!!Nancy Rothwell - List of Publications
\\
__Research papers (P) all peer reviewed__
\\ \\
__1978__\\ \\
P1 A paradox in the control of energy intake in the rat.  Rothwell, N.J. & Stock, M.J.  (1978)  Nature 273: 146 147.

__1979__\\ \\
P2  In vivo determination of body composition by tritium dilution in the rat.  Rothwell, N.J. &  Stock, M.J.  (1979) Br J Nutr 41: 625 628.

P3  A role for brown adipose tissue in diet induced thermogenesis.  Rothwell, N.J. & Stock, M.J.  (1979)   Nature 281: 31 35.

P4  Regulation of energy balance in two models of reversible obesity in the rat.  Rothwell, N.J. & Stock. M.J. (1979)  J Comp Physiol Psychol 93: 1024 1034.

__1980__\\ \\
P5 Effects of manipulating dietary protein and energy intake on energy balance and thermogenesis in the pig.  Gurr, M.J., Mawson, R., Rothwell, N.J. & Stock, M.J.  (1980)  J Nutr  110: 532 542.

P6 Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet induced thermogenesis.   Brooks, S.L., Rothwell, N.J., Stock, M.J., Goodbody, A.E. & Trayhurn, P.  (1980)  Nature 286: 274 276.

P7  Similarities between cold  and diet induced thermogenesis in the rat.   Rothwell, N.J. & Stock, M.J.  (1980)  Can J Physiol Pharmacol 58: 842 848.

1981
P8 Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus. Perkins, M.N., Rothwell, N.J., Stock, M.J. & Stone, TW. (1981)  Nature 289: 401 402.

P9  Reply to Hervey and Tobin.  Rothwell, N.J. & Stock, M.J.  (1981)  Nature 289: 699 700.

P10 Influence of noradrenaline on blood flow to brown adipose tissue in rats exhibiting diet induced thermogenesis.  Rothwell, N.J. & Stock, M.J.  (1981)  Pflügers Archiv 389: 237 242.

P11  Na+K+ ATPase activity and noradrenaline turnover in brown adipose tissue of rats exhibiting diet induced thermogenesis.  Rothwell, N.J., Stock, M.J. & Wyllie, M.G.   (1981)  Biochem Pharm 30: 1709 1712.

P12  A role for insulin in the diet induced thermogenesis of cafeteria fed rats.  Rothwell, N.J. & Stock, M.J.  (1981)  Metabolism 30: 673 678.

P13  Sympathetic activation of brown adipose tissue thermogenesis in cachexia.   Brooks, S.L., Neville, A.M., Rothwell, N.J., Stock, M.J. & Wilson, S.  (1981)  Bioscience Rep 1: 509 517.

P14 Acute effects of food, 2 deoxy D glucose and noradrenaline on metabolic rate and brown adipose tissue in normal and atropinised lean and obese (fa/fa) Zucker rats.   Rothwell, N.J., Saville, M.E. & Stock, M.J.  (1981) Pflügers Archiv 392: 172 177.       

__1982__\\ \\
P15 Dopaminergic mechanisms in diet induced thermogenesis and brown adipose tissue metabolism.  Rothwell, N.J., Stock, M.J. & Wyllie, M.G.  (1982)  Eur J Pharmacol  77: 45 48.

P16  Factors influencing the acute effect of food on oxygen consumption in the rat.  Rothwell, N.J., Saville, M.E. & Stock, M.J.  (1982)  Int J Obesity  6: 53 59.

P17  Effects of diet and acute noradrenaline treatment on brown adipose tissue development and mitochondrial purine nucleotide binding.  Brooks, S.L., Rothwell, N.J. & Stock, M.J.  (1982)  Q J Exp Physiol  67: 259 268.

P18 Effects of early overnutrition and undernutrition in rats on the metabolic responses to overnutrition in later life.  Rothwell, N.J. & Stock, M.J.  (1982)  J Nutr 112: 426 435.       

P19  Energy expenditure of 'cafeteria fed' rats determined from measurements of energy balance and indirect calorimetry.  Rothwell, N.J. & Stock, M.J.  (1982)  J Physiol 328: 371 377.

P20 Changes in metabolic rate and brown adipose tissue composition during nutritional rehabilitation of postnatally undernourished rats.   Rothwell, N.J., Stephens, D.N. & Stock, M.J.  (1982)  Biol Neonate 42: 93 99.

P21  Effect of diet and cold exposure on norepinephrine turnover in brown adipose tissue of the rat.  Young, J.B., Saville, M.E., Rothwell, N.J., Stock, M.J. &  Landsberg, L.  (1982)  J Clin Invest 69: 1061 1071.

P22  Sympathetic and thyroid influences on metabolic rate in fed, fasted and refed rats.  Rothwell, N.J., Saville, M.E. & Stock, M.J.  (1982)  Am J Physiol 243: R339 346.

P23 Catecholamine and thyroid hormone influence on brown fat Na+,K+ ATPase activity and thermogenesis in the rat.  Rothwell, N.J., Saville, M.E., Stock, M.J. & Wyllie, M.G.  (1982)  Horm Metab Res 14: 261 265.

P24  Effects of feeding a palatable 'cafeteria' diet on energy balance in young and adult lean (+/?) Zucker rats.  Rothwell, N.J. & Stock, M.J.  (1982)  Br J Nutr 47: 461 471.

P25  Effects of feeding a 'cafeteria' diet on energy balance and diet induced thermogenesis in four strains of rat. Rothwell, N.J., Saville, M.E., & Stock, M.J.  (1982)  J Nutr  112: 1515 1524.  

P26  Effect of chronic food restriction on energy balance, thermogenic capacity and brown adipose tissue activity in the rat.  Rothwell, N.J. & Stock, M.J.  (1982)  Bioscience Rep  2: 543 549.  

P27   Energy balance and mitochondrial function in liver and brown fat of rats fed 'cafeteria' diets of varying protein content.   Rothwell, N.J., Stock, M.J. & Tyzbir, R.S.  (1982)  J Nutr 112: 1663 1672.

__1983__\\ \\
P28  Mechanisms of thermogenesis induced by low protein diets.   Rothwell, N.J., Stock, M.J. & Tyzibr, R.S.  (1983)  Metabolism  32: 257 261.

P29  Acute effects of fat and carbohydrate on metabolic rate in normal, cold acclimated and lean and obese (fa/fa) Zucker rats. Rothwell, N.J., Stock, M.J.  (1983)  Metabolism  32: 371 376.  

P30  Metabolic responses to fasting and refeeding in lean and genetically obese rats. Rothwell, N.J., Saville, M.E., &  Stock, M.J.  (1983)  Am J Physiol  244: R615 620.       

P31  Reduced lipogenesis in cafeteria fed rats exhibiting diet induced thermogenesis. Rothwell, N.J., Stock, M.J. & Trayhurn, P.  (1983)  Bioscience Rep  3: 217 224.       

P32 Diurnal variations in circulating hormone levels and brown adipose tissue activity in "cafeteria" fed rats.   Rothwell, N.J., Stock, M.J., Warwick, B.P. & Winter, P.D.O.'B.  (1983)  Comp Biochem Physiol 75A: 461 465.

P33  The effects of high fat and high carbohydrate cafeteria  diets on diet induced thermogenesis in the rat. Rothwell, N.J., Stock, M.J. & Warwick, B.P.  (1983)  Int J Obesity 7: 263 270.

P34 Influence of chronic administration of ciclazindol on energy balance and brown adipose tissue in adult "cafeteria" fed rats. Rothwell, N.J., Stock, M.J. &  Wyllie, M.G.  (1983)  J Autonomic Pharmacol 3: 73 78.

P35  Physical changes associated with the onset of precocious puberty in rats after treatment with PMSG. Everard, D.M.,  Rothwell, N.J., Stock, M.J. & Wilson, C.A.  (1983)  Int J Reprod Fert  69: 201 206.

P36  Energy balance, diet induced thermogenesis and brown adipose tissue in lean and obese (fa/fa) Zucker rats after adrenalectomy. Marchington, D., Rothwell, N.J., Stock, M.J. & York, D.A.  (1983)  J Nutr 113: 1395 1402.       

P37 Protein synthesis in liver, skeletal muscle and brown adipose tissue of rats fed a protein deficient diet. Emery, P. W., Rothwell, N.J. & Stock, M.J.  (1983)  Biosci Rep  3: 569 575. 

P38  Decerebration activates thermogenesis in the rat.  Rothwell, N.J., Stock, M.J. & Thexton, A.J.  (1983)  J Physiol 342: 15 22.

P39  Role of insulin in the thermogenic response to refeeding in 3 day fasting rats. Rothwell, N.J., Saville, M.E. & Stock, M.J.  (1983)  Am J Physiol 245: E160 165.       

P40 Influence of thyroid hormone on diet induced thermogenesis in the rat. Rothwell, N.J., Saville, M.E., Stock, M.J., & Wyllie, M.G.  (1983)  Horm Metab Res 15: 394 398.

P41 Identification of two mitochondrial GDP binding sites in rat brown adipose tissue. Bryant, K.R., Rothwell, N.J., Stock, M.J. & Stribling, D.  (1983)  Biosci Rep  3: 589 598.

P42  Effects of age on diet induced thermogenesis and brown adipose tissue metabolism in the rat. Rothwell, N.J. & Stock, M.J.  (1983)  Int J Obesity 7: 583 589.

P43  Parasympathetic effects on diet induced thermogenesis.  Bryant, K. R., Rothwell, N. J., Stock, M. J. & Wyllie, M.G.  (1983)  Eur J Pharmacol  95: 291 294.

__1984__\\ \\
P44 Effect of noradrenaline on oxygen consumption and tissue blood flow in young pigs. Jamieson, L., Stribling, D., Rothwell, N. J., & Stock, M. J.  (1984)  Can J Physiol Pharmacol 62: 136 141.

P45  Chronic effects of 2 adrenergic agonists on body composition and protein synthesis in the rat. Emery, P.W., Rothwell, N.J., Stock, M.J. & Winter, P.D.  (1984)  Biosci Rep 4: 83 91.       

P46  Brown fat activity in fasted and refed rats. Rothwell, N.J., Saville, M.E. & Stock, M.J.  (1984)  Biosci Rep 4: 351 357.       

P47  The effect of age and gene dosage on brown adipose tissue of Zucker obese fa/fa rats. York, D.A., Holt, S., Rothwell, N.J. & Stock, M.J.  (1984)  Am J Physiol  246: E391 396.

P48  Influence of sodium intake on thermogenesis and brown adipose tissue in the rat. Bryant, K.R., Rothwell, N.J.& Stock, M.J.  (1984)  Int J Obesity  8: 221 231.

P49  Effects of adrenalectomy on energy balance, diet induced thermogenesis and  body composition in adult cafeteria fed rats. Rothwell, N.J., Stock, M.J. & York, D.A.  (1984)  Comp Biochem Physiol  78A: 565 569.       

P50  Acute influences on the two GDP binding sites in brown adipose tissue mitochondria.  Bryant, K.R., Rothwell, N.J. & Stock, M.J.  (1984)  Biosci Rep  4: 523 533.       

P51  Influence of alcohol and sucrose consumption on energy balance and brown fat activity in the rat. Rothwell, N.J. & Stock, M.J.  (1984)  Metabolism 33: 768 771.       

P52  Tissue blood flow in control and cold adapted hyperthyroid rats. Rothwell, N.J. & Stock, M.J.  (1984)  Can J Physiol Pharmacol  62: 928 933.

P53  Effects of denervating brown adipose tissue on the responses to cold, hyperphagia and noradrenaline treatment in the rat. Rothwell, N.J. & Stock, M.J.  (1984)  J Physiol  355: 457 463. 

P54 Energy balance, thermogenesis and brown adipose tissue  activity in tube fed rats. Rothwell, N.J. & Stock, M.J.  (1984)  J Nutr 114: 1965 1970.

