Irene Tracey - Publications#

H-factor: 76 (Scopus)

Selected publications only:

1: Davis KD, Aghaeepour N, Ahn AH, Angst MS, Borsook D, Brenton A, Burczynski ME, Crean C, Edwards R, Gaudilliere B, Hergenroeder GW, Iadarola MJ, Iyengar S, Jiang Y, Kong JT, Mackey S, Saab CY, Sang CN, Scholz J, Segerdahl M, Tracey I,

Veasley C, Wang J, Wager TD, Wasan AD, Pelleymounter MA. Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities. Nat Rev Neurol. 2020 Jul;16(7):381-400.

2: Holmes EA, O'Connor RC, Perry VH, Tracey I, Wessely S, Arseneault L, Ballard C, Christensen H, Cohen Silver R, Everall I, Ford T, John A, Kabir T, King K,

Madan I, Michie S, Przybylski AK, Shafran R, Sweeney A, Worthman CM, Yardley L, Cowan K, Cope C, Hotopf M, Bullmore E. Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science. Lancet Psychiatry. 2020 Jun;7(6):547-560.

3: Beard DJ, Campbell MK, Blazeby JM, Carr AJ, Weijer C, Cuthbertson BH, Buchbinder R, Pinkney T, Bishop FL, Pugh J, Cousins S, Harris IA, Lohmander LS, Blencowe N, Gillies K, Probst P, Brennan C, Cook A, Farrar-Hockley D, Savulescu J, Huxtable R, Rangan A, Tracey I, Brocklehurst P, Ferreira ML, Nicholl J, Reeves BC, Hamdy F, Rowley SC, Cook JA. Considerations and methods for placebo controls in surgical trials (ASPIRE guidelines). Lancet. 2020 Mar 7;395(10226):828-838.

4: Tracey I, Woolf CJ, Andrews NA. Composite Pain Biomarker Signatures for Objective Assessment and Effective Treatment. Neuron. 2019 Mar 6;101(5):783-800.

5: McDermott LA, Weir GA, Themistocleous AC, Segerdahl AR, Blesneac I, Baskozos G, Clark AJ, Millar V, Peck LJ, Ebner D, Tracey I, Serra J, Bennett DL. Defining the Functional Role of Na<sub>V</sub>1.7 in Human Nociception. Neuron. 2019 Mar 6;101(5):905-919.e8.

6: Kikkert S, Mezue M, O'Shea J, Henderson Slater D, Johansen-Berg H, Tracey I, Makin TR. Neural basis of induced phantom limb pain relief. Ann Neurol. 2019 Jan;85(1):59-73.

7: Soni A, Wanigasekera V, Mezue M, Cooper C, Javaid MK, Price AJ, Tracey I. Central Sensitization in Knee Osteoarthritis: Relating Presurgical Brainstem Neuroimaging and PainDETECT-Based Patient Stratification to Arthroplasty Outcome. Arthritis Rheumatol. 2019 Apr;71(4):550-560.

8: Berna C, Leknes S, Ahmad AH, Mhuircheartaigh RN, Goodwin GM, Tracey I. Opioid-Independent and Opioid-Mediated Modes of Pain Modulation. J Neurosci. 2018 Oct 17;38(42):9047-9058.

9: Goksan S, Baxter L, Moultrie F, Duff E, Hathway G, Hartley C, Tracey I, Slater R. The influence of the descending pain modulatory system on infant pain-related brain activity. Elife. 2018 Sep 11;7:e37125.

10: Zunhammer M, Bingel U, Wager TD; Placebo Imaging Consortium. Placebo Effects on the Neurologic Pain Signature: A Meta-analysis of Individual Participant Functional Magnetic Resonance Imaging Data. JAMA Neurol. 2018 Nov 1;75(11):1321-1330.

11: Sleigh J, Warnaby C, Tracey I. General anaesthesia as fragmentation of selfhood: insights from electroencephalography and neuroimaging. Br J Anaesth. 2018 Jul;121(1):233-240.

