Publications#

Total of 55 publications, including 41 as lead author, >7800 citations (Google Scholar)


Selected publications:

• Paoletti P and Ascher P (1994) Mechanosensitivity of NMDA receptors in cultured mouse central neurons. Neuron, 13, 645-55.

• Paoletti P, Neyton J and Ascher P (1995) A glycine-independent and subunit-specific potentiation of NMDA responses by extracellular Mg2+. Neuron, 15, 1109-20.

• Paoletti P, Ascher P and Neyton J (1997) High-affinity zinc inhibition of NMDA NR1-NR2A receptors. Journal of Neuroscience, 17, 5711-25.

• Paoletti P, Young EC and Siegelbaum SA (1999) C-linker of cyclic nucleotide-gated channels controls coupling of ligand binding to channel gating. Journal of General Physiology, 113, 17-33

• Paoletti P, Perin-Dureau F, Fayyazuddin A, Le Goff A, Callebaut I and Neyton J (2000) Molecular organization of a zinc binding N-terminal modulatory domain in a NMDA receptor subunit. Neuron, 28, 911-25.

• Perin-Dureau F, Rachline J, Neyton J and Paoletti P (2002) Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors. Journal of Neuroscience, 22, 5955-65.

• Rachline J, Perin-Dureau F, Le Goff A, Neyton J and Paoletti P (2005) The micromolar zinc-binding domain on the NMDA receptor subunit NR2B. Journal of Neuroscience, 25, 308-17.

• Hatton CJ and Paoletti P (2005) Modulation of triheteromeric NMDA receptors by N-terminal domain ligands. Neuron, 46, 261-74.

• Neyton J and Paoletti P (2006) Relating NMDA receptor function to receptor subunit composition: limitations of the pharmacological approach. Journal of Neuroscience, 26, 1331-33.

• Paoletti P and Neyton J (2007) NMDA receptor subunits: function and pharmacology. Current Opinion in Pharmacology, 7, 39-47. (Review)

• Gielen M, Le Goff A, Stroebel D, Johnson JW, Neyton J and Paoletti P (2008) Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition. Neuron 57, 80-93.

• Gielen M, Siegler Rechtless B, Mony L, Johnson JW and Paoletti P (2009) Mechanism of differential control of NMDA receptor activity by NR2 subunits. Nature, 459, 703-707.

• Paoletti P, Vergnano A, Barbour B and Casado M (2009) Zinc at glutamatergic synapses. Neuroscience, 158, 126-136. (Review)

• Mony L, Kew JN, Gunthorpe MJ and Paoletti P (2009) Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential. British Journal of Pharmacology, 157, 1301-1317. (Review)

• Nozaki C, Vergnano A, Filliol D, Ouagazzal A, Le Goff A, Carvalho S, Reiss D, Gaveriaux-Ruff C, Neyton J, Paoletti P# and Kieffer B# (2011) Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit. Nature Neuroscience, 14, 1017-1082. #co-senior author

• Mony L, Zhu S, Carvalho S and Paoletti P (2011) Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines. EMBO Journal, 30, 3134-3146.

• Paoletti P (2011) Molecular basis of NMDA receptor functional diversity. European Journal of Neuroscience, 33(8):1351-65. (Review)

• Zhu S, Stroebel D, Yao CA, Taly A and Paoletti P (2013) Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain. Nature Structural & Molecular Biology, 20, 477-485.

• Paoletti P, Bellone C and Zhou Q (2013) NMDA receptor subunit diversity: impact of receptor properties, synaptic plasticity and disease. Nature Reviews Neuroscience, 14, 383-400. (Review)

• Zhu S, Riou M, Yao CA, Carvalho S, Rodriguez P, Bensaude O, Paoletti P# and Ye S# (2014) Genetically encoding a light switch in an ionotropic glutamate receptor reveals subunit-specific interfaces. Proc. Nat. Acad. Sci. (USA), 111, 6081-6. #co-senior author

• Stroebel D, Carvalho S, Grand T, Zhu S and Paoletti P (2014) Controlling NMDA receptor subunit composition using ectopic retention signals. Journal of Neuroscience, 34, 16630-6.

• Vergnano AM, Rebola N, Savtchenko LP, Pinheiro PS, Casado M, Kieffer BL, Rusakov DA, Mulle C and Paoletti P (2014) Zinc dynamics and action at excitatory synapses. Neuron, 82(5),1101-14.

• Zhu S and Paoletti P (2015) Allosteric modulators of NMDA receptors: multiple sites and mechanisms. Current Opinion in Pharmacology, 20, 14-23. (Review)

• Klippenstein V, Hoppmann C, Ye S, Wang L, Paoletti P (2017) Optocontrol of glutamate receptor gating and permeation by single side-chain photoisomerization. eLife, 6, e25808.

• Grand T, Abi Gerges S, David M, Diana MA, Paoletti P (2018) Unmasking GluN1/GluN3A excitatory glycine NMDA receptors. Nature Communications, 9(1):4769

• Stroebel D, Casado M, Paoletti P. (2018) Triheteromeric NMDA receptors: from structure to synaptic physiology. Current Opinion in Physiology, 2:1-12.

• Esmenjaud JB, Stroebel D, Chan K, Grand T, David M, Wollmuth LP, Taly A, Paoletti P (2019) An inter-dimer allosteric switch controls NMDA receptor activity. EMBO Journal, 15;38(2).

• Paoletti P, Ellis-Davies GCR, Mourot A (2019) Optical control of neuronal ion channels and receptors. Nature Reviews Neuroscience, Jul 9. doi: 10.1038