P55  Sympathetic and adrenocorticoid influences on diet induced thermogenesis and brown fat activity in the rat.  Rothwell, N.J. & Stock, M.J.  (1984)  Comp Biochem Physiol 79A: 575 579.

P56 Effect of histamine anatagonists on noradrenaline stimulated blood flow and oxygen consumption of brown adipose tissue in the rat.  Rothwell, N.J., Stock, M.J. & Wyllie, M.G.  (1984)  Pflügers Archiv  402: 325 329.

P57  Thermogenic properties of ciclazindol and mazindol in rodents.  Wyllie, M.G., Fletcher, A., Rothwell, N.J. & Stock, M.J.  (1984)  Int J Obesity 3: 85 92.

1985
P58  Involvement of insulin in the acute thermogenic responses to food and non metabolisable substances. Rothwell, N.J., Stock, M.J. & Warwick, B.P.  (1985)  Metabolism  34: 43 47.

P59  Acute and chronic effects of ACTH in thermogenesis and brown adipose tissue in the rat.  Rothwell, N.J. & Stock, M.J.  (1985)  Comp Biochem Physiol  81A: 99 102.
P60   adrenoreceptors in rat brown adipose tissue: proportions of 1 and 2 subtypes.  Rothwell, N.J., Stock, M.J. &  Sudera, D.K.  (1985)  Am J Physiol  248: E397 402.

P61  Effects of sub diaphragmatic vagotomy on energy balance and thermogenesis in the rat. Andrews, P.L.R., Rothwell, N.J. & Stock, M.J.  (1985)  J Physiol  362: 1 12.

P62  Thermogenic capacity and brown adipose tissue activity in the common marmoset. Rothwell, N.J. & Stock, M.J.  (1985)  Comp Biochem Physiol  81A: 683 686.
       
P63   Brown fat, thermogenesis and physiological birth in a marsupial. Loudon, A., Rothwell, N.J. & Stock, M.J. (1985)  Comp Biochem Physiol  81A: 815 819.

P64  Changes in adrenoreceptor density in brown adipose tissue from hyperthyroid rats.  Rothwell, N.J., Stock, M.J. &  Sudera, D.K.  (1985)  Eur J Pharmacol  114: 227 229.

P65  Influence of subdiaphragmatic vagotomy and brown fat sympathetectomy on thermogenesis in rats.  Andrews, P.L.R., Rothwell, N.J. & Stock, M.J.  (1985)  Am J Physiol 249: E239 243.   

P66  Energy balance and brown fat activity in rats fed cafeteria diets or high fat semisynthetic diets at several levels of intake. Rothwell, N.J., Stock, M.J. & Warwick, B.P.  (1985)  Metabolism 34: 474 480.

P67  Hormonal and metabolic responses to fasting and refeeding.  Rothwell, N.J., Saville, M.E. & Stock, M.J. (1985)  Int J Obesity 9: 49 54.

P68  Thermogenesis and brown adipose tissue activity in hypophysectomised rats with and without corticotropin replacement.  Rothwell, N.J. & Stock, M.J.  (1985)  Am J Physiol 249: E333 E336.

P69  Baclofen is a potent activator of brown fat metabolism. Rothwell, N.J., Addae, J.I., Stock, M.J., Stone, T.W.  (1985)  J Pharm Pharmacol  37: 926 927.

P70  Modification of body composition by clenbuterol in normal and dystrophic (mdx) mice.  Rothwell, N.J. & Stock, M.J.  (1985)  Biosci Rep 5: 755 760.

__1986__\\ \\
P71  Spontaneous and experimental variations in body weight, food intake and metabolic rate in captive dormice (Glis glis).  Rothwell, N.J. & Stock, M.J.  (1986)  Comp Biochem Physiol  84A: 141 147.

P72 Thermogenesis and sympathetic activity in brown adipose tissue of overfed rats after adrenalectomy.  Marchington, D., Rothwell, N.J., Stock, M.J. & York, D.A.  (1986) Am J Physiol 250: E362 E366.

P73  Body weight and brown fat activity in hyperphagic cafeteria fed female rats and their offspring.  Rothwell, N.J. & Stock, M.J.  (1986)  Biol Neonate 49: 284 291.

P74  Activation of thermogenesis in brown fat of rats by baclofen.  Addae, J.I., Rothwell, N.J., Stock, M.J. & Stone, T.W.  (1986)  Neuropharmacol  25: 627 631.

P75 Thermogenic responses to adrenoreceptor agonists and brown fat adrenoreceptors in overfed rats. Rothwell, N.J. Stock, M.J. & Sudera, D.K.  (1986)  Eur J Pharmacol 125: 313 323.

P76  Energy balance and brown fat activity in adrenalectomized male, female and castrated male rats.  Rothwell, N.J. &  Stock, M.J.  (1986)  Metabolism 35: 657 660.       

P77 Influence of environmental temperature on energy balance,  diet induced thermogenesis and brown fat activity in cafeteria fed rats.  Rothwell, N.J. & Stock, M.J.  (1986)  J Nutr 56: 123 129.

__1987__\\ \\
P78  Changes in tissue blood flow and β receptor density of skeletal muscle in rats treated with the β %%sub 2/%-adrenoceptor agonist clenbuterol. Rothwell, N.J., Stock, M.J. & Sudera, D.K.  (1987)  Br J Pharm 90: 601 607.

P79 Stimulation of thermogenesis and brown fat activity in rats fed medium chain triglyceride.  Rothwell, N.J. &  Stock, M.J.  (1987)  Metabolism 36: 128 130.

P80  Regional blood flow and skeletal muscle energy status in endotoxemic rats. Jepson, M.M., Cox, M., Bates, P.C., Rothwell, N.J., Stock, M.J., Cady, E.B. & Millward, D.J.  (1987)  Am J Physiol 252: E581 E587.
P81  Effects of ciglitazone on energy balance, thermogenesis and brown fat activity in the rat. Rothwell, N.J., Stock, M.J. & Tedstone, A.E.  (1987)  Mol Cell Endocrinol  57: 253 257.

P82  Activation of brown fat thermogenesis in response to central injection of CRF in the rat. LeFeuvre, R.A., Rothwell, N.J. & Stock, M.J.  (1987)  Neuropharmacol  26: 1217 1221.

P83  Effects of environmental temperature on energy balance and thermogenesis in rats fed normal or low protein diets.  Rothwell, N.J. & Stock, M.J.  (1987)  J Nutr 117: 833 837.

P84  Effect of diet and fenfluramine on thermogenesis in the rat: possible involvement of serotonergic mechanisms.  Rothwell, N.J. & Stock, M.J.  (1987)  Int J Obesity 11: 319 324.

P85  Influence of clenbuterol on energy balance, thermogenesis and body composition in lean and genetically obese Zucker rats.  Rothwell, N.J. & Stock, M.J.  (1987)  Int J Obesity 11: 641 647.

P86  Influence of carbohydrate and fat intake on diet induced thermogenesis and brown fat activity in rats fed low protein diets.  Rothwell, N.J. & Stock, M.J.  (1987)  J Nutr 117: 1721 1726.

__1988__\\ \\
P87  Changes in thermogenesis and brown fat activity  in response to tumour necrosis factor in the rat.  Coombes, R.C., Rothwell, N.J., Shah, P. & Stock, M.J.  (1988)  Biosci Rep 10: 791 799.

P88  Influence of adrenalectomy on age related changes in energy balance, thermogenesis and brown fat activity in the rat. Rothwell, N.J. & Stock, M.J.  (1988)  J Comp Biochem Physiol 89A: 265 269.

P89  Thermogenic effects of thyrotropin releasing hormone and its analogues in the rat. Griffiths, E.C., Rothwell, N.J. & Stock, M.J.  (1988)  Experientia  44: 41 42.

P90 Opposing effects of activation of central GABAA and GABAB receptors on brown fat thermogenesis in the rat. Horton, R.W., LeFeuvre, R.A., Rothwell, N.J. & Stock, M.J.  (1988)  Neuropharmacol  27: 363 366.

P91  Effect of hypophysectomy on energy balance and brown fat activity in obese Zucker rats. Holt, S., Rothwell, N.J., Stock, M.J. & York, D.A.  (1988)  Am J Physiol 254: E163 E166.

P92  Chronic inhibition of GABA transaminase results in activation of thermogenesis and brown fat in the rat.  Horton, R., Rothwell, N.J. & Stock, M.J.  (1988)  Gen Pharmac 19: 403 405.

P93  Effect of a selective β%%sub 2/% adrenergic agonist (clenbuterol) on energy balance and body composition in normal and protein deficient rats.  Rothwell, N.J. & Stock, M.J.  (1988)  Biosci Rep 7: 933 939.

P94  Thermogenic effects of dihydrocodeine in the rat.  Rothwell, N.J., Stock, M.J. & Tedstone, A.E.  (1988)  Can J Physiol Pharmacol 66: 61 65.

P95  The cafeteria diet as a tool for studies of thermogenesis.  Rothwell, N.J. & Stock, M.J.  (1988)  J Nutr  118: 925 928.

P96  Central effects of TNF in the rat.  Rothwell, N.J.  (1988)  Biosci Rep  8: 345 352.

P97  Increased body weight gain and body protein in castrated and adrenalectomised rats treated with clenbuterol.  Rothwell, N.J. & Stock, M.J.  (1988)  Br J Nutr  60: 355 360.

P98  Involvement of the sympathetic nervous system and brown fat in endotoxin induced fever in the rat.  Jepson, M.M., Millward, D.J., Rothwell, N.J. & Stock, M.J.  (1988)  Am J Physiol  255: E617 E623.

P99  Changes in body composition, brown adipose tissue activity and thermogenic capacity in BN/BiRij rats undergoing senescence.  Horan, M.A., Little, R.A., Rothwell, N.J. & Stock, M.J.  (1988)  Exp Gerontol 23: 455 462.

__1989__\\ \\
P100  Pyrogenic and thermogenic effects of interleukin 1β in the rat.  Dascombe, M.J., Rothwell, N.J., Sagay, B.O. & Stock, M.J.  (1989)  Am J Physiol  256: E7 E11.

P101  Thermogenic effects of the antiglucocorticoid RU 486 in the rat: Involvement of corticotropin releasing factor and sympathetic activation of brown adipose tissue.  Hardwick, A.J., Linton, E.A. & Rothwell, N.J.   (1989) Endocrinol  l24: 1684 1688.

P102 Effects of cafeteria feeding from weaning on body composition lipofuscin accumulation and longevity in male and female rats.  Connoley, I.P., Rothwell, N.J., Stock, M.J. & Sheen, C.L.  (1989)  In Obesity in Europe '88 Eds. Bjorntorp, P., Rossner, S.  J. Libbey, London 127 132.

P103  Thermogenic effects of TRH and its analogues in the rat.  Griffiths, E.C., Rothwell, N.J. & Stock, M.J.  (1989)  Proc Nat Acad Sci  553: 569 570.

P104  Energy balance and brown adipose tissue thermogenesis during chronic endotoxaemia in the rat.  Arnold, J., Little, R.A. & Rothwell, N.J.  (1989)  J Appl Physiol 69: 1970 1975.

P105  CRF is involved in the pyrogenic and thermogenic effects of interleukin lß in the rat.  Rothwell, N.J.  (1989)  Am J Physiol  256: E111 E115.

P106  Impaired effects of interleukin 1ß on fever thermogenesis and brown fat in genetically obese rats.  Dascombe, M.J., Hardwick, A., LeFeuvre, R.A. & Rothwell, N.J.  (1989)  Int J Obesity 13: 367 374.

P107  Bacterial infection (Legionella pneumonophila) stimulates fever, metabolic rate and brown adipose tissue activity in the guinea pig.  Cooper, A.L., Fitzgeorge, R.B., Baskerville, A., Little, R.A. & Rothwell, N.J.  (1989)  Life Sci 45: 843 847.

