!!Hans-Uwe Simon - Selected Publications
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__Scopus h-index:__ 91\\
 __Citations:__ 40’738\\
 __Scopus ID number:__ 7402135360\\
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1.  H.-U. Simon, S.G. Plötz, R. Dummer, K. Blaser: Abnormal clones of T cells producing interleukin 5 in idiopathic eosinophilia. N. Engl. J. Med. 341 (1999), 1112-1120.\\
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Chief investigator and first author investigating a large cohort of patients with hypereosinophilic syndrome and describing the clonal expansion of T cells expressing abnormal immunophenotypes as a cause of eosinophilia.\\
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2.  I. Daigle, S. Yousefi, M. Colonna, D.R. Green, H.-U. Simon: Death receptors bind SHP-1 and block cytokine-induced antiapoptotic signaling in neutrophils. Nat. Med. 8 (2002), 61-67.\\
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Senior author of a paper investigating the effect of concurrent activation of neutrophils with both survival and death factors.\\
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3.  S. Yousefi, R. Perozzo, I. Schmid, A. Ziemiecki, T. Schaffner, L. Scapozza, T. Brunner, H.-U. Simon: Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat. Cell Biol. 8 (2006), 1124-1132.\\
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Senior author of a landmark paper describing a molecular switch from autophagy to apoptosis.\\
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4. S. Conus, R. Perozzo, T. Reinheckel, C. Peters, L. Scapozza, S. Yousefi, H.-U. Simon: Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation. J. Exp. Med. 205 (2008), 685-698.\\
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Senior author of a paper identifying a new cell organelle (azurophilic granule) in apoptosis and describing its role in the resolution of neutrophilic inflammation.\\
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5. S. Yousefi, J.A. Gold, N. Andina, J.J. Lee, A.M. Kelly, E. Kozlowski, I. Schmid, A. Straumann, J. Reichenbach, G.J. Gleich, H.-U. Simon: Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat. Med. 14 (2008), 949-953.\\
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Senior author of a landmark paper describing for the first time eosinophil extracellular DNA traps formed by viable eosinophils.\\
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6. D. Maskey, S. Yousefi, I. Schmid, I. Zlobec, A. Perren, R. Friis, H.-U. Simon: A novel role for ATG5 in drug-induced mitotic catastrophe independent of autophagy. Nat. Commun. 4 (2013), 2130.\\
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Senior author of a paper describing a molecular switch from mitotic catastrophe to apoptosis.\\
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7.  H. Liu, Z. He, T. von Rütte, S. Yousefi, R.E. Hunger, H.-U. Simon: Down-regulation of autophagy-related protein 5 (ATG5) contributes to the pathogenesis of early-stage cutaneous melanoma. Sci. Transl. Med. 5 (2013), 202ra123.\\
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Senior author of a paper demonstrating the link between defective autophagy and tumorigenesis.\\
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8.  S. Radonjic-Hoesli, X. Wang, E. de Graauw, C. Stoeckle, B. Styp-Rekowska, R. Hlushchuk, D. Simon, P.J. Spaeth, S. Yousefi, H.-U. Simon: Adhesion-induced eosinophil cytolysis requires the RIPK3-MLKL signaling pathway which is counter-regulated by autophagy. J. Allergy Clin. Immunol. 140 (2017), 1632-1642.\\
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Senior author of a paper describing the molecular mechanism of eosinophil cytolysis, a phenomen often observed in eosinophilic tissues.\\
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9.  P. Amini, D. Stojkov, A. Felser, C.B. Jackson, C. Courage, A. Schaller, L. Gelman, M.E. Soriano, J.M. Nuoffer, L. Scorrano, C. Benarafa, S. Yousefi, H.-U. Simon: Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production.  Nat. Commun. 9 (2018), 2958.\\
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Senior author of a paper demonstrating the requirement of glycolytic ATP production in the formation of neutrophil extracellular traps (NETs).\\
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10.  N. Germic, A. Hosseini, D. Stojkov, K. Oberson, M. Claus, C. Benarafa, S. Calzavarini, A. Angelillo-Scherrer, I.C. Arnold, A. Müller, C. Riether, S. Yousefi, H.-U. Simon: ATG5 promotes eosinopoiesis, but inhibits eosinophil effector functions. Blood 137 (2021), 2958-2969.\\
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Senior author of a paper investigating the role of autophagy in eosinophil functions.