Mazel Didier - Selected Publications#

Escudero JA, Nivina A, Kemble H, Loot C, Tenaillon O and Mazel D. Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions. eLife (2020) 9:e58061. doi: 10.7554/eLife.58061.

Nivina A, Grieb MJ*, Loot C*, Bikard D, Cury J, Shehata L, Bernardes J, and Mazel D. Structure-specific DNA recombination sites: design, validation and machine learning based refinement. Science advances (2020) 6(30):eaay2922. doi: 10.1126/sciadv.aay2922 (*equal contributions).

Soler-Bistué A., Aguilar Pierlé S., Garcia-Garcerá M, Val M.-E., Sismeiro O., Varet H. Sieira R , Krin E, Skovgaard O., Comerci D.J., Rocha E.P.C., and Mazel D. Macromolecular crowding links ribosomal protein gene dosage to growth rate in Vibrio cholerae. BMC Biology (2020) 18(1):43. doi: 10.1186/s12915-020-00777-5.

Lopez-Igual R, Bernal-Bayard J, Rodriguez-Paton A, Ghigo J-M and Mazel D. Engineering synthetic toxin-intein weapons as specific antimicrobials. Nature Biotechnology (2019) 37(7):755-760. doi : 10.1038/s41587-019-0105-3 /
* NEWS AND VIEWS in Nature
* NEWS AND VIEWS in Nature Biomedical Engineering
* Spotlight in Molecular Cell
* F1000

Krin E, Aguilar Pierlé S, Sismeiro O, Jagla B, Dillies M-A, Varet H, Irazoki O, Campoy S, Rouy Z, Cruveiller S, Médigue C, Coppée J-Y and Mazel D. Expansion of the SOS regulon of Vibrio cholerae through extensive transcriptome analysis and experimental validation. BMC Genomics (2018) 19(1):373. doi: 10.1186/s12864-018-4716-8.

Loot C, Nivina A, Cury J, Escudero JA, Ducos-Galand M, Bikard D, Rocha EPC and Mazel D. Differences in integron cassette excision dynamics shape a trade-off between evolvability and genetic capacitance. mBio (2017) 8(2) pii: e02296-16. doi: 10.1128/mBio.02296-16

San Millan A, Escudero JA, Gifford DR, Mazel D and MacLean RC. Multicopy plasmids potentiate the evolution of antibiotic resistance genes in bacteria. Nature Ecology & Evolution (2016) 1: 0010 doi:10.1038/s41559-016-0010
* F1000

Val ME, Marbouty M, de Lemos Martins F, Kennedy SP, Kemble H, Bland MJ, Possoz C, Koszul R, Skovgaard O and Mazel D. A check-point control orchestrates the replication of the two chromosomes of Vibrio cholerae. Science Advances (2016) 2(4): e150914. doi: 10.1126/sciadv.1501914. Research highlight in Nature Reviews Microbiology 2016
* Research highlight in Nature Reviews Microbiology

Escudero JA, Loot C, Parissi V, Nivina A, Bouchier C and Mazel D. Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation. Nature Communications (2016) 7:10937. doi: 10.1038/ncomms10937.
* F1000

Iqbal N, Guérout A-M, Krin E., Le Roux F and Mazel D. Comprehensive functional analysis of the eighteen Vibrio cholerae N16961 toxin-antitoxin systems substantiates their role in stabilizing the superintegron. J. Bacteriology (2015) 197(13):2150-9.
* Editor’s spotlight