P108  Central activation of thermogenesis and fever by interleukin 1β and interleukin 1β involves different mechanisms.  Busbridge, N.J., Dascombe, M.J., Tilders, F.J.H., van Oers, J.W.A.M., Linton, E.A. & Rothwell, N.J.  (1989)  Biochem Biophys Res Commun  162: 591 596.

P109  Surgical removal of brown fat results in rapid and complete compensation by other depots.  Rothwell, N.J. & Stock, M.J.  (1989)  Am J Physiol  257: 253 258.

P110  A comparison of the thermogenic effects of CRF, sauvagine and urotensin I in the rat. LeFeuvre, R.A., Rothwell, N.J. & White, A.  (1989)  Horm Metabol Res 21: 525 526.

P111  Muscle wasting associated with endotoxaemia in the rat: modification by clenbuterol.  Choo, J.J., Horan, M.A., Little, R.A. & Rothwell, N.J.  (1989)  Biosci Report 9: 615 621

P112  Effects of malaria on O%%sub 2/% consumption and brown adipose tissue activity in mice.  Cooper, A.C., Dascombe, M.J., Rothwell, N.J. & Vale, M.J.  (1989)  J Appl Physiol  67: 1020-1023.

P113  Increased brown adipose tissue activity in children with malignant diseases.  Bianchi, A., Bruce, J., Cooper, A.C., Childs, C., Kohli, M., Morris, I.D., Morris Jones, P. & Rothwell, N.J.  (1989)  Horm Metabol Res 21: 587 642.

P114  Impaired effects of interleukin 1β on fever thermogenesis and brown fat in genetically obese rats.  Dascombe, M.J., Hardwick, A., LeFeuvre, R.A. & Rothwell, N.J.  (1989)  Int J Obesity  13: 367 374.

P115  Central effects of interleukin 1 on fever and thermogenesis.  Rothwell, N.J., Busbridge, N.J., Hissey, P. & Humphray, H.  (1989)  Cytokine 1: 153 154.

P116  Effect of βadrenoceptor blockade on the cardiovascular and metabolic responses to typhoid vaccine in human subjects.  Cooper, A.C., Horan, M.A., Little, R.A., Rothwell, N.J. & Strijbos, P.J.  (1989)   Br J Clin Pharm 29: 154-155.

P117  Comparison of the effects of several endotoxin preparations on body temperature and metabolic rate in the rat.  Horan, M.A., Little, R.A., Rothwell, N.J. & Strijbos, P.J.L.M.  (1989)  Can J Physiol Pharmacol  67: 1011-1014.

P118  Effect of a TRH analogue RX77368 on infarct size and cerebral blood flow in local cerebral ischaemia in the rat.  O'Shaughnessy, C.T., Rothwell, N.J. & Shrewsbury Gee, J.  (1989)  Can J Physiol Pharmacol  67:  1345 1350.

__1990__\\ \\
P119  Dopamine-β hydroxylase inhibition reveals a selective influence of endotoxin on catecholamine content of rat tissues.  Arnold, J., Choo, J.J., Little, R.A. & Rothwell, N.J.  (1990)  Circulatory Shock  31: 387-394.

P120  Lipocortin 1 fragment modifies the pyrogenic actions of cytokines in the rat.  Carey, F., Forder, R., Edge, M.D., Greene, A.R., Horan, M.A., Strijbos, P.J.L.M. & Rothwell, N.J.  (1990)  Am J Physiol 259: R266-269.

P121  Central actions of interleukin 1β on fever and thermogenesis.  Rothwell, N.J., Busbridge, N.J., Humphray, H. & Hussey, P.  (1990)  Prog Leukocyte Biol 10B: 307-311.

P122  Effects of the α%%sub 2/% adrenoreceptor agonist clenbuterol on muscle atrophy due to food deprivation in the rat. Choo, J.J., Horan, M.A., Little, R.A. & Rothwell, N.J.  (1990)  Metabolism  39: 647-650.

P123  Adrenalectomy reverses the impaired pyrogenic responses to interleukin-1 in obese Zucker rats.  Busbridge, N.J., Carnie, J. A., Dascombe, M.J., Johnson, J.J. & Rothwell, N.J.  (1990)  Int J Obesity 14: 809-819.

P124  The adrenergic beta 2 agonist clenbuterol fails to modify muscle atrophy due to femur fracture.  Choo, J.J., Horan, M.A., Little, R.A., Rothwell, N.J. & Wareham, A.C. (1990)  Circulatory Shock  32: 165-171.

P125  Central actions of IL-8 in the rat are independent of prostaglandins.  Rothwell, N.J., Hardwick, A.J. & Lindley, I.  (1990)  Horm Metabol Res 22: 595-596.

P126  Central activation of thermogenesis by prostaglandin dependence on CRF.  Rothwell, N.J.  (1990)  Horm Metabol Res 22: 599-656.

P127  Sympathetically mediated hypermetabolic response to cerebral ischaemia in the rat.  O'Shaughnessy, C.T., Rothwell, N.J. & Shrewsbury-Gee, J.  (1990)  Can J Physiol Pharmacol  68: 1334-1337.

__1991__\\ \\
P128  Central actions of CRF on thermogenesis are mediated by pro-opiomelanocortin products. Rothwell, N.J., Hardwick, A., Le Feuvre R.A., Crosby, S.R. & White, A.  (1991)  Brain Res  541: 89-92.

P129  Brown adipose tissue activity and oxygen consumption after scald injury in the rat.  Rothwell, N.J., Little, R.A. & Rose, J.G.  (1991)  Circulatory Shock  33: 33-36.

P130  Dose-dependent effects of anabolic steroid, nandrolone phenyl proprionate (Durabolin), on body composition and muscle protein metabolism in female rats.  Choo, J.J., Emery, P.W. & Rothwell, N.J.  (1991)  Ann Nutr Metab  35: 141-147.

P131  Effects of central injection of glucose on thermogenesis in normal VMH lesioned and genetically obese rats.  Le Feuvre, R.A., Woods, A., Stock, M.J. & Rothwell, N.J.  (1991)  Brain Res  547: 110-114.

P132  Lipocortin-1 is an endogenous inhibitor of ischaemic damage in the rat brain.  Relton, J.K., Strijbos, P.J.L.M., O'Shaugnessy, C.T., Carey, F., Forder, R.A., Tilders, F.J.H. & Rothwell, N.J.  (1991)  J Exp Med 174: 305-310.

P133  Involvement of corticotrophin releasing factor (CRF) in the thermogenic and anorexic actions of serotin (5HT) and related compounds.  LeFeuvre, R.A., Aisenthal, L. & Rothwell, N.J.  (1991)  Brain Res  555: 245-250.   
P134  Localisation of immunoreactive lipocortin-1 in the brain and pituitary gland of the rat.  Effects of adrenalectomy, dexamethasone and colchicine treatment.  Strijbos, P.J.L.M., Tilders, F.J.H., Carey, F., Forder, R. & Rothwell, N.J.  (1991)  Brain Res  553: 249-260.

P135  Interleukin-6 is a centrally acting endogenous pyrogen in the rat.  Rothwell, N.J., Busbridge, N.J., LeFeuvre, R.A., Hardwick, A.J., Gauldie, J. & Hopkins, S.J.  (1991)   Can J Physiol Pharmacol  69: 1465-1469.

P136  Mechanisms of early and late hypermetabolism and fever after localised tissue injury in rats.  Cooper, A.L. & Rothwell, N.J.  (1991)  Am J Physiol  261: E698-E705.  

__1992__\\ \\
P137  Thermogenic actions of tryptophan in the rat are mediated independently of 5-HT.  Seria, F., LeFeuvre, R., Slater, D., Palau, A. & Rothwell, N.J.  (1992)  Brain Res  578: 327-334.

P138  Metabolic and febrile responses to typhoid vaccine in humans: effect of -adrenergic blockade.  Cooper, A.L., Horan, M.A., Little, R.A. & Rothwell, N.J.  (1992)   Am J Physiol 72: 2322-2328.

P139  Anabolic effects of clenbuterol on skeletal muscle are mediated by 2-adrenoreceptor activation. Choo, J.J., Horan, M.A., Little, R.A. & Rothwell, N.J.  (1992)  Am J Physiol 263: E50-E56.

P140  Lipocortin-1 inhibits NMDA-receptor mediated neuronal damage in striatum of the rat. Black, M.D., Carey, F., Crossman, A.R., Relton, J.K. & Rothwell, N.J.  (1992)  Brain Res 585: 135-140.

P141  Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat.  Relton, J.K. & Rothwell, N.J.  (1992)  Brain Res Bull 29: 243-246.

P142  Thermogenesis, brown adipose tissue and dexfenfluramine in animal studies.  Rothwell, N.J. & LeFeuvre, R.A.  (1992)  Int J Obesity 16:  67-71.

P143  Salbutamol a ß%%sub 2/% adrenoreceptor agonist increases muscle strength in young men. Martineau, L., Horan, M.A., Rothwell, N.J. & Little, R.A.  (1992)  Clin Science 83: 615-621.

P144  Inhibition of the central actions of cytokines on fever and thermogenesis by lipocortin-1 involves CRF.  Strijbos. P.L.M.J., Hardwick, A.J., Relton, J.K., Carey, F. & Rothwell, N.J.  (1992)  Am J Physiol 263: E632-E636.

P145  Different receptor mechanisms mediate thermogenic and behavioural effects of interleukin-1.  Kent, S., Bluthe, R.M., Dantzer, R., Hardwick, A.J., Kelley, K.N., Rothwell, N.J. & Vannice, J.L.  (1992)  Proc Natl Acad Sci 89: 9117-9120

__1993__\\ \\
P146  Clenbuterol, a β%%sub 2/%-adrenergic agonist, reverses muscle wasting due to scald injury in the rat. Martineau, L., Little, R.A., Rothwell, N.J. & Fisher, M.I.  (1993)  Burns 19: 26-34.

P147  Chronic effects of interleukin-1β on fever, oxygen consumption and food intake in the rat. Busbridge, N.J., Dascombe, M.J. & Rothwell, N.J.  (1993)  Horm Metab Res 25: 222-227.

P148   Effect of dietary fish oil supplementation on fever and cytokine production in human volunteers.  Cooper, A.L., Gibbons, L., Horan, M.A., Little, R.A. & Rothwell, N.J.  (1993)  Clin Nutr  12: 321-328.

P149  Dietary N-3 fatty acids inhibit ischaemic and excitotoxic brain damage in the rat.  Relton, J.K., Strijbos, P.J.L.M., Cooper, A.L. & Rothwell, N.J.  (1993)  Brain Res Bull 32: 223-226.

P150  Impaired febrile responses of aging mice are mediated by endogenous lipocortin-1 (annexin-1) Strijbos, P.J.L.M., Horan, M.A., Carey, F. & Rothwell, N.J.  (1993)  Am J Physiol 256: E289-E297.

P151  Inhibition of the thermogenic and pyrogenic responses to interleukin-1β in the rat by dietary N-3 fatty acid supplementation. Cooper, A.L. & Rothwell, N.J.  (1993)  Prostaglandins, Leukotrienes, Essential Fatty Acids 49: 615-626.

P152  Importance of brain IL-1 type II receptors in fever and thermogenesis in the rat.  Luheshi, G., Hopkins, S.J., Lefeuvre, R.A., Dascombe, M.J., Ghiara, P. & Rothwell, N.J.  (1993)  Am J Physiol  265: E585-E591.

P153  The neuropeptide CRF is involved in the modulation of the baroreflex during hind limb ischaemia in the anaesthetised rat.  Turnbull, A.V., Kirkman, E., Rothwell, N.J. & Little, R.A.  (1993)  J Physiol 468: 529-541.

P154  Dexamethasone inhibits the pyrogenic activity of prostaglandin F%%sub 2/%, but not prostaglandin E%%sub 2/%. Coelho, M.M., Pela, I.R. & Rothwell, N.J.  (1993)  Eur J Pharm 238: 391-394.