12: Wanigasekera V, Wartolowska K, Huggins JP, Duff EP, Vennart W, Whitlock M, Massat N, Pauer L, Rogers P, Hoggart B, Tracey I. Disambiguating pharmacological mechanisms from placebo in neuropathic pain using functional neuroimaging. Br J Anaesth. 2018 Feb;120(2):299-307.

13: Segerdahl AR, Themistocleous AC, Fido D, Bennett DL, Tracey I. A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy. Brain. 2018 Feb 1;141(2):357-364.

14: Beard DJ, Rees JL, Cook JA, Rombach I, Cooper C, Merritt N, Shirkey BA, Donovan JL, Gwilym S, Savulescu J, Moser J, Gray A, Jepson M, Tracey I, Judge A, Wartolowska K, Carr AJ; CSAW Study Group. Arthroscopic subacromial decompression for subacromial shoulder pain (CSAW): a multicentre, pragmatic, parallel group, placebo-controlled, three-group, randomised surgical trial. Lancet. 2018 Jan 27;391(10118):329-338.

15: Davis KD, Flor H, Greely HT, Iannetti GD, Mackey S, Ploner M, Pustilnik A, Tracey I, Treede RD, Wager TD. Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations. Nat Rev Neurol. 2017 Oct;13(10):624-638.

16: Warnaby CE, Sleigh JW, Hight D, Jbabdi S, Tracey I. Investigation of Slow- wave Activity Saturation during Surgical Anesthesia Reveals a Signature of Neural Inertia in Humans. Anesthesiology. 2017 Oct;127(4):645-657.

17: Lin RL, Douaud G, Filippini N, Okell TW, Stagg CJ, Tracey I. Structural Connectivity Variances Underlie Functional and Behavioral Changes During Pain Relief Induced by Neuromodulation. Sci Rep. 2017 Feb 2;7:41603.

18: Tracey I. Neuroimaging mechanisms in pain: from discovery to translation. Pain. 2017 Apr;158 Suppl 1:S115-S122.
19: Eippert F, Kong Y, Winkler AM, Andersson JL, Finsterbusch J, Büchel C, Brooks JCW, Tracey I. Investigating resting-state functional connectivity in the cervical spinal cord at 3T. Neuroimage. 2017 Feb 15;147:589-601.

20: Warnaby CE, Seretny M, Ní Mhuircheartaigh R, Rogers R, Jbabdi S, Sleigh J, Tracey I. Anesthesia-induced Suppression of Human Dorsal Anterior Insula Responsivity at Loss of Volitional Behavioral Response. Anesthesiology. 2016 Apr;124(4):766-78.

21: Wanigasekera V, Mezue M, Andersson J, Kong Y, Tracey I. Disambiguating Pharmacodynamic Efficacy from Behavior with Neuroimaging: Implications for Analgesic Drug Development. Anesthesiology. 2016 Jan;124(1):159-68.

22: Makin TR, Scholz J, Henderson Slater D, Johansen-Berg H, Tracey I. Reassessing cortical reorganization in the primary sensorimotor cortex following arm amputation. Brain. 2015 Aug;138(Pt 8):2140-6.

23: Goksan S, Hartley C, Emery F, Cockrill N, Poorun R, Moultrie F, Rogers R, Campbell J, Sanders M, Adams E, Clare S, Jenkinson M, Tracey I, Slater R. fMRI\ reveals neural activity overlap between adult and infant pain. Elife. 2015 Apr 21;4:e06356.

24: Segerdahl AR, Mezue M, Okell TW, Farrar JT, Tracey I. The dorsal posterior insula subserves a fundamental role in human pain. Nat Neurosci. 2015 Apr;18(4):499-500.

