!!Ronald Thomas Hay - Selected publications
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My most significant achievement was to establish conjugation with Small Ubiquitin-like Modifier (SUMO) as an important regulatory mechanism in eukaryotes. My lab (and the Blobel lab) were first to demonstrate that the enzyme involved in SUMO conjugation was Ubc9. We demonstrated that the acceptor lysine for SUMO modification in IkBa was also the acceptor\\
for ubiquitylation. This established the paradigm of SUMO and ubiquitin modifying the same lysine residue, allowing proteins to switch between different modes of activity and regulating many biological processes. (Desterro, Rodriguez, Hay. SUMO-1 modification of IkBa inhibits NF-kB activation. Mol Cell. 1998 2:233-9. 745 citations). My work has been cited 14,008 times and I have an h-index of 62 and an i10-index of 135\\
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1. Yin Y, Seifert A, Chua SJ, Maure J-F, Golebiowski F, Hay RT.  Sumo-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage Genes and Development 2012 26: 1st June issue\\
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2. Plechanovova A, Jaffray EG, McMahon SA, Johnson KA, Navratilova I, Naismith JH, Hay RT. Mechanism of ubiquitylation by dimeric RING ligase RNF4. Nature Structural and Molecular Biology 2011 18:1052-9\\
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3. Tatham MH, Matic I, Mann M, Hay RT. Comparative Proteomic Analysis Identifies a Role for SUMO in Protein Quality Control. Science Signaling. 2011 4: rs4.\\
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4. Bruderer R, Tatham MH, Plechanovova A, Matic I, Garg AK, Hay RT. Purification and identification of endogenous polySUMO conjugates. EMBO Reports. 2011 12:142-8.\\
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5. Golebiowski F, Matic I, Tatham MH, Cole C, Yin Y, Nakamura A, Cox J, Barton GJ,\\
Mann M, Hay RT. System-wide changes to SUMO modifications in response to heat\\
shock. Science Signaling. 2009 2:ra24.\\
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6. Tatham MH, Geoffroy MC, Shen L, Plechanovova A, Hattersley N, Jaffray EG, Palvimo JJ, Hay RT. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nature Cell Biology 2008 10:538-46. (220 citations).\\
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7. Shen L, Tatham MH, Dong C, Zagorska A, Naismith JH, Hay RT. SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nature Structural and Molecular Biology 2006 13:1069-77.\\
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8. Shen L, Liu H, Dong C, Xirodimas D, Naismith JH, Hay RT. Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme. NEDP1. EMBO Journal. 2005 24:1341-51.\\
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9. Tatham MH, Kim S, Jaffray E, Song J, Chen Y, Hay RT. Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection. Nature Structural and Molecular Biology 2005 12:67-74.\\
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10. Girdwood D, Bumpass D, Vaughan OA, Thain A, Anderson LA, Snowden AW, Garcia-Wilson E, Perkins ND, Hay RT. P300 transcriptional repression is mediated by SUMO modification. Molecular Cell. 2003 11:1043-54. (330 citations).