1994
P155  Fever and thermogenesis in response to bacterial endotoxin involve macrophage-dependent mechanisms in rats.  Derijk, R.H., Strijbos, P.J.L.M., van Rooijen, N., Rothwell, N.J. & Berkenbosch, F.  (1994) Am J Physiol  265: R1179-R1183.

P156  Corticotrophin-releasing factor antagonist inhibits neuronal damage induced by focal cerebral ischaemia or activation of NMDA receptors in the rat brain. Strijbos, P.J.L.M., Relton, J.K. & Rothwell, N.J.  (1994)  Brain Res 656: 405-408.

P157  Anabolic effects of clenbuterol after long-term treatment and withdrawal in the rat.  Cartanà, J., Sequés, T., Yebras, M., Rothwell, N.J. & Stock, M.J.  (1994)  Metabolism 43: 1086-1092.

P158  Dietary fatty acids inhibit fever induced by inflammation in the rat.  Cooper, A.L., Turnbull, A.V., Hopkins, S.J. & Rothwell, N.J.  (1994)  Mediators Inflamm 3: 353-357.

__1995__\\ \\
P159  Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat.  Toulmond, S. & Rothwell, N.J.  (1995)  Brain Res 671: 261-266.

P160 Tumour necrosis factor-α and fever induced by inflammation in the rat.  Cooper, A.L., Brouwer, S., Turnbull, A.V., Luheshi, G.N., Hopkins, S.J., Kunkel, S.L. & Rothwell, N.J.  (1995)  Am J Physiol 36: R1431-R1436.

P161  Multiple mechanisms mediate antipyretic action of glucocorticoids. Coelho, M.M., Luheshi, G., Hopkins, S.J., Pela, I.R. & Rothwell, N.J.  (1995)  Am J Physiol 38:  R527-R535.

P162  Interleukin-1β attenuates excitatory amino acid induced neurodegeneration in vitro: involvement of nerve growth factor.  Strijbos, P.J.L.M. & Rothwell, N.J.  (l995)  J Neurosci 15: 3468-3474.

P163  Neurotoxic mechanisms of transactivating protein Tat of Maedi-Visna virus   Strijbos, P.J.L.M., Zamani, M.R., Rothwell, N.J., Arbuthnott, G. & Harkiss, G.  (1995)  Neuroscience Lett 197: 215-218.

P164 Corticotrophin releasing hormone CRH mRNA is rapidly induced in rat cerebral cortex and amygdala during focal cerebral ischaemia.  Wong, M-L., Loddick, S.A., Bongiorno, P.B., Gold, P.W., Rothwell, N.J. & Licinio, J.  (1995)  Neuroreport 6: 1785-1788.

P165 MIP-1α Molecular cloning, expression and biological activities of a novel CC chemokine that is constitutively secreted in vivo.  Poltorak, A.N., Bazzoni, F., Smirnova, I.I., Alejos, E., Thompson, P., Luheshi, G., Rothwell, N.J. & Beutler, B.  (1995)  J Inflamm 45: 207-219.

__1996__\\ \\
P166  Lipocortin-1 inhibits CRH stimulation of plasma ACTH and IL-1ß-stimulated hypothalamic CRH release in rats.  Sudlow, A.W., Carey, F., Forder, R. & Rothwell, N.J.  (1996)  Am J Physiol 270: R54-R60.

P167  Interleukin-1 receptor antagonist inhibits endotoxin fever and systemic interleukin-1 induction in the rat.  Luheshi, G., Miller, A.J., Brouwer, S., Dascombe, M.J., Rothwell, N.J. & Hopkins, S.J.  (1996)  Am J Physiol 270: E91-E95.

P168  The role of lipocortin-1 in dexamethasone-induced suppression of PGE%%sub 2/% and TNFα release from human peripheral blood mononuclear cells.  Sudlow, A.W., Carey, F., Forder, R & Rothwell, N.J. (1996)  Br J Pharmacol 117: 1449-1456.

P169   An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat.  Loddick, S.A., MacKenzie, A. & Rothwell, N.J.  (1996)  Neuroreport 7: 1465-1468.

P170  Mechanisms of cachexia induced by T-cell leukemia in the rat.   Roe, S., Cooper, A., Morris, I.D. & Rothwell, N.J.  (1996)  Metabolism 45: 645-651.

P171  The role of TNFα in fever: opposing actions of human and murine TNFα and interactions with ILβ in the rat.  Stefferl, A., Hopkins, S.J., Rothwell, N.J. & Luheshi, G.N.  (1996)  Br J Pharmacol 118: 1919-1924.

P172  Neuroprotective effects of human recombitant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat. Loddick, S.A. & Rothwell, N.J.   (1996)  J Cereb Blood Flow Metab 16: 932-940.

__1997__\\ \\
P173  Local cytokine induction by LPS in the rat air pouch and its relationship to the febrile response.  Miller, A.J., Luheshi, G.N., Rothwell, N.J. & Hopkins, S.J.  (1997)  Am J Physiol 272:R857-R860.

P174  Febrile response to tissue inflammation involved both peripheral and brain IL-1 and TNF-α in the rat.  Luheshi, G.N., Stefferl, A., Turnbull, A.V., Dascombe, M.J., Brouwer, S., Hopkins, S.J. & Rothwell, N.J.  (1997) Am J Physiol 272: R862-R868.

P175  Involvement of cytokines in cachexia induced by T-cell leukaemia in the rat. Roe, S.Y., Cooper, A.L., Morris, I.D., Hopkins, S.J. & Rothwell, N.J.  (1997)   Eur Cytokine Netw 8, 1:45-49.

P176  Involvement of prostaglandins in cachexia Induced by T-cell leukemia in the rat.  Roe, S.Y., Cooper, A.L., Morris, I.D. & Rothwell, N.J.  (1997)  Metabolism 46: 359-365.
P177  Endogenous interleukin-1 receptor antagonist is neuroprotective. Loddick, S.A., Wong, M-L, Bongiorno, P.B., Gold, P.W., Licinio, J. & Rothwell, N.J.  (1997)  Biochem Biophys Res Commun 234:211-215.

P178 Cortical protection by localised striatal injection of IL-1ra following cerebral ischaemia in the rat.   Stroemer R.P. & Rothwell, N.J.   (1997)  J Cereb Blood Flow Metab17:597-604.

P179  Regional and cellular localisation of presenilin-2 RNA in rat and human brain. Benkovic, S.A., McGowan, E.M., Rothwell, N.J., Hutton, M., Morgan, D.G., & Gordon, M.N.  (1997)  Exp Neurol 145: 555-564.

P180  Whole body metabolic responses to brain trauma in the rat.  Roe, S.Y. & Rothwell, N.J.  (1997) Neurotrauma 14: 399-408.

__1998__\\ \\
P181  Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischaemia in the rat.  Loddick, S.A., Turnbull, A.V. & Rothwell, N.J.  (1998)  J Cereb Blood Flow Metab 18: 176-179.

P182  Effect of annexin-1 on experimental autoimmune encephalomyelitis (EAE) in the rat. Hutinga, I., Bauer, J., Strijbos, P.J.L.M., Rothwell, N.J., Dijkstra, C.D. & Tilders, F.J.H.  (1998)  Clin Exp Immunol 111: 198-204.

P183  Interleukin-1 and interleukin-1 receptor antagonist do not affect glutamate release or calcium entry in rat striatal synaptosomes.  Allan, S.M., Lawrence, C.A. & Rothwell, N.J.  (1998)  J Mol Psychiatry 3: 178-182.

P184  Evidence for the involvement of corticotrophin releasing factor (CRH) in the pathogenesis of traumatic brain injury.  Roe, S.Y., McGowan, E.M. & Rothwell, N.J.  (1998)  Eur J Neurosci 10: 553-559.

P185 Interleukin-1β and the interleukin-1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat.   Lawrence, C.A., Allan, S.M. & Rothwell, N.J.  (1998)  Eur J Neurosci 10: 1188-1195.

P186  Caspases mediate 6-hydroxydopamine-induced apoptosis but not necrosis in PC12 cells. Ochu, E., Rothwell, N.J. & Waters, C.M. (1998)  J Neurochem 70: 2637-2640.

P187  Exacerbation of ischaemic brain damage by localised striatal injection of IL-1β In the rat.  Stroemer, R.P. & Rothwell, N.J.  (1998)  J Cereb Blood Flow Metab 18: 833-839.

P188   Cloning of rat brain interleukin-18 cDNA  Culhane A.C., Hall M.D., Rothwell N.J., & Luheshi G.N.  (1998) Mol Psychiatry 3: 352-366.

P189 Leptin affects food intake via CRF-receptor-mediated pathways.  Gardner J.D., Rothwell N.J. & Luheshi G.N.  (1998)  Nature Neurosci 1: 103.

P190  Biological activity and brain actions of recombinant rat interleukin-1α and interleukin-1β  Anforth A.R., Bluthe R-M., Bristow A., Hopkins S., Lenczowski M.J.P., Luheshi G.N., Lundkvist J., Michaud B., Mistry Y., van Dam A-M., Zhen C., Dantzer R., Poole S., Rothwell N.J., Tilders, F.J.H. & Wollman, E.E.  (1998)  Eur. Cytokine Netw 9: 279-288.

P191  An integrated analysis of the progression of cell responses induced by permanent focal middle cerebral artery occlusion in the rat.   Davies, C.A., Loddick, S.A., Stroemer, P., Hunt, J. & Rothwell, N.J.  (1998)  Exp Neurol  154: 199-212.

__1999__\\ \\
P192   The progression and topographical distribution of interleukin-1β after permanent occlusion of the middle cerebral artery in the rat.  Davies, C.A. , Hunt, J., Loddick, S.A., Stroemer, R.P. & Rothwell, N.J.  (1999)  J Cereb Blood Flow Metab 19:87-98 

P193   Excitotoxic brain damage in the rat induces interleukin-1β protein in microglia and astrocytes: correlation with the progression of cell death.  Pearson, V.L.,Rothwell, N.J. & Toulmond, S.  (1999)  Glia 25: 311-323

P194  Central administration of rat interleukin-6 induces hypothalamus-pituitary-adrenal activation and fever but not sickness behaviour in rats.  Lenczowski, M.J.P., Bluthe, R-M, Roth, J., Rees, G.S., Rushforth, D.A., Van Dam, A-M, Tilders, F.J.H., Dantzer, R., Rothwell, N,J. & Luheshi, G.N.  (1999)  Am J Physiol 276: R652-R658.

P195  Dissociation between the effects of interleukin-1 on excitotoxic brain damage and body temperature in the rat. Grundy, R.I.,Rothwell, N.J., Allan, S.  (1999)  Brain Res 830: 32-27.

P196  Leptin actions on food intake and body temperature are mediated by interleukin-1.  Luheshi, G.N., Gardner, J.D., Loudon, A.S. & Rothwell, N.J.  (1999)  Proc Nat Acad Sci, USA 96: 7047-7052.

P197  Brain sites of action of endogenous interleukin-1 in the febrile response to localised inflammation in the rat.  Cartmell, T., Luheshi, G.N. & Rothwell, N.J.  (1999)  J Physiol 518: 585-594.

P198  Tumour necrosis factor alpha is a critical component of interleukin-13 mediated protective T helper cell type 2 responses during helmuth infection.   Artis, D., Humphreys, N.E., Bancroft, A.J., Rothwell, N.J., Potten, C.S. & Grencis, R.K.  (1999)  J Exp Med 190: 953-962

__2000__\\ \\
P199  Detection of the interleukin 18 family in rat brain by RT-PCR. Wheeler, R.D., Culhane, A.C., Hall, M.D., Pickering-Brown, S., Rothwell, N.J. & Luheshi, G.N.  (2000)  Mol Brain Res 77: 290-293.

P200  Circulating interleukin-6 mediates the febrile response to localised inflammation in rats.  Cartmell, T., Poole, S., Turnbull, A.V., Rothwell, N.J. & Luheshi, G.N.  (2000)  J Physiol  526.3: 653-661.

