!!Jonathan Flint - Publications
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__Major depression: the CONVERGE papers, molecular genetic findings__\\
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N. Cai, J. A. Revez, M. J. Adams, T. F. M. Andlauer, G. Breen, E. M. Byrne, T. K. Clarke, A. J. Forstner, H. J. Grabe, S. P. Hamilton, D. F. Levinson, C. M. Lewis, G. Lewis, N. G. Martin, Y. Milaneschi, O. Mors, B. Muller-Myhsok, B. Penninx, R. H. Perlis, G. Pistis, J. B. Potash, M. Preisig, J. Shi, J. W. Smoller, F. Streit, H. Tiemeier, R. Uher, S. Van der Auwera, A. Viktorin, M. M. Weissman, M. D. D. W. G. o. t. P. G. Consortium, K. S. Kendler, J. Flint. Minimal phenotyping yields genome-wide association signals of low specificity for major depression. Nat Genet 52, 437-447 (2020) PMC7906795\\
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CONVERGE Consortium  (Flint, J.)(2015) Sparse whole-genome sequencing identifies two loci for major depressive disorder. Nature 523, 588-591\\
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__Mouse genomes papers__\\
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Yalcin B, Wong K, Agam A, Goodson M, Keane TM, Gan X, Nellaker C, Goodstadt L, Nicod J, Bhomra A, Hernandez-Pliego P, Whitley H, Cleak J, Dutton R, Janowitz D, Mott R, Adams DJ, Flint J (2011) Sequence-based characterization of structural variation in the mouse genome. Nature 477, 326-329 \\
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Keane TM, Goodstadt L, Danecek P, White MA, Wong K, Yalcin B, Heger A, Agam A, Slater G, Goodson M, Furlotte NA, Eskin E, Nellaker C, Whitley H, Cleak J, Janowitz D, Hernandez-Pliego P, Edwards A, Belgard TG, Oliver PL, McIntyre RE, Bhomra A, Nicod J, Gan X, Yuan W, van der Weyden L, Steward CA, Bala S, Stalker J, Mott R, Durbin R, Jackson IJ, Czechanski A, Guerra-Assuncao JA, Donahue LR, Reinholdt LG, Payseur BA, Ponting CP, Birney E, Flint J, Adams DJ (2011) Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477, 289-294 \\
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__Using mouse resources to understand human genetic disease__\\
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Keays DA, Tian G, Poirier K, Huang GJ, Siebold C, Cleak J, Oliver PL, Fray M, Harvey RJ, Molnar Z, Pinon MC, Dear N, Valdar W, Brown SD, Davies KE, Rawlins JN, Cowan NJ, Nolan P, Chelly J, Flint J (2007) Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans. Cell 128, 45-57 \\
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Nicod, R. W. Davies, N. Cai, C. Hassett, L. Goodstadt, C. Cosgrove, B. K. Yee, V. Lionikaite, R. E. McIntyre, C. A. Remme, E. M. Lodder, J. S. Gregory, T. Hough, R. Joynson, H. Phelps, B. Nell, C. Rowe, J. Wood, A. Walling, N. Bopp, A. Bhomra, P. Hernandez-Pliego, J. Callebert, R. M. Aspden, N. P. Talbot, P. A. Robbins, M. Harrison, M. Fray, J. M. Launay, Y. M. Pinto, D. A. Blizard, C. R. Bezzina, D. J. Adams, P. Franken, T. Weaver, S. Wells, S. D. Brown, P. K. Potter, P. Klenerman, A. Lionikas, R. Mott, J. Flint. Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing. Nat Genet 48, 912-918 (2016). PMC4966644\\
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Mott R, Yuan W, Kaisaki P, Gan X, Cleak J, Edwards A, Baud A, Flint J (2014) The architecture of parent-of-origin effects in mice. Cell 156, 332-342 \\
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Baud A, Hermsen R, Guryev V, Stridh P, Graham D, McBride MW, Foroud T, Calderari S, Diez M, Ockinger J, Beyeen AD, Gillett A, Abdelmagid N, Guerreiro-Cacais AO, Jagodic M, Tuncel J, Norin U, Beattie E, Huynh N, Miller WH, Koller DL, Alam I, Falak S, Osborne-Pellegrin M, Martinez-Membrives E, Canete T, Blazquez G, Vicens-Costa E, Mont-Cardona C, Diaz-Moran S, Tobena A, Hummel O, Zelenika D, Saar K, Patone G, Bauerfeind A, Bihoreau MT, Heinig M, Lee YA, Rintisch C, Schulz H, Wheeler DA, Worley KC, Muzny DM, Gibbs RA, Lathrop M, Lansu N, Toonen P, Ruzius FP, de Bruijn E, Hauser H, Adams DJ, Keane T, Atanur SS, Aitman TJ, Flicek P, Malinauskas T, Jones EY, Ekman D, Lopez-Aumatell R, Dominiczak AF, Johannesson M, Holmdahl R, Olsson T, Gauguier D, Hubner N, Fernandez-Teruel A, Cuppen E, Mott R, Flint J (2013) Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nat Genet 45, 767-775 \\
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Valdar W, Solberg LC, Gauguier D, Burnett S, Klenerman P, Cookson WO, Taylor MS, Rawlins JN, Mott R, Flint J (2006) Genome-wide genetic association of complex traits in heterogeneous stock mice. Nat Genet 38, 879-887  \\
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Yalcin B, Willis-Owen SA, Fullerton J, Meesaq A, Deacon RM, Rawlins JN, Copley RR, Morris AP, Flint J, Mott R (2004) Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet 36, 1197-1202