!!Matthias Peter - Curriculum Vitae
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__Research interests: __

*Biochemistry and Cell Biology\\

* Research in the Peter laboratory is focused on understanding mechanisms that govern cell growth and division. His laboratory has made key contributions on how ubiquitin-dependent mechanisms regulate DNA replication and mitosis. Moreover, his laboratory studies how selective degradation of excess and/or damaged protein complexes and organelles by autophagy ensures quality control and contributes to survival during nutrient starvation.

* The ETH Zürich is a renowned engineering school that has a strong interdisciplinary research and teaching program in all aspects of Life Sciences. In particular, the Department of Biology aims at understanding molecular mechanisms governing health and disease, with a balance of experts focusing on technology/method development and researchers that apply these methods to relevant biological processes.
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__Brief biography__
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*Since 2002  Professor for Biochemistry, ETH Zurich\\
*2011-2015  Chair of the Department of Biology, ETH Zurich\\
*2008-2011 Vice-chair of the Department of Biology, ETH Zurich\\
*2003-2004  Chair of the Institute of Biochemistry, ETH Zurich\\
*1996-2002  Assistant/Associate Professor at the Swiss Institute for Exp. Cancer Research (ISREC), Epalinges s/Lausanne\\
*1991-1996 Post-doctoral fellow with Prof. Ira Herskowitz, UCSF/USA\\
*1988-1991 PhD with Dr. Erich Nigg, Swiss Institute for Exp. Cancer Research (ISREC), Epalinges s/Lausanne \\
*1987 ETH Zurich Diploma with Specification in Gene Technology and Cell Biology \\
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__Main publications:__\\
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Brodersen, M.L., , Lampert, F., Barnes, C.A., Soste, M., Piwko, W., and Peter, M. (2016) CRL4WDR23-mediated SLBP ubiquitylation ensures histone supply during DNA replication.\\
Mol. Cell, in press.\\
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Mosadeghi, R., Reichermeier, K., Winkler, M., Schreiber, A., Reitsma, J.M., Zhang, Y., Stengel, F., Cao, J., Kim, M., Sweredoski, M.J., Hess, S., Leitner, A., Aebersold, R., Peter. M.*, Deshaies, R.J.*, and Enchev, R.I.* (2016) Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle. *corresponding authors.\\
Elife, in press.\\
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Hegemann, B., Unger, M., Lee, S.S., Stoffel-Studer, I., van den Heuvel, J., Pelet, S., Koeppl, H., and Peter, M. (2015) A Cellular System for Spatial Signal Decoding in Chemical Gradients. \\
Dev Cell, 35, 1-13. \\
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Dechant, R., Saad, S., Ibáñez, J., and Peter, M., (2014) Cytosolic pH regulates cell growth through distinct GTPases, Arf1 and Gtr1, to promote Ras/PKA and TORC1 activity.\\
Mol. Cell, 55(3), 409-21.\\
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Beck, J.*, Maerki, S.*, Posch, M., Metzger, T., Persaud, A., Scheel, H., Hofmann, K., Rotin, D., Pedrioli, P., Swedlow, J.R., Peter, M.*, and Sumara, I.* (2013) Ubiquitylation-dependent localization of PLK1 in mitosis.\\
Nat. Cell. Biol., 15 (4), 430-9, *equal contribution.\\
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Enchev, R, Scott, D, da Fonseca, P, Schreiber, A, Monda, J, Schulman, B A*, Peter, M*, and Morris, E* (2012). Structural basis for a reciprocal regulation between SCF and CSN. \\
Cell Reports, 2, 3, 616-627. *corresponding author’s.\\
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Pelet, S., Rudolf, F., Nadal-Ribelles, M., de Nadal, E., Posas, F. and Peter, M. (2011)\\
Transient activation of the HOG MAPK pathway regulates bimodal gene expression.\\
Science, 332, 732-735 (cited: 52x).\\
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Leidel S, Pedrioli PGA, Bucher T, Brost R, Costanzo M, Schmidt A, Aebersold R, Boone C, Hofmann K, and Peter M (2009) Ubiquitin-related modifier Urm1 acts as a sulfur-carrier in thiolation of eukaryotic tRNA. \\
Nature, 458, 228-232 (cited: 102x).\\
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Kraft, C., Deplazes, A., Sohrmann, M., and Peter, M. (2008) Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease. \\
Nature Cell Biology, 10, (5), 602-610 (cited: 281x).\\
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Kurz, T., Ozlü, N., O’Rourke, S., Rudolf, F., Luke, B., Hyman, A.A., Bowerman, B., and Peter, M. (2005) The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. \\
Nature, 435, 1257-61 (cited: 101x).\\
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Pintard, L. Willis, J., Willems, A., Johnson, J., Srayko, M., Kurz, T., Glaser, S., Mains, P., Tyers, M., Bowerman, B. and Peter, M. (2003) The BTB-containing protein MEL-26 functions as a substrate-specific adapter of the CUL-3 ubiquitin ligase. \\
Nature, 425, 311-316 (cited: 275x).\\
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Butty AC, Pryciak PM, Huang LS, Herskowitz I, and Peter M. (1998) The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating.\\
Science, 282,1511-6 (cited: 146x).\\
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__Main prizes/awards:__
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*2011 ERC Advanced Grant\\
*2006  MIT lecture\\
*2001 EMBO member\\
*2001 Promotion to ISREC Senior Scientist/Associate Professor\\
*1997 Helmut Horten Incentive award\\
*1996  Career development award START\\
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__Languages:__ German, French, English\\
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__Personal website:__ [http://www.bc.biol.ethz.ch/research/peter/people/matthias-peter.html]