P201  Cortical death caused by striatal administration of AMPA and interleukin-1 is mediated by activation of cortical NMDA receptors  Allan, S.M. & Rothwell, N.J.  (2000)  J Cereb Blood Flow Metab 20: 1409-1413.

P203  IL-1β-induced changes in hypothalamic IL-1RI and IL-1R2 mRNA expression in the rat.   Parker, L.C., Rushforth, D.A., Rothwell, N.J. & Luheshi, G.N.  (2000)  Mol Brain Res 79: 156-158.

P204   Cortical cell death induced by interleukin-1 is mediated via actions in the hypothalamus of the rat.   Allan, S.A., Parker, L.C., Collins, B., Davies, R., Luheshi, G.N. & Rothwell, N.J.  (2000)  Proc Nat Acad Sci, USA  97: 5580-5585

P205  Influence of corticotrophin releasing factor on neuronal cell death in vitro and in vivo. Craighead, M.W., Boutin, H., Middlehurst, K.M., Allan, S.M., Brooks, N., Kimber, I. & Rothwell, N.J.   (2000)  Brain Res 881: 139-143.

P206  Involvement of interleukin-1 in glial responses to lipopolysaccharide: endogenous vs exogenous interleukin-1 actions.  Molina-Holgado, F., Toulmond, S. & Rothwell, N.J.  (2000)  J Neuroimmunol  111: 1-9.

P207  Interleukin (IL)-6 release and fever induced by a pre-formed pyrogenic factor (PFPF) derived from LPS-stimulated macrophages.   Zampronio, A.R., Hoadley, M.E., Luheshi, G.N., Rothwell, N.J., Souza, G.E. & Hopkins, S.J.  (2000)  Eur Cytokine Netw 11: 589-596.

__2001__\\ \\
P208  Actions of exogenous and endogenous IL-10 on glial responses to bacterial LPS/cytokines.  Molina-Holgado, F., Grencis, R. & Rothwell, N.J.  (2001)  Glia 33: 97-106.

P209  Anorexic but not pyrogenic actions of interleukin-1 are modulated by central melanocortin-3/4 receptors in the rat.  Lawrence, C.B. & Rothwell, N.J.  (2001)  J Neuroendocrinol 13: 490-495.

P210 Role of endogenous interleukin-1 receptor antagonist in regulating fever induced by localized inflammation in the rat.  Cartmell, T., Luheshi, G.N., Hopkins, S.J., Rothwell, N.J. & Poole, S.  (2001)  J Physiol 531: 171-80

P211  Role of IL-1α and IL-1β in ischaemic brain damage.   Boutin, H., LeFeuvre, RA., Horai, R., Asano, M., Iwakura, Y. & Rothwell, N.J.  (2001)  J Neurosci 21: 5528-34.

P212  Priming of macrophages with LPS potentiates P2X7 mediated cell death via a caspase-1 dependent mechanism, independently of cytokine production.  LeFeuvre, R.A., Brough, D., Iwakura, Y., Takeda, K. & Rothwell, N.J.  (2001)  J Biol Chem 277: 3210-3218.

213  Selective increases in cytokine expression in the rat brain in response to striatal injection of α-amini-3-dydroxy-5-methyl-4-sioaxazolepropionate and interleukin-1.  All, A.M., Harrison, D.C., Read, S., Collins, B., Parsons, A.A., Philpott, K. & Rothwell, N.J.  (2001)  Mol Brain Res 93: 180-189.

214  Oxidised adenosine 5’-triphosphate, a P2X7 antogonist, is toxic to rat cerebellar granule neurons in vitro.  Craighead, M.W., Middlehurst, K.M.L., LeFeuvre, R., Kimber, I. & Rothwell, N.J.  (2001)  Neurosci Lett 311: 77-80.
2002
P215  Site-specific actions of interleukin-1 on excitotoxic cell death in the rat striatum. Grundy, R.I., Rothwell, N.J. & Allan, S.M.  (2002)   Brain Res 926: 142-148.

P216 Role of CB%%sub 1/% and  CB%%sub 2/% receptors in the inhibitory effects of cannabanoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures.  Molina-Holgado, F., Molino-Holgado, E., Guaza, C. & Rothwell, N.J. (2002)  J Neurosci Res 67: 829-836.

P217  Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism. Brough, D., LeFeuvre, R.A., Iwakura, Y. & Rothwell, N.J.  (2002)  Mol Cell Neurosci 19:272-280.

P218  Involvement of caspases and calpains in cerbrocortical neuronal cell death is stimulus-dependent. Moore, J.D., Rothwell, N.J. & Gibson, R.M.  (2002)  Br J Pharm 135: 1069-1077.

P219  PRL-releasing peptide interacts with leptin to reduce food intake and body weight. Ellacott, K.L., Lawrence, C.B., Rothwell, N.J. & Luckman, S.M.  (2002)  Endocrinol 143: 368-374.

P220  IL-1beta signalling in glial cells in wildtype and IL-1RI deficient mice. Parker, L.C., Luheshi, G.N., Rothwell, N.J. & Pinteaux, E.  (2002)  Br J Pharm 136: 312-20.

P221   Interleukin-1 influences ischaemic brain damage in the mouse independently of the interleukin-1 type 1 receptor. Touzani, O., Boutin, H., LeFeuvre, R.A., Parker, L., Miller, A., Luheshi, G. & Rothwell, N.J.  (2002)  J Neurosci 22: 38-43.

P222 The influence of litter size and brain damage caused by hypoxic-ischaemic injury in the neonatal rat.Oakden. L., Chiswick, M., Rothwell, N.J. & Loddick S.A.  (2002)  Paed. Res 52: 692-696.

P223  Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells. Pinteaux, E., Parker, L.C., Rothwell, N.J. & Luheshi, G.N.  (2002)   J Neurochem 83: 754-763.

P224  Extracellular ATP and P2X7 receptors in neurodegeneration. LeFeuvre, R., Brough, D. & Rothwell, N.J. (2002)  Eur J Pharm 477: 261-269.

__2003__\\ \\
P225  Ca%%sup 2+/% stores and Ca%%sup 2+/% entry differentially contribute to the release of IL-1β and IL-1α from murine macrophages. Brough, D., LeFeuvre, R.A., Wheeler, R.D., Solovyova, N., Hilfiker, S., Rothwell, N.J. & Verkhratsky, A.  (2003)  J Immunol 170: 3029-3036.

P226  Role of P2X%%sub 7/% receptors in ischaemic and excitotoxic brain injury in vivo. LeFeuvre, R.A., Brough, D., Touzani, O. & Rothwell, N.J.  (2003)   J Cereb Blood Flow Metab 23: 381-384.

P227  No role for interleukin-18 in acute murine stroke-induced brain injury. Wheeler, R.D., Boutin, H., Touzani, O., Luheshi, G.N., Kiyoshi T & Rothwell, N.J.  (2003)  J Cereb Blood Flow Metab 23: 531-535.

P228  Up-regulation of IL-18BP, but not IL-18 mRNA in rat liver by LPS. Wheeler, R.D., Young, E.A., Rothwell, N.J., Hall, M.D. & Luheshi, G.N.  (2003)  Cytokine 21: 161-166.

P229  Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurones and glia. Molina-Holgado, F., Pinteaux, E., Moore, J.D., Molina-Holgado, E., Guaza, C., Gibson, R.M. & Rothwell, N.J.  (2003)  J Neurosci 23: 6470-6474.

P230  The expanding interleukin-1 family and its receptors: do alternative IL-1 receptor/signalling pathways exist in the brain?  Boutin, H., Kimber, I., Rothwell, N.J. & Pinteaux, E.  (2003)  Mol Neurobiol 27: 239-248.

P231  An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis.  Emsley, H.C.A., Smith, C.J., Gavin, C.M., Georgiou, R.F., Vail, A., Barbera, E.M., Hallenbeck, J.M., del Zoppo, G.J., Rothwell, N.J., Tyrrell, P.J. & Hopkins, S.J.  (2003)  J Neuroimmunol 139: 93-101.

P232  Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat.  Mulcahy, N.J., Ross, J., Rothwell, N.J. & Loddick, S.A.  (2003)  Br J Pharmacol 140:471-476.

P233  IL-1Rrp2 expression and IL-1F9 (IL-H1) actions in brain cells.  Berglof, E., Andre, R., Renshaw, B.R., Allan, S.M., Lawrence, C.B., Rothwell, N.J. & Pinteaux, E.  (2003)  J Neuroimmunol 139: 36-43.

P234  Inflammation in central nervous system injury.  Allan, S.M. & Rothwell, N.J.  (2003)  Phil Trans Roy Soc London 358: 1669-1677.

P235  Identification of a truncated IL-18Rβ mRNA: a putative regulator of IL-18 expressed in rat brain.  Andre, R., Wheeler, R.D., Collins, P.D., Luheshi, G.N., Pickering-Brown, S., Kimber, I., Rothwell, N.J. & Pinteaux, E. (2003)  J Immunol 145: 40-45.

P234  Interleukin-18 induces expression and release of cytokines from murine cells: interactions with interleukin-1 beta.  Wheeler, R.D., Brough, D., Le Feuvre, R.A., Takeda, K., Iwakura, Y., Luheshi, G.N. & Rothwell, N.J.  (2003)  J Neurochem 85: 1412-20.

P235  A dual role for interleukin-1 in LTP in mouse hippocampal slices.  Ross, F.M. Allan, S.M., Rothwell, N.J. & Verkhratsky, A.  (2003)  J Neuroimmunol 144: 61-7.

__2004__\\ \\
P235  Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by phoshatidylinositol 3-kinase/AKT signaling.  Molino-Holgado, F., Pinteaux, E., Heenan. K., Moore, J.D., Rothwell, N.J. & Gibson, R.M.  (2004)  Mol Cell Neurosci 28: 189-194.

P236  Peak plasma interleukin-6 and other peripheral makers of inflammation first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. Smith, C.J., Emsley, H.C., Gavin, C.M., Georgiou, R.F., Vail, A., Barberan, E.M., del Zoppo, G.J., Hallenbeck, J.M., Rothwell, N.J., Hopkins, S.J. & Tyrrell, P.J.  (2004)  BMC Neurol 4: 2-8.

__2005__\\ \\
P237  Differential actions of IL-1 alpha and IL-1 beta in glial cells share common IL-1 signalling pathways.  Andre, R., Pinteaux, E., Kimber, I. & Rothwell, N.J.  (2005)  Neuroreport 16: 153-7.

P238  Correlation of systemic inflammatory response with infarct volume in acute ischaemic stroke patients.  Emsley, H.C., Smith, C.J., Georgiou, R.F., Vail, A., Tyrrell, P.J., Barberan, E.M., Rothwell, N.J. & Hopkins, S.J.  (2005)  Stroke 36:228-9.

P239  Cleavage of the plasma membrane Na(+)/Ca(2+) exchanger in excitotoxic injury.  Bano, D., Young, K.W., Ruerin, C.J. Lefeuvre, R.A., Rothwell, N.J., Naldini, L., Rizzuto, R., Carafoli, E. & Nicotera, P.  (2005)   Cell 120: 275-85.

P240  The interleukin-1 related cytokine IL-1F8 is expressed in glial cells, but fails to induce IL-1beta signaling response.  Wang, P., Meinhardt, B., Andre, R., Renshaw, B.R., Kimber, I, Rothwell, N.J. & Pinteaux E.  (2005)  Cytokine 21: 245-50.

P241  Regulation of expression of the novel IL-1 receptor family members in the mouse brain.  Andre, R., Lerouet D., Kimber, E., Pinteaux, E. & Rothwell, N.J.  (2005)  J Neurochem 95: 324.30.

P242  A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients.  Emsley, H.C.A., Smith, C.J., Georgiou, R.F., Vail, A., Hopkins, S.J., Rothwell, N.J. & Tyrrell, P.J. (2005)  J Neurol Neurosurg Psychiatry  97:1366-72.

