!!John Geddes - Selected Publications
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1. Taquet M, Geddes JR, Husain M, Luciano S, Harrison PJ. 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records. Lancet Psychiatry. 2021 May;8(5):416-427. doi: 10.1016/S2215-0366(21)00084-5.  (Scopus Dec 2022 638 citations)\\
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Large observational study using innovative methods and providing urgently needed evidence on CNS sequelae of COVID-19 infection\\
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2. Cipriani, A., Furukawa, T. A., Salanti, G., Chaimani, A., Atkinson, L. Z., Ogawa, Y., . . . Geddes, J. R. (2018). Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis.. Lancet, 391(10128), 1357-1366   (Scopus Dec 2022 1293 citations)\\
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Highly cited, influential and innovative sysnthesis of comparative evidence across currently available antidepressant drugs \\
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3. Geddes, J. R., Gardiner, A., Rendell, J., Voysey, M., Tunbridge, E., Hinds, C., . . . CEQUEL Investigators and Collaborators. (2016). Comparative evaluation of quetiapine plus lamotrigine combination versus quetiapine monotherapy (and folic acid versus placebo) in bipolar depression (CEQUEL): a 2 × 2 factorial randomised trial.. Lancet Psychiatry, 3(1), 31-39. (Scopus Dec 2022 62 citations)\\
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Innovative and successful trial providing much need evidence on lamotrigine - and unexpected potential negative interaction with folate\\
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4. Geddes, J. R., & Miklowitz, D. J. (2013). Bipolar Disorder  Treatment of bipolar disorder. The Lancet, 381(9878), 1672-1682. doi:10.1016/S0140-6736(13)60857-0 (Scopus Dec 2022  489 citations)\\
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Invited overview of current state of evidence \\
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5. McKnight, R. F., Adida, M., Budge, K., Stockton, S., Goodwin, G. M., & Geddes, J. R. (2012). Lithium toxicity profile: a systematic review and meta-analysis.. Lancet (London, England), 379(9817), 721-728. doi:10.1016/s0140-6736(11)61516-x (Scopus Dec 2022 559 citations)\\
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Huge synthesis of evidence concerning lithium toxicity \\
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6. Geddes JR, Goodwin GM, Rendell J, Azorin JM, Ostacher MJ, Morriss R, Alder N, Juszczak E for the BALANCE investigators and collaborators. Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial. Lancet,2010, 375, 385-395 (Scopus Dec 2022 402 citations)\\
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Largest long term 4 country (UK, France, Italy, US) trial comparing lithium and valproate alone and in combination \\
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7. Fazel, S., Khosla, V., Doll, H., & Geddes, J. (2008). The prevalence of mental disorders among the homeless in western countries: systematic review and meta-regression analysis.. PLoS medicine, 5(12), e225. doi:10.1371/journal.pmed.0050225 2  (Scopus Dec 2022 693 citations)\\
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Building on long term contribution to this neglected, highly disadvantaged group.  \\
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8.  Geddes J.R. et al for the UK ECT Review Group. (2003). Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis.. Lancet (London, England), 361(9360), 799-808. doi:10.1016/s0140-6736(03)12705-5 (Scopus Dec 2022 1196 citations)\\
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State of the art overview of evidence on ECT, highly cited internationally \\
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9.  Geddes, J. R., Carney, S. M., Davies, C., Furukawa, T. A., Kupfer, D. J., Frank, E., & Goodwin, G. M. (2003). Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review.. Lancet (London, England), 361(9358), 653-661. doi:10.1016/s0140-6736(03)12599-8 (Scopus Dec 2022 678 citations)\\
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Influential research synthesis yielding unexpectedly strong evidence for long term treatment with antidepressants \\
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10. Geddes, J., Freemantle, N., Harrison, P., & Bebbington, P. (2000). Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis.. BMJ (Clinical research ed.), 321(7273), 1371-1376. doi:10.1136/bmj.321.7273.1371 (Scopus Dec 2022 962 citations) \\
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Important research synthesis highlighting limitations of evidence for presumed superiority of atypical antipsychotics - used as key reference to make case for NIMH CATIE and NIHR CUTLASS trials\\ \\[{ALLOW view All}][{ALLOW edit jgeddes}][{ALLOW upload jgeddes}][{ALLOW comment All}]
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