Elmars Grens#

Recent/Representative Publications

E.Grens. Regulatory Mechanisms of Replication in RNA Bacteriophages, 1974, Riga: Zinatne, 232 pp. (in Russian).

P.Pumpen, V.Bauman, A.Dishler, E.Gren. Control of replication in RNA bacteriophages. - J.Virol., 1978, vol. 28, pp. 725-735.

P.Pumpen, A.Dishler, T.Kozlovskaya, V.Bichko, E.Gren, M.Rivkina, A.Grinberg, R.Kukaine. Cloning of hepatitis B virus DNA in Escherichia coli . - Proc. USSR Acad. Sci., 1981, vol. 220, N 4, pp. 1022-1024 (in Russian).

T.Kozlovskaya, G.Borisova, V.Bichko, J.Kalis, R.Kukaine, E.Gren. Expression of hepatitis B virus surface antigen gene in E.coli. - Gene, 1984, vol. 30, pp. 207-216.

E.Gren, P.Pumpen. Recombinant virus capsids as new generation of immunogenic proteins and vaccines. - J. All-Union Mendeleyev’s Chem. Soc., 1988, vol. 33, pp. 531-536 (in Russian).

G.Borisova, B.Arya, A.Dishlers, O.Borschukova, V.Tsibinogin, D.Skrastina, M.Eldarov, P.Pumpens, K.G.Skryabin, E.Grens. Hybrid hepatitis B virus nucleocapsid bearing immunodominant region from hepatitis B virus surface. - J.Virol., 1993, vol. 67, N 6, pp. 3696-3701.

M.Sallberg, P.Pushko, I.Berzinsh, V.Bichko, P.Sillekens, M.Noah, P.Pumpens, E.Grens, B.Wahren, L.O.Magnius. Immunochemical structure of the carboxy-terminal part of hepatitis B e antigen: identification of internal and surface-exposed sequences. - J. Gen. Virol., 1993, vol. 74, pp. 1335-1340.

V.Skrivelis, Yu.Steinberg, V.Bichko, E.Gren, A.Tsimanis. The structure of the variable regions of mouse monoclonal antibodies to hepatitis B virus core antigen. - Scand. J. Immunol., 1993, vol. 37, pp. 637-643.

P.Pushko, T.Kozlovskaya, I.Sominskaya, A.Brede, E.Stankevica, V.Ose, P.Pumpens, E.Grens. Analysis of RNA phage fr coat protein assembly by insertion, deletion and substitution mutagenesis. - Protein Engineering, 1993, vol. 6, pp. 883-891.

I.Berzins, R.Ulrich, H.Meisel, D.H.Kruger, G.Borisova, P.Pumpens, E.Grens, H.Gelderblom, A.-M. Ladhoff, P. Schnitzler, G.Darai, E.K.F. Bautz. Sites in the core antigen of hepatitis B virus allowing insertion of foreign epitopes. - Vaccine, 1994, pp. 301-308.

E.Jankevics, G.Makarenkova, A.Tsimanis, E.Gren. Structure and analysis of the 5’flanking region of the human interleukin-2 gene. - BBA, 1994, vol. 1217, pp. 235-238.

H.Meisel, I.Sominskaya, P.Pumpens, P.Pushko, G.Borisova, R.Deepen, X.Lu, G.H.Spiller, D.H.Kruger, E.Grens, W.H.Gerlich. Fine-mapping and functional characterization of two immuno-dominant regions from the preS2 sequence of hepatitis B virus. - Intervirology, 1995, vol. 37, pp. 330-339.

P.Pumpens, G.Borisova, R.A.Crowther, E.Grens. HBV core particles as epitope carriers. - Intervirology, 1995, vol. 38, pp. 63-74.

G.Borisova, O.Borschukova (Wanst), G.Mezule, D.Skrastina, I.Petrovskis, A.Dislers, P. Pumpens, E.Grens. Spatial structure and insertion capacity of immunodominant region of hepatitis B core antigen. - Intervirology, 1996, vol. 39, pp. 16-22.

G.Borisova, O.Borschukova, D.Skrastina, G.Mezule, A.Dislers, I.Petrovskis, V.Ose, I.Gusars, P.Pumpens, E.Grens. Display vectors. I. Hepatitis B core particle as a display moiety. - Proc. Latv. Acad. Sci., 1997, vol. 51, pp. 1-7.

E.Avota, V.Berzins, E.Grens, Y.Vishnevsky, Rudiger Luce and Cristof K.Biebricher. The natural 6 S RNA found in Qb-infected cells is derived from host and phase RNA. - J.Mol.Biol., 1998, vol.276, pp. 7-17.

P.Pumpens, E.Grens. Hepatitis B core particles as a universal display model: a structure-function basis for development. - FEBS Letters, 1999, vol. 442, pp. 1-6.

G.Borisova, O.Borschukova, D.Skrastina, A.Dislers, V.Ose, P. Pumpens, E.Grens. Behavior of a short preS1 epitope on the surface of hepatitis B core particles. - Biol.Chem, 1999, vol. 380, pp.315-324.

P.Preikschat, G.Borisova, O.Borschukova, A.Dislers, G.Mezule, E.Grens, D.H.Krüger, P. Pumpens, H.Meisel. Expression and assembly competence of hepatitis B virus core gene deletion variants occuring in infected liver cells. - J.Gen.Virol., 1999, vol. 80, pp. 1777-1788.

P.Pumpens, E.Grens. Hepatitis B core particles as a carrier for B cell/T cell epitopes. - Intervirology, 2001, vol. 44, N 2/3, pp. 98-114.

P.Pumpens, E.Grens. Artificial genes for chimeric virus-like particles. - In: Artificial DNA: Methods and Applications, CRC Press LLC, Boca Raton, 2002, pp. 249-327.

P.Pumpens, E.Grens, M.Nassal. Molecular epidemiology and immunology of hepatitis B virus infection - an update. - Intervirology, 2002, vol. 45, N 4-6, pp. 218-232.

V.Pirags, E.Grens. The Latvian Genome Projrct. - In: Society and Genetic Information. Codes and Laws in the Genetic Era, 2003, CEU Press, Budapest - New York, pp. 225-231.

Pumpens P., Ulrich R., sasnauskas K., Kazaks A., Ose V., Grens E. Construction of novel vacines on the basis of the virus-like particles: Hepatitis B virus proteins as vaccine carriers. - In: Y.Khudyakov (ed.). Medicinal Protein Engineering, 2008, CRC Press, Taylor & Francis Group, Boca Raton London, New York, pp. 205-248.