25: Duff EP, Vennart W, Wise RG, Howard MA, Harris RE, Lee M, Wartolowska K, Wanigasekera V, Wilson FJ, Whitlock M, Tracey I, Woolrich MW, Smith SM. Learning to identify CNS drug action and efficacy using multistudy fMRI data. Sci Transl Med. 2015 Feb 11;7(274):274ra16.

26: Kong Y, Eippert F, Beckmann CF, Andersson J, Finsterbusch J, Büchel C, Tracey I, Brooks JC. Intrinsically organized resting state networks in the human spinal cord. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):18067-72.

27: Tracey I, Flower R. The warrior in the machine: neuroscience goes to war. Nat Rev Neurosci. 2014 Dec;15(12):825-34.

28: Wiech K, Vandekerckhove J, Zaman J, Tuerlinckx F, Vlaeyen JW, Tracey I. Influence of prior information on pain involves biased perceptual decision-making. Curr Biol. 2014 Aug 4;24(15):R679-81.

29: Denk F, McMahon SB, Tracey I. Pain vulnerability: a neurobiological perspective. Nat Neurosci. 2014 Feb;17(2):192-200.

30: Wiech K, Jbabdi S, Lin CS, Andersson J, Tracey I. Differential structural and resting state connectivity between insular subdivisions and other pain-related brain regions. Pain. 2014 Oct;155(10):2047-55.

31: Makin TR, Cramer AO, Scholz J, Hahamy A, Henderson Slater D, Tracey I, Johansen-Berg H. Deprivation-related and use-dependent plasticity go hand in hand. Elife. 2013 Nov 12;2:e01273.

32: Ní Mhuircheartaigh R, Warnaby C, Rogers R, Jbabdi S, Tracey I. Slow-wave activity saturation and thalamocortical isolation during propofol anesthesia in humans. Sci Transl Med. 2013 Oct 23;5(208):208ra148.

33: Makin TR, Scholz J, Filippini N, Henderson Slater D, Tracey I, Johansen-Berg H. Phantom pain is associated with preserved structure and function in the former hand area. Nat Commun. 2013;4:1570.

34: Leknes S, Berna C, Lee MC, Snyder GD, Biele G, Tracey I. The importance of context: when relative relief renders pain pleasant. Pain. 2013 Mar;154(3):402-10.

35: Vincent K, Warnaby C, Stagg CJ, Moore J, Kennedy S, Tracey I. Brain imaging reveals that engagement of descending inhibitory pain pathways in healthy women in a low endogenous estradiol state varies with testosterone. Pain. 2013 Apr;154(4):515-24.

36: Wiech K, Kahane G, Shackel N, Farias M, Savulescu J, Tracey I. Cold or calculating? Reduced activity in the subgenual cingulate cortex reflects decreased emotional aversion to harming in counterintuitive utilitarian judgment. Cognition. 2013 Mar;126(3):364-72.

37: Lee MC, Ploner M, Wiech K, Bingel U, Wanigasekera V, Brooks J, Menon DK, Tracey I. Amygdala activity contributes to the dissociative effect of cannabis on pain perception. Pain. 2013 Jan;154(1):124-34.

38: Wanigasekera V, Lee MC, Rogers R, Kong Y, Leknes S, Andersson J, Tracey I. Baseline reward circuitry activity and trait reward responsiveness predict expression of opioid analgesia in healthy subjects. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17705-10.

39: Brodersen KH, Wiech K, Lomakina EI, Lin CS, Buhmann JM, Bingel U, Ploner M, Stephan KE, Tracey I. Decoding the perception of pain from fMRI using multivariate pattern analysis. Neuroimage. 2012 Nov 15;63(3):1162-70.

40: Tracey I, Dickenson A. SnapShot: Pain perception. Cell. 2012 Mar 16;148(6):1308-1308.e2.

41: Segerdahl AR, Xie J, Paterson K, Ramirez JD, Tracey I, Bennett DL. Imaging the neural correlates of neuropathic pain and pleasurable relief associated with inherited erythromelalgia in a single subject with quantitative arterial spin labelling. Pain. 2012 May;153(5):1122-7.