P243  Animal experiments and the development of surgical therapies.  Rothwell, N.J.  (2005)  Int J Surgery 3: 17-20.

P244  Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity.  Patel, H.C., Ross, F.M., Heenan, L.E., Davies, R.E., Rothwell, N.J. & Allan, S.M.  (2005)  J Neurosci Res 83(3):385-91.

P245  Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by phosphatidylinositol 3-kinase/AKT signaling.  Molina-Holgado F., Pinteaux E., Heenan L., Moore J.D., Rothwell N.J., Gibson R.M.  (2005)  Mol Cell Neurosci. 28(1):189-94.

__2006__\\ \\
P246   The role of inflammation in CNS injury and disease.  Lucas, S-M., Rothwell, N.J. & Gibson, R.M.  (2006) Br J Pharmacol 147: S232.

P247   Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain.  Andre, R., Moggs, J.G., Kimber, I., Rothwell, N.J. & Pinteaux, E.  (2006)  Glia 53:477-83.

P248  Interleukin-1 induced neurotoxicity is mediated by glia and requires caspase activation and free radical release.  Thornton, P., Pinteaux, E., Gibson, R.M., Allan, S.M., Rothwell, N.J.  (2006)  J Neurochem 258-66.

P249   Neuroprotective  actions of endogenous interleukin-1 receptor antagonist (IL-1RA) are mediated by glia. Pinteaux, E., Rothwell, N.J., Boutin. H.  (2006)  Glia 53: 551-6.

P250  Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity.  Patel, H.C., Ross, F.M., Heenan, L.E., Davies, R.E., Rothwell, N.J., Allan, S.M.  (2006)  J Neurosci Res 83: 385-91.

P251  Gene regulation by IL-1beta independent of IL-1RI in the mouse brain.   Andre, R., Moggs, J.G., Kimber, I., Rothwell, N.J., Pinteaux, E.  (2006)  Glia 53: 477-83.

P252  Variability of the systemic acute phase response after ischemic stroke.  Smith, C.J., Emsley, H.C.A., Vail, A., Georgiou, R.F., Rothwell, N.J., Tyrrell, P.J. & Hopkins, S.J.  (2006)  J Neurol Sci 251: 77-81.

P253  Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons.  Watson, P.M., Humphries, M.J., Relton, J., Rothwell, N.J., Verkhratsky, A. & Gibson, R.M.  (2006)   Mol Cell Neurosci 34: 147-54.

__2007__\\ \\
P254  Caspase-1 dependent processing of pro-interleukin-1β is cystosolic and precedes cell death.  Brough, D. & Rothwell, N.J.  (2007)  J Cell Sci 120: 772-81.

P255  NF-{k}B activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Miggin, S.M., Palsson-McDermott, E., unne, A., Jefferies, C., Pinteaux, E., Banahan, K.,  Murpy, C., Moynagh, P., Yamamoto, M., Akira, S., Rothwell, N.J., Golenbock, D., Fitzgerald, K.A., & O’Neill, L.  (2007)  Proc Nat Acad Sci, USA 104: 3372-3377.

P256 Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1- and neutrophil-dependent mechanisms.  McColl, B.W., Rothwell, N.J. & Allan, SM.  (2007)  J Neurosci 27: 4403-4412.

P257  Leptin induces interleukin-1β release from rat microglial cells through a caspase 1 independent mechanisms.  Pinteaux, E., Inoue, W., Schmidt, L., Molina-Holgado, F., Rothwell, N.J. & Luheshi G.N.  (2007)  J Neurochem 102: 826-833.

P258  A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischaemia in the rat.  (2007)  Ross, J., Brough, D., Gibson, R.M., Loddick, S.A., Rothwell, N.J.  Neuropharmacol  53: 638-642.

P259   Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations.  Clark, S.R.,  McMahon, C.J.,  Gueorguieva, I., Rowland, M., Scarth, S., Georgiou, R., Tyrrell, P.J. , Hopkins, S.J. & Rothwell,  N.J.   (2007)  J Cereb Blood Flow Metab 28: 387-394.

P260  Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1RA. Hutchinson, P.J., O’Connell, M.T., Rothwell, N.J., Hopkins, S.J., Nortje, J., Carpenter, K.L., Timofeev, I., Al-Rawi, P.G., Menton, D.K., Pickard, J.D.  (2007)  J Neurotrauma 10: 1545-57.

P261  Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production.  Emsley, H.C., Smith, C.J., Gavin, C.M., Georgiou, R.F., Vail, A., Barberan E.M., Illingworth, K., Scarth, S., Wickramasinghe, V., Hoadley, M.E., Rothwell, N.J., Tyrell, P.J. & Hopkins, S.J.   (2007)  BMC Neurol 28: 7:5.

P262   Mechanisms of interleukin-6 synthesis and release induced by interleukin-1 and cell depolarization in neurons.    Tsakiri, N., Kimber, I., Rothwell, N.J. & Pinteaux, E.  (2007)  Mol Cell Neurosci  37: 110-118.

P263 Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity.  Thornton, P., Pinteaux, E., Allan, S.M. & Rothwell, N.J.  (2007)  Mol Cell Neurosci  37: 135-142.

P264  Cell density regulates nuclear localization of interleukin-1 alpha and beta in murine microglia.  Luheshi, N.M., Rothwell, N.J., & Brough, D.  (2007)  Neuron Glia Biol 2: 102-102.

__2008__\\ \\
P265   Interleukin-1 exacerbates focal cerebral ischaemia and reduces ischaemic brain temperature in the rat.  Parry-Jones, A.R., Liimatainen, T., Kauppinen, R.A., Grohn, O.H., Rothwell, N.J.  (2008)  Magn Reson Med 59: 1239-1249. 

P266  Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurons.  Tsakiri, N., Kimber, I., Rothwell, N.J. & Pinteaux, E.  (2008)  Mol Cell Neurosci  38: 259-265.

P267  Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage  Gueorguiveva, I., Clark, S.R., McMahon, C.J., Scarth, S., Rothwell, N.J., Tyrrell, P.J., Hopkins, S.J. & Rowland, M.  (2008)  Br J Clin  Pharm 66: 754-754.

P268  Neuronal injury induces the release of pro-interleukin-1 beta from activated microglia in vitro.  Wang, P., Rothwell, N.J., Pinteaux, E. & Brough, D.  (2008)  Brain Res 1236: 1-7.

P269  Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental storke in mice.   McColl, B.W., Rothwell, N.J. & Allan, S.M.  (2008)  J Neurosci 28: 9451-9462.

P270  Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage.  Gueorguiveva, I., Clark, S.R., McMahon, C.J., Scarth, S., Rothwell, N.J., Tyrrell, P.J., Hopkins, S.J. & Rowland, M.  (2008)  Br J Clin. Pharmacol 65: 317-325.

P271  Interleukin-1 induced interleukin-6 synthesis is ediated by the neutral sphingomyelinase/Src kinase pathway in neurones.  Tsakiri. N., Kimber, I., Rothwell, N.J.  (2008)  Br J Pharmacol  153: 775-783.

__2009__\\ \\
P272  Potential surrogate markers of cerebral microvascular angiopathy in asymptomatic subjects at risk of stroke. Selvarajah J, Scott M, Stivaros S, Hulme S, Georgiou R, Rothwell N, Tyrrell P, Jackson A. (2009).  Eur Radiol. 19(4): 1011-8.

P273  Pannexin-1-dependent caspase-1 activation and secretion of IL-1β is regulated by zinc.  Brough, D., Pelegrin, P. & Rothwell, N.J.  (2009)  Eur J Immunol 39: 1-7.

P273 Systemic infection, inflammation and acute ischemic stroke.  McColl, B.W., Allan, S.M. & Rothwell, N.J.  (2009)  Neurosci 158: 1049-1061.

P275  The dynamics and mechanisms of interleukin-1 alpha and beta nuclear import.  Luheshi, N.M., Rothwell, N.J. & Brough, D.  (2009)  Traffic 10: 16-25.

P276  Transport of interleukin-1 across cerebromicrovascular endothelial cells.  Skinner, R.A., Gibson, R.M., Rothwell, N.J., Pinteaux, E. & Penny, J.I.  (2009)  Br J Pharmacol 156(7): 1115-23.

P277  Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy. Luheshi NM, Rothwell NJ, Brough D. Br J Pharmacol. (2009) 157(8): 1318-29.

P278  A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke.  (2009)  Chapman KZ, Dale VQ, Denes A, Bennett G, Rothwell NJ, Allan SM, & McColl BW.  J Cereb Blood Flow Metab 29(11): 1764-8.

P279  Inflammation and brain injury: Acute cerebral ischemia, peripheral and central inflammation.  (2009)  Denes A, Thornton P, Rothwell NJ & Allan SM.  (2009)  Brain Behav. Immun.   Sep 19 [Epub ahead of print]

P280   Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice
after experimental stroke. McColl BW, Rose N, Robson FH, Rothwell NJ, Lawrence CB.  (2009)  J Cereb Blood 
Flow Metab. Oct 14. [Epub ahead of print]
\\ \\

__Review articles __
\\ \\
__1979__\\ \\
R1  Energy balance in reversible obesity.  Stock, M.J. &  Rothwell, N.J.  (1979)  In: Animal Models of Obesity, Ed. Festing, M.W.F. Macmillan 141 151.

__1980__\\ \\
R2  Thermogenesis in pigs.   Rothwell, N.J., Stock, M.J., Gurr, M.I., Mawson, R. & Fisher, C.  (1980)  In:  Energy Metabolism, Ed. Mount, L.E.,  Butterworths 243 247.

__1981__\\ \\
R3  Hyperphagia, thermogenesis and leanness.  Rothwell, N.J. & Stock, M.J.  (1981)  In:  Recent Advances in Obesity Research 111, Eds.  Bjorntorp, P., Cairella, M. & Howard, A.N. Libbey, London 214 219.

R4  Regulation of energy balance. Rothwell, N.J. & Stock, M.J.  (1981)  Ann Rev Nutr 1: 235 256.

R5  Thermogenesis:  Comparative and evolutionary considerations.  Rothwell, N.J. & Stock, M.J.  (1981)  In: The Body Weight Regulatory System: Normal and Disturbed  Mechanisms. Eds. Cioffi, L.A., James, W.P.T. & Van Itallie, T.B.  Raven Press, New York 335 343.

R6  Diet induced thermogenesis:  A role for brown adipose tissue.  Stock, M.J. & Rothwell, N.J.  (1981)  In: Nutritional Factors:  Modulating Effects of Metabolic Processes. Eds. Beers, R.F. &  Bassett, E.G.  Raven Press, New York 101 113.

R7  Sympathetic control of brown adipose tissue in the regulation of body weight.  Stock, M.J. & Rothwell, N.J. (1981)  Biochem Soc Trans 9: 525 527.

R8 Effects of cold and hypoxia on diet induced thermogenesis.  Rothwell, N.J. & Stock. M.J.  (1981)  In: Contributions to Thermal Physiology. Eds. Szelenyi, Z & Szekely, M.  Pergamon Press 511 513.

__1982__\\ \\
R9  Obesity thermogenesis and carbohydrate metabolism. Stock, M.J. & Rothwell, N.J.  (1982)  In: Nutritive Sweeteners.  Eds. Birch, G.G. &  Parker, K.J.  Applied Science Publishers, London 231 246.

R10 Neural regulation of thermogenesis.  Rothwell, N.J. & Stock, M.J.  (1982)  Trends in Neuroscience  5: 124 126.

R11  Evidence for diet induced thermogenesis in hyperphagic cafeteria fed rats. Stock, M.J. & Rothwell, N.J. (1982)  Proc Nutr Soc 41: 133 135.

R12  Diet induced thermogenesis.  Rothwell, N.J., Stock, M.J. & Stribling, D.  (1982)  Pharmacol Ther 17: 251 268.

R13  Obesity & leanness, Basic Aspects  Stock, M.J., & Rothwell, N.J.  (1982)  Libbey, J & Co London. Book.

