!!Patrick Yizhi Cai - Curriculum Vitae
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__Career__
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*Aug 2017 - present Chair Professor of Synthetic Genomics, Dept. of Chemistry, The University of Manchester\\
*Mar 2017 - Jul, 2017 Reader, School of Biological Sciences, University of Edinburgh\\
*Jul 2013 - Jul, 2017 Chancellor’s Fellow, School of Biological Sciences, University of Edinburgh\\
*Jun 2010 - Jun, 2013 Postdoc Fellow with Autodesk Distinguished Scholarship, Johns Hopkins University
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__Education__
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*Jan 2007 - May 2010 Ph.D in Genetics, Bioinformatics and Computational Biology, Virginia Tech, USA\\
*Sep 2005 - Nov 2006 Master of Sciences, majored in Bioinformatics, University of Edinburgh, Edinburgh, UK\\
*Sep 2001 - Jun 2005  Bachelor of Engineering in Computer Sciences, Central South University, China\\
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__Other Managerial Positions__
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*Chair of Geneva Science and Diplomacy Anticipator, Synthetic Biology\\
*Committee Council member, Hong Kong Research Grant Council International Coordinator, International\\
*Synthetic Yeast Consortium Associate Editor, ACS Synthetic Biology Founding co-Director, Edinburgh Genome Foundry
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__Selected Honors and Awards:__
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*Distinguished visiting professorships from MIT (USA), LMB Cambridge & Wellcome Sanger Institute (UK), Hong Kong University and Chinese Academy of Sciences (China) \\
*ERC consolidator award \\
*EPSRC Open Plus Fellowship \\
* Wellcome Trust Frontier Innovator \\
*ICG11 Raising Star in Science \\
*Autodesk Distinguished Scholarship \\
*2023 KAUST Dean’s Distinguished Lecture \\
*The DeLill Nasser Award for Progressional Development, The Genetic Society of America
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__Selected Publications (total 89, with 11 in Science, Nature and Cell. H-index 37):__
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*James, J. S et al., “The design and engineering of synthetic genomes”. Nature Review Genetics. 2024 Nov 6. doi: 10.1038/s41576-024-00786-y. PMID: 39506144, (2024). \\
*S. A. Hoffmann, Y. Cai. “Engineering stringent genetic biocontainment of yeast with a protein stability switch”. Nature Communications, vol. 15, iss. 1060, (2024). \\
*D. Schindler, et al., “Design, Construction, and Functional Characterization of a tRNA Neochromosome in Yeast”. with Cover at Cell, vol. 186, iss. 24, pp. 5237–5253, 2023. \\
*Y. Shen et al., “Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast”. with Cover at Cell Genomics, vol. 3, iss. 11, no. 100364, 2023. \\
*Y. Zhao et al., “Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions”, with Cover at Cell, 2023, Nov 22;186(24):5220-5236.e16. \\
*Shen et al. , “A 770kb fully synthetic yeast chromosome II reveals genomic plasticity and robustness through deep functional profiling”, with Cover at Science. 2017 Mar 10;355(6329). pii: eaaf4791.
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__Selected Current Support (of total 15, £29.7M)__
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*Jan 2025 - Dec 2030, Wellcome Trust, “Synthetic Human Genome.” (£9.8M ), Role: co-PI \\
*Dec 2024 - Dec 2026, Chan Zuckerberg Initiative, “Mating-Inspired Methods for Synthetic Human Chromosomes.” ($1.37M ), Role: co-PI \\
*Jan 2024 - Dec 2028, ERC Consolidator Award, “Genome Refactoring and Engineering Approach to study non-coding genes driving Translation.” (€2M), Role: PI \\
*Oct 2022 - Sep 2027 , EPSRC, “Open Plus Fellowship: Engineering and safeguarding synthetic genomes.” (£1.64M ), Role: PI \\
*Feb 2024 - Aug 2025, BBSRC 23IPAP International Partnering Awards Plus on AI for Bioscience , “AI- assisted DBTL cycle for synthetic yeast promoters.” (£312K ), Role: PI\\ \\[{ALLOW view All}][{ALLOW edit pcai}][{ALLOW upload pcai}][{ALLOW comment All}]