42: Kahane G, Wiech K, Shackel N, Farias M, Savulescu J, Tracey I. The neural basis of intuitive and counterintuitive moral judgment. Soc Cogn Affect Neurosci. 2012 Apr;7(4):393-402.

43: Vincent K, Warnaby C, Stagg CJ, Moore J, Kennedy S, Tracey I. Dysmenorrhoea is associated with central changes in otherwise healthy women. Pain. 2011 Sep;152(9):1966-75.

44: Wartolowska K, Hough MG, Jenkinson M, Andersson J, Wordsworth BP, Tracey I. Structural changes of the brain in rheumatoid arthritis. Arthritis Rheum. 2012 Feb;64(2):371-9.

45: Wanigasekera V, Lee MC, Rogers R, Hu P, Tracey I. Neural correlates of an injury-free model of central sensitization induced by opioid withdrawal in humans. J Neurosci. 2011 Feb 23;31(8):2835-42.

46: Bingel U, Wanigasekera V, Wiech K, Ni Mhuircheartaigh R, Lee MC, Ploner M, Tracey I. The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanil. Sci Transl Med. 2011 Feb 16;3(70):70ra14.

47: Tracey I. Can neuroimaging studies identify pain endophenotypes in humans? Nat Rev Neurol. 2011 Mar;7(3):173-81.
48: Wiech K, Lin CS, Brodersen KH, Bingel U, Ploner M, Tracey I. Anterior insula integrates information about salience into perceptual decisions about pain. J Neurosci. 2010 Dec 1;30(48):16324-31.

49: Tracey I. Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humans. Nat Med. 2010 Nov;16(11):1277-83.

50: Baumgärtner U, Iannetti GD, Zambreanu L, Stoeter P, Treede RD, Tracey I. Multiple somatotopic representations of heat and mechanical pain in the operculo-insular cortex: a high-resolution fMRI study. J Neurophysiol. 2010 Nov;104(5):2863-72.

51: Mhuircheartaigh RN, Rosenorn-Lanng D, Wise R, Jbabdi S, Rogers R, Tracey I. Cortical and subcortical connectivity changes during decreasing levels of consciousness in humans: a functional magnetic resonance imaging study using propofol. J Neurosci. 2010 Jul 7;30(27):9095-102.

52: Ploner M, Lee MC, Wiech K, Bingel U, Tracey I. Flexible cerebral connectivity patterns subserve contextual modulations of pain. Cereb Cortex. 2011 Mar;21(3):719-26.

53: Gwilym SE, Filippini N, Douaud G, Carr AJ, Tracey I. Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study. Arthritis Rheum. 2010 Oct;62(10):2930-40.

54: Berna C, Leknes S, Holmes EA, Edwards RR, Goodwin GM, Tracey I. Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness. Biol Psychiatry. 2010 Jun 1;67(11):1083-90.

55: Ploner M, Lee MC, Wiech K, Bingel U, Tracey I. Prestimulus functional connectivity determines pain perception in humans. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):355-60.

56: Tracey I, Bushnell MC. How neuroimaging studies have challenged us to rethink: is chronic pain a disease? J Pain. 2009 Nov;10(11):1113-20.

57: Wartolowska K, Tracey I. Neuroimaging as a tool for pain diagnosis and analgesic development. Neurotherapeutics. 2009 Oct;6(4):755-60.

58: Gwilym SE, Keltner JR, Warnaby CE, Carr AJ, Chizh B, Chessell I, Tracey I. Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients. Arthritis Rheum. 2009 Sep 15;61(9):1226-34.

59: Lee MC, Zambreanu L, Menon DK, Tracey I. Identifying brain activity specifically related to the maintenance and perceptual consequence of central sensitization in humans. J Neurosci. 2008 Nov 5;28(45):11642-9.