__1983__\\ \\
R14  Diet induced thermogenesis.  Rothwell, N.J. & Stock, M.J.  (1983)  Ed. Draper, H.H. Adv Nutr Res Plenum, New York, 201-220.  

R15  Luxosconsumption, diet induced thermogenesis and brown fat: the case in favour.  Rothwell, N.J. & Stock, M.J.  (1983)  Clin Sci 64: 19 23.

R16  The role of brown adipose tissue in overfeeding: a review. Stock, M.J. & Rothwell, N.J.  (1983)  J Roy Soc Ed  76: 71 73.

R17 Diet induced thermogenesis. Rothwell, N.J., & Stock, M.J.  (1983)  In: Mammalian Thermogenesis. Eds. Girardier, L. &  Stock, M.L.  Chapman & Hall, London 208 233.

R18  Overfeeding, diet induced thermogenesis and brown fat.  Stock, M.J. & Rothwell, N.J.  (1983)  J Obesity Weight Reg 2: 64 68.

R19  Pharmacological modifications of thermogenesis and energy balance. Rothwell, N.J. & Stock, M.J.  (1983) J Obesity Weight Reg 2: 84 87.

__1984__\\ \\
R20  Brown adipose tissue. Rothwell, N.J. & Stock, M.J.  (1984)  In: Recent Advances in Physiology 10  Ed. Baker, P.F. Churchill Livingstone, Edinburgh 349-384.

R21  Non shivering and diet induced thermogenesis: The role of brown adipose tissue. Rothwell, N. J. & Stock, M.J.  (1984)  In: Thermal Physiology Ed. Hales, J.R.S. Raven Press, New York 145 153.

R22  Diet induced thermogenesis and brown fat. Rothwell, N.J. & Stock, M.J.  (1984)  In: Endocrinology, Eds. Labrie, F & Proulx, L, Elsevier, Amsterdam 419 422.

R23  The development of obesity in animals:  The role of dietary factors.  Rothwell, N.J. & Stock, M.J.  (1984) Clin Endoc Metab  l3: 437 449.

__1985__\\ \\
R24  Is Na,K ATPase involved in the control of metabolic rate in rats?  Rothwell, N.J., Stock, M.J. & Wyllie, M.G (1985)  In: The Sodium Pump: Eds. Glynn, I & Ellory, C., The Company of Biologists, London 717 719.

R25  Factors influencing brown fat and the capacity for diet induced thermogenesis. Stock, M.J. & Rothwell, N.J.  (1985)  Int J Obesity 9: 9 15.

R26  Biological distribution and significance of brown adipose tissue.  Rothwell, N.J. & Stock, M.J.  (1985)   Comp Biochem Physiol 85A: 745 751.

__1986__\\ \\
R27  Whither brown fat?  Rothwell, N.J. & Stock, M.J.  (1986)  Biosci Rep  6: 13 18.

R28  Effects of  adrenergic agonists on metabolism and body composition. Stock, M.J. & Rothwell, N.J.  (1986)  In: Control and manipulation of Animal Growth. Eds. Buttery, P.J., Hayes, N.B. & Lindsay,  D. B.,  Butterworths, London 249 257.

R29  Brown adipose tissue and the response to overfeeding.  Stock, M.J. & Rothwell, N.J.  (1986)  Biochem Soc Trans 14: 239 240.

R30  Diet induced thermogenesis.  Rothwell, N.J. &  Stock, M.J.  (1986)  Nutr Int  2: 95 99.

R31  Brown adipose tissue and diet induced thermogenesis.  Rothwell, N.J. & Stock, M.J.  (1986)  In: Brown Adipose Tissue  Eds. Trayhurn, P. & Nicholls, D.G., Arnold, London, 269 298.

__1987__\\ \\
R32  Diet induced thermogenesis and energy flux through brown adipose tissue.  Stock, M.J. & Rothwell, N.J. (1987)  In: Proc XIII Internat Congress Nutr Eds. Taylor, T.G. & Jenkins, N.K., Libbey, London 321 325.

__1988__\\ \\
R33  Criteria and experimental evidence for luxoskonsumption.  Stock, M.J. & Rothwell,, N.J.  (1988)  In: Recent Advances in Obesity Research,  Eds. Berry, E.M., Blondheim, S.H., Eliahou, H.E. & Shafrir, E., Libbey, London 124 130.

R34  Insulin and thermogenesis.  Rothwell, N.J. & Stock, M.J.  (1988)  Int J Obesity 12: 93 102.

R35  Diet induced thermogenesis: concepts and mechanisms.  Rothwell, N.J. & Stock, M.J.  (1988)  J Obesity Weight Regul 6: l62 l69.

R36  Brown adipose tissue: does it play a role in the development of obesity?  Rothwell, N.J. & Stock, M.J. (1988)  Diabet Metab 4: 595 60l.

__1989__\\ \\
R37  The role of brown adipose tissue in adaptive diet induced thermogenesis.  Stock, M.J. & Rothwell, N.J. (1989) In: Hormones, Thermogenesis and Obesity.  Proc. l8th Steenbock Symposium Eds. Lardy, H. & Stratman, F.  Elsevier, NY 95 l03.

R38  Central control of brown adipose tissue thermogenesis.  LeFeuvre, R.A., Rothwell, N.J. & Stock, M.J. (1989)  In Obesity in Europe '88 Eds Bjorntorp, P. & Rossner, S.  J. Libbey, London 240 241.

R39  Central control of brown adipose tissue.  Rothwell, N.J.  (1989)  Proc Nutr Soc  48: 241 250.

R40  Regulation of energy balance in homeotherms.  Rothwell, N.J.  (1989)  Proc 10%%sup th/%  Conference Eur Soc Comp Physiol & Biochem Eds. Weiser, W. & Graiger, E. Verlag, Stuttgart  110 115.

__1990__\\ \\
R41  Central effects of CRF on metabolism and energy balance.  Rothwell, N.J. (1990)  Neuroscience  Behav Revs 14: 263-271.

R42  Mechanisms of the pyrogenic actions of cytokines.  Rothwell, N.J. (1990)  Eur Cytokine Net 1: 211-213.

R43  Thermogenesis in obesity and cachexia.  Rothwell, N.J.  (1990)  In: Hormones and Nutrition in Obesity and Cachexia Ed. Muller, M.J. Springer-Verlag 77-85.  

R44  Neuroendocrine mechanisms in the thermogenic responses to diet, infection and trauma Rothwell, N.J.  (1990)  Adv Exp Med & Biol 371-380.

R45  Thermoregulation and autonomic function.  Rothwell, N.J.  (19990)  Curr Opinion Neurol & Neurosurg 3: 486-489.

__1991__\\ \\
R46  Autonomic and central control of thermogenesis.  Rothwell, N.J.  (1991)  In: Obesity & Cachexia  Eds. Rothwell, N.J. & Stock, M.J.  Wiley & Sons 13-34.

R47  Functions and mechanisms of interleukin-1 in the brain.  Rothwell, N.J.  (1991)  Trends Pharmacol Sci 12: 430-436.

R48  Thermogenesis, brown adipose tissue and fenfluramines in animal studies.  Rothwell, N.J. & LeFeuvre, R.A.  (1991)  Int J Obesity 15: 274-277.

R49  The endocrine significance of cytokines.  Rothwell, N.J.  (1991)  J Endoc 128: 171-173.

1992
R50  Hypothalamus and thermogenesis.  Rothwell, N.J.  (1992)  In: Energy Metabolism: Tissue determinants and cellular corollaries Eds. Kinney, J.M. &Tucker, H.N. Raven Press NY 229-246.

R51  Alzheimer's disease: pathology to potential treatments.  Royston, M.C., Rothwell, N.J. & Roberts G.W.  (1992)  Trends Pharmacol Sci 13: 131-133.

R52  Lipocortin-1 exhibits novel actions providing clinical opportunities.   Rothwell, N.J. & Flower, R.  (1992) Trends Pharmacol Sci 13: 45-46.

R53  Eicosanoids, thermogenesis and thermoregulation.  Rothwell, N.J.  (1992)  Prostaglandins, Leukotrienes Essential Fatty Acids  46: 1-7.

R54  Metabolic and nutritional effects of TNF.  Rothwell, N.J. (1992)  In: Tumour Necrosis Factors. The molecules and their emerging role in medicine Ed. Beutler, B  Raven Press Ltd, NY 237-253.

R55  Metabolic responses to interleukin-1. Rothwell, N.J.  (1992)  In: Interleukin-1 in the brain Eds. Rothwell, N.J. & Dantzer, R. Pergamon Press 115-134.

R56  Cytokines, CRF and BAT on fever. Rothwell, N.J. & Cooper, A.L.  (1992)  In: Neuroimmunology of fever Eds. Bartfai T & Otteson, D Pergamon Press 257-272.

R57  Thermogenesis, brown adipose  tissue and dexfenfluramine in animal studies.  Rothwell, N.J. & LeFeuvre, R.A.  (1992)  Int J Obesity 16: S67-S71.

__1993__\\ \\
R58  Involvement of cytokines in acute neurodegeneration in the CNS. Rothwell, N.J. & Relton, J.K.  (1993) Neurosci Biobehav Rev 17: 217-227

R59  Involvement of interleukin-1 and lipocortin-1 in ischaemic brain damage. Rothwell, N.J. & Relton, J.K.  (1993)  Cerebrovasc Brain Metab Rev 5: 178-198.

R60  Thermogenic effects of Cytokines : Methods and mechanisms in neurobiology of cytokines. Busbridge, N.J, Rothwell, N.J.  (1993)  Ed. De Souza, E.B.  Academic Press, San Diego 96-110. 

R61  Actions of cytokines in the brain and possible interactions with nitric oxide.  In: Nitric Oxide: Brain and Immune System. Rothwell, N.J., LeFeuvre, R.A. & Strijbos, P.J.L.M.  (1993)  Eds.  Moncada, S., Nistico, G. & Higgs, E.A.  Portland Press, London 163-171.

R62  Cytokines and thermogenesis  Rothwell, N.J.  (1993)  Int J Obesity  17: S98-S101.

__1994__\\ \\
R63  CNS regulation of thermogenesis.  Rothwell N.J.  (1994)  Critical Rev Neurobiol  8: 1-10.

R64  Lipocortin-1: cellular mechanisms and clinical relevance.  Flower, R.J. & Rothwell, N.J.  (1994)  Trends Pharmacol Sci 15: 71-76.

R65  Pharmacology of Interleukin-1 actions in the brain. Rothwell, N.J. & Luheshi, G.N.  (1994)  Adv Pharmacol 25: 1-20.

R66  Mechanisms of activation of the pituitary-adrenal axis by tissue injury in the rat.  Turnbull, A.V., Dow, R.C., Hopkins, S.J., White, A., Fink, G. & Rothwell, N.J.  (1994)  Psychoneuroendocrinol 19: 165-178.

R67  Brain control of responses to trauma.  Eds. Rothwell, N.J. & Berkenbosch, F.  (1994)  Cambridge University Press.

R68  Cytokines and cerebral ischaemia.  Rothwell, N.J., Lawrence, C.B., Loddick, S.A., Strijbos, P.J.L.M. & Toulmond, S.  (1994)  Eds. Krieglstein, J. & Oberpichler-Schwenk, H. Pharmacol Cerebral Ischaemia 419-425

__1995__\\ \\
R69  Cytokines in the nervous system I: Expression and recognition.  Hopkins, S.J. & Rothwell, N.J.  (1995) Trends Neurosci 18: 83-88.

R70  Cytokines and the nervous system II: Actions and mechanisms of action.  Rothwell, N.J. & Hopkins, S.J.  (1995)  Trends Neurosci 18: 130-136.

R71  Cytokines in neurodegeneration and repair.  Rothwell, N.J. & Strijbos, P.J.L.M. (1995)  Int J Devl Neuroscience 13: 179-185.

R72  Cytokines and the nervous system.  Rothwell, N.J., Loddick, S. & Lawrence, C. (1995)  Bios Scientific, London 77-99.

R73  Immune responses in the nervous system. Ed. Rothwell, N.J. (1995)  Bios Scientific, London

__1996__\\ \\
R74 Cytokines and fever. Luheshi, G. & Rothwell, N.J. (1996)  Int Arch Allergy Immunol 109: 301-307.

R75  Cytokines and their receptors in the central nervous system: physiology, pharmacology and pathology. Rothwell, N.J., Luheshi, G & Toulmond, S. (1996)  Pharmacol Ther 69: 85-95.

R76   Brain TNF damage limitation or damaged reputation.  Rothwell N.J. & Luheshi, G.N. (1996)   Nature  Med (News & Views) 2: 746-747.  

R77  Cytokines in the nervous system.  Ed. Rothwell, N.J. (1996)  Springer/R.G. Landes, USA

R78  The role of cytokines in neurodegeneration.  Rothwell, N.J. (1996)  In: Cytokines in the Nervous System Ed. Rothwell, N.J., Springer/R.G. Landes, USA 145-162.

R79  Actions of IL-1 in neurodegeneration.  Rothwell, N.J. Stroemer, P., Lawrence, C. & Davies, C. (1996)  Ed. Krieglstein, J. Pharm Cerebral Isch 125-129.

__1997__\\ \\
R80 Cytokines in the brain: Cytokines and acute neurodegeneration.  Rothwell, N.J. (1997) Molecular Psychiatry  2: 120-121.

R81  Neuroimmune interactions: the role of cytokines. Rothwell, N.J. (1997)  Br J Pharm 121: 841-847.

R82  The role of IL-1 in acute neurodegeneration and stroke.  Pathophysiological and therapeutic applications. Rothwell N,J., Allan, S.M. & Toulmond, S. (1997)  J Clin Invest 100: 2648-2652..

R83  Cytokines and acute neurodegeneration.  Rothwell, N.J.  (1997)  Mol Psychiatry 2:120-121.

R84  Interleukins and cerebral ischaemia.  Rothwell, N.J., Loddick, S.A., Stroemer, P.  (1997)  Int Rev Neurobiol 40: 281-289.

R85  The role for brown adopose tissue in diet-induced thermogenesis.  Rothwell, N.J. & Stock, M.J. (1997) Obes Res 5:650-656. 

__1998__\\ \\
R86  Interleukin-1 and neurodegeneration.  Rothwell, N.J. (1998)  The Neuroscientist 4: 195-201.

R87  The relationship between interleukin-1 and interleukin-1 receptor antagonist during the development of fever in the rat.  Cartmell, T., Poole, S., Rothwell, N.J. & Luheshi, G.N.  (1998)  Ann New York Acad Sci 856: 252-255.

R88  Cytokines in acute brain injury and stroke. Rothwell, N.J., Toulmond, S., Allan, S.M., Stroemer, R.P. &  Davies, C. (1998)  In: Pharm Cereb Isch Ed. Krieglstein, J. Medpharm, Stuttgart  471-478.

R89  Neuroprotective effects of corticotrophin-releasing factor receptor antagonists. Loddick, S.A., Chalmers, D.T., Yatsushiro, K., McCulloch, J., Foster, A.C., Rothwell, N.J. & De Souza, E.B.  (1998)   In: Pharm Cereb Isch Ed. Krieglstein, J. Medpharm, Stuttgart 371-378

R90   Sites and mechanisms of interleukin-1 action. Allan, S.M., Lawrence, C.B., Grundy, R.I., Stroemer, R.P. & Rothwell, N.J. (1998)  In: Pharm Cereb Isch Ed.  Krieglstein, J. Medpharm, Stuttgart 395-399.

__1999__\\ \\
R91  Cytokines – killers in the brain?  Rothwell, N.J. (1999)  J  Physiol  1: 3-17.

R92  Potential mechanisms of interleukin-1 involvement in cerebral ischaemia. Touzani, O., Boutin, H., Chuquet, J. & Rothwell, N.J. (1999)  J Neuroimmunol 100: 203-215.

R93  Hypothalamic control of feeding.  Lawrence, C.B., Turnbull, A.V. & Rothwell, N.J.  (1999)  Curr Opinion Neurobiol 9: 778-783.

R94  Mechanisms of tumour necrosis factor  action on neurodegeneration: interaction with insulin-like growth factor-1.   Loddick, S.A. & Rothwell, N.J. (1999)  Proc Nat Acad Sci USA 96: 9449-9451.

R95  Brain killers: understanding degenerative diseases of the brain.   Rothwell, N.J.  (1999)  Proc Royal Institution of Great Britain 70: 63-74.

__2000__\\ \\
R96  Interleukin-1 in the brain: biology, pathology and therapeutic target.   Rothwell, N.J. & Luheshi, G.N.  (2000)  Trends in Neurosci 23: 618-625.

__2001__\\ \\
R97  Thermogenesis: where are we and where are we going? Report of a workshop held in London 21st April 2001, convened by Professor Mike Stock.  Rothwell, N.J. (2001)  Int J Obesity 25: 1272-1274.

R98  Cytokines and acute neurodegeneration. Allan, S.M.& Rothwell, N.J. (2001)  Nature Revs Neurosci 2:  734-744.

__2002__\\ \\
R99  Extracellular ATP and P2X7 receptors in neurodegeneration.  LeFeuvre, R.A., Brough, D. & Rothwell, N.J.  (2002)  Eur J Pharm 447: 261-269.

R100  Cerebral ischaemic processes and cytokines: can transgenic mice help? Boutin, H. & Rothwell, N.J. (2002)   Eds Krieglstein, J & Klumpp, S. Pharm Cereb Isch pp 183-190.

R101  Molecular and cellular processes responsible for the neuroprotective activity of transforming growth factor-beta during cerebral ischaemia. Ali, C., Nicole, O., Docagne, F., Ruocco, A., MacKenzie, E.T., Loddick, S.A., Rothwell, N.J., Buisson, A. & Vivien, D. (2002)   Eds Krieglstein, J & Klumpp, S Pharm Cereb Isch pp 355-361.

R102  Mechanisms of expression, release and actions of IL-1 in ischaemic brain damage. Allan, S.M., Brough, D., LeFeuvre, R.A., Loddick, S.A., Patel, H., Ross, J. & Rothwell, N.J. (2002)  Eds Krieglstein, J & Klumpp, S. Pharm Cereb Isch pp 383-386.

__2003__\\ \\
R103  Interleukin-1 and neuronal injury: mechanisms, modification and therapeutic potential. Rothwell, N.J. (2003)  Brain Behav Immun 17: 152-157.

R104  The expanding interleukin-1 family and its receptors: do alternative IL-1 receptor/signalling pathways exist in the brain?  Boutin, H., Kimber, I., Rothwell, N.J. & Pinteaux, E.  (2003)  Mol Neurobiol 27: 239-248.

R105  A dual role for interleukin-1 in LTP in mouse hippocampal slices.  Ross, R.M., Allan, S.M., Rothwell, N.J. & Verkhratsky, A.  (2003)  J Neuroimmunol 144: 61-67.

R106  Inflammation in central nervous system injury.  Allan, S.M. & Rothwell, N.J.  (2003)  Philos Trans R Soc Lond B Biol Sci 358: 1669-77.

__2004__\\ \\
R106  IL-1ra in acute clinical stroke: safety and biological activity.  Emsley, H.C.A., Georgiou, R.F., Hopkins, S.J., Smith, C.J., Vail, A., Rothwell, N.J. & Tyrrell, P.J. (2004)  Krieglstein, J & Klumpp, S (Eds) Pharm of Cerebral Isch. Pp 543-548 

R107  CNS injury: the role of the cytokine IL-1.  Gibson, R.M., Rothwell, N.J. & LeFeuvre, R.A. (2004)  Vet J 168: 230-237.

__2005__\\ \\
R108  IL-1 and acute neuronal injury.  Allan, S.M., Tyrrell, P. & Rothwell, N.J. (2005)  Nature Rev Immunol 8: 629-40.

R109  Interleukin-6 and acute ischaemic stroke.  Emsley, H.C., Smith, C.J., Georgiou, R.F., Vale, A., Barberan, E.M., Rothwell, N.J., Tyrrell, P.J., Hopkins, S.J.  (2005)  Acta Neurol Scand 112:273-4.

__2006__\\ \\
R110  Lucas, S-M., Rothwell, N.J. & Gibson, R.M.  (2006)  The role of inflammation in CNS injury and disease.  Br J Pharmacol 147: S232-40.

R111  Skinner, R., Georgiou, R., Thornton, P. & Rothwell, N.J.  (2006)  Psychoneuroimmunology of Stroke.  Neurol Clin 24: 561-583.

R112  Skinner, R., Georgiou, R., Thornton, P. & Rothwell, N.J.  (2006)  Psychoneuroimmunology of stroke.  Neurol Clin 24: 561-583.

__2007__\\ \\
R113  Inflammation and reperfusion injury within the penunbra.  Parry-Jones, A., Selvarajah, J. R., Tyrrell, P.J. & Rothwell, N.J.  (2007)  Eds Donnan, G.A., Baron, J-C., Davis, S.M. & Sharp, F.R.  Informa Healthcare pp 125 -135.

R114  Interleukin-1 and inflammatory neurodegeneration.  (2007)  Simi, A., Tsakiri, N., Wang, P. & Rothwell, N.J.  Biochem Soc Trans 5: 1122-6.

R115  Systemic inflammation and stroke: aetiology, pathology and targets for therapy.  (2007)  McColl, B.W., Allan, S.M. & Rothwell, N.J.  Biochem Soc Trans 5: 1163-5.

R116  Improving outcome after stroke: Overcoming the translational roadblock.  Endres, E., Engelhardt, B., Koistinabo, J., Lindvall, O., Meairs, D., Mohr, J.P., Planas, A., Rothwell, N.J., Schwaninger, M., Schwab, M.E., Vivien, D., Wieloch,  Dirnagl, U.  (2007)  Cerebrovascular Diseases In Press.

__2008__\\ \\
R117  Acute neurodegeneration: cerebral ischaemia and stroke.  Smith CJ, Ross J, Rothwell NJ, Tyrrell PJ. In Tomlinson S, Heagarty AM, Wheetman AP, Malik RA, eds. Mechanisms of Disease (Second edition). (2008) Cambridge University Press: 191-209.

__2009 __\\ \\
R118  Psychoneuroimmunoloy of stroke.  Skinner R, Georgiou R, Thornton P & Rothwell NJ.  (2009)  Immunol Allergy Clin North Am 2: 359-79.
\\ \\

__Recent  non-research articles  __
\\ \\
Why so few?  Nobel Prize Women in Science: their struggles and momentous discoveries.  Rothwell, N.J. (1999)  Bio Essays 21: 892-893.

Show them how its really done. Rothwell, N.J. (2000)  Nature 405: 621.

The delicate balance.  Rothwell, N.J.  (2000)  Science & Public Affairs.  Editorial  August p5.

Homeostasis.  Rothwell, N.J. (2000)  Biological Sciences Review 12: 2-5.

Animals in research: A scientists view.  Rothwell, N.J. (2001)  Endocrinologist  p13.

Scientific progress and animal welfare: conflicting goals or complementary opportunities?  Rothwell, N.J. (2001) ATLA  29: 209-210.

Brain waves: Stroke and interleukin-1.  Rothwell, N.J. (2001)  The Biochemist June 23-25

Scientific progress and animal welfare: conflicting goals or complementary opportunities.  Rothwell, N.J. (2001) ATLA 29: 209-210.

Who wants to be a scientist? Rothwell, N.J. (2002)  Camb University Press.

Science, not art: ten scientists diaries. (ed Turney, J)  Rothwell, N.J. & Blagbrough, S. (2003)  Nature 425: 902-903.

One more thing…  Rothwell, N.J.  (2004)  Nature 427: 683.

Monthly column in the Times Higher Education Supplement