60: Wiech K, Farias M, Kahane G, Shackel N, Tiede W, Tracey I. An fMRI study measuring analgesia enhanced by religion as a belief system. Pain. 2008 Oct 15;139(2):467-76.

61: Leknes S, Tracey I. A common neurobiology for pain and pleasure. Nat Rev Neurosci. 2008 Apr;9(4):314-20.

62: Wiech K, Ploner M, Tracey I. Neurocognitive aspects of pain perception. Trends Cogn Sci. 2008 Aug;12(8):306-13.
63: Tracey I, Mantyh PW. The cerebral signature for pain perception and its modulation. Neuron. 2007 Aug 2;55(3):377-91.

64: Iannetti GD, Zambreanu L, Wise RG, Buchanan TJ, Huggins JP, Smart TS, Vennart W, Tracey I. Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18195-200.

65: Tracey I. Nociceptive processing in the human brain. Curr Opin Neurobiol. 2005 Aug;15(4):478-87.

66: Zambreanu L, Wise RG, Brooks JC, Iannetti GD, Tracey I. A role for the brainstem in central sensitisation in humans. Evidence from functional magnetic resonance imaging. Pain. 2005 Apr;114(3):397-407.

67: Rogers R, Wise RG, Painter DJ, Longe SE, Tracey I. An investigation to dissociate the analgesic and anesthetic properties of ketamine using functional magnetic resonance imaging. Anesthesiology. 2004 Feb;100(2):292-301.

68: Wise RG, Williams P, Tracey I. Using fMRI to quantify the time dependence of remifentanil analgesia in the human brain. Neuropsychopharmacology. 2004 Mar;29(3):626-35.

69: Wise RG, Rogers R, Painter D, Bantick S, Ploghaus A, Williams P, Rapeport G, Tracey I. Combining fMRI with a pharmacokinetic model to determine which brain areas activated by painful stimulation are specifically modulated by remifentanil. Neuroimage. 2002 Aug;16(4):999-1014.

70: Tracey I, Ploghaus A, Gati JS, Clare S, Smith S, Menon RS, Matthews PM. Imaging attentional modulation of pain in the periaqueductal gray in humans. J Neurosci. 2002 Apr 1;22(7):2748-52.

71: Bantick SJ, Wise RG, Ploghaus A, Clare S, Smith SM, Tracey I. Imaging how attention modulates pain in humans using functional MRI. Brain. 2002 Feb;125(Pt 2):310-9.

72: Ploghaus A, Narain C, Beckmann CF, Clare S, Bantick S, Wise R, Matthews PM, Rawlins JN, Tracey I. Exacerbation of pain by anxiety is associated with activity in a hippocampal network. J Neurosci. 2001 Dec 15;21(24):9896-903.

73: Ploghaus A, Tracey I, Clare S, Gati JS, Rawlins JN, Matthews PM. Learning about pain: the neural substrate of the prediction error for aversive events. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9281-6.

74: Ploghaus A, Tracey I, Gati JS, Clare S, Menon RS, Matthews PM, Rawlins JN. Dissociating pain from its anticipation in the human brain. Science. 1999 Jun 18;284(5422):1979-81.

75: Tracey I, Dunn JF, Radda GK. Brain metabolism is abnormal in the mdx model of Duchenne muscular dystrophy. Brain. 1996 Jun;119 ( Pt 3):1039-44.

76: Tracey I, Carr CA, Guimaraes AR, Worth JL, Navia BA, González RG. Brain choline-containing compounds are elevated in HIV-positive patients before the onset of AIDS dementia complex: A proton magnetic resonance spectroscopic study. Neurology. 1996 Mar;46(3):783-8.

77: Tracey I, Scott RB, Thompson CH, Dunn JF, Barnes PR, Styles P, Kemp GJ, Rae CD, Pike M, Radda GK. Brain abnormalities in Duchenne muscular dystrophy: phosphorus-31 magnetic resonance spectroscopy and neuropsychological study. Lancet. 1995 May 20;345(8960):